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The Visceral Adiposity Index (VAI) assesses visceral fat and related metabolic risks. However, its precise correlation with sarcopenia is unclear. This study aimed to examine this correlation. A cross-sectional analysis was conducted using NHANES data from 2011 to 2018. To correct VAI skewness, a logarithmic transformation was applied. Multiple covariates were included, and logistic regression was employed to explore the relationship between VAI and sarcopenia. Restricted cubic spline (RCS) and threshold saturation analyses were used to investigate the nonlinear relationship. Subgroup analyses evaluated the effects of various stratification factors. Sensitivity and additive analyses tested the robustness of the findings. The study included 4688 individuals. Participants with sarcopenia had significantly higher VAI values. Logistic regression revealed a significant positive connection between Log VAI and sarcopenia (OR 2.09, 95% CI 1.80–2.43) after adjusting for variables. RCS analysis showed a nonlinear correlation, identifying a breakpoint at VAI = 1.51. To the left of this breakpoint, each unit increase in VAI significantly correlated with a higher likelihood of sarcopenia (OR 2.54, 95% CI 1.74–3.79); to the right, increases in VAI did not significantly affect prevalence. Subgroup analyses suggested VAI as an independent risk factor. Sensitivity and additive analyses confirmed the main findings’ robustness. Among American adults, the VAI is significantly associated with sarcopenia, with higher VAI values potentially increasing the prevalence of sarcopenia. Monitoring VAI is critical for early identification of high-risk individuals and interventions to delay or minimize the onset and progression of sarcopenia.

The emergence of Homo sapiens in Eastern Asia is a topic of significant research interest. However, well-preserved human fossils in secure, dateable contexts in this region are extremely rare, and often the subject of intense debate owing to stratigraphic and geochronological problems. Tongtianyan cave, in Liujiang District of Liuzhou City, southern China is one of the most important fossils finds of H. sapiens , though its age has been debated, with chronometric dates ranging from the late Middle Pleistocene to the early Late Pleistocene. Here we provide new age estimates and revised provenience information for the Liujiang human fossils, which represent one of the most complete fossil skeletons of H. sapiens in China. U-series dating on the human fossils and radiocarbon and optically stimulated luminescence dating on the fossil-bearing sediments provided ages ranging from ~33,000 to 23,000 years ago (ka). The revised age estimates correspond with the dates of other human fossils in northern China, at Tianyuan Cave (~40.8–38.1 ka) and Zhoukoudian Upper Cave (39.0–36.3 ka), indicating the geographically widespread presence of H. sapiens across Eastern Asia in the Late Pleistocene, which is significant for better understanding human dispersals and adaptations in the region. Here the authors provide new radiocarbon, U-series, and OSL dates for Homo sapiens fossils from Tongtianyan cave, southern China, placing them at 33-23 thousand years ago and indicating widespread presence of Homo sapiens across eastern Asia in the Late Pleistocene.

The detailed anatomy of Termination I (TI) is well depicted, but whether changes across Termination II (TII) resemble TI remains controversial. Here we present high-resolution Asian monsoon records covering TII using Shima Cave stalagmites from China. Correlating marine and ice-core records to our U/Th-dated records via millennial-scale variabilities, we find an initial CO 2 rise from 139 ± 1 ka BP concordant with boreal summer insolation increase, which was followed by a major rise phase of CO 2 between 135.7 ± 1 and 129 ± 1 ka BP. The major rise phases of CO 2 were comparable during TI and TII, but the initial CO 2 rise before TII was distinct from CO 2 behavior before TI, likely forced by the Earth’s internal variabilities, in particular an ice-sheet collapse event and a 50% reduction in southern hemisphere dust flux. Here, we show that ~4000–5000-year-long gradual changes in CO 2 , along with insolation rise, preconditioned glacial terminations, supporting the “tipping point” theory. U/Th-dated Asian monsoon records from Shima Cave, covering 142–122 ka BP, constrain the timing of a CO 2 rise at ~139 ka BP caused by millennial-scale variabilities, which, along with increasing orbital solar radiation, prepare for the end of ice age.

