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Cobalt oxide (Co 3 O 4 ), a transition metal oxide known for its favourable capacitive properties and surface characteristics, is a promising candidate for electrode materials in supercapacitive energy storage applications. This study presents a comprehensive analysis of cobalt oxide nanoparticles synthesized through the hydrothermal method at varying synthesis temperatures, focusing on their structural, optical, electrochemical, and surface properties. X-ray diffraction analysis confirmed the cubic spinel structure of Co 3 O 4 , while Raman spectroscopy verified the phase composition of the nanoparticles. X-ray photoelectron spectroscopy offered insights into the near-surface chemistry of the synthesized material. The study determined two direct bandgaps of Co 3 O 4 through absorption spectra and Tauc plots. To assess surface morphology and particle size distribution, field-emitting scanning electron microscopy and transmission electron microscopy were employed. Electrochemical investigations involved cyclic voltammetry and Nyquist plots, while galvanostatic charge–discharge tests demonstrated a specific capacitance ( C sp ) of 450 Fg −1 at 1 Ag −1 . Impedance analysis indicated favourable capacitive behaviour with low charge transfer resistance. Furthermore, the study observed cyclic stability with a capacitive retention rate exceeding 88% at a current density of 20 Ag −1 over 10,000 cycles. The paper also discusses the capacitive and diffusion-controlled charge storage mechanisms at lower scan rates, emphasizing the potential of Co 3 O 4 nanoparticles as the electrode material in the development of supercapacitor devices.

To develop and evaluate the effectiveness of a home based intervention in reducing caregiver burden, promoting caregiver mental health and reducing behavioural problems in elderly persons with dementia. This was a randomised controlled trial in which the person with dementia-caregiver dyad was randomly allocated either to receive the intervention immediately or to a waiting list group which received the intervention after 6 months. It was carried out in communities based in two talukas (administrative blocks) in Goa, India. Mild to moderate cases with dementia (diagnosed using the DSM IV criteria and graded using the Clinical Dementia Rating scale) and their caregivers were included in the trial. Community based intervention provided by a team consisting of Home Care Advisors who were supervised by a counselor and a psychiatrist, focusing on supporting the caregiver through information on dementia, guidance on behaviour management, a single psychiatric assessment and psychotropic medication if needed. We measured caregiver mental health (General Health Questionnaire), caregiver burden (Zarit Burden Score), distress due to behavioural disturbances (NPI-D), behavioural problems in the subject (NPI-S) and activities of daily living in the elder with dementia (EASI). Outcome evaluations were masked to the allocation status. We analysed each outcome with a mixed effects model. 81 families enrolled in the trial; 41 were randomly allocated to the intervention. 59 completed the trial and 18 died during the trial. The intervention led to a significant reduction of GHQ (-1.12, 95% CI -2.07 to -0.17) and NPI-D scores (-1.96, 95%CI -3.51 to -0.41) and non-significant reductions in the ZBS, EASI and NPI-S scores. We also observed a non-significant reduction in the total number of deaths in people with dementia in the intervention arm (OR 0.34, 95% CI 0.01 to 1.03). Home based support for caregivers of persons with dementia, which emphasizes the use of locally available, low-cost human resources, is feasible, acceptable and leads to significant improvements in caregiver mental health and burden of caring. ClinicalTrials.gov NCT00479271.

In our present study we focus on characterizing copper oxide (CuO) thin films synthesized at various substrate temperatures and to assess the electrochemical performance of the optimized sample. The spray pyrolysis method was used to fabricate CuO thin film samples, with the substrate temperatures ranging from 250 to 400 °C. The coatings underwent characterization through different analytical techniques, including X-ray diffraction, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, field emission scanning electron microscopy, Raman spectroscopy, and Hall effect measurements. All the thin film samples were confirmed to have a monoclinic phase. The presence of Cu=O was confirmed by Raman spectroscopy. All the samples exhibited P type conductivity except the one synthesized at 400 °C. Galvanostatic charge–discharge studies revealed a pseudocapacitive nature for the optimized sample synthesized at 350 °C. The symmetrical charging and discharging curves imply excellent material reversibility, indicating long-term cyclic stability. The Nyquist plot exhibited a semicircle at high frequencies, representing the material’s intrinsic resistance and a linear behavior at low frequencies, depicting the ion transfer resistance. The electrode demonstrated favorable electrochemical properties and potential use of the material in supercapacitor applications.

