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"Shen, Quan"
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أفكار حول تعميق الإصلاح
يناقش الكتاب سلسلة من الإيضاحات الهامة قدمها الرئيس الصيني والأمين العام للجنة المركزية للحزب الشيوعي الصيني، شي جين بينغ، وتدور حول أفكار الإصلاح وتوسيع الانفتاح على نحو شامل في الصين. يضم الكتاب أكثر من 70 وثيقة هامة على صورة كلمات شي جين بينغ وخطاباته وتعليقاته وتوجيهاته وينقسم الكتاب إلى 12 موضوعا خاصا تتضمن 274 قطعة من مقتطفات الأقوال، نشر بعضها لأول مرة.
Book
Thermal management of chips by a device prototype using synergistic effects of 3-D heat-conductive network and electrocaloric refrigeration
With speeding up development of 5 G chips, high-efficient thermal structure and precise management of tremendous heat becomes a substantial challenge to the power-hungry electronics. Here, we demonstrate an interpenetrating architecture of electrocaloric polymer with highly thermally conductive pathways that achieves a 240% increase in the electrocaloric performance and a 300% enhancement in the thermal conductivity of the polymer. A scaled-up version of the device prototype for a single heat spot cooling of 5 G chip is fabricated utilizing this electrocaloric composite and electromagnetic actuation. The continuous three-dimensional (3-D) thermal conductive network embedded in the polymer acts as nucleation sites of the ordered dipoles under applied electric field, efficiently collects thermal energy at the hot-spots arising from field-driven dipolar entropy change, and opens up the high-speed conduction path of phonons. The synergy of two components, thus, tackles the challenge of sluggish heat dissipation of the electroactive polymers and their contact interfaces with low thermal conductivity, and more importantly, significantly reduces the electric energy for switching the dipolar states during the electrocaloric cycles, and increases the manipulable entropy at the low fields. Such a feasible solution is inevitable to the precisely fixed-point thermal management of next-generation smart microelectronic devices.
Efficient thermal structure and precise heat management become a substantial challenge for electronics. Here, authors utilize the synergistic effect of classic heat transfer and electrocaloric cooling for fixed-point thermal management of chips.
Journal Article
Aspirin intervention before ICU admission reduced the mortality in critically ill patients with acute kidney injury: results from the MIMIC-IV
Background: Aspirin, with its pleiotropic effects such as anti-inflammatory and anti-platelet aggregation, has been widely used for anti-inflammatory, analgesic, and cardiovascular diseases. However, the association between the use of aspirin before the intensive care unit (ICU) and clinical outcomes in critically ill patients with acute kidney injury (AKI) is unknown. Methods: Patients with AKI in this retrospective observational study were selected from the Marketplace for Medical Information in Intensive Care IV (MIMIC-IV). The association between aspirin intervention and 30-day mortality was assessed using Cox proportional hazards model. Logistic regression models were used to assess the association of aspirin intervention with the risks of intracranial hemorrhage, gastrointestinal bleeding and blood transfusion. The propensity score matching (PSM) method was adopted to balance the baseline variables. Sensitivity analysis was performed to validate the results by multiple interpolations for the missing data. Results: The study included 4237 pre-ICU aspirin users and 9745 non-users. In multivariate models, we found a decreased risk of mortality in those who received aspirin before ICU compared to those who did not (30-day:hazard ratio [HR], 0.70; 95% CI, 0.62–0.79; p < 0.001; 90-day:HR, 0.70; 95% CI, 0.63–0.77, p < 0.001; 180-day:HR, 0.72; 95%CI,0.65–0.79, p < 0.001). This benefit was consistent in the post-PSM analyses, sensitivity analyses, and subgroup analyses. Moreover, aspirin intervention was associated with a reduced risk of intracranial hemorrhage and gastrointestinal bleeding (HR, 0.16; 95% CI, 0.10–0.25; p < 0.001; HR, 0.59; 95% CI, 0.38–0.88, p = 0.012) after being adjusted by relating covariates, whereas with a increased risk of blood transfusion (HR, 1.28; 95% CI, 1.16–1.46; p < 0.001). Conclusion: Patients with AKI treated with aspirin before ICU admission might have reduced 30-day, 90-day and 180-day mortality without increasing the risk of intracranial hemorrhage (ICH) or gastrointestinal bleeding, but may increase the risk of transfusion.
Journal Article
Trastuzumab does not bind rat or mouse ErbB2/neu: implications for selection of non-clinical safety models for trastuzumab-based therapeutics
Purpose
Assessment of non-clinical safety signals relies on understanding species selectivity of antibodies. This is particularly important with antibody–drug conjugates, where it is key to determine target-dependent versus target-independent toxicity. Although it appears to be widely accepted that trastuzumab does not bind mouse or rat HER2/ErbB2/neu, numerous investigators continue to use mouse models to investigate safety signals of trastuzumab and trastuzumab emtansine (T-DM1). We, therefore, conducted a broad array of both binding and biologic studies to demonstrate selectivity of trastuzumab for human HER2 versus mouse/rat neu.
