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Chitosan-Based Composite Materials for Prospective Hemostatic Applications
Effective hemostasis is vital to reduce the pain and mortality of patients, and the research and development of hemostatic materials are prerequisite for effective hemostasis. Chitosan (CS), with good biodegradability, biocompatibility and non-toxicity, has been widely applied in bio-medicine, the chemical industry, the food industry and cosmetics. The excellent hemostatic properties of CS have been extensively studied. As a result, chitosan-based composite hemostatic materials have been emerging. In this review, the hemostatic mechanism of chitosan is briefly discussed, and then the progress of research on chitosan-based composite hemostatic materials with multiple forms such as films, sponges, hydrogels, particles and fibers are introduced. Finally, future perspectives of chitosan-based composite hemostatic materials are given. The objective of this review is to provide a reference for further research and development of effective hemostatic materials.
Journal Article
Oceanic Forcings of the Interdecadal Variability in East Asian Summer Rainfall
In this study, it was found that the Pacific decadal oscillation (PDO) and the Atlantic multidecadal oscillation (AMO) are shown to be the two major drivers of the interdecadal variability of summer rainfall over East Asia. The first leading mode (PC1) of this interdecadal variability—associated with an in-phase variation of rainfall anomalies along the Yangtze River valley and Huanghe–Huaihe River valley in China—is attributed to the PDO, while the second leading mode (PC2)—associated with seesawlike rainfall anomalies between the Yangtze River valley and Huanghe–Huaihe River valley—is attributed to the AMO. The AMO teleconnects its influence to the East Asian region, and beyond, through a circumglobal stationary baroclinic wave train extending from the Atlantic Ocean, through the Eurasian continent, and extending to North America. The AMO also altered the nature of the PDO through this atmospheric teleconnection, resulting in the occurrence of a different PDO pattern (“pseudo-PDO”) between the 1960s and 2010s. The pseudo-PDO has a different anomalous SST pattern in both the tropical and midlatitude Pacific compared to the conventional PDO. The pseudo-PDO causes a distinct atmospheric response in East Asia leading to an opposite relationship with the PC1 compared to the conventional PDO, thus leading to a change in the direction of the influence of the PDO on PC1 between the 1880s–1950s and the 1960s–2010s.
Journal Article
DeepTracer for fast de novo cryo-EM protein structure modeling and special studies on CoV-related complexes
Information about macromolecular structure of protein complexes and related cellular and molecular mechanisms can assist the search for vaccines and drug development processes. To obtain such structural information, we present DeepTracer, a fully automated deep learning-based method for fast de novo multichain protein complex structure determination from high-resolution cryoelectron microscopy (cryo-EM) maps. We applied DeepTracer on a previously published set of 476 raw experimental cryo-EM maps and compared the results with a current state of the art method. The residue coverage increased by over 30% using Deep-Tracer, and the rmsd value improved from 1.29 Å to 1.18 Å. Additionally, we applied DeepTracer on a set of 62 coronavirus-related cryo-EM maps, among them 10 with no deposited structure available in EMDataResource. We observed an average residue match of 84% with the deposited structures and an average rmsd of 0.93 Å. Additional tests with related methods further exemplify DeepTracer’s competitive accuracy and efficiency of structure modeling. DeepTracer allows for exceptionally fast computations, making it possible to trace around 60,000 residues in 350 chains within only 2 h. The web service is globally accessible at https://deeptracer.uw.edu.
Journal Article
Mussel-Inspired Catechol-Functionalized Hydrogels and Their Medical Applications
Mussel adhesive proteins (MAPs) have a unique ability to firmly adhere to different surfaces in aqueous environments via the special amino acid, 3,4-dihydroxyphenylalanine (DOPA). The catechol groups in DOPA are a key group for adhesive proteins, which is highly informative for the biomedical domain. By simulating MAPs, medical products can be developed for tissue adhesion, drug delivery, and wound healing. Hydrogel is a common formulation that is highly adaptable to numerous medical applications. Based on a discussion of the adhesion mechanism of MAPs, this paper reviews the formation and adhesion mechanism of catechol-functionalized hydrogels, types of hydrogels and main factors affecting adhesion, and medical applications of hydrogels, and future the development of catechol-functionalized hydrogels.
