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"Shi, Jia"
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\"رواية ذات طابع غريب، لم أقرأ مثلها من قبل. تدور القصة حول موضوع الطعام، وبشكل خاص عن \"الشراهة\". لم يكن طرفا القصة صديقين في البداية، ولا كانا أعداء أيضا. كان أحدهما يرى الآخر بلا قيمة، لكن مع مرور الأحداث سيتبين أن لا شخص بلا قيمة مطلقا. فكل شخص ينظر إلى الموجودات والأشخاص بطريقة تختلف عن الآخرين، وقدراته أيضا ترى بشكل نسبي. القصة تدور في مدينة سوجو الصينية، المشهورة بفن الطهي والأكلات القديمة، ولكننا نتنقل بين تيارات سياسية مختلفة، كل منها يرى الطعام بطريقته الخاصة. بعضهم يعتبر الطعام الغالي رفاهية لا حاجة لها، بينما يراه آخرون شيئا طبيعيا، ومنهم من يرى الشراهة خطيئة، وآخرون يعتبرونها أمرا طبيعيا. مع مرور الزمن وتطور الأفكار، يبدأ الشخص العنيد في رؤية ما كان غامضا له طوال سنوات. فيكتشف أن الشره، والبدانة، والأكل المتآكل، والخوف، والعداوة التي كانت تشكل عقله حول مذاق الطعام ليست كل شيء. يتعلم أن التذوق ليس مجرد كلمة، بل هو خبرة حياتية تكتسب من خلال العديد من التجارب، والأطباق المأكولة، واللحظات المتمتعة. القصة مليئة بالتفاصيل الشيقة، رغم أن هناك بعض الملل في المنتصف، لكنها رواية بنكهة ممتعة ومذاق فائق الجودة.\"
Book
An integrated machine learning framework for a discriminative analysis of schizophrenia using multi-biological data
Finding effective and objective biomarkers to inform the diagnosis of schizophrenia is of great importance yet remains challenging. Relatively little work has been conducted on multi-biological data for the diagnosis of schizophrenia. In this cross-sectional study, we extracted multiple features from three types of biological data, including gut microbiota data, blood data, and electroencephalogram data. Then, an integrated framework of machine learning consisting of five classifiers, three feature selection algorithms, and four cross validation methods was used to discriminate patients with schizophrenia from healthy controls. Our results show that the support vector machine classifier without feature selection using the input features of multi-biological data achieved the best performance, with an accuracy of 91.7% and an AUC of 96.5% (
p
< 0.05). These results indicate that multi-biological data showed better discriminative capacity for patients with schizophrenia than single biological data. The top 5% discriminative features selected from the optimal model include the gut microbiota features (
Lactobacillus
,
Haemophilus
, and
Prevotella
), the blood features (superoxide dismutase level, monocyte-lymphocyte ratio, and neutrophil count), and the electroencephalogram features (nodal local efficiency, nodal efficiency, and nodal shortest path length in the temporal and frontal-parietal brain areas). The proposed integrated framework may be helpful for understanding the pathophysiology of schizophrenia and developing biomarkers for schizophrenia using multi-biological data.
Journal Article
Common knowledge about Chinese culture
Traditional Chinese ideology - Traditional virtues of China - Ancient Chinese literature - Science and technology of ancient China - Traditional Chinese art - Chinese cultural relics - Ancient Chinese architecture - Chinese arts and crafts - Chinese folk customs - Life of the Chinese people.
Book
A defensin-like protein drives cadmium efflux and allocation in rice
Pollution by heavy metals limits the area of land available for cultivation of food crops. A potential solution to this problem might lie in the molecular breeding of food crops for phytoremediation that accumulate toxic metals in straw while producing safe and nutritious grains. Here, we identify a rice quantitative trait locus we name cadmium (Cd) accumulation in leaf 1 (
CAL1
), which encodes a defensin-like protein. CAL1 is expressed preferentially in root exodermis and xylem parenchyma cells. We provide evidence that CAL1 acts by chelating Cd in the cytosol and facilitating Cd secretion to extracellular spaces, hence lowering cytosolic Cd concentration while driving long-distance Cd transport via xylem vessels. CAL1 does not appear to affect Cd accumulation in rice grains or the accumulation of other essential metals, thus providing an efficient molecular tool to breed dual-function rice varieties that produce safe grains while remediating paddy soils.
Crops that allocate heavy metals to leaves rather than grains could allow phytoremediation of polluted soil while producing food that is safe to eat. Here, the authors show that a defensin-like protein promotes cadmium secretion from rice cells and allocation to leaves without causing accumulation in grain.
