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The outbreak of the COVID-19 pandemic accelerated the global shift to online education at all levels, presenting dramatic changes and challenges. For foreign language teaching (FLT) in particular, the need to tackle difficulties and improve teaching requires a re-examination of teacher agency from an ecological perspective, especially the evolving and ever-changing roles undertaken by teachers at different stages of the teaching process. This study systematically reviews existing research on online FLT at the college level during the pandemic, aiming to develop a comprehensive model of teacher agency based on teachers’ roles and identities that proved effective during this period. After conducting a keyword search among Web of Science database in four categories (SSCI, SCI-Ex, A&HCI, and ESCI) and following the Preferred Reporting Items for Systematic Review and Meta-analysis Protocol (PRISMA-P 2020) and the clustering techniques of VOSviewer, we selected 39 peer-reviewed publications for this study. Our findings suggest that effective online FLT requires teachers to integrate multiple roles at different stages: before, during, and after online teaching. Specifically, six critical roles were identified, including technician, designer, motivator, communicator, assessor and facilitator, which as a whole contribute to the ecology of teacher agency. This review provides a model for understanding teacher agency during the pandemic, offering key insights for future research on online FLT.

[...]those vulnerabilities lie with both human and nonhuman individuals: the Anthropocene demands that human-nonhuman as well as intra-human injustices are dealt with, that the ways in which global systems are interlocked with planetary ones are properly understood. Anthropocene Criticality: The Planetary, the Global, and the World What kind of Anthropocene criticality would be both an act of recognition of human responsibility and a reckoning across boundaries (whether intra- or interspecies) of agency, power, and vulnerability? Cheah argues that the original \"effete idealist\" (26) account of world literature as Weitliteratur as put forward by Goethe, which offers an educative, cosmopolitan, and ultimately unifying function, has been replaced with a more pernicious celebration of the circulation and exchange of texts and ideas; this, however, ignores the market realities of trade and commodification that underwrite the traffic of texts. [...]globalization and worldliness are conflated in a way that ignores \"the vulnerability of world literature to the techniques of the global culture industry\" (30), writes Cheah.

Cervical cancer is considered to be one of the most serious malignant tumors in women. Natural compounds have been considered as important sources in the search for new anticancer agents. Polygonum chinense (PC) has been used as herbal medicine and Chinese cool tea. By activity-guided of the extracts from PC, PCwater shows good growth inhibition on SiHa cell, then by chromatographic analysis (HPLC and HPLC-MS/MS), we found twelve components, seven were phenolic compounds (PHE), two PHE named ellagic acid and corilagin were found to show strong growth inhibition effects in SiHa cell dose-dependently, while the seven phenolic compounds showed low inhibition on the common human HcerEpic cell. Further research found ellagic acid and corilagin induced G2 phase cell cycle arrest by upregulating levels of P53, Bcl-2, caspase 3, and caspase 9, while the Bax was reduced. These results suggested that PHE from PC might have potential anticancer effects against SiHa cells by acting through the apoptosis pathway, PHE from PC might have the potential to be used as a nutraceutical for the prevention and treatment of ovarian cancer.

The future of mobile computing increases the urgent need for predictions of network bandwidth to guide the users’ operating habits. For instance it‘s assumed that servers, which are used for listening online music and watching video (streaming service) in our life, and the users of the network are immobile and will not change within a certain time. But the actual network is filled with regular changes. If we can predict the amount of network bandwidth, which users use in the next period of time, we can guide the users to transmittal and cache data in good transmission of the network status. At the same time, we do not transfer data in the bad network status or even when we can not receive the signal. It can improve the efficiency of network transmission in order to save the energy consumption of the data transmission. The real-time measuring network bandwidth value need upload files from client to server, and then to download files from the server to the client. We must get the uploading or downloading time. This approach generally takes a long time; therefore the test will not be able to proceed frequently in the limited time. In addition, the measurement of periodic real-time network bandwidth leads to the larger energy consumption in the mobile terminal. In this paper, we design an accurate and low cost forecasting method. First, we get a mapping relationship between human and environmental factors through large-scale data collection and analysis. Secondly, we use the method of trajectory match to predict the mobile network status in order to get the results which the users wish to get. At the end of the paper, we make our designed model simulation predictions and compare to the real measurement data to validate our predictive analysis.

