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Skin lesions are a severe disease globally. Early detection of melanoma in dermoscopy images significantly increases the survival rate. However, the accurate recognition of melanoma is extremely challenging due to the following reasons: low contrast between lesions and skin, visual similarity between melanoma and non-melanoma lesions, etc. Hence, reliable automatic detection of skin tumors is very useful to increase the accuracy and efficiency of pathologists. In this paper, we proposed two deep learning methods to address three main tasks emerging in the area of skin lesion image processing, i.e., lesion segmentation (task 1), lesion dermoscopic feature extraction (task 2) and lesion classification (task 3). A deep learning framework consisting of two fully convolutional residual networks (FCRN) is proposed to simultaneously produce the segmentation result and the coarse classification result. A lesion index calculation unit (LICU) is developed to refine the coarse classification results by calculating the distance heat-map. A straight-forward CNN is proposed for the dermoscopic feature extraction task. The proposed deep learning frameworks were evaluated on the ISIC 2017 dataset. Experimental results show the promising accuracies of our frameworks, i.e., 0.753 for task 1, 0.848 for task 2 and 0.912 for task 3 were achieved.

Background Due to the recent advances in deep learning, this model attracted researchers who have applied it to medical image analysis. However, pathological image analysis based on deep learning networks faces a number of challenges, such as the high resolution (gigapixel) of pathological images and the lack of annotation capabilities. To address these challenges, we propose a training strategy called deep-reverse active learning (DRAL) and atrous DenseNet (ADN) for pathological image classification. The proposed DRAL can improve the classification accuracy of widely used deep learning networks such as VGG-16 and ResNet by removing mislabeled patches in the training set. As the size of a cancer area varies widely in pathological images, the proposed ADN integrates the atrous convolutions with the dense block for multiscale feature extraction. Results The proposed DRAL and ADN are evaluated using the following three pathological datasets: BACH, CCG, and UCSB. The experiment results demonstrate the excellent performance of the proposed DRAL + ADN framework, achieving patch-level average classification accuracies (ACA) of 94.10%, 92.05% and 97.63% on the BACH, CCG, and UCSB validation sets, respectively. Conclusions The DRAL + ADN framework is a potential candidate for boosting the performance of deep learning models for partially mislabeled training datasets.

Assistive powered wheelchairs will bring patients and elderly the ability of remain mobile without the direct intervention from caregivers. Vital signs from users can be collected and analyzed remotely to allow better disease prevention and proactive management of health and chronic conditions. This research proposes an autonomous wheelchair prototype system integrated with biophysical sensors based on Internet of Thing (IoT). A powered wheelchair system was developed with three biophysical sensors to collect, transmit and analysis users’ four vital signs to provide real-time feedback to users and clinicians. A user interface software embedded with the cloud artificial intelligence (AI) algorithms was developed for the data visualization and analysis. An improved data compression algorithm Minimalist, Adaptive and Streaming R-bit (O-MAS-R) was proposed to achieve a higher compression ratio with minimum 7.1%, maximum 45.25% compared with MAS algorithm during the data transmission. At the same time, the prototype wheelchair, accompanied with a smart-chair app, assimilates data from the onboard sensors and characteristics features within the surroundings in real-time to achieve the functions including obstruct laser scanning, autonomous localization, and point-to-point route planning and moving within a predefined area. In conclusion, the wheelchair prototype uses AI algorithms and navigation technology to help patients and elderly maintain their independent mobility and monitor their healthcare information in real-time.

Programmed cell death ligend-1 (PD-L1) expression by immunohistochemistry (IHC) assays is a predictive marker of anti-PD-1/PD-L1 therapy response. With the popularity of anti-PD-1/PD-L1 inhibitor drugs, quantitative assessment of PD-L1 expression becomes a new labor for pathologists. Manually counting the PD-L1 positive stained tumor cells is an obviously subjective and time-consuming process. In this paper, we developed a new computer aided Automated Tumor Proportion Scoring System (ATPSS) to determine the comparability of image analysis with pathologist scores. A three-stage process was performed using both image processing and deep learning techniques to mimic the actual diagnostic flow of the pathologists. We conducted a multi-reader multi-case study to evaluate the agreement between pathologists and ATPSS. Fifty-one surgically resected lung squamous cell carcinoma were prepared and stained using the Dako PD-L1 (22C3) assay, and six pathologists with different experience levels were involved in this study. The TPS predicted by the proposed model had high and statistically significant correlation with sub-specialty pathologists’ scores with Mean Absolute Error (MAE) of 8.65 (95% confidence interval (CI): 6.42–10.90) and Pearson Correlation Coefficient (PCC) of 0.9436 ( p < 0.001 ), and the performance on PD-L1 positive cases achieved by our method surpassed that of non-subspecialty and trainee pathologists. Those experimental results indicate that the proposed automated system can be a powerful tool to improve the PD-L1 TPS assessment of pathologists.

