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The fashion industry is the second most polluting industry, contributing 8% of all carbon emissions and 20% of all global wastewater, with an anticipated 50% increase in greenhouse gas emissions by 2030. To gain a better understanding of the state of the academic literature on the environmental impacts of the fast fashion industry, we systematically identified 65 publications from 1996 to November 2021 that were subjected to (i) bibliometric, (ii) text, and (iii) content analysis. We found that there is a growing research interest surrounding fast fashion and water quality, with 74% of the articles published in the last 5 years, and the majority of publications and citations are from China and European countries. We summarise the evaluation of production processes, such as carbon and water footprints, along with recycling practices aimed to increase the sustainability of the fashion industry. Circular economy, social environmental responsibility, and sustainability governance are key areas for future research in this growing field.

The vast diversity of microbial communities reside in various locations of the human body, and they are collectively named as the ‘Human Microbiota.’ The majority of those microbes are found in the gastrointestinal and respiratory tracts. The microorganisms present in the gastrointestinal and the respiratory tracts are called the gut microbiota and the airway microbiota, respectively. These microbial communities are known to affect both the metabolic functions and the immune responses of the host. Among multiple factors determining the composition of gut microbiota, diet has played a pivotal role. The gut microbes possess enzymatic machinery for assimilating dietary fibers and releasing different metabolites, primarily short-chain fatty acids (SCFAs). The SCFAs modulate the immune responses of not only the gut but other distal mucosal sites as well, such as the lungs. Dysbiosis in normal gut flora is one of the factors involved in the development of asthma and other respiratory disorders. Of note, several human and murine studies have indicated significant cross-talk between gut microbiota and lung immunity, known as the gut–lung axis. Here, in this review, we summarize the recent state of the field concerning the effect of dietary metabolites, particularly SCFAs, on the “gut–lung axis” as well as discuss its impact on lung health. Moreover, we have highlighted the role of the “gut–lung axis” in SARS-CoV-2 mediated inflammation. Also, to analyze the global research progress on the gut–lung axis and to identify the knowledge gap in this field, we have also utilized the bibliographic tools Dimension database and VOS viewer analysis software. Through network mapping and visualization analysis, we can predict the present research trend and the possibility to explore new directions.

Objectives: Diabetes mellitus is a chronic disease requiring lifelong medical attention. With hundreds of millions suffering worldwide and a rapidly rising incidence, diabetes mellitus poses a great burden on health care systems. Recent studies investigating the underlying mechanisms involved in disease development in diabetes point to the role of the dysregulation of the intestinal barrier. Hyperglycemia-mediated tight junction deformity is known to contribute to leaky gut in various metabolic disorders. The present study aimed to investigate the role of oxidative stress on intestinal epithelial tight junction (TJ) barrier functions in hyperglycemia. Because many flavonoids are known to influence the cellular redox state, exploring these flavonoids may help to understand the role of TJ barrier in hyperglycemia-mediated oxidative stress, which in turn might unfold the association of oxidative stress and dysfunction of barrier-forming TJs. Methods: Caco-2 cells were stimulated with high glucose (HG), with or without flavonoids (quercetin, morin, naringenin), for 24 h. We determined cellular viability, levels of reactive oxygen species, and mitochondrial membrane potential in flavonoids treated HG-Caco-2 cells. The levels of the proinflammatory cytokines, glucose uptake, and expression of glucose transporters were determined on flavonoids treatment. We investigated the effect of flavonoids on TJs functions by measuring transepithelial electrical resistance (a TJ integrity marker), membrane permeability using tracer compounds, and the expressions levels of TJs related molecules on hyperglycemic Caco-2 cell monolayers. Results: We found that high glucose treatment resulted in reduced cell viability, increased reactive oxygen species production, measurable mitochondrial dysfunction, and decreased transepithelial electrical resistance, with increased membrane permeability. Treatment with the test flavonoids produced increased cell viability and reduced glucose uptake of HG-Caco-2 cells. A concomitant decrease in reactive oxygen species production, proinflammatory cytokines, and Glut-associated genes and proteins were identified with flavonoid treatment. Flavonoids prevented derangement of TJs protein interaction and stabilized membrane permeability. Conclusions: These findings indicate that flavonoids confer protection against hyperglycemia-mediated oxidative stress and enhance intestinal barrier functions by modulating underlying intracellular molecular mechanisms. •Quercetin, morin, and naringenin modulate hyperglycemia-induced oxidative stress.•Flavonoids reduced glucose uptake and regulated GLUT expression levels in HG-Caco-2 cells.•Flavonoids promoted membrane integrity and limited permeability in HG-Caco-2 cells.•Flavonoids enhanced the expression levels of TJ-associated proteins in HG-Caco-2 cells.

