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"Sheff, David"
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Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes
Phosphatidylserine (PS) is a relatively minor constituent of biological membranes. Despite its low abundance, PS in the plasma membrane (PM) plays key roles in various phenomena such as the coagulation cascade, clearance of apoptotic cells, and recruitment of signaling molecules. PS also localizes in endocytic organelles, but how this relates to its cellular functions remains unknown. Here we report that PS is essential for retrograde membrane traffic at recycling endosomes (REs). PS was most concentrated in REs among intracellular organelles, and evectin-2 (evt-2), a protein of previously unknown function, was targeted to REs by the binding of its pleckstrin homology (PH) domain to PS. X-ray analysis supported the specificity of the binding of PS to the PH domain. Depletion of evt-2 or masking of intracellular PS suppressed membrane traffic from REs to the Golgi. These findings uncover the molecular basis that controls the RE-to-Golgi transport and identify a unique PH domain that specifically recognizes PS but not polyphosphoinositides.
Journal Article
High : everything you want to know about drugs, alcohol, and addiction
With drug education for children more important than ever, this book draws on the experiences of a \"New York Times\"-bestselling father-son team to provide all the information teens and tweens need to know about drugs, alcohol, and addiction.
Book
Playboy Interview
People still approach him on the street and ask for his autograph (they don’t get it—he hands them a preprinted card instead). They plead with him to do the shtick they remember from his many appearances onThe Tonight ShowandSaturday Night Live.
Steve Martin refuses. Long gone are his days onstage in his trademark white suit with a fake arrow sticking through his head. The new Steve Martin plays an evangelist, an architect, a producer, or a sentimental dad in hit Hollywood movies. The wild and crazy Steve Martin has given way to the mature and sedate
Book Chapter
Golgi biogenesis in Toxoplasma gondii
Two models have been put forward to explain the growth of new Golgi during the cell cycle. The first suggests that a new Golgi grows out of the endoplasmic reticulum by de novo synthesis. The second suggests that a pre-existing Golgi is needed for the growth of a new one, that is, the Golgi is an autonomously replicating organelle. To resolve this issue, we have exploited the simplicity of the apicomplexan parasite Toxoplasma gondii, which has only a single Golgi stack. Here we show, by using video fluorescence microscopy and three-dimensional reconstructions of serial thin sections, that the Golgi grows by a process of lateral extension followed by medial fission. Further fission leads to the inheritance by each daughter of a pair of Golgi structures, which then coalesce to re-form a single Golgi. Our results indicate that new Golgi grow by autonomous duplication and raise the possibility that the Golgi is a paired structure that is analogous to centrioles.
Journal Article
THE DOCTOR WILL SAVE YOU NOW
Gallifrey's most famous son offers enjoyment to millions, his intelligent and compassionate approach to crises is a welcome relief in a violent, cynical world. David Sheff takes a trip on board the Tardis. Destination? Anywhere...
Journal Article