Journal Article
Incidence and risk factors for proximal junctional kyphosis: a meta-analysis
Purpose
To analyse the incidence and risk factors associated with proximal junctional kyphosis (PJK) following spinal fusion, we collect relative statistics from the articles on PJK and perform a meta-analysis.
Methods
An extensive search of literature was performed in PubMed, Embase, and The Cochrane Library (up to April 2015). The following risk factors were extracted: age at surgery, gender, combined anterior-posterior surgery, use of pedicle screw at top of construct, hybrid instrumentation, thoracoplasty, fusion to sacrum (S1), preoperative thoracic kyphosis angle (T5–T12) >40°, bone mineral density (BMD) and preoperative to postoperative sagittal vertical axis (SVA difference) >5 cm. Data analysis was conducted with RevMan 5.3 and STATA 12.0.
Results
A total of 14 unique studies including 2215 patients were included in the final analyses. The pooled analysis showed that there were significant difference in age at surgery >55 years old (OR 2.19, 95 % CI 1.36–3.53,
p
= 0.001), fusion to S1 (OR 2.12, 95 % CI 1.57–2.87,
p
< 0.001), T5–T12 >40° (OR 2.68, 95 % CI 1.73–4.13,
p
< 0.001), low BMD (OR 2.37, 95 % CI 1.45–3.87,
p
< 0.001) and SVA difference >5 cm (OR 2.53, 95 % CI 1.24–5.18,
p
= 0.01). However, there was no significant difference in gender (OR 0.98, 95 % CI 0.74–1.30,
p
= 0.87), combined anterior-posterior surgery (OR 1.55, 95 % CI 0.98–2.46,
p
= 0.06), use of pedicle screw at top of construct (OR 1.55, 95 % CI 0.67–3.59,
p
= 0.30), hybrid instrumentation (OR 1.31, 95 % CI 0.92–1.87,
p
= 0.13) and thoracoplasty (OR 1.55, 95 % CI 0.89–2.72,
p
= 0.13). The incidence of PJK following spinal fusion was 30 % (ranged from 17 to 62 %) based on the 14 studies.
Conclusions
The results of our meta-analysis suggest that age at surgery >55 years, fusion to S1, T5–T12 >40°, low BMD and SVA difference >5 cm are risk factors for PJK. However, gender, combined anterior–posterior surgery, use of pedicle screw at top of construct, hybrid instrumentation and thoracoplasty are not associated with PJK.
Journal Article
Decadal Change in the Correlation Pattern between the Tibetan Plateau Winter Snow and the East Asian Summer Precipitation during 1979–2011
Observational evidence indicates that the correlation between Tibetan Plateau (TP) winter snow and East Asian (EA) summer precipitation changed in the late 1990s. During the period 1979–99, the positive correlation between the TP winter snow and the summer precipitation along the Yangtze River valley (YRV) and southern Japan was disrupted by the decadal climate shift. In contrast, the summer precipitation over the Huaihe River valley (HRV) and the Korean Peninsula showed a strong positive correlation with the preceding winter snow over the TP during the period 2000–11.
The radiosonde temperature measurements over the TP show a pronounced warming since the late 1990s. This warming is associated with the significant increase in surface sensible heat flux and longwave radiation into atmosphere. The latter is closely related to the decrease of surface albedo and the soil hydrological effect of melting snow due to the decadal decrease in the preceding winter and spring snow over the TP. The TP warming induced by the decrease in winter snow, together with the cooling of the sea surface temperature in the tropical central and eastern Pacific, intensifies the land–sea thermal contrast in the subsequent spring and summer over EA, thus causing a northward advance of the EA summer monsoon. Accompanying the northward migration of the summer monsoon, the summer precipitation belt over EA shifts northward. Consequently, the high summer precipitation region over EA correlating with the preceding winter snow over the TP has shifted northward from the YRV and southern Japan to the HRV and the Korean Peninsula since the late 1990s.
Journal Article