IntroductionParkinson’s disease (PD) is managed primarily by dopamine agonists and physiotherapy while virtual reality (VR) has emerged recently as a complementary method. The present study reviewed the effectiveness of VR in rehabilitation of patients with PD.MethodsLiterature search up to June 2019 identified ten studies (n = 343 participants) suitable for meta-analysis and 27 studies (n = 688 participants) for systematic review. Standard mean difference (SMD) and 95% confidence intervals (CI) were calculated using a random effects model.ResultsIn meta-analysis, compared with active rehabilitation intervention, VR training led to greater improvement of stride length, SMD = 0.70 (95%CI = 0.32–1.08, p = 0.0003), and was as effective for gait speed, balance and co-ordination, cognitive function and mental health, quality of life and activities of daily living. Compared with passive rehabilitation intervention, VR had greater effects on balance: SMD = 1.02 (95%CI = 0.38–1.65, p = 0.002). Results from single randomised controlled trials showed that VR training was better than passive rehabilitation intervention for improving gait speed SMD = 1.43 (95%CI = 0.51–2.34, p = 0.002), stride length SMD = 1.27 (95%CI = 0.38–2.16, p = 0.005) and activities of daily living SMD = 0.96 (95%CI = 0.02–1.89). Systematic review showed that VR training significantly (p < 0.05) improved motor function, balance and co-ordination, cognitive function and mental health, and quality of life and activities of daily living.ConclusionVR used in rehabilitation for patients with PD improves a number of outcomes and may be considered for routine use in rehabilitation.

Forensic entomology is a branch of science that uses insects as evidence in medicolegal investigations as they could provide valuable information regarding the cause and time since death specially in the case of buried bodies. The present study was the first attempt in India to compare the decomposition and associated insects on pig carcasses above the ground and those buried at two different depths (40 and 80 cm) during spring season over two consecutive years. Two pigs were buried at each depth and one pig carcass was placed above the ground. One of the buried carcasses was exhumed frequently and other one was kept undisturbed to investigate the decomposition rate and insect access to the carcass. The rate of decomposition was found to be faster above the ground as compared to the buried environment. Also, the carcass buried at 80 cm depth exhibited slower decomposition rates and had limited insect activity as compared to the one buried at 40 cm. Species within the Calliphoridae and Sarcophagidae families were dominant on the surface-exposed carcass, whereas Phoridae were more prevalent on the buried carcasses even at a depth of 80 cm. The findings of the study highlights the significant influence of burial depth and exhumation on decomposition rate and insect arrival and colonization.

Ice provides a range of ecosystem services—including fish harvest1, cultural traditions2, transportation3, recreation4 and regulation of the hydrological cycle5—to more than half of the world’s 117 million lakes. One of the earliest observed impacts of climatic warming has been the loss of freshwater ice6, with corresponding climatic and ecological consequences7. However, while trends in ice cover phenology have been widely documented2,6,8,9, a comprehensive large-scale assessment of lake ice loss is absent. Here, using observations from 513 lakes around the Northern Hemisphere, we identify lakes vulnerable to ice-free winters. Our analyses reveal the importance of air temperature, lake depth, elevation and shoreline complexity in governing ice cover. We estimate that 14,800 lakes currently experience intermittent winter ice cover, increasing to 35,300 and 230,400 at 2 and 8 °C, respectively, and impacting up to 394 and 656 million people. Our study illustrates that an extensive loss of lake ice will occur within the next generation, stressing the importance of climate mitigation strategies to preserve ecosystem structure and function, as well as local winter cultural heritage.Up to 35,000 lakes in the Northern Hemisphere may be at risk of intermittent winter ice cover at 2 °C warming, reveals an observation-based study. This would affect 394 million people reliant on lake ice for ecosystem services.

