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The selection of an effective anode material is a core component in the development of sodium‐ion batteries (NIBs) as an achievable alternative to lithium‐ion batteries. The foremost considerations include cost‐effectiveness, availability, sustainability, and the physicochemical properties required for sodium‐ion storage. Biomass‐derived hard carbon is among the most promising anode materials due to its favorable structural characteristics, high sodium storage capacity, and low cost of raw material sourcing. However, the main limitations of hard carbon anodes remain restricted by their low initial Coulombic efficiency (ICE) and specific capacity. Herein, corncob‐derived hard carbon anodes are synthesized using a two‐step process involving hydrothermal carbonization and high‐temperature annealing at 1000, 1250, and 1500 °C. The structural and electrochemical properties of the resulting materials are systematically investigated using multiple characterization techniques. Electrochemical characterization demonstrates that the hard carbon annealed at 1500 °C exhibits the highest reversible capacity of 319 mAh g−1 at a C/20 rate, along with an ICE of 89%, attributed to optimized porosity, improved structural order and reduced defect density. These findings highlight the potential of corncob‐derived hard carbon as a sustainable and efficient anode material for next‐generation NIBs. A low‐surface‐area hard carbon anode is synthesized from corncob waste through a two‐step process. The material treated at the highest temperature exhibits reduced irreversible reactions and enhances sodium storage performance, due to optimized porosity and structural order, highlighting a sustainable strategy for advanced sodium‐ion battery materials.

Biochar (BC) boasts diverse environmental applications. However, its potential for environmental biomonitoring has, surprisingly, remained largely unexplored. This study presents a preliminary analysis of BC’s potential as a biomonitor for the environmental availability of ionic Cd, utilizing the lichen Evernia prunastri (L.) Ach. as a reference organism. For this purpose, the lichen E. prunastri and two types of wood-derived biochar, biochar 1 (BC1) and biochar 2 (BC2), obtained from two anonymous producers, were investigated for their ability to accumulate, or sequester and subsequently release, Cd when exposed to Cd-depleted conditions. Samples of lichen and biochar (fractions between 2 and 4 mm) were soaked for 1 h in a solution containing deionized water (control), 10 µM, and 100 µM Cd2+ (accumulation phase). Then, 50% of the treated samples were soaked for 24 h in deionized water (depuration phase). The lichen showed a very good ability to adsorb ionic Cd, higher than the two biochar samples (more than 46.5%), and a weak ability to release the metal (ca. 6%). As compared to the lichen, BC2 showed a lower capacity for Cd accumulation (−48%) and release (ca. 3%). BC1, on the other hand, showed a slightly higher Cd accumulation capacity than BC2 (+3.6%), but a release capacity similar to that of the lichen (ca. 5%). The surface area and the cation exchange capacity of the organism and the tested materials seem to play a key role in their ability to accumulate and sequester Cd, respectively. This study suggests the potential use of BC as a (bio)monitor for the presence of PTEs in atmospheric depositions and, perhaps, water bodies.

Biochar (BC) boasts diverse environmental applications. However, its potential for environmental biomonitoring has, surprisingly, remained largely unexplored. This study presents a preliminary analysis of BC’s potential as a biomonitor for the environmental availability of ionic Cd, utilizing the lichen Evernia prunastri (L.) Ach. as a reference organism. For this purpose, the lichen E. prunastri and two types of wood-derived biochar, biochar 1 (BC1) and biochar 2 (BC2), obtained from two anonymous producers, were investigated for their ability to accumulate, or sequester and subsequently release, Cd when exposed to Cd-depleted conditions. Samples of lichen and biochar (fractions between 2 and 4 mm) were soaked for 1 h in a solution containing deionized water (control), 10 µM, and 100 µM Cd[sup.2+] (accumulation phase). Then, 50% of the treated samples were soaked for 24 h in deionized water (depuration phase). The lichen showed a very good ability to adsorb ionic Cd, higher than the two biochar samples (more than 46.5%), and a weak ability to release the metal (ca. 6%). As compared to the lichen, BC2 showed a lower capacity for Cd accumulation (−48%) and release (ca. 3%). BC1, on the other hand, showed a slightly higher Cd accumulation capacity than BC2 (+3.6%), but a release capacity similar to that of the lichen (ca. 5%). The surface area and the cation exchange capacity of the organism and the tested materials seem to play a key role in their ability to accumulate and sequester Cd, respectively. This study suggests the potential use of BC as a (bio)monitor for the presence of PTEs in atmospheric depositions and, perhaps, water bodies.