Methods
Binding of anti-neu and anti-HER2 antibodies was assessed by ELISA, FACS, IHC, Scatchard, and immunoblot methods in human, rat, and mouse cell lines. In human hepatocytes, T-DM1 uptake and catabolism were measured by LC-MS/MS; cell viability changes were determined using CellTiter-Glo.
Results
Our data demonstrate, using different binding methods, lack of trastuzumab binding to rat or mouse neu. Structural studies show important amino acid differences in the trastuzumab-HER2 binding interface between mouse/rat and human HER2 ECD. Substitution of these rodent amino acid residues into human HER2 abolish binding of trastuzumab. Cell viability changes, uptake, and catabolism of T-DM1 versus a DM1 non-targeted control ADC were comparable, indicating target-independent effects of the DM1-containing ADCs. Moreover, trastuzumab binding to human or mouse hepatocytes was not detected.
Conclusions
These data, in total, demonstrate that trastuzumab, and by extension T-DM1, do not bind rat or mouse neu, underscoring the importance of species selection for safety studies investigating trastuzumab or trastuzumab-based therapeutics.
Journal Article
Mechanism and monitoring and early warning technology for rockburst in coal mines
On the basis of the massive amount of published literature and the long-term practice of our research group in the field of prevention and control of rockburst, the research progress and shortcomings in understanding the rockburst phenomenon have been comprehensively investigated. This study focuses on the occurrence mechanism and monitoring and early warning technology for rockburst in coal mines. Results showed that the prevention and control of rockburst had made significant progress. However, with the increasing mining depth, several unresolved concerns remain challenging. From the in-depth research and analysis, it can be inferred that rockburst disasters involve three main problems, i.e., the induction factors are complicated, the mechanism is still unclear, and the accuracy of the monitoring equipment and multi-source stereo monitoring technology is insufficient. The monitoring and warning standards of rockburst need to be further clarified and improved. Combined with the Internet of Things, cloud computing, and big data, a study of the trend of rockburst needs to be conducted. Furthermore, the mechanism of multiphase and multi-field coupling induced by rockburst on a large scale needs to be explored. A multisystem and multiparameter integrated monitoring and early warning system and remote monitoring cloud platform for rockburst should be explored and developed. High-reliability sensing technology and equipment and perfect monitoring and early warning standards are considered to be the development direction of rockburst in the future. This research will help experts and technicians adopt effective measures for controlling rockburst disasters.
Journal Article
Compound Effects of Sodium Chloride and Gypsum on the Compressive Strength and Sulfate Resistance of Slag-Based Geopolymer Concrete
Based on compressive strength, sulfate resistance, mass change, and relative dynamic elastic modulus tests, and XRD and SEM analysis, the effects of sodium chloride (NaCl) and gypsum on the mechanical properties and resistance to sulfate attack of slag-based geopolymer concrete activated by quicklime as well as the mechanism of action were studied. The results indicate that: (1) with appropriate dosages of NaCl or gypsum, the compressive strength of geopolymer concrete can be increased by 55.8% or 245.3% at 3 days and 23.9% or 82.3% at 28 days, respectively. When NaCl and gypsum are combined, Friedel’s salt, Kuzel’s salt, and NaOH are generated, and the strength is increased by 90.8% at 3 days, and 180.3% at 28 days. (2) With 2% NaCl alone, the mass loss is reduced from 5.29% to 2.44%, and the relative dynamic elastic modulus is increased from 0.37 to 0.41. When compounded with 7.5% gypsum, the mass is increased by 0.26%, and the relative dynamic elastic modulus is increased to 1.04. With a further increase of NaCl to 4%, the mass is increased by 0.27%, and the relative dynamic elastic modulus is increased to 1.09. The sulfate corrosion resistance coefficient of geopolymer concrete is increased from 0.64 to 1.02 when it is immersed with 7.5% gypsum alone for 90 days, and it can be further increased to 1.11 when compounded with 4% NaCl. (3) The geopolymer prepared with sodium chloride: gypsum: quicklime: slag = 4:7.5:13.5:75 can be used to replace 32.5 slag Portland cement in plain concrete. The cost and carbon emissions are reduced by 25% and 48%, respectively, and the sulfate corrosion resistance coefficient is higher by 38.8% than with slag Portland cement.
Journal Article
Targeting sphingosine-1-phosphate receptor 1 alleviates neuropathic pain associated with pancreatic ductal adenocarcinoma in mice and inhibits tumor progression
Background:
Pancreatic neuropathy occurs during the development of pancreatic ductal adenocarcinoma (PDAC), with changes correlating to pancreatic neuropathic pain and increased expression of nociceptive genes in sensory ganglia. Emerging evidence suggests that sphingosine-1-phosphate receptor 1 (S1PR1) plays critical roles in the onset and maintenance of pain. However, whether S1PR1 in sensory ganglia contributes to PDAC-associated neuropathic pain remains unclear.