Glutamatergic activity in the rostral ventrolateral medulla (RVLM), which is an important brain area where angiotensin II (Ang II) elicits its pressor effects, contributes to the onset of hypertension. The present study aimed to explore the effect of central Ang II type 1 receptor (AT R) blockade on glutamatergic actions in the RVLM of stress-induced hypertensive rats (SIHR). The stress-induced hypertension (SIH) model was established by electric foot shocks combined with noises. Normotensive Sprague-Dawley rats (control) and SIHR were intracerebroventricularly infused with the AT R antagonist candesartan or artificial cerebrospinal fluid for 14 days. Mean arterial pressure (MAP), heart rate (HR), plasma norepinephrine (NE), glutamate, and the expression of N-methyl-D-aspartic acid (NMDA) receptor subunit NR1, and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in the RVLM increased in the SIH group. These increases were blunted by candesartan. Bilateral microinjection of the ionotropic glutamate receptor antagonist kynurenic acid, the NMDA receptor antagonist D-2-amino-5-phosphonopentanoate, or the AMPA/kainate receptors antagonist 6-cyano-7-nitroquinoxaline-2,3-dione into the RVLM caused a depressor response in the SIH group, but not in other groups. NR1 and AMPA receptors expressed in the glutamatergic neurons of the RVLM, and glutamate levels, increased in the intermediolateral column of the spinal cord of SIHR. Central Ang II elicits release of glutamate, which binds to the enhanced ionotropic NMDA and AMPA receptors via AT R, resulting in activation of glutamatergic neurons in the RVLM, increasing sympathetic excitation in SIHR.

Caricature is an exaggerated pictorial representation of a person, which is widely used in entertainment and political media. Recently, GAN-based methods achieved automatic caricature generation through transferring caricature style and performing shape exaggeration simultaneously. However, the caricature synthesized by these methods cannot perfectly reflect the characteristics of the subject, whose shape exaggeration are not reasonable and requires facial landmarks of caricature. In addition, the existing methods always produce the bad cases in caricature style due to the simpleness of their style transfer method. In this paper, we propose a Style Attention based Global-local Aware GAN to apply the characteristics of a subject to generate personalized caricature. To integrate the facial characteristics of a subject, we introduce a landmark-based warp controller for personalized shape exaggeration, which employs the facial landmarks as control points to warp image according to its facial features, without requirement of the facial landmarks of caricature. To fuse the facial feature with caricature style appropriately, we introduce a style-attention module, which adopts an attention mechanism, instead of the simple Adaptive Instance Normalization (AdaIN) for style transfer. To reduce the bad cases and increase the quality of generated caricatures, we propose a multi-scale discriminator to both globally and locally discriminate the synthesized and real caricature, which improves the whole structure and realistic details of the synthesized caricature. Experimental results on two publicly available datasets, the WebCaricature and the CaVINet datasets, validate the effectiveness of our proposed method and suggest that our proposed method achieves better performance than the existing methods. The caricatures generated by the proposed method can not only preserve the identity of input photo but also the characteristic shape exaggeration for each person, which are highly close to the real caricatures drawn by real artists. It indicates that our method can be adopted in the real application.

Anomaly detection is a challenging task, especially detecting and segmenting tiny defect regions in images without anomaly priors. Although deep encoder‐decoder‐based convolutional neural networks have achieved good anomaly detection results, existing methods operate uniformly on all extracted image features without considering disentangling these features. To fully explore the texture and semantic information of images, A novel unsupervised anomaly detection method is proposed. Specifically, discriminative features are extracted from images by using a deep pre‐trained network, where shallow and deep features are aggregated into texture and semantic modules, respectively. Then, a feature fusion module is developed to interactively enable feature information in two different modules. The texture and semantic segmentation results are obtained by comparing the texture features and semantic features before and after reconstruction, respectively. Finally, an anomaly segmentation module is designed to generate anomaly detection results by integrating the results of the texture and semantic modules by setting a threshold. Experimental results on benchmark datasets for anomaly detection demonstrate that our proposed method can efficiently and effectively detect anomalies, outperforming some state‐of‐the‐art methods by 2.7% and 0.6% in classification and segmentation.