ABSTRACT Background: There are more than 5 million people with dementia in India. Multicentre studies looking at details of treatment for people with dementia In India are lacking. Clinical audit is a quality improvement process which aims to systematically assess, evaluate, and improve patient care. Evaluating current practice is the key to a clinical audit cycle. Aim: This study aimed to assess the diagnostic patterns and prescribing practices of psychiatrists for patients with dementia in India. Method: A retrospective case file study was conducted across several centers in India. Results: Information from the case records of 586 patients with dementia was obtained. Mean age of the patients was 71.14 years (standard deviation = 9.42). Three hundred twenty one (54.8%) were men. Alzheimer's disease (349; 59.6%) was the most frequent diagnosis followed by vascular dementia (117; 20%). Three hundred fifty five (60.6%) patients had medical disorders and 47.4% patients were taking medications for their medical conditions. Eighty one (69.2%) patients with vascular dementia had cardiovascular problems. Majority of the patients (524; 89.4%) were on medications for dementia. Most frequently prescribed treatment was Donepezil (230; 39.2%) followed by Donepezil-Memantine combination (225; 38.4%). Overall, 380 (64.8%) patients were on antipsychotics. Quetiapine (213, 36.3%) was the most frequently used antipsychotic. Overall, 113 (19.3%) patients were on antidepressants, 80 (13.7%) patients were on sedatives/hypnotics, and 16 (2.7%) patients were on mood stabilizers. Three hundred nineteen (55.4%) patients and caregivers of 374 (65%) patients were receiving psychosocial interventions. Conclusions: Diagnostic and prescription patterns in dementia which emerged from this study are comparable to other studies both nationally and internationally. Comparing current practices at individual and national levels against accepted guidelines, obtaining feedback, identifying gaps and instituting remedial measures help to improve the standard of care provided.

Misophonia is characterized by an autonomic response (e.g., increased heart rate) that is elicited by certain innocuous or repetitive sounds, and individuals with misophonia may display an extreme, overt response commonly associated with rage, hatred, and a loss of self-control. In this investigation, we used a combined respondent and operant approach to treat problem behavior evoked by bodily sounds (i.e., coughing, sneezing, sniffling, and clearing throat) for an adult with autism spectrum disorder. The intervention produced immediate reductions of problem behavior and the effects of treatment maintained during progressively lean schedules of reinforcement. The results of this study will be discussed in light of past research, along with limitations, and future directions for research and clinical practice.

Indium Sulfide (In2S3) is a promising candidate to replace Cadmium Sulfide (CdS) as a buffer layer in thin film solar cells because of its n-type conductivity and wide energy band gap. In this study, In2S3 thin films are deposited on glass substrates at different substrate temperatures in the range of 200–350 °C by co-evaporation technique. The X-ray diffraction and Raman analysis confirm the formation of tetragonal β-In2S3 thin films. The X-ray Photoelectron Spectroscopy and Energy Dispersive X-ray Spectroscopy results reveal presence of constituent elements. The energy band gap was observed in the range of 2.45–2.54 eV and band gap is increasing with increase of substrate temperature. Hall Effect measurement shows n-type conductivity for all films. Photodetectors were fabricated and tested under the light illumination by solar simulator with AM 1.5G filter. The photo detection parameters like sensitivity, responsivity and detectivity were calculated for all photodetectors.

Though \"Reversible\" causes are less frequent, they carry good prognosis with prompt treatment of the underlying condition. [...]the evaluation for all potentially reversible conditions which cause dementia syndrome is the first most important step in the assessment of dementia syndrome and this is essential in all cases presenting with features of dmentia. Specification of features for possible subtypes. Because of the possibility that subtypes exist, it is recommended that the following characteristics be ascertained as a basis for a further classification: age at onset; rate of progression; the configuration of the clinical features, particularly the relative prominence (or lack) of temporal, parietal or frontal lobe signs; any neuropathological or neurochemical abnormalities, and their pattern. Unequal distribution of deficits in higher cognitive functions, with some affected and others relatively spared. [...]memory may be quite markedly affected while thinking, reasoning and information processing may show only mild decline. [...]there has been very active global effort to develop effective disease modifying drug for Alzheimer's disease in the past decade.