Journal Article
The Impact of Natural External Forcing on Ocean Heat Uptake Efficiency Since the 1980s
We investigate the temporal evolution of ocean heat uptake efficiency (OHUE) using observations and large ensemble model simulations. OHUE, defined as the ratio of ocean heat uptake rate to changes in global mean surface temperature anomalies, has exhibited significant variability over recent decades. We found a relatively low OHUE in the late 1980s, a peak around 2000, and a subsequent decline. A key finding is the significant influence of volcanic eruptions, particularly the 1991 Mount Pinatubo eruption, which caused abrupt cooling followed by a gradual recovery, leading recent variation of OHUE. Moreover, the Southern Ocean is becoming less efficient at absorbing heat into interior ocean in recent period associated with increased stratification. These results highlight the role of natural external forcing in climate dynamics and the importance of mid‐latitudes in global OHUE variability, underscoring the need for idealized experiments to quantify the potential effects of future volcanic eruptions on OHUE.
Journal Article
إدارة الأزمات في زمن الأوبئة : مقالات لـ 56 عالما في الإدارة
يضم هذا الكتاب خلاصة تجارب وعصارة أفكار 56 عالما، هم من أبرز علماء الإدارة في الصين، وقد حملوا على عاتقهم مسؤولية قيادة المؤسسات الصينية لسنوات عديدة، وهو كتاب مرجعي لكل المؤسسات على المستوى العالمي والتي إن حدث لها ضرر في فترات الأزمات أو الأوبئة، فلن يتوقف هذا الضرر عند ملاكها أو المنتفعين منها، بل سيمتد أثره إلى قطاعات عريضة من العمالة، وسيضرب القوة الإنتاجية ولا سيما الصادرات والواردات وغيرها من الموارد. ومن ثم فهم محاربون على الخطوط الأولى، مثلهم مثل الأطباء في أزمة انتشار فيروس كورونا المستجد، وإن كان مجال تخصص كل مختلفا منهم عن الآخر، ففريق منهم ينقذ حياة الناس، بينما الفريق الآخر ينقذ أقواتهم. ولغة الكتاب لغة سهلة وبسيطة، تنطلق أفكاره من مواقف عامة وليست من مواقف خاصة محددة، ومن هنا تعد أفكاره صالحة للتطبيق على المؤسسات الصغيرة والمتوسطة في كل مكان، والتي أصبح لزاما عليها أن تلجأ للابتكار والإبداع إن أرادت الاستمرار على قيد الحياة، وبات عليها أن تبحث وسط ركام الأزمة عن الإيجابيات التي يمكن أن تهب لها حياة جديدة وسبلا مبتكرة للخلاص.
Book
Ocean warming and accelerating Southern Ocean zonal flow
The Southern Ocean (>30° S) has taken up a large amount of anthropogenic heat north of the Subantarctic Front (SAF) of the Antarctic Circumpolar Current (ACC). Poor sampling before the 1990s and decadal variability have heretofore masked the ocean’s dynamic response to this warming. Here we use the lengthening satellite altimetry and Argo float records to show robust acceleration of zonally averaged Southern Ocean zonal flow at 48° S–58° S. This acceleration is reproduced in a hierarchy of climate models, including an ocean-eddy-resolving model. Anthropogenic ocean warming is the dominant driver, as large (small) heat gain in the downwelling (upwelling) regime north (south) of the SAF causes zonal acceleration on the northern flank of the ACC and adjacent subtropics due to increased baroclinicity; strengthened wind stress is of secondary importance. In Drake Passage, little warming occurs and the SAF velocity remains largely unchanged. Continued ocean warming could further accelerate Southern Ocean zonal flow.The remoteness and paucity of historic observations of the Southern Ocean limit understanding of the effects of climate change on circulation. Using observations, CMIP6 and eddy-resolving models, this Article shows that acceleration of its zonal flow emerged in recent decades as a result of uneven ocean warming.
Journal Article
CCL2: An important cytokine in normal and pathological pregnancies: A review
C-C motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an integral chemotactic factor which recruits macrophages for the immune response. Together with its receptors (e.g., CCR2, ACKR1, and ACKR2), they exert noticeable influences on various diseases of different systems. At the maternal-fetal interface, CCL2 is detected to be expressed in trophoblasts, decidual tissue, the myometrium, and others. Meanwhile, existing reports have determined a series of physiological regulators of CCL2, which functions in maintaining normal recruitment of immunocytes, tissue remodeling, and angiogenesis. However, abnormal levels of CCL2 have also been reported to be associated with adverse pregnancy outcomes such as spontaneous abortion, preeclampsia and preterm labor. In this review, we concentrate on CCL2 expression at the maternal-fetal interface, as well as its precise regulatory mechanisms and classic signaling pathways, to reveal the multidimensional aspects of CCL2 in pregnancy.
Journal Article