Infantile Epileptic Spasms Syndrome (IESS) is a devastating epileptic encephalopathy of infancy that carries a high risk of lifelong neurodevelopmental disability. Timely diagnosis is critical, as every week of delay in effective treatment is associated with worse cognitive outcomes. Although synchronized electroencephalogram (EEG) and surface electromyography (EMG) recordings capture both the electrophysiological and motor signatures of spasms, accurate automated detection remains challenging due to the non-stationary nature of the signals and the absence of physiologically plausible inter-modal fusion in current deep learning approaches. We introduce IESS-FusionNet, an end-to-end dual-stream framework specifically designed for accurate, real-time IESS detection from simultaneous EEG and EMG. Each modality is processed by a dedicated Unimodal Encoder that hierarchically integrates Continuous Wavelet Transform, Spatio-Temporal Convolution, and Bidirectional Mamba to efficiently extract frequency-specific, spatially structured, local and long-range temporal features within a compact module. A novel Cross Time-Mixing module, built upon the linear recurrent attention of the Receptance Weighted Key Value (RWKV) architecture, subsequently performs efficient, time-decaying, bidirectional cross-modal integration that explicitly respects the causal and physiological properties of cortico-muscular coupling during spasms. Evaluated on an in-house clinical dataset of synchronized EEG-EMG recordings from infants with confirmed IESS, IESS-FusionNet achieves 89.5% accuracy, 90.7% specificity, and 88.3% sensitivity, significantly outperforming recent unimodal and multimodal baselines. Comprehensive ablation studies validate the contribution of each component, while the proposed cross-modal fusion requires approximately 60% fewer parameters than equivalent quadratic cross-attention mechanisms, making it suitable for real-time clinical deployment. IESS-FusionNet delivers an accurate, computationally efficient solution with physiologically inspired cross-modal fusion for the automated detection of infantile epileptic spasms, offering promise for future clinical applications in reducing diagnostic delay.

The uneven illumination phenomenon caused by thin clouds will reduce the quality of remote sensing images, and bring adverse effects to the image interpretation. To remove the effect of thin clouds on images, an uneven illumination correction can be applied. In this paper, an effective uneven illumination correction algorithm is proposed to remove the effect of thin clouds and to restore the ground information of the optical remote sensing image. The imaging model of remote sensing images covered by thin clouds is analyzed. Due to the transmission attenuation, reflection, and scattering, the thin cloud cover usually increases region brightness and reduces saturation and contrast of the image. As a result, a wavelet domain enhancement is performed for the image in Hue-Saturation-Value (HSV) color space. We use images with thin clouds in Wuhan area captured by QuickBird and ZiYuan-3 (ZY-3) satellites for experiments. Three traditional uneven illumination correction algorithms, i.e., multi-scale Retinex (MSR) algorithm, homomorphic filtering (HF)-based algorithm, and wavelet transform-based MASK (WT-MASK) algorithm are performed for comparison. Five indicators, i.e., mean value, standard deviation, information entropy, average gradient, and hue deviation index (HDI) are used to analyze the effect of the algorithms. The experimental results show that the proposed algorithm can effectively eliminate the influences of thin clouds and restore the real color of ground objects under thin clouds.

Precise vertebrae segmentation is essential for the image-related analysis of spine pathologies such as vertebral compression fractures and other abnormalities, as well as for clinical diagnostic treatment and surgical planning. An automatic and objective system for vertebra segmentation is required, but its development is likely to run into difficulties such as low segmentation accuracy and the requirement of prior knowledge or human intervention. Recently, vertebral segmentation methods have focused on deep learning-based techniques. To mitigate the challenges involved, we propose deep learning primitives and stacked Sparse autoencoder-based patch classification modeling for Vertebrae segmentation (SVseg) from Computed Tomography (CT) images. After data preprocessing, we extract overlapping patches from CT images as input to train the model. The stacked sparse autoencoder learns high-level features from unlabeled image patches in an unsupervised way. Furthermore, we employ supervised learning to refine the feature representation to improve the discriminability of learned features. These high-level features are fed into a logistic regression classifier to fine-tune the model. A sigmoid classifier is added to the network to discriminate the vertebrae patches from non-vertebrae patches by selecting the class with the highest probabilities. We validated our proposed SVseg model on the publicly available MICCAI Computational Spine Imaging (CSI) dataset. After configuration optimization, our proposed SVseg model achieved impressive performance, with 87.39% in Dice Similarity Coefficient (DSC), 77.60% in Jaccard Similarity Coefficient (JSC), 91.53% in precision (PRE), and 90.88% in sensitivity (SEN). The experimental results demonstrated the method’s efficiency and significant potential for diagnosing and treating clinical spinal diseases.