Electronic health records (EHRs) are increasingly replacing traditional paper-based medical records due to their speed, security, and ability to eliminate redundant data. However, challenges such as EHR interoperability and privacy concerns remain unresolved. Blockchain, a distributed ledger technology comprising connected, encrypted data blocks, presents a promising solution. This study explores how blockchain technology can revolutionize hospital EHR management. Our proposed solution securely transfers medical records between patients and doctors using the InterPlanetary File System (IPFS) and the Ethereum platform. Utilizing smart contracts automates data transfers, ensuring patient anonymity and reducing computational complexity while securely storing patient data on the network. Patient records are stored locally on the Ganache server, with the front end managed using HTML, CSS, ReactJS, and JavaScript, and the backend developed in Solidity. Blockchain technologies combined with Role- Based access control instead of attribute -based access control. The system’s throughput increases linearly with the number of users and requests, enhancing the framework’s efficiency and scalability. The minimum recorded latency is 14 ms.

Dementia is emerging as an important health problem of elderly people in India. To investigate the prevalence, psychosocial correlates and risk factors of various dementing disorders in an urban population in Kerala, southern India. A door-to-door survey was conducted in the city of Kochi (Cochin) to identify residents aged > or =65 years using cluster sampling. Of 1934 people screened with a vernacular adaptation of the Mini-Mental State Examination, all those scoring at or below the cut-off of 23 were evaluated further and those with confirmed cognitive and functional impairment were assigned diagnoses according to DSM-IV criteria. Identified cases were categorised by ICD-10 criteria. Ten per cent of those screened as negative were evaluated at each stage. Prevalence of dementia was 33.6 per 1000 (95% CI 27.3-40.7). Alzheimer's disease was the most common type (54%) followed by vascular dementia (39%), and 7% of cases were due to causes such as infection, tumour and trauma. Family history of dementia was a risk factor for Alzheimer's disease and history of hypertension was a risk factor for vascular dementia. Dementia is an important health problem of the elderly population. Identification of risk factors points towards the possibility of prevention.

IntroductionIn low/middle-income countries (LMICs), the prevalence of people diagnosed with dementia is expected to increase substantially and treatment options are limited, with acetylcholinesterase inhibitors not used as frequently as in high-income countries (HICs). Cognitive stimulation therapy (CST) is a group-based, brief, non-pharmacological intervention for people with dementia that significantly improves cognition and quality of life in clinical trials and is cost-effective in HIC. However, its implementation in other countries is less researched. This protocol describes CST-International; an implementation research study of CST. The aim of this research is to develop, test, refine and disseminate implementation strategies for CST for people with mild to moderate dementia in three LMICs: Brazil (upper middle-income), India (lower middle-income) and Tanzania (low-income).Methods and analysisFour overlapping phases: (1) exploration of barriers to implementation in each country using meetings with stakeholders, including clinicians, policymakers, people with dementia and their families; (2) development of implementation plans for each country; (3) evaluation of implementation plans using a study of CST in each country (n=50, total n=150). Outcomes will include adherence, attendance, acceptability and attrition, agreed parameters of success, outcomes (cognition, quality of life, activities of daily living) and cost/affordability; (4) refinement and dissemination of implementation strategies, enabling ongoing pathways to practice which address barriers and facilitators to implementation.Ethics and disseminationEthical approval has been granted for each country. There are no documented adverse effects associated with CST and data held will be in accordance with relevant legislation. Train the trainer models will be developed to increase CST provision in each country and policymakers/governmental bodies will be continually engaged with to aid successful implementation. Findings will be disseminated at conferences, in peer-reviewed articles and newsletters, in collaboration with Alzheimer’s Disease International, and via ongoing engagement with key policymakers.