North African coastal Middle Stone Age (MSA) sites are key to study the development and expansion of early H . sapiens . El Mnasra cave on the Atlantic coast of Morocco (Témara region) is a crucial site associated with MSA archaeological materials considered advanced cognitive hallmarks of behavioural innovation, such as numerous Nassariidae perforated shells, hematite pigments, bones industry and coastal resources exploitation. We provide new trapped-charges dates (OSL and combined US-ESR ages). Our Bayesian modelling strengthens the new lithostratigraphic interpretation of the cave stratigraphic units (US) and we propose an updated chronostratigraphic model for the Middle Stone Age archaeo-sequence of El Mnasra Cave. We confirm a human presence between 124–104 ka, earlier than what the previous OSL and US-ESR data showed. Our time range intervals allowed us to also extend the age of the MSA occupations considerably to the MIS 4/3 (~62–30 ka), marked by the disappearance of the Nassariidae perforated shells. Outstandingly, our model pushed back the age of the largest record of Nassariidae perforated shells and placed the age of their use by the Aterian groups at El Mnasra from the MIS 5d-5b (~115–94 ka).

The Mauer mandible, holotype of Homo heidelbergensis, was found in 1907 in fluvial sands deposited by the Neckar River 10 km southeast of Heidelberg, Germany. The fossil is an important key to understanding early human occupation of Europe north of the Alps. Given the associated mammal fauna and the geological context, the find layer has been placed in the early Middle Pleistocene, but confirmatory chronometric evidence has hitherto been missing. Here we show that two independent techniques, the combined electron spin resonance/U-series method used with mammal teeth and infrared radiofluorescence applied to sand grains, date the type-site of Homo heidelbergensis at Mauer to 609 ± 40 ka. This result demonstrates that the mandible is the oldest hominin fossil reported to date from central and northern Europe and raises questions concerning the phyletic relationship of Homo heidelbergensis to more ancient populations documented from southern Europe and in Africa. We address the paleoanthropological significance of the Mauer jaw in light of this dating evidence.

The isotopic records of two 230Th-dated stalagmites from Longfugong Cave, Mt. Shennongjia, central China, reveal a highly resolved Asian summer monsoon (ASM) history from 29.5 to 14.5 ka BP. The two δ18O records are consistent with other Chinese cave δ18O records, suggesting that our new records are of regional significance. Due to the reservoir mixing of seepage water in the epikarst system, the stalagmite δ18O signals in this cave are more severely muted than those in other caves. Here, we observed that the amplitude of the δ13C variability is approximately twice that of the δ18O signal and can be used as a sensitive proxy of East Asian monsoon climates. First, the two stalagmite δ13C records are consistent with each other on decadal to centennial timescales. Second, there are high correlation coefficients between the δ13C and δ18O signals over shorter timescales. Third, from 25.2 to 19.6 ka BP, six peaks in the δ13C records were identified and are coincident with corresponding warming events in the Greenland ice-core δ18O records, suggesting that strong coupling occurred between the high- and low-latitude northern climates on centennial timescales. Therefore, we propose that atmospheric transmission mechanisms probably played an important role in linking the ASM and Greenland climates on short timescales. A shift in westerly winds associated with variability in the extent of temperature in the North Atlantic likely influenced changes in hydrological and thermal conditions at the cave site, leading to changes in vegetation cover and soil CO2 concentrations above the cave. Therefore, the calcite δ13C records probably had faster and more sensitive responses to rapid climate shifts compared with their related δ18O records.

To date, in Africa, evidence for animal processing and consumption in caves routinely used as living spaces is only documented in the late Middle Pleistocene of the North and South of the continent and postdates the Middle Pleistocene in East Africa. Here we report the earliest evidence in a North-African cave (Grotte des Rhinocéros at Casablanca, Morocco) of cut, percussion and human gnawing marks on faunal remains directly associated with lithic knapping activities in the same space and in a well-documented stratified context. Ages for this Acheulean site are provided by the dating of herbivorous teeth to 690–720 ka and 520–550 ka (lower and upper sets) by combined Electron Spin Resonance (ESR) and U-series techniques. Traces of butchery on gazelle, alcelaphin, and zebra bones demonstrate that hominins had primary access to herbivore carcasses. Hominins brought and consumed meat in the cave, as documented by herbivore bones bearing human tooth marks concentrated in a circumscribed area of the excavation. In Africa, this site provides the earliest evidence for in situ carcass processing and meat-eating in cave, directly associated with lithic production and demonstrates the recurrent use by early Middle Pleistocene hominins of a North African cave site 400 000 years before that by Homo sapiens at Jebel Irhoud (Morocco).

