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In the educational context, understanding factors affecting secondary school students’ academic performance is crucial. This study aimed to explore impacts of cognitive ability, self-control, and study plans and their interactions. Using data from 1477 students aged 15–18, the moderated mediation model was applied. Results verified a positive link between cognitive ability and performance, found self-control as a mediator, and revealed study plans’ moderating effect. In conclusion, these elements play key roles, providing a theoretical basis for educators to optimize strategies and promote students’ overall development.

This work is aimed at revealing the mesophysical process and mechanical behaviors of fine-grained tailing sand during seepage failure. The macroscopic seepage tests combined with posttest X-ray computed tomography (CT) were employed to study the fractal characteristics of mesostructure. Results show that before and after the seepage failure of fine-grained tailing sand, fractal of pore distribution (Dpd) and fractal dimension of pore size (Dps) show a relatively obvious positive correlation with porosity. Tailing particles migrate along the seepage direction during the seepage process, resulting in the gradual decrease of Dpd and pore distribution area. The Dps reflects the variation characteristics of pore number distribution with different pore sizes. The increase in Dps leads to a decrease in the uniformity of pore size and an increase in the size difference between pores. The mass fractal dimension (Dm) of fine-grained tailing sand samples ranges from 1.6472 to 1.8256. With the increase of Dm, the coefficient of uniformity (Cu) of tailing sand tends to increase. The Dm method can discern the seepage failure type of fine-grained tailing sand, and it is more accurate than the traditional method. This study provides a reference for the prevention and control of the seepage failure of tailing dam.

In the present research, cognitive ability was segmented into five distinct faculties: memory, representational, information processing, logical reasoning, and thinking conversion. The strength of a person’s cognitive ability affects the effectiveness of his or her knowledge acquisition and the efficiency of learning. The influence of these five faculties on academic performance was meticulously examined. Utilizing structural equation modeling (SEM), the mediating role of perseverance in the relationship between cognitive ability and academic performance was explored. Additionally, the intervening influence of self-discipline on this mediation was probed, positioning self-discipline as a moderating variable. Findings revealed a pronounced positive correlation between cognitive capability and academic performance. Perseverance was discerned to act as a partial mediator in this relationship. Notably, the moderation of self-discipline was salient in the initial phase of this mediation, suggesting that as self-discipline levels augment, the influence of cognitive ability on perseverance intensifies. Consequently, in scenarios of elevated self-discipline, the mediation becomes more robust, validating the moderated mediation model.

Background Development of dental tissue is regulated by extensive cell crosstalk based on various signaling molecules, such as bone morphogenetic protein (BMP) and fibroblast growth factor (FGF) pathways. However, an intact network of the intercellular regulation is still lacking. Result To gain an unbiased and comprehensive view of this dental cell interactome, we applied single-cell RNA-seq on immature human tooth germ of the growing third molar, discovered refined cell subtypes, and applied multiple network analysis to identify the central signaling pathways. We found that immune cells made up over 80% of all tooth germ cells, which exhibited profound regulation on dental cells via Transforming growth factor-β, Tumor necrosis factor (TNF) and Interleukin-1. During osteoblast differentiation, expression of genes related to extracellular matrix and mineralization was continuously elevated by signals from BMP and FGF family. As for the self-renewal of apical papilla stem cell, BMP-FGFR1-MSX1 pathway directly regulated the G0-to-S cell cycle transition. We also confirmed that Colony Stimulating Factor 1 secreted from pericyte and TNF Superfamily Member 11 secreted from osteoblast regulated a large proportion of genes related to osteoclast transformation from macrophage and monocyte. Conclusions We constructed the intercellular signaling networks that regulated the essential developmental process of human tooth, which served as a foundation for future dental regeneration engineering and the understanding of oral pathology.

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a clinical condition that specifically occurs in the oral cavity, characterized by retarded wound healing in oral mucosa accelerating the exposure of bone. Moreover, the pathological mechanism remains poorly understood. Gingival mesenchymal stem cells (GMSCs) play a critical role in gingival healing and soft tissue regeneration. Although previous studies have showed that bisphosphonates (BPs) are highly toxic to healthy GMSC, there is overall lack of direct evidence demonstrating the characterization of GMSCs derived from BRONJ patients. In present study, we isolated GMSCs for the first time from the central area of BRONJ patients’ gingiva (center-BRONJ GMSCs) and the peripheral area (peri-BRONJ GMSCs), and found that they exhibited decreased proliferation, adhesion, migration capacities and underwent early apoptosis in vitro compared control GMSCs. Notably, the central and peripheral BRONJ GMSCs transplantation in a mice excisional skin model also displayed lower cell survival rate and poor healing effects than that of controls. Mechanistically, TGF-β1 signaling pathway was suppressed not only in BRONJ patients’ gingival lesions but also in BRONJ GMSCs transplantation animal model. The results above suggested that under the microenvironment of BRONJ patients, the dysfunction of GMSCs and the suppressed TGF-β1 signaling pathway may be the vital factors in impaired gingival healing, thus contributing to persistent exposure of underlying bone and development of BRONJ. This study provides new insights into the prevention for BRONJ by improving the functions of GMSCs and upregulating TGF-β1 in accelerating gingival wound healing.Schematic illustration of the dysfunction of BRONJ GMSCs in vitro and BRONJ GMSCs transplantation in a mice skin model delaying cutaneous wound healing mainly via suppressing TGF-β1 signaling pathway.

