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A newly proposed low-noise and high temporal resolution X-ray imaging detector based on the curved solenoid design is described in this paper. Three-dimensional models are developed in CST Particle Studio (CST-PS) to systematically investigate the temporal and spatial magnifications. The effects of the ramp rate of the modulation signal between the photocathode and the acceleration mesh, the different electron emission positions of the photocathode, the magnetic field strength, and the distance between the microchannel plate (MCP) and the curved solenoid outlet on the overall performance of the whole structure are studied, which shows that the electron emission position has a dominant effect over the temporal transit and temporal dispersion. Additionally, the temporal magnification factor increases with the ramp rate of the modulated signal. Within the effective photocathode of 16 mm, the temporal magnification factor exceeds 13. Furthermore, the spatial magnification is linearly proportional to the distance between the MCP and the solenoid outlet, suggesting that MCPs of varying sizes can be effectively coupled.

Streak Tube Imaging Lidar (STIL), with advantages of non-scanning working mode, small distortion, high image framing rate, high resolution in low contrast environment, compact structure, easy miniaturization and high reliability, has a wide range of applications in military, aerospace, space confrontation, attack and defense, and marine law enforcement. This article introduces the principle of single-slit and multi-slit streak tube imaging lidar. It also introduces a single-slit general streak camera that can be used for imaging lidar. In addition, a multi-slit miniaturized streak tube with a single-lens focusing system with a total length of about 200 mm has been designed. The results of the 3D electromagnetic simulation show that the effective photocathode area of this streak tube reaches 36 mm × 36 mm, the temporal resolution is better than 50 ps, the dynamic spatial resolution can reach 12 lp/mm, and the whole photocathode can accommodate at least 19 slits in the effective detection range. The streak tube has a meshless structure, which is highly reliable. The streak tube can be used to increase the field of view of the imaging lidar system, improve the reliability, and achieve system miniaturization.

Streak tubes with large-format and high spatial resolution are central to mm-spatial-resolved STIL detection system and hyperspectral resolved ICF experiment. In this paper, we established a large-format streak tube with a three-coaxial-cylindrical single-lens focusing system, a spherically curved photocathode and phosphor screen model in CST Particle Studio. The temporal and spatial resolution were calculated and mimicked based on the Monte-Carlo sampling method in static and dynamic mode. The simulated results show that the static spatial resolution reaches 50 lp/mm over the whole 50 mm effective photocathode length, and the physical temporal resolution is better than 45 ps. Furthermore, in dynamic working mode, the streak tube can achieve spatial resolution of 10 lp/mm and temporal resolution of 60 ps. The simulation results will be used to guide the design and production for large-format with high spatial resolution streak tube development.

The electron collection efficiency ( ) of the photomultiplier tube based on microchannel plates (MCP-PMT) is limited by the MCP open area fraction. Coating MCP with a high secondary yield material is supposed to be an effective approach to improve . Both typical and coated MCP-PMTs are developed. A relative measurement method is proposed to characterize the collection efficiency performance. Results show that the PMT based on the coated MCPs has a significant improvement on , a good gain uniformity and a high precise energy resolution.

The streak tubes are widely used in National Ignition Facility (NIF), Inertial Confinement Fusion (ICF), and streak tube imaging lidar (STIL) as radiation or imaging detectors. The spatial resolution and effective photocathode area of the streak tube are strongly dependent on its operating and geometry parameters (electron optical structure and applied voltage). Studies about this dependence do not cover the full range of the parameters. In this paper, 3-D models are developed in Computer Simulation Technology Particle Studio (CST-PS) to comprehensively calculate the spatial resolution for various parameters. Monte Carlo Sampling method (M-C method) and spatial modulation transfer function method (SMTF) are employed in our simulation. Simulated results of the optimized spatial resolution are validated by the experimental data. Finally, the radii of the photocathode ( ) and phosphor screen ( ) are optimized. Geometry parameters of =60 mm and =80 mm are proposed to optimize the streak tube performances. Simulation and experimental results show that the spatial resolution and effective photocathode area of this streak tube are expected to reach 16 lp/mm and 30 mm-length while the voltage between cathode and grid ( ) is 150 V.

Aiming at the characteristics of large capacity and high energy density energy storage equipment on the market, a liquid cooled battery management system suitable for high voltage energy storage systems was designed. The overall protection level of the system is IP65. The cooling method adopts liquid cooling heat dissipation, which is common with the overall energy storage system. Compared with traditional air cooling heat dissipation, it has the advantages of high cooling efficiency, low noise and fast cooling speed.