Recent clashes between China and Hong Kong have attracted worldwide attention. Behind such clashes, I see anxieties over the Hong Kong identity. Based on Ackbar Abbas' theorization of the \"politics of disappearance\" in Hong Kong, this dissertation focuses on the postwar period in Hong Kong from 1945 to 1966. I argue going back to this historical era, which help us understand how Chineseness in Hong Kong influences people's imagination of Hong Kong. Concentrating on four novels written between 1945 and 1966, this dissertation pays close attention to the ways in which the (re)interpretations of Chineseness in these Hong Kong novels make it possible for people to find their place in Hong Kong. I contend that these various possibilities to find one's niche in postwar Hong Kong reflect the flexible locality of Hong Kong. I include fictions written both in English and Chinese, and by native Hongkongers and non-native Hongkongers. My juxtaposition of them will show that all four novels reflect how negotiations of locality in postwar Hong Kong is possible through a reinterpretation of Chineseness in Hong Kong, regardless of the different nationalities of the author, the languages of the novels, or their different focuses on the city of Hong Kong. More specifically, I analyze the nostalgia for \"authentic\" Chineseness as imagined by expatriate writers such as Richard Mason; the mixedness of Chinese world and western worlds in Han Suyin's Hong Kong; Lü Lun's socialistic realistic depiction of Hong Kong from the perspectives of refugees; and Liu Yichang's dilemma between his elitism as a Chinese intellectual and the overwhelming commercialization of literature in Hong Kong. These different representations of Hong Kong in the 1950s and 1960s in my opinion, are negotiations between colonialist, nationalistic, and capitalistic perceptions of local Chineseness. In other words, negotiations of Chineseness make it possible for people to reinterpret their ethnicity, customs, cultures, and ultimately their identities in the city of Hong Kong.

Innovation is the core driving force behind the ability to cope with risks and enhance urban competitiveness. Against the backdrop of frequent global crises and intensified competition, improving urban innovation performance is important. This study uses 283 Chinese cities from 2012 to 2023 to empirically analyze the impact of artificial intelligence (AI) applications on urban innovation performance and the underlying mechanism. The results show that AI significantly promotes urban innovation performance while simultaneously improving both the quality and quantity of urban innovation. Moreover, through testing, it was found that the enhancement of human capital and absorptive capacity has become an important channel through which AI drives urban innovation. Additionally, the degree of government intervention weakens the positive impact of AI applications on urban innovation performance. Further research reveals that the impact of AI applications on urban innovation performance varies according to geographical region, implementation time of policies, and scale of cities.

Based on panel data from 210 prefecture-level cities in China from 2003 to 2021, this study employs the Time-Varying Differences-in-Differences (Time-Varying DID) approach to systematically examine the impact of smart city construction on pollution emissions and its underlying mechanisms. Additionally, the Propensity Score Matching–Differences-in-Differences method is employed for further validation. The research findings indicate that Smart City Construction (SCC) significantly reduces urban Volume of Sewage Discharge (VSD), sulfur dioxide emissions (SO 2 ), and Emissions of Fumes and Dust (EFD), thereby mitigating pollution emissions (PE) and enhancing environmental quality. Mechanism analysis reveals that SCC achieves these effects through scale effects, structural effects, and technological effects. City heterogeneity analysis shows that provincial capital cities exhibit a stronger suppression effect on pollution emissions compared to non-provincial capital cities. Moreover, cities with lower levels of education attainment demonstrate a stronger ability to curb pollution emissions, while larger cities exhibit a more pronounced impact on mitigating pollution emissions. The marginal contributions of this study mainly consist of three aspects: Firstly, it enriches the literature on environmental impact factors by assessing, for the first time, the influence of SCC on PE. Secondly, a comprehensive approach is employed, integrating VSD, EFD, SO 2 data, and economic and pollution data at the city level. Time-Varying DID is used to evaluate the policy effects of SCC. Finally, the study analyzes the impact mechanisms of SCC policy on environmental emissions from various perspectives.

IntroductionTalaromycosis is a severe fungal infection caused by Talaromyces marneffei that predominantly affects people living with HIV (PLWH), particularly in southern China where it contributes substantially to AIDS-related mortality. While liposomal amphotericin B (L-AMB) is preferred for induction therapy due to its superior safety profile over conventional amphotericin B deoxycholate (AmBD), the efficacy of a single high-dose L-AMB regimen in talaromycosis remains unestablished. Furthermore, current guidelines recommend initiating antiretroviral therapy (ART) within 1 week of antifungal treatment, though real-world evidence in Chinese populations is limited. This study aims to evaluate the efficacy and safety of single high-dose L-AMB for AIDS-associated talaromycosis and provide clinical evidence on early initiation of bictegravir/emtricitabine/tenofovir alafenamide fumarate (B/F/TAF) in this population.Methods and analysisThis multicentre, randomised controlled phase II clinical trial compares the efficacy and safety of single high-dose L-AMB (10 mg/kg), followed by itraconazole capsule 200 mg every 12 hours for the remaining 13 days of induction therapy, versus AmBD (0.5 mg/kg/day for 14 days) as induction therapy for AIDS-associated talaromycosis in PLWH adults with microbiologically confirmed diagnosis. Eligible participants (n=116) will be randomly assigned (1:1) at four Chinese centres to receive either treatment, followed by 10 weeks of itraconazole capsule consolidation therapy and secondary prophylaxis until CD4+ T-lymphocyte counts exceed 100 cells/mm³ for ≥6 months, with ART initiated within 7 days of antifungal treatment according to current ART guidelines. The primary endpoint is clinical resolution rate after induction, while secondary endpoints include overall survival, organ function recovery and adverse event incidence.Ethics and disseminationThis study was approved by the Institutional Review Board of Shanghai Public Health Clinical Centre (Approval No. 2025-S039-01) and the ethics committees of all participating study centres: Guiyang Public Health Treatment Centre, Mengchao Hepatobiliary Hospital of Fujian Medical University and Chest Hospital of Guangxi Zhuang Autonomous Region. All procedures were conducted in accordance with the ethical standards of the Declaration of Helsinki and national regulations. Written informed consent was obtained from all participants prior to enrolment. The findings of this study will be disseminated through publications in international peer-reviewed journals and presentations at scientific conferences. Participants who express interest in the study results will be provided with a summary report following the release of the primary findings.Trial registration numberClinicalTrials. gov NCT06926569.