Objectives Currently, there are various surgical options for the treatment of lateral ankle sprains, and deciding which surgical option to use is a question worth considering. Furthermore, there is a relative scarcity of mechanical research comparing suture anchor repair (SAR) and suture tape augmentation (STA) internal brace for the repair of the anterior talofibular ligament (ATFL). Therefore, this study aimed to compare the efficacy of arthroscopically all‐inside ATFL SAR and STA for reconstruction to treat lateral ankle sprains through biomechanical testing. Methods Eighteen fresh‐frozen cadaver ankles were used for the study and divided into one of three groups: (1) intact ATFL group, (2) arthroscopically reconstructed with suture tape augmentation internal brace of the ATFL (STA group), and (3) arthroscopically repaired ATFL with suture anchors (SAR group). We used custom fixtures to test the specimens for loading to ultimate failure and stiffness. Results The mean load to failure of the STA group (311.20 ± 52.56 N) was significantly higher than that of the intact ATFL group (157.37 ± 63.87 N; p = 0.0016) and the SAR group (165.27 ± 66.81 N; p = 0.0025). The mean stiffness of the STA group (30.10 ± 5.10 N/mm) was significantly higher than that of the intact ATFL (14.17 ± 6.35 N/mm; p = 0.0012) and the SAR group (15.15 ± 6.89 N/mm; p = 0.0021). The suture anchor repair withstood failure loads and stiffness similar to the intact ATFL. Conclusions In terms of failure load and stiffness, the reconstructive outcome of ATFL reconstruction with STA is markedly superior to that of SAR reconstruction of the ATFL and the intact ATFL. Additionally, the novel technique of the SAR was a reliable technique that offered biomechanical properties similar to intact ATFL. This biomechanical study compared the efficacy of suture tape augmentation versus suture anchor repair in the reconstruction of the anterior talofibular ligament (ATFL). The study demonstrated that suture tape augmentation achieved superior reconstructive outcomes compared to suture anchor repair and the intact ATFL. Furthermore, both suture tape augmentation and suture anchor repair for ATFL reconstruction exhibited good biomechanical properties.

Osteoarthritis (OA) is increasingly recognized as a whole‐organ disease predominantly affecting the elderly, characterized by typical alterations in subchondral bone and cartilage, along with recurrent synovial inflammation. Despite the availability of various therapeutics and medications, a complete resolution of OA remains elusive. In this study, novel functional hydrogels are developed by integrating natural bioactive molecules for OA treatment. Specifically, baicalin (Bai) is combined with 2‐hydroxyethyl acrylate (HEA) to form a polymerizable monomer (HEA‐Bai) through esterification, which is subjected to reversible addition‐fragmentation chain transfer (RAFT) polymerization to produce Bai‐based polymer (Pm). These macromolecules are incorporated into Schiff‐base hydrogels, which demonstrate excellent mechanical properties and self‐healing performance. Notably, the Bai‐based formulations are taken up by fibroblast‐like synoviocytes (FLSs), where they regulate glycolysis. Mechanistically, inhibition of yes‐associated protein 1 (YAP1) by the formulations suppressed the FLSs glycolysis and reduced the secretion of inflammatory factors, including interleukin 1β (IL‐1β), IL‐6, and IL‐8. Furthermore, the functional hydrogel (AG‐Pm)‐OC, severing as a lubricant and nutrient, prolonged joint retention of Bai, thereby reducing cartilage degradation and synovial inflammation. Meanwhile, (AG‐Pm)‐OC alleviated joint pain by targeting the YAP1 signaling and inhibiting macrophage recruitment and polarization. Taken together, this flavonoid‐based injectable hydrogel exhibits enhanced biocompatibility and efficacy against OA. This study reveals that novel baicalin (Bai) macromolecules based on esterification and reversible addition‐fragmentation chain transfer (RAFT) polymerization alleviate osteoarthritis (OA) progression by integrated into dynamic crosslinked networks. The formulations target the YAP1 signaling and inhibit macrophage polarization, effectively suppressing the glycolysis of fibroblast‐like synoviocytes (FLSs) and reducing the secretion of inflammatory factors, thereby decreasing cartilage degradation and synovial inflammation.

The study of geomagnetic excursions is key for understanding the behavior of the magnetic field of the Earth. In this paper, we present the geomagnetic record in a 2.29-m-long continuous core sampled in a flowstone in Liguria (Italy) and dated to the Lower Brunhes. The cored flowstone developed from Marine Isotopic Stage (MIS) 13 to MIS 7, according to 21 U-series dates. The mean growth rate is closely related to glacial and interglacial isotopic stages. Magnetic remanence was measured using u-channel and deconvolved. Four geomagnetic excursions were recorded at the same location, in a single flowstone, during interglacial MIS 11 and 13; Basura 1, 2, 3 and 4, at depths of 213 cm, 181, 160 and 92 cm, respectively. Due to the uncertainties of U-Th dating, the timing of the three events, namely Basura 1, 2 and 3 overlaps. The Basura 4 is well-dated to 417 + −7/8 ka and is clearly distinguishable from the others. It should therefore be considered as a possible excursion.