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Objective The purpose of this review was to collate evidence on the prognostic ability of the geriatric nutritional risk index (GNRI) for predicting overall survival (OS) and disease-free survival (DFS) in non-small cell lung cancer (NSCLC). Methods The datasets of PubMed, Scopus, Embase, CENTRAL, and Google Scholar were searched up to 24 May 2022 for English-language studies reporting the association between GNRI and OS or DFS in NSCLC patients. Results Eleven studies with 2865 patients were included. We noted that low GNRI was a significant predictor of poor OS (HR: 1.96 95% CI 1.66, 2.30 I 2  = 0% p  < 0.00001) and poor DFS (HR: 1.74 95% CI: 1.36, 2.23 I 2  = 34% p  < 0.0001) in NSCLC patients. The results did not change on sensitivity analysis. There was no evidence of publication bias. Most results were significant on subgroup analysis based on study location, tumor stage, therapy type, sample size, and GNRI cut-off. Conclusion Data indicate that GNRI has good prognostic ability in patients with NSCLC. Individuals with low GNRI are at an increased risk of poor OS and DFS. GNRI could be incorporated as a simple, easy-to-use tool for the initial stratification of patients thereby allowing focused treatment plans.

Background Fistulas have puzzled us all the time and stem cell therapy for it is still in its infancy. We conducted a meta-analysis and systematic review to evaluate the efficacy of stem cells and its potential mechanisms in the management of Crohn’s fistula. Methods Electronic databases were searched comprehensively for studies reporting the efficacy and safety of stem cells in patients with any form of Crohn’s fistula. A random-effects model was used, and all outcomes were calculated by SPSS 24.0. Results Twenty-nine articles with 1252 patients were included. It showed that stem cell group had a higher rate of fistula healing compared to placebo group in patients of Crohn’s fistula (61.75% vs 40.46%, OR 2.21, 95% CI 1.19 to 4.11, P < 0 . 05 ). 3 × 10 7 cells/mL stem cell (SC) group had an advantage in fistula healing rate with 71.0% compared to other doses group of stem cells (RR 1.3, 95% CI 0.76 to 2.22). And the healing rates of patients with perianal and transsphincteric fistulas (77.95%, 76.41%) were higher than those with rectovaginal fistulas. It was an amazing phenomenon that CDAI and PDAI scores occurred an obviously transient rise with the use of stem cells after 1 month (both of P < 0 . 05 ), while they returned to the baseline level by giving stem cells 3 months later. Furthermore, the incidence rate of treatment-related adverse events in the stem cell group was significantly lower than in the placebo group (RR 0.58, 95% CI 0.30 to 1.14). Conclusions Our study has highlighted that stem cells was a promising method in the treatment of Crohn’s fistula based on its higher efficacy and lower incidence of adverse events, especially ADSCs and Cx601. While it also needs more clinical and pre-clinical studies to strengthen evidences in the future.

Background Surgery is the optimal choice for early invasive mucinous lung adenocarcinoma (IMA). A systematic review and meta-analysis were conducted to explore the prognostic factors for resected IMA. Methods We systematically reviewed the prognostic role of clinicopathological and genomic factors in resected IMA patients. Eligible studies on the treatment of IMA following the systematic search of PubMed, Embase and the Cochrane Library from January 2015 to January 2024 were identified. Outcomes of interest were overall survival (OS) and disease-free survival/recurrence-free survival (DFS/RFS). The hazard ratio (HR) and 95% confidence interval (CI) were used as impact indicators for systematic review and meta-analysis. Results Sixteen studies involving 3,484 patients with IMA were included. The results of the combined analysis showed that male and smoking were associated with a worse prognosis. Furthermore, advanced clinical stage, poor differentiation grade, presence of visceral pleural invasion (VPI) and spread through air spaces (STAS), and presence of KRAS mutations were also associated with worse prognosis. Conclusions Gender, smoking, clinical stage, tumor size, differentiation grading, VPI, STAS and KRAS mutation affect DFS/RFS and OS of IMA patients after surgery. Identifying these factors may aid physicians in developing more individualized treatment plans for resectable IMA patients.