Sulforaphane (SFN), a compound derived from cruciferous vegetables that has been shown to be safe and nontoxic, with minimal/no side effects, has been extensively studied due to its numerous bioactivities, such as anticancer and antioxidant activities. SFN exerts its anticancer effects by modulating key signaling pathways and genes involved in the induction of apoptosis, cell cycle arrest, and inhibition of angiogenesis. SFN also upregulates a series of cytoprotective genes by activating nuclear factor erythroid-2- (NF-E2-) related factor 2 (Nrf2), a critical transcription factor activated in response to oxidative stress; Nrf2 activation is also involved in the cancer-preventive effects of SFN. Accumulating evidence supports that epigenetic modification is an important factor in carcinogenesis and cancer progression, as epigenetic alterations often contribute to the inhibition of tumor-suppressor genes and the activation of oncogenes, which enables cells to acquire cancer-promoting properties. Studies on the mechanisms underlying the anticancer effects of SFN have shown that SFN can reverse such epigenetic alterations in cancers by targeting DNA methyltransferases (DNMTs), histone deacetyltransferases (HDACs), and noncoding RNAs. Therefore, in this review, we will discuss the anticancer activities of SFN and its mechanisms, with a particular emphasis on epigenetic modifications, including epigenetic reactivation of Nrf2.

Background High-order chromatin structure plays important roles in gene regulation. However, the diversity of the three-dimensional (3D) genome across plant accessions are seldom reported. Results Here, we perform the pan-3D genome analysis using Hi-C sequencing data from 27 soybean accessions and comprehensively investigate the relationships between 3D genomic variations and structural variations (SVs) as well as gene expression. We find that intersection regions between A/B compartments largely contribute to compartment divergence. Topologically associating domain (TAD) boundaries in A compartments exhibit significantly higher density compared to those in B compartments. Pan-3D genome analysis shows that core TAD boundaries have the highest transcription start site (TSS) density and lowest GC content and repeat percentage. Further investigation shows that non-long terminal repeat (non-LTR) retrotransposons play important roles in maintaining TAD boundaries, while Gypsy elements and satellite repeats are associated with private TAD boundaries. Moreover, presence and absence variation (PAV) is found to be the major contributor to 3D genome variations. Nevertheless, approximately 55% of 3D genome variations are not associated with obvious genetic variations, and half of them affect the flanking gene expression. In addition, we find that the 3D genome may also undergo selection during soybean domestication. Conclusion Our study sheds light on the role of 3D genomes in plant genetic diversity and provides a valuable resource for studying gene regulation and genome evolution.

Nine new mycophenolic acid derivatives, penicacids O–W (1–9), two first-time reported natural products (10, 11), and five known compounds (12–16), were isolated from a marine-derived fungus Penicillium senticosum RCDB005 found in a South China Sea sediment sample. Their structures were determined using NMR, HRESIMS, and optical rotatory dispersion (ORD) spectra, electronic circular dichroism (ECD) calculations, X-ray crystallography, and modified Mosher’s methods. Eight of these compounds were evaluated for anti-proliferative effects against nine human cancer cell lines and the IC50 values ranged from nM to μM levels. Compounds 5, 7–9 showed potent inhibition activity against MOLM-13 acute myeloid leukemia cells with IC50 values between 0.13 and 1.13 μM.

Biochar prepared from crop straw is an economical method for adsorbing bromocresol green (BCG) from textile industrial wastewater. However, there is limited research on the adsorption mechanism of biochar for the removal of BCG. This study utilized cucumber straw as raw material to prepare biochar with good adsorption potential and characterized its physicochemical properties. Through adsorption experiments, the effects of solution pH, biochar dosage, and initial dye concentration on adsorption performance were examined. The adsorption mechanism of cucumber straw biochar (CBC) for BCG was elucidated at the molecular level using adsorption kinetics, adsorption isotherm models, and density functional theory (DFT) calculations. Results show that the specific surface area of the CBC is 101.58 m2/g, and it has a high degree of carbonization, similar to the structure of graphite crystals. The presence of aromatic rings, –OH groups, and –COOH groups in CBC provides abundant adsorption sites for BCG. The adsorption process of CBC for BCG is influenced by both physical and chemical adsorption, and can be described by the Langmuir isotherm model, indicating a monolayer adsorption process. The theoretical maximum monolayer adsorption capacity (qm) of BCG at 298 K was calculated to be 99.18 mg/g. DFT calculations reveal interactions between BCG and CBC involving electrostatic interactions, van der Waals forces, halogen–π interactions, π–π interactions, and hydrogen bonds. Additionally, the interaction of hydrogen bonds between BCG and the –COOH group of biochar is stronger than that between BCG and the –OH group. These findings provide valuable insights into the preparation and application of efficient organic dye adsorbents.