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Drug use is highly concordant among members of adolescent and young adult peer groups. One potential explanation for this observation is that drugs may increase the reinforcing effects of social contact, leading to greater motivation to establish and maintain contact with other members of the peer group. Several classes of drugs, particularly drugs that increase synaptic dopamine, increase the reinforcing effects of contextual stimuli, but the extent to which these drugs enhance the reinforcing effects of social contact is not known. The purpose of this study was to determine the extent to which drugs that increase synaptic dopamine, norepinephrine, and serotonin enhance the positive reinforcing effects of social contact. To this end, male and female Long-Evans rats were pretreated with acute doses of the selective dopamine reuptake inhibitor, WIN-35,428, the selective norepinephrine reuptake inhibitor, atomoxetine, the selective serotonin reuptake inhibitor, fluoxetine, the nonselective monoamine reuptake inhibitor, cocaine, and the nonselective monoamine releasers d-amphetamine and (±)-MDMA. Ten minutes later, the positive reinforcing effects of 30-s access to a same-sex social partner was examined on a progressive ratio schedule of reinforcement. To determine whether the reinforcement-altering effects of these drugs were specific to the social stimulus, the reinforcing effects of a nonsocial stimulus (30-s access to an athletic sock of similar size and coloring as another rat) was determined in control subjects. WIN-35,428, d-amphetamine, and cocaine, but not atomoxetine, fluoxetine, or MDMA, dose-dependently increased breakpoints maintained by a social partner under conditions in which responding maintained by a nonsocial stimulus was not affected. These data indicate that increases in extracellular dopamine, but not extracellular norepinephrine or serotonin, increases the positive reinforcing effects of social contact in both male and female rats. These data also provide support for the hypothesis that some drugs with high abuse liability increase the motivation to establish and maintain contact with social peers.

RationalePrevious studies have shown that gonadal hormones influence opioid self-administration in female rodents, but very few studies have examined these effects in male rodents. ObjectivesThe purpose of this study was to examine the effects of chronic hormone treatment on intravenous heroin self-administration in gonadectomized male rats using both physiological and supraphysiological doses of testosterone, estradiol, or progesterone.MethodsGonadectomized male rats were surgically implanted with intravenous catheters and trained to self-administer heroin on a fixed ratio (FR1) schedule of reinforcement. Using a between-subjects design, rats were treated daily with testosterone (0.175 or 1.75 mg, sc), estradiol (0.0005 or 0.005 mg, sc), progesterone, (0.0125 or 0.125 mg, sc), or their vehicles. After 14 days of chronic treatment, a dose–effect curve was determined for heroin (0.0003—0.03 mg/kg/infusion) over the course of one week. ResultsNeither testosterone nor estradiol altered responding maintained by heroin. In contrast, the high dose of progesterone (0.125 mg) reduced responding maintained by all doses of heroin to saline-control levels. This dose of progesterone did not reduce responding maintained by food on a progressive ratio schedule in either food-restricted or food-sated rats.ConclusionsThese data indicate that exogenous progesterone or a pharmacologically active metabolite selectively decreases heroin intake in male rodents, which may have therapeutic implications for men with opioid use disorder.

Drug-using peers are recognized as a leading factor influencing drug use among adolescents and young adults. One mechanism by which peers influence drug use is by providing social reinforcement for using drugs. Social reinforcement may be provided in multiple ways, including by making social contact contingent on drug use (i.e., an individual must use drugs to gain/maintain access to a peer). The purpose of this study was to develop a preclinical model in which intravenous cocaine self-administration was positively reinforced by access to a social partner. Young adult male rats were trained to self-administer cocaine in operant conditioning chambers with a guillotine door that could be opened to an adjacent compartment housing either a social partner or a non-social stimulus. Once cocaine self-administration was established, the guillotine door was activated, and cocaine intake was reinforced by brief access to either a social (age- and sex-matched peer) or non-social (black-and-white athletic sock) stimulus. Contingent access to a social partner rapidly increased cocaine self-administration. Total cocaine intake was 2- to 3-fold greater in rats assigned to the social versus non-social condition across a 100-fold dose range. Cocaine intake rapidly increased when rats in the original non-social group were later provided with social partners, whereas cocaine intake resisted change and remained elevated when rats in the original social group had their partners removed. These data indicate that contingent access to a social partner increases drug intake and suggest that social reinforcement may represent a vulnerability factor that is particularly resistant to psychosocial interventions.

Boredom coping strategies were incorporated with control-value theory variables of control, value, boredom and academic performance to test an integrated model of the antecedents and effects of boredom experienced while studying among university students. A diverse sample of 177 Australian university students with a mean age of 29.64 years (SD = 10.03 years) completed an online survey for the study. Independently, students’ lower appraisals of value and control for their course of study were associated with higher experiences of boredom. Additionally, a conditional process analysis revealed dually moderated mediation where the interaction of control and value appraisals negatively predicted experience of boredom while studying, and the combination of higher boredom and a high tendency for behavioural avoidance coping was subsequently linked to lower academic performance. Practical implications for students and universities are discussed, as well as suggestions about future research to further extend our understanding in these important areas of research.