High-velocity reentry objects suffer from plasma sheath during reentry through the atmosphere, which affects the propagation characteristics of radar signals. The existing research mainly focuses on the time-frequency characteristics of radar signals, neglecting the polarization within the geomagnetic environment. In this article, the distortion of polarization characteristics for L-band fully polarimetric radar is analyzed, and the influence of the geomagnetic field is evaluated. Based on the Appleton–Hartree formula, the refractive index of the plasma sheath considering the geomagnetic field is derived and analyzed. The error model for the polarization deflection (PD) of radar waves is then established based on the phase screen model. The magnetized plasma sheath causes the deflection of the polarization plane for the radar signal, leading to distortion in the polarization characteristics and the attenuation of the echo amplitude. Considering the typical parameters of the plasma sheath, the influences of the electron density, collision frequency, the geomagnetic field and the radar frequency are analyzed quantitatively. Specifically, the PD anomaly phenomenon is analyzed and the corresponding analytical result of radar frequency is also derived. The relationship between the geomagnetic field and the PD, as well as the attenuation, is considered to be approximately linear. The absorption attenuation is primarily influenced by collision frequency and is immune to the geomagnetic field. In addition, the increasing electron density expands them, whereas the radar frequency and the collision frequency have the opposite effect. Simulations with real SAR data from ALOS-2 demonstrate the distortions resulting from the magnetized plasma sheath on the radar echoes in an L-band fully polarimetric radar system.

Ralstonia solanacearum is an important bacterial pathogen that can infect a broad range of plants worldwide. A previous study showed that R. solanacearum could respond to exogenous organic acids or amino acids to modulate cell motility. However, it was unclear whether R. solanacearum uses these compounds to control infection. In this study, we found that R. solanacearum GMI1000 uses host plant metabolites to enhance the biosynthesis of virulence factors. We demonstrated that l‐glutamic acid from host plants is the key active component associated with increased extracellular polysaccharide production, cellulase activity, swimming motility, and biofilm formation in R. solanacearum GMI1000. In addition, l‐glutamic acid also promoted colonization of R. solanacearum cells in the roots and stems of tomato plants and accelerated disease incidence. Furthermore, genetic screening and biochemical analysis suggested that RS01577, a hybrid sensor histidine kinase/response regulator, is involved in l‐glutamic acid signalling in R. solanacearum. Mutations in RS01577 and exogenous addition of l‐glutamic acid to the GMI1000 wild‐type strain had overlapping effects on both the transcriptome and biological functions of R. solanacearum, including on motility, biofilm formation, and virulence. Thus, our results have established a new interaction mechanism between R. solanacearum and host plants that highlights the complexity of the virulence regulation mechanism and may provide new insight into disease control. Ralstonia solanacearum perceives l‐glutamic acid from host plants to enhance extracellular polysaccharide production, cellulase activity, swimming motility, biofilm formation, and virulence.

Introduction Comprehensive information about the genome analysis and its prognostic values of NSCLC patients in Chinese population are still needed. Patients A total of 117 Chinese patients with NSCLC were enrolled in this study. Tumor tissues or blood were collected and sequenced by targeted next-generation sequencing of 556 cancer related genes. The associations between clinical outcomes and clinical characteristics, TMB, mutated genes, treatment therapies were analyzed using Kaplan-Meier methods and further evaluated using multivariable Cox proportional hazards regression model. Results A total of 899 mutations were identified by targeted NGS. The most frequently mutations included EGFR (47%), TP53 (46%), KRAS (18%), LRP1B (12%) and SPTA1 (10%). Patients with mutant TP53 , PREX2 , ARID1A , PTPRT and PIK3CG had lower median overall survival (OS) than those patients with wild-type ( P  = 0.0056, P  < 0.001, P  < 0.0001, P  < 0.0001 and P  = 0.036, respectively). Using a multivariate Cox regression model, PREX2 ( P  < 0.001), ARID1A ( P  < 0.001) and PIK3CG ( P  = 0.04) were independent prognostic factors in NSCLC. In the patients received chemotherapy, squamous patients had a significantly longer median OS than adenocarcinoma patients ( P  = 0.011). In the patients received targeted therapy, adenocarcinoma patients had a significantly longer survival period than squamous patients ( P  = 0.01). Conclusions Our study provided comprehensive genomic alterations in a cohort of Chinese NSCLC. We also identified new prognostic biomarkers, which could provide potential clues for targeted therapies.

