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The current study aims at exploring the beneficial effect of silica fume (SF) and acrylic emulsion polymer (PR) on the enhanced properties of polypropylene fiber reinforced concrete (FRC) with the supplementary cementitious binder comprised of the Portland cement, slag, silica fume and fly ash. The compressive strength and impact-abrasion resistance were used for the estimation of engineering properties while the water absorption performance, surface electricity resistance, and rapid chloride penetration resistance were used for estimation of durability. Experimental results showed that a sole addition of SF increased the compressive strengths but decreased the abrasion-impact resistances of modified FRCs, which was just opposite to the influence of a sole addition of PR. A sole addition of either the SF or PR could moderately improve the durability of modified FRCs, respectively. However, due to the beneficial effect of the complementary interaction between SF and the optimal amount of PR, the mechanical properties and durability of modified FRCs seemed to become significantly improved.

Concrete slabs are widely used in modern railways to increase the inherent resilient quality of the tracks, provide safe and smooth rides, and reduce the maintenance frequency. In this paper, the elastic performance of a novel slab trackform for high-speed railways is investigated using three-dimensional finite element modelling in Abaqus. It is then compared to the performance of a ballasted track. First, slab and ballasted track models are developed to replicate the full-scale testing of track sections. Once the models are calibrated with the experimental results, the novel slab model is developed and compared against the calibrated slab track results. The slab and ballasted track models are then extended to create linear dynamic models, considering the track geodynamics, and simulating train passages at various speeds, for which the Ledsgård documented case was used to validate the models. Trains travelling at low and high speeds are analysed to investigate the track deflections and the wave propagation in the soil, considering the issues associated with critical speeds. Various train loading methods are discussed, and the most practical approach is retained and described. Moreover, correlations are made between the geotechnical parameters of modern high-speed rail and conventional standards. It is found that considering the same ground condition, the slab track deflections are considerably smaller than those of the ballasted track at high speeds, while they show similar behaviour at low speeds.

The fragile histidine triad (FHIT) gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a tumour suppressor gene involved in different tumour types including non-small-cell lung cancers (NSCLCs). In the current study, we examined for allelic deletion at the FHIT locus in 58 primary and microdissected NSCLCs, for which a clinicopathologic profile was available. We found a loss of 87.7% in heterozygosity (LOH) frequency at one or more microsatellite markers (D3S1289, D3S2408, D3S1766, D3S1312, D3S1600). Allelic deletion of D3S1766 was related to tumour histology in 10 of 11 squamous cell carcinomas (90.9%) displaying LOH compared with nine of 17 adenocarcinomas (52.9%; P =0.049). Besides, in the subset of adenocarcinomas, a higher rate of LOH at D3S1289 was observed in male (six out of eight, 75%) than in female patients (four out of 17, 23.5%; P =0.028). However, FHIT LOH was not correlated overall with a variety of clinical parameters including sex, smoking status, staging, lymph node metastasis and survival. These results indicated that the high frequency of FHIT gene disruption was important in the development of both squamous cell carcinomas and adenocarcinomas. Furthermore, there was no association between LOH at FHIT and protein expression, suggesting the presence of complex mechanisms of Fhit inactivation. On the other hand, the association between FHIT LOH and p53 protein overexpression assessment reached statistical significance ( P =0.026), implying that common alterations affect the two genes in tumour progression.

Abnormalities of fragile histidine triad (FHIT) and TP53 have been found frequently in nonsmall cell lung cancers. In the current study, 263 primary nonsmall cell lung cancers were investigated for the expressions of Fhit and p53 by immunohistochemistry. Marked reduction of Fhit immunoreactivity (<10% positivity) in 156 (59%) tumours and overexpression of p53 protein (>10% positivity) in 89 (34%) tumours were found. Reduced Fhit expression was also noted in most squamous cell carcinomas (80 out of 99, 81%), and in a smaller fraction of adenocarcinomas (76 out of 164, 46%; P <0.001). p53 nuclear staining was demonstrated in 54 out of 99 (55%) squamous cell carcinomas and in 35 out of 164 (21%) adenocarcinomas ( P <0.001). The loss of Fhit expression and p53 overexpression was significantly more common in tumours occurring in smokers (93 out of 113, 82% and 56 out of 113, 50%) than in those of nonsmokers (63 out of 150, 42%; P <0.001 and 33 out of 150, 22%; P <0.001). Notably, p53 overexpression was associated with distant metastasis of patients in the whole series ( P =0.027) and in adenocarcinoma ( P =0.001). It was also associated with a poorer survival of patients with adenocarcinoma ( P =0.032).

Mycobacterium haemophilum is emerging as a pathogen of immunocompetent children and immunocompromised adults, particularly those who have AIDS, have received organ transplants, and have undergone cytotoxic chemotherapy. Frequently, results of acid-fast stains of aspirates or biopsy specimens are positive, but the organism fails to grow under routine conditions used to isolate mycobacteria. Cases of tenosynovitis, septic arthritis, and osteomyelitis attributed to M. haemophilum have been described. To our knowledge, pyomyositis due to M. haemophilum has not been reported previously. We describe a patient with multisite pyomyositis due to M. haemophilum, which occurred during long-term steroid treatment for polymyositis.

Tracheal botryomycosis has never been reported in the literature. A 68 year old man presented with progressive dyspnoea and an exophytic mass below the vocal cords was found by bronchoscopy. Pathological study of the mass showed tracheal botryomycosis probably associated with Peptostreptococcus spp infection. The patient was given intravenous penicillin for six weeks. Tracheal obstruction necessitated tracheal resection and the surgical specimen revealed typical findings of tracheopathia osteochondroplastica without residual lesions of botryomycosis.

A 78-year-old man consulted for acute exacerbation of chronic obstructive pulmonary disease (COPD) and an incidental finding of an anterior mediastinal tumor on chest radiograph was noted on admission. Chest computed tomography (CT) revealed a fat-containing mediastinal mass with solid component. Mediastinal liposarcoma was the initial diagnosis based on image characteristics but histopathologic examination of the excised tumor revealed lymphoma infiltration of the mediastinal adipose tissue. To our knowledge, this is the first case report of lymphomatous growth in mediastinal lipomatosis.

A prediction model of prevalent pulmonary tuberculosis (TB) in HIV negative/unknown individuals was developed to assist systematic screening. Data from a large TB screening trial were used. A multivariable logistic regression model was developed in the South African (SA) training dataset, using TB symptoms and risk factors as predictors. The model was converted into a scoring system for risk stratification and was evaluated in separate SA and Zambian validation datasets. The number of TB cases were 355, 176, and 107 in the SA training, SA validation, and Zambian validation datasets respectively. The area under curve (AUC) of the scoring system was 0·68 (95% CI 0·64-0·72) in the SA validation set, compared to prolonged cough (0·58, 95% CI 0·54-0·62) and any TB symptoms (0·6, 95% CI 0·56–0·64). In the Zambian dataset the AUC of the scoring system was 0·66 (95% CI 0·60–0·72). In the cost-effectiveness analysis, the scoring system dominated the conventional strategies. The cost per TB case detected ranged from 429 to 1,848 USD in the SA validation set and from 171 to 10,518 USD in the Zambian dataset. The scoring system may help targeted TB case finding under budget constraints.