The optimal intensity of conditioning regimens for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients diagnosed with myelodysplastic syndromes with excess blasts (MDS-EB) remains debated. We retrospectively analyzed the clinical outcomes of 102 MDS-EB patients who received an individualized conditioning protocol based on age and comorbidity, including busulfan, fludarabine, cytarabine, and low-dose total body irradiation (TBI). All patients achieved successful engraftment, with a median time to neutrophil and platelet engraftment of 12 and 13 days, respectively. The cumulative incidence of grade II-IV acute graft-versus-host disease (GVHD) at 180 days was 16.9%, while moderate-to-severe chronic GVHD at 2 years occurred in 15.0% of patients. After a median follow-up of 23 months, the 2-year relapse incidence was 11.5%. The 2-year overall survival (OS), progression-free survival (PFS), and GVHD-free/relapse-free survival (GRFS) were 81.9%, 77.3%, and 66.4%, respectively. The very high-risk subgroup of the International Prognostic Scoring System for MDS (IPSS-M) exhibited significantly higher relapse rates compared with the lower-risk groups (17.8% vs 2.4%, P = 0.03). Multivariate analysis identified IPSS-M as the only independent predictor of PFS (hazard ratio (HR) = 3.30, P = 0.04), whereas transplant conditioning intensity (TCI) showed no association with survival outcomes. These findings suggest that the age- and comorbidity-adjusted conditioning regimen achieves high engraftment rates, low relapse, and favorable survival in MDS-EB patients, with disease biology (IPSS-M) outweighing conditioning intensity in prognostic relevance. Graphical Abstract

Background Lysine succinylation is an emerging posttranslational modification that has garnered increased attention recently, but its role in gastric cancer (GC) remains underexplored. Methods Proteomic quantification of lysine succinylation was performed in human GC tissues and adjacent normal tissues by mass spectrometry. The mRNA and protein levels of lactate dehydrogenase A (LDHA) in GC and adjacent normal tissues were analyzed by qRT-PCR and western blot, respectively. The expression of K222-succinylated LDHA was measured in GC tissue microarray by the K222 succinylation-specific antibody. The interaction between LDHA and sequestosome 1 (SQSTM1) was measured by co-immunoprecipitation (co-IP) and proximity ligation assay (PLA). The binding of carnitine palmitoyltransferase 1A (CPT1A) to LDHA was determined by co-IP. The effect of K222-succinylated LDHA on tumor growth and metastasis was evaluated by in vitro and in vivo experiments. Results Altogether, 503 lysine succinylation sites in 303 proteins were identified. Lactate dehydrogenase A (LDHA), the key enzyme in Warburg effect, was found highly succinylated at K222 in GC. Intriguingly, this modification did not affect LDHA ubiquitination, but reduced the binding of ubiquitinated LDHA to SQSTM1, thereby decreasing its lysosomal degradation. We demonstrated that CPT1A functions as a lysine succinyltransferase that interacts with and succinylates LDHA. Moreover, high K222-succinylation of LDHA was associated with poor prognosis in patients with GC. Finally, overexpression of a succinylation-mimic mutant of LDHA promoted cell proliferation, invasion, and migration. Conclusions Our data revealed a novel lysosomal pathway of LDHA degradation, which is mediated by the binding of K63-ubiquitinated LDHA to SQSTM1. Strikingly, CPT1A succinylates LDHA on K222, which thereby reduces the binding and inhibits the degradation of LDHA, as well as promotes GC invasion and proliferation. This study thus uncovers a new role of lysine succinylation and the mechanism underlying LDHA upregulation in GC.