Pyroptosis has been implicated in the pathophysiology of myocardial infarction (MI) in rodents, but its contribution to reperfusion injury in MI patients is unclear. Here, we evaluated pyroptosis in MI patients in vitro and in vivo models of myocardial ischemia/reperfusion (I/R) injury. We also investigated the molecular mechanisms that regulate pyroptosis and myocardial I/R injury in these in vitro and in vivo models. The study showed that MI patients exhibited elevated serum concentrations of the pyroptosis-related pro-inflammatory cytokines IL-1β and IL-18. Increased levels of IL-1β and IL-18 as well as the pyroptosis-related inflammatory caspases (caspase-1 and 11) were detected in cultured cardiomyocytes after anoxia/reoxygenation (A/R) and in cardiac tissues after I/R. Circ-NNT and USP46 were upregulated while miR-33a-5p was downregulated in MI patients, as well as in cultured cardiomyocytes after A/R and cardiac tissues after I/R. Circ-NNT or USP46 knockdown or miR-33a-5p overexpression inhibited the expression of pro-caspase-1, cleaved caspase-1, pro-caspase-11, cleaved caspase-11, IL-1β, and IL-18 in A/R cardiomyocytes and attenuated myocardial infarction in I/R mice. The results from luciferase reporter assays and gene overexpression/knockdown studies indicated that miR-33a-5p directly targets USP46, and circ-NNT regulates USP46 by acting as a miR-33a-5p sponge. Direct association between circ-NNT and miR-33a-5p in cardiomyocytes was confirmed by pull-down assays. In summary, pyroptosis is activated during myocardial I/R and contributes to reperfusion injury. Circ-NNT promotes pyroptosis and myocardial I/R injury by acting as a miR-33a-5p sponge to regulate USP46. This circ-NNT→miR-33a-5p→USP46 signaling axis may serve as a potential target for the development of cardio-protective agents to improve the clinical outcome of reperfusion therapy.

This article systematically reviews ferroptosis—an iron-dependent, lipid peroxidation-driven form of programmed cell death. It provides a detailed analysis of its core regulatory mechanisms, encompassing the drive from lipid peroxidation, the collapse of antioxidant defenses such as the glutathione peroxidase 4( GPX4 )axis and alternative pathways like Ferroptosis Suppressor Protein 1 ( FSP1 ), and the remodeling of iron and lipid metabolism. The interplay between ferroptosis and other cell death modalities, such as apoptosis and necroptosis, is also elucidated. The review focuses on the pivotal roles of key signaling pathways, including NRF2, p53, and Hippo-YAP , within the ferroptosis regulatory network. In the context of cancer therapy, the article emphasizes the potential of inducing ferroptosis for reversing drug resistance, inhibiting metastasis, and synergizing with immunotherapy. It systematically outlines direct induction strategies (e.g., small-molecule inducers, nanodelivery systems) and combination strategies with conventional therapies, targeted therapy, and immunotherapy. This review highlights that the bidirectional interplay between ferroptosis and the tumor immune microenvironment constitutes a novel therapeutic paradigm for combination therapy. Specifically, it elucidates how ferroptosis modulates immune cells such as CD8 + T cells and macrophages, reshaping the tumor immune microenvironment and offering new avenues for combination immunotherapy. We conclude by providing a roadmap for translating these insights into clinical practice, addressing current challenges, and outlining future directions for developing next-generation anticancer strategies.

To investigate type 2 diabetes self-management behaviors and glycemic control under the impacts of COVID-19 legacy and Diabetes Prevention and Control Action, and explore the heterogeneous impacts of five self-management activities on glycemic control and how these impacts differ across key groups. A cross-sectional survey was conducted between April and September 2023 in hospitals and communities in China. Overall, 1817 adults with type 2 diabetes and normal cognitive and behavioral capacities completed a questionnaire regarding diabetes self-management behaviors and glycemic control. Ordinary least squares regression analyses were conducted. Mean score of overall self-management behaviors was 5.89. About 26.86% reported good glycemic control. Among five self-management activities, medication adherence was the best (mean = 6.77) but glucose-monitoring adherence was the worst (mean = 5.18). Overall self-management behaviors and the five activities (coefficient = 0.031-0.146, all p < 0.001) all exerted positive impacts on glycemic control, with dietary control showing the greatest impact while medication adherence the least. Younger persons, rural persons, and persons with financial difficulties were key groups benefiting less from self-management. Diabetes self-management behaviors and glycemic control were suboptimal. Customized health promotions should focus on key groups and addressing the deficiencies in self-management activities especially dietary control.

In this paper, a one-dimensional (1-D) range profile of the hypersonic target enveloped by a plasma sheath is investigated. Firstly, the non-uniform property of the plasma sheath is studied and its impact on the wideband electromagnetic (EM) wave is analyzed. A wideband radar echo model for the plasma-sheath-enveloped hypersonic target is constructed. Then, by exploiting the relationship among the incident depth, reflection intensity, and plasma velocity, it reveals that distinct scatter points in various areas of the target will suffer from varying reflection intensity and coupled velocity, leading to severe defocusing in the range profile. To tackle this issue, a novel focusing algorithm combing the Fractional Fourier Transform (FRFT) with the CLEAN technique is developed, which independently calculates the coupled plasma velocity and compensates for the phase error via a series of iterative procedures. Finally, the influence of the plasma sheath on the 1-D range profile and the effectiveness of the proposed focusing algorithm are validated through simulations.