Extracellular vesicles (EVs) transport biomolecules that mediate intercellular communication. We previously showed that EVs contain DNA (EV-DNA) representing the entire genome. However, the mechanism of genomic EV-DNA packaging and its role in cancer remain elusive. We now demonstrate that EV-DNA is predominantly localized on the vesicle surface and associated with uniquely modified and cleaved histones. Moreover, a genome-wide clustered regularly interspaced short palindromic repeats knockout screen revealed that immune developmental pathways and genes, including apoptotic peptidase activating factor 1 ( APAF1 ) and neutrophil cytosolic factor 1 ( NCF1 ), regulate EV-DNA packaging. Furthermore, in colorectal cancer models, uptake of EV-DNA by pre-metastatic liver Kupffer cells (KCs) activated DNA damage responses. This activation rewired KC cytokine production and promoted the formation of tertiary lymphoid structures, thereby suppressing liver metastasis. Conversely, loss of APAF1 decreased EV-DNA packaging and promoted liver metastasis. Importantly, colorectal cancer biopsy EV-DNA secretion could serve as a predictive biomarker for postoperative metastasis. Taken together, our findings indicate that uniquely chromatinized EV-DNA induces antitumor immunity. Lyden and colleagues find that immune developmental genes, such as apoptotic peptidase activating factor 1 ( APAF1 ), support DNA packaging on the surface of tumor-derived extracellular vesicles that are taken up by resident liver macrophages, thereby suppressing metastasis.

Extracellular vesicles (EVs) transport biomolecules that mediate intercellular communication. We previously showed that EVs contain DNA (EV-DNA) representing the entire genome. However, the mechanism of genomic EV-DNA packaging and its role in cancer remains elusive. We now demonstrate that EV-DNA is predominantly localized on the vesicle surface and associated with uniquely modified and cleaved histones. Moreover, a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) knockout screen revealed that immune developmental pathways and genes, including apoptotic peptidase activating factor 1 (APAF1) and neutrophil cytosolic factor 1(NCF1), regulated EV-DNA packaging. Furthermore, in colorectal cancer models, uptake of EV-DNA by pre-metastatic liver Kupffer cells (KC) activated DNA-damage responses. This activation rewired KC cytokine production and promoted the formation of tertiary lymphoid structures, thereby suppressing liver metastasis. Conversely, loss of APAF1 decreased EV-DNA packaging and promoted liver metastasis. Importantly, colorectal cancer biopsy EV-DNA secretion could serve as a predictive biomarker for postoperative metastasis. Taken together, our findings indicate that uniquely chromatinized EV-DNA induces anti-tumor immunity.

We report the results of XMM-Newton and BeppoSAX observations of the radio and X-ray emitting star LS I +61 303, likely associated with the gamma-ray source 2CG 135+01 and recently detected also at TeV energies. The data include a long XMM-Newton pointing carried out in January 2005, which provides the deepest look ever obtained for this object in the 0.3-12 keV range. During this observation the source flux decreased from a high level of 13E12 erg/cm2/s to 4E12 erg/cm2/s within 2-3 hours.This flux range is the same seen in shorter and less sensitive observations carried out in the past, but the new data show for the first time that transitions between the two levels can occur on short time scales. The flux decrease was accompanied by a significant softening of the spectrum, which is well described by a power law with photon index changing from 1.62+/-0.1 to 1.83+/-0.1. A correlation between hardness and intensity is also found when comparing different short observations spanning almost 10 years and covering various orbital phases.LS I +61 303 was detected in the 15-70 keV range with the PDS instrument in one of the BeppoSAX observations, providing evidence for variability also in the hard X-ray range. The X-ray spectra, discussed in the context of multiwavelength observations, place some interesting constraints on the properties and location of the high-energy emitting region.