RationaleHeroin intake decreases during the proestrus phase of the estrous cycle in female rats. Circulating concentrations of both estradiol and progesterone peak during proestrus, and it is not known which of these hormones, or their combination, are responsible for these effects.ObjectivesThe purpose of this study was to determine the effects of estradiol, progesterone, and their combination on heroin self-administration in female rats.MethodsIn Experiment 1, the estrous cycle of intact female rats was tracked daily. If a rat was in proestrus, either the estrogen receptor antagonist, raloxifene, the progesterone receptor antagonist, mifepristone, or their combination was administered 30 min prior to a heroin self-administration session. In Experiment 2, separate groups of ovariectomized female rats were treated chronically with exogenous estradiol, progesterone, estradiol + progesterone, or vehicle, and heroin intake was examined over a 100-fold dose range.ResultsIn Experiment 1, raloxifene, but not mifepristone, significantly blocked proestrus-associated decreases in heroin intake. In Experiment 2, estrogentreated rats self-administered less heroin than any other group and significantly less heroin than rats treated with progesterone.ConclusionsThese data suggest that (1) estradiol but not progesterone is responsible for proestrus-associated decreases in heroin intake and (2) estradiol decreases heroin intake relative to progesterone. These data differ from those reported previously with stimulants and suggest that estrogen-based pharmacotherapies may be of value to women with opioid use disorder.

A review of literature from the past 30 years establishes psychological distress as both a longstanding and current issue affecting university students worldwide. Poorer academic outcomes and problematic health behaviours are linked to students’ distress, and these wider implications also highlight the need for appropriate policies and services to support students during what is clearly a challenging time. Further review identified various socio-demographic, situational and academic factors as potential bases of students’ distress. Undoubtedly, the demands of the university lifestyle are inherently stressful; yet experiencing these as distressing is not inevitable. Rather, a review of links between university students’ psychological attributes and psychological distress indicates such attributes might be ideal points of intervention to ensure students are best equipped to manage the stressors of university, and greater attention in this area is recommended.

Background. Men diagnosed with localized prostate cancer (LPC) often face a dilemma in choosing between available treatment options that have similar survival rates but for which the perceived advantages and disadvantages of each treatment differ. The Navigate decision aid was created to assist Australian men with LPC in making informed decisions about treatment that align with their personal values and preferences. Navigate presents current, unbiased information, including an interactive values clarification exercise. Objective. This study was a qualitative investigation of men’s treatment decision making for LPC, and their experiences using the Navigate Web site, to identify areas for improvement and inform implementation. Methods. Semi-structured interviews were conducted with 20 men diagnosed with LPC who completed the intervention arm of the Navigate randomized controlled trial. Interview transcripts were thematically analyzed. Results: Five main themes emerged: 1) diagnosis experiences varied, although men were strongly influenced by their clinician to make an early initial treatment decision; 2) men sought resources and support they trusted; 3) men valued Navigate’s multiformatted content and design; 4) men suggested more content was needed on a) the diagnosis journey and b) new treatment updates; and 5) men identified design flaws in the values clarification exercise on Navigate but appreciated the tool being available. Conclusions. Specialist authority influenced men to make an early treatment decision. However, Navigate was helpful in supporting men’s ongoing treatment decision making, particularly men on active surveillance who may face further treatment decisions if their cancer progresses. To gain trust and improve engagement from Navigate users, credentials and sources of information need to be prominent. Trustworthiness, timing of access, and the clinician’s role in empowering men to use available decision aids are crucial elements to be considered when implementing Navigate in clinical settings. Highlights The Navigate decision aid Web site was created to help Australian men diagnosed with localized prostate cancer (LPC) make an informed decision about their treatment. Navigate was helpful in supporting men’s ongoing treatment decision making for LPC. Men’s treatment decision making for LPC was greatly influenced by perceived authority and trust in their clinician. Trustworthiness, timing of access, and the clinician’s role in empowering men to use available decision aids are crucial. Graphical Abstract This is a visual representation of the abstract.

Researchers in the fields of neuroscience and psychology have written about belonging for over seven decades. Much has been written about the concept of belonging and one thing is clear – humans have a need to belong to a group. Each of us has a need to be seen, valued, and respected. When that need is unmet, our health and well-being are negatively impacted. This research study was designed to learn more about belonging in the workplace. Specifically, the study hoped to learn more about the relationship between workplace belonging and employee race, employee well-being, organizational identification, and loneliness. Using a mixed-methods approach, this research study found that employee sense of belonging is positively correlated with employee well-being and organizational identification. While a relationship between employee race and belonging was not identified, respondents did express a strong desire for more racial diversity in their workplaces. Of note, participants defined belonging as the need to be valued for one’s authentic self and having the safety to express themselves. This study provides a framework of sorts for organizational actors working to create a deeper sense of belonging within their organizations.

Current research in serial pattern learning suggests parallel processing in acquisition and retention of structured serial patterns but the effects of interference and spaced practice had not yet been assessed. Interference impairs acquisition and retention of serial pattern elements, while spacing practice improves acquisition. Previous work has demonstrated that structured elements and elements that violate structure are learned concurrently through different mechanisms. While data suggest that the presence of a violation element does not interfere with acquisition of structured elements, little work has been done to evaluate how a violation element affects retention of structured elements. In order to assess the effects of interference on retention, rats were trained to criterion on one of two serial patterns: a pattern that contained two types of structured elements (chunk-boundary and within-chunk elements) or a pattern that contained structured elements with an added violation element. Rats were then tested for retention of both structured elements at 24-hour, 2-, 4-week retention intervals. The presence of the violation element impaired retention of chunk-boundary elements without affecting retention of within-chunk elements. A third experiment assessed how spacing practice over longer periods of time affected acquisition of the violation element in male and female rats. Spaced practice improved acquisition of the violation element relative to massed practice in only female rats. These studies demonstrated that acquisition, while resistant to interference, is improved by spaced training. Additionally, Experiments 1 and 2 found that retention for different types of elements are differentially susceptible to interference. The present studies provide further support for parallel processing in serial pattern learning and that separate processes are differentially impacted by interference and spaced practice.