Methods:
We collected histopathological sections and pain-related data from patients who underwent surgical resection and were pathologically confirmed as having PDAC. S1PR1 levels in intrapancreatic nerves were measured using immunohistochemistry. A mouse model of PDAC-associated pain was established in C57BL/6J mice via orthotopic transplantation of MT5 cells. Pain behaviors were evaluated through abdominal mechanical hyperalgesia, hunch score, and open-field tests. The changes and subcellular localization of S1PR1 in dorsal root ganglia (DRGs) were observed. Subsequently, the S1PR1 antagonists W146 and FTY720 were administered to investigate the underlying molecular mechanisms. We further assessed the analgesic efficacy and its impact on tumor progression of the S1PR1 antagonist FTY720.
Results:
S1PR1 levels in nerves from PDAC patients experiencing cancer-associated pain were significantly higher compared to those without such pain. In the DRGs of a PDAC mouse model, S1PR1 expression was upregulated and colocalized with neurons and satellite glial cells. Intrathecal injection of S1PR1 antagonists W146 and FTY720 effectively alleviated PDAC-induced neuropathic pain hypersensitivity and suppressed the upregulation of transient receptor potential vanilloid 1 (TRPV1) and calcitonin gene-related peptide (CGRP). Additionally, FTY720 alleviated pancreatic cancer-related neuropathic pain and demonstrated partial anti-tumor effects.
Conclusions:
Our findings indicate that S1PR1 in DRGs plays a pivotal role in PDAC-associated neuropathic pain. Inhibition of S1PR1 signaling may alleviate PDAC-related neuropathic pain, and targeting S1PR1 represents a promising strategy for adjuvant management of pancreatic cancer-related pain.
Journal Article
Washed microbiota transplantation vs. manual fecal microbiota transplantation: clinical findings, animal studies and in vitro screening
Fecal microbiota transplantation (FMT) by manual preparation has been applied to treat diseases for thousands of years. However, this method still endures safety risks and challenges the psychological endurance and acceptance of doctors, patients and donors. Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events. This washing preparation makes delivering a precise dose of the enriched microbiota feasible, instead of using the weight of stool. Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration. The toxic reactions that include death, the change in the level of peripheral white blood cells, and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted. The metagenomic next-generation sequencing (NGS) indicated the increasing types and amount of viruses could be washed out during the washing process. Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4, corticosterone, and prostaglandin G2 could be removed by repeated washing. Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess. In conclusion, this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation (WMT) is safer, more precise and more quality-controllable than the crude FMT by manual.
Journal Article
Differences in the relationship among grit, self-regulation, competition preparation, and sport confidence across performance levels: a multi-group analysis
In the literature on high-competition sports, some evidence has been suggested regarding the relationships between athletes’ grit, self-regulation, competition preparation, and confidence. However, there has been a lack of integrated approaches to examine the relationships among these variables, and the performance level of athletes have not been considered. Therefore, this study (a) analyzed the structural relationships between grit, self-regulation, competition preparation, and confidence, and (b) investigated how these relationships vary according to athletes’ performance levels. Participants were 270 student-athletes (209 males, 61 females) from various sports, all of whom were involved in highly competitive sports in South Korea. Athletes who had won at least one national-level competition were classified into the medal winner group (
n
= 112), while those without such experience were classified into the non-medal winner group (
n
= 158). Multi-group analysis showed that the structural relationships among grit, self-regulation, competition preparation, and confidence varied according to the athletes’ performance levels. In the medal winner group, self-regulation fully mediated the effect of competition preparation on confidence, whereas in the non-medal winner group, the mediation was partial. Furthermore, the path estimates for self-regulation, competition preparation, and confidence were found to be greater in the medal winner group. This study highlights that coaches should understand athletes’ performance levels and apply appropriate strategies accordingly.
Journal Article
A cotton organ segmentation method with phenotypic measurements from a point cloud using a transformer
Cotton phenomics plays a crucial role in understanding and managing the growth and development of cotton plants. The segmentation of point clouds, a process that underpins the measurement of plant organ structures through 3D point clouds, is necessary for obtaining precise phenotypic parameters. This study proposes a cotton point cloud organ semantic segmentation method named TPointNetPlus, which combines PointNet++ and Transformer algorithms. Firstly, a dedicated point cloud dataset for cotton plants is constructed using multi-view images. Secondly, the attention module Transformer is introduced into the PointNet++ model to increase the accuracy of feature extraction. Finally, organ-level cotton plant point cloud segmentation is performed using the HDBSCAN algorithm, successfully segmenting cotton leaves, bolls, and branches from the entire plant, and obtaining their phenotypic feature parameters. The research results indicate that the TPointNetPlus model achieved a high accuracy of 98.39% in leaf semantic segmentation. The correlation coefficients between the measured values of four phenotypic parameters (plant height, leaf area, and boll volume) ranged from 0.95 to 0.97, demonstrating the accurate predictive capability of the model for these key traits. The proposed method, which enables automated data analysis from a plant's 3D point cloud to phenotypic parameters, provides a reliable reference for in-depth studies of plant phenotypes.
Journal Article