Pinostrobin (PN) is a naturally occurring dietary bioflavonoid, found in various medicinal herbs/plants. Though anti-cancer potential of many such similar constituents has been demonstrated, critical biochemical targets and exact mechanism for their apoptosis-inducing actions have not been fully elucidated. The present study was aimed to investigate if PN induced apoptosis in cervical cancer cells (HeLa) of human origin. It is demonstrated that PN at increasing dose effectivity reduced the cell viability as well as GSH and NO2- levels. Condensed nuclei with fragmented chromatin and changes in mitochondrial matrix morphology clearly indicated the role of mitochondria in PN induced apoptosis. A marked reduction in mitochondrial membrane potential and increased ROS production after PN treatment showed involvement of free radicals, which in turn further augment ROS levels. PN treatment resulted in DNA damage, which could have been triggered by an increase in ROS levels. Decrease in apoptotic cells in the presence of caspase 3 inhibitor in PN-treated cells suggested that PN induced apoptosis via caspase dependent pathways. Additionally, a significant increase in the expression of proteins of extrinsic (TRAIL R1/DR4, TRAIL R2/DR5, TNF RI/TNFRSF1A, FADD, Fas/TNFRSF6) and intrinsic pathway (Bad, Bax, HTRA2/Omi, SMAC/Diablo, cytochrome C, Pro-Caspase-3, Cleaved Caspase-3) was observed in the cells exposed to PN. Taken together, these observations suggest that PN efficiently induces apoptosis through ROS mediated extrinsic and intrinsic dependent signaling pathways, as well as ROS mediated mitochondrial damage in HeLa cells.

Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that Syrian hamsters, in contrast to mice, are highly permissive to SARS-CoV-2 and develop bronchopneumonia and strong inflammatory responses in the lungs with neutrophil infiltration and edema, further confirmed as consolidations visualized by micro-CT alike in clinical practice. Moreover, we identify an exuberant innate immune response as key player in pathogenesis, in which STAT2 signaling plays a dual role, driving severe lung injury on the one hand, yet restricting systemic virus dissemination on the other. Our results reveal the importance of STAT2-dependent interferon responses in the pathogenesis and virus control during SARS-CoV-2 infection and may help rationalizing new strategies for the treatment of COVID-19 patients. SARS-CoV-2 infection can result in severe lung inflammation and pathology, but host response remains incompletely understood. Here the authors show in Syrian hamsters that STAT2 signaling restricts systemic virus dissemination but also drives severe lung injury, playing a dual role in SARS-CoV-2 infection.

South Asian diaspora comprise one of the largest ethnic minority groups in the world yet data about atrial fibrillation (AF) in this demographic is understudied. Our aim is to identify differences in AF prevalence and treatment between South Asians and white British stroke patients. The UK arm of a prospective ongoing large international repository on stroke was analysed. Ethnic differences in AF prevalence and management in those with ischemic stroke were analysed. Of the 3515 individuals recruited with ischemic stroke, 1482 (men: 972, women: 510) were South Asian and 2033 (men:1141, women:892) of white British ethnicity. AF was present in 462 white British and 193 South Asians stroke patients, with South Asians displaying a lower prevalence of AF (South Asians: 13.0% vs white British 22.7%, P<0.001). Despite adjustment for traditional AF risk factors, South Asians had a significantly lower OR of AF compared to white British stroke patients (OR: 0.40, 95%CI: 0.33:0.49, P<0.001). Among confirmed AF cases, 31.8% of South Asians and 41.4% of white British were untreated at admission (P = 0.02). Antiplatelet treatment was significantly higher among South Asians at both admission (South Asian: 47.4% vs. white British: 29.9%, P<0.001) and discharge (South Asian: 49.5% vs. white British: 34.7%, P = 0.001), although anticoagulation treatment was similar across both ethnic groups at admission (South Asian: 28.5% vs white British: 28.1%, P = 0.93), and discharge (South Asian: 45.1% vs white British: 43.1%, P = 0.64). Stroke patients of South Asian descent are at significantly lower risk of AF but more likely to be on antiplatelet treatment compared to their white British counterparts.

Lake ice is an important socio-economic resource that is threatened by climate change. The cover and duration of lake ice are expected to decline as air temperatures warm in the coming decades, disrupting a previously reliable source of income for many activities dependent on lake ice. The economic consequences of climate-induced lake ice loss remain unexplored, creating a significant research gap. The purpose of this study was to quantify the monetary spending associated with lake ice and how climate change may impact that value. Using a series of General Circulation Models (GCMs), greenhouse gas emissions scenarios, and models for lake ice cover, we predicted changes in lake ice by the end of the 21st century for the Northern Hemisphere. We also synthesized examples of spending associated with lake ice activities and discussed the potential implications expected with declining ice cover. We found that lake ice will decrease in area by 44,000–177,000 km 2 and shorten in duration by 13–43 days by 2100. Using 31 examples of revenue from lake ice, we found that lake ice generates spending of over USD 2.04 billion to local communities and economies. We also found that countries predicted to experience the greatest ice loss by the end of the century are those that currently have the largest GDP, highest greenhouse gas emissions, and are most dependent on freshwater withdrawal. Our findings confirm predicted losses in lake ice that are expected because of climate change and quantify some of the potential consequences for local communities. Here we highlight lake ice as another casualty of human-caused climate change that will have profound socio-economic implications.