Characterizing the natural selection of complex traits is important for understanding human evolution and both biological and pathological mechanisms. We leveraged genome-wide summary statistics for 870 polygenic traits and attempted to quantify signals of selection on traits of different forms in European ancestry across four periods in human history and evolution. We found that 88% of these traits underwent polygenic change in the past 2,000–3,000 years. Recent selection was associated with ancient selection signals in the same trait. Traits related to pigmentation, body measurement and nutritional intake exhibited strong selection signals across different time scales. Our findings are limited by our use of exclusively European data and the use of genome-wide association study data, which identify associations between genetic variants and phenotypes that may not be causal. In sum, we provide an overview of signals of selection on human polygenic traits and their characteristics across human evolution, based on a European subset of human genetic diversity. These findings could serve as a foundation for further populational and medical genetic studies. Song et al. quantify the signal of natural selection on 870 complex traits in European individuals, finding that 88% of traits showed signals of selection in the past 3,000 years, including traits related to pigmentation, body shape and food intake.

Background Dentigerous cyst (DC) is a bone destructive disease and remains a challenge for clinicians. Marsupialization enables the bone to regenerate with capsule maintaining, making it a preferred therapeutic means for DC adjacent to vital anatomical structures. Given that capsules of DC are derived from odontogenic epithelium remnants at the embryonic stage, we investigated whether there were mesenchymal stem cells (MSCs) located in DC capsules and the role that they played in the bone regeneration after marsupialization. Methods Samples obtained before and after marsupialization were used for histological detection and cell culture. The stemness of cells isolated from fresh tissues was analyzed by morphology, surface marker, and multi-differentiation assays. Comparison of proliferation ability between MSCs isolated from DC capsules before (Bm-DCSCs) and after (Am-DCSCs) marsupialization was evaluated by Cell Counting Kit-8 (CCK-8), fibroblast colony-forming units (CFU-F), and 5′-ethynyl-2′-deoxyuridine (EdU) assay. Their osteogenic capacity in vitro was detected by alkaline phosphatase (ALP) and Alizarin Red staining (ARS), combined with real-time polymerase chain reaction (RT-PCR) and immunofluorescence (IF) staining. Subcutaneous ectopic osteogenesis as well as cranial bone defect model in nude mice was performed to detect their bone regeneration and bone defect repairability. Results Bone tissue and strong ALP activity were detected in the capsule of DC after marsupialization. Two types of MSCs were isolated from fibrous capsules of DC both before (Bm-DCSCs) and after (Am-DCSCs) marsupialization. These fibroblast-like, colony-forming cells expressed MSC markers (CD44+, CD90+, CD31−, CD34−, CD45−), and they could differentiate into osteoblast-, adipocyte-, and chondrocyte-like cells under induction. Notably, Am-DCSCs performed better in cell proliferation and self-renewal. Moreover, Am-DCSCs showed a greater osteogenic capacity both in vitro and in vivo compared with Bm-DCSCs. Conclusions There are MSCs residing in capsules of DC, and the cell viability as well as the osteogenic capacity of them is largely enhanced after marsupialization. Our findings suggested that MSCs might play a crucial role in the healing process of DC after marsupialization, thus providing new insight into the treatment for DC by promoting the osteogenic differentiation of MSCs inside capsules.

This paper explores the microstructural evolution characteristics of tailings sand samples of different types of infiltration failure during the infiltration failure process. The homemade small infiltration deformation instrument is used to test the infiltration failure characteristics of the tailings sand during the infiltration failure process. Evolutionary characteristics of the internal microstructure pores and particle distribution were also studied. Using CT (computerized tomography) technology to establish digital image information, the distribution of the microscopic characteristics of the particle distribution and pore structure after tailing sand infiltration were studied. Microscopic analysis was also performed to analyze the microscopic process of infiltration and destruction, as well as to see the microscopic structural characteristics of the infiltration and destruction of the total tailings. The test results show that there are obvious differences in the microstructure characterization of fluid soil and piping-type infiltration failures. Microstructure parameters have a certain functional relationship with macrofactors. Combining the relationship between macrophysical and mechanical parameters and microstructural parameters, new ideas for future research and the prevention of tailings sand infiltration and failure mechanisms is provided.

Previous research has shown that parenting behaviors are strongly related to adolescents’ creativity development. Based on the ecological systems model of creativity development, the componential model of creativity, and the self-determination theory, our study investigated the indirect roles of autonomous and controlled motivations in the association between parenting behaviors and creativity in Chinese adolescents. Participants ( N  = 411) completed the Parenting Behaviors Scale, Learning Self-regulation Scale, Creativity Self-report Scale, and two tasks in the Torrance Tests of Creative Thinking. Correlation analysis revealed that autonomy support is positively related to autonomous motivation, controlled motivation, and creativity; psychological control is positively related to controlled motivation and creativity; and autonomous motivation and controlled motivation are both positively related to creativity. Structural equation modeling suggested that autonomy support was positively associated with creativity both directly ( p  = 0.009, 95% confidence interval (CI) [0.029, 0.205]) and via autonomous motivation ( p  < 0.001, CI [0.045, 0.127]), whereas psychological control was negatively associated with creativity via controlled motivation ( p  = 0.032, CI [−0.074, −0.009]). Generally, autonomous motivation and controlled motivation play indirect roles in the association between parenting behaviors and creativity. The results provided insights into the relationship between parenting behaviors and creativity and its indirect mechanism, as well as suggested implications for the pathways of creativity improvement in parenting. Highlights The relationships between parenting behaviors, motivation, and creativity are examined in Chinese junior school students. Autonomous motivation means individuals’ spontaneous engagement in personally meaningful actions. Controlled motivation means individuals’ engagement in actions under environmental pressure. Autonomous motivation plays an indirect role in the relationship between parental autonomy support and creativity. Controlled motivation plays an indirect role in the relationship between parental psychological control and creativity.