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Circular economy (CE) principles have gained prominence in the fashion industry since it is a highly polluting industry and requires sustainable changes. Even though there are several CE initiatives already in place within the fashion production chain, changes towards CE are still slow. This study seeks to identify the drivers, barriers, and practices that influence implementing circular economy concepts in the fashion industry production chain using a systematic literature review. The results show that some more barriers and criteria keep consumers away from circular fashion concepts than drivers. These barriers include fast fashion consumer culture, even though more consumers are environmentally conscious. This is because awareness has not reached large-scale populations, despite the world being more aware of social and environmental issues. Consumers still do not see ethical and ecological problems associated with the fashion industry and continue to be targeted for large fast fashion retailers that sell a misguided version of consumerism. This study contributes to both academia and new fashion business models that seek to become more sustainable since it presents opportunities for investments and the obstacles that must be overcome for reaching CE within this sector.

Objective The aim of this study was to evaluate the efficacy of supplementary techniques (ultrasonic tip/XP-endo Finisher R) in removing remaining filling materials (gutta-percha/AHPlus/BCSealer) from oval-shaped root canals during non-surgical endodontic retreatment. Material and methods Twenty-eight distal roots of human mandibular molars with single and oval-shaped canals were initially shaped with a R40 instrument and filled with gutta-percha points and AH Plus ( n  = 14) or BC Sealer ( n  = 14) followed by an initial micro-CT scanning. Initial filling material removal was performed in all 28 samples with an R50 instrument, and all samples submitted to a second micro-CT. Supplementary techniques with ultrasonic tips or XP-endo Finisher R instruments were performed in each sealer group, and all samples submitted to a third micro-CT. The volume of remaining filling material was calculated for the entire canal as well as for the coronal, middle, and apical thirds. Statistical analyses were performed using T, ANOVA 3-way, and Tukey tests. Results Lower values of remnant filling material were found for BC Sealer (16.06 ± 14.34) compared to AH Plus (28.30 ± 10.54) ( P  < 0.001), and considering the supplementary technique, lower values of remnant filling material were found for the ultrasonic tip (18.95 ± 11.05) compared to XP-endo Finisher R (25.41 ± 15.81) ( P  = 0.025). Ultrasonic instruments significantly reduced the percentage of remaining filling material for both AH Plus ( P  = 0.04) and BC Sealer ( P  = 0.02) while XP-endo Finisher R was effective for AHPlus only ( P  = 0.04). The remaining filling material was observed in all samples regardless the filling material or the supplementary technique employed. Conclusions Supplementary techniques increased filling material removal; however, none of them was able to render root canals completely free from root fillings. Ultrasonic tips should be considered a good option for endodontic retreatment, especially for bioceramic cases. Clinical relevance Supplementary instrumentation techniques are effective tools to reduce the amount of filling materials during root canal retreatment.

Machine learning methods have revolutionized studies in several areas of knowledge, helping to understand and extract information from experimental data. Recently, these data-driven methods have also been used to discover structures of mathematical models. The sparse identification of nonlinear dynamics (SINDy) method has been proposed with the aim of identifying nonlinear dynamical systems, assuming that the equations have only a few important terms that govern the dynamics. By defining a library of possible terms, the SINDy approach solves a sparse regression problem by eliminating terms whose coefficients are smaller than a threshold. However, the choice of this threshold is decisive for the correct identification of the model structure. In this work, we build on the SINDy method by integrating it with a global sensitivity analysis (SA) technique that allows to hierarchize terms according to their importance in relation to the desired quantity of interest, thus circumventing the need to define the SINDy threshold. The proposed SINDy-SA framework also includes the formulation of different experimental settings, recalibration of each identified model, and the use of model selection techniques to select the best and most parsimonious model. We investigate the use of the proposed SINDy-SA framework in a variety of applications. We also compare the results against the original SINDy method. The results demonstrate that the SINDy-SA framework is a promising methodology to accurately identify interpretable data-driven models. The online version contains supplementary material available at 10.1007/s11071-022-07755-2.

Summary Desiccation tolerance is the ability that some organisms show to equilibrate their water content with that of dry air and recover when water supplies are re‐established. This is a widespread although rare strategy in angiosperms, and most desiccation‐tolerant (DT) species are restricted to tropical rock outcrops. Such restricted ecological range is attributed to weak competitive potential caused by low productivity, due to the temporal limitation in carbon assimilation that occurs when plants desiccate. However, few studies addressing this question in angiosperms have been conducted. We investigate 20 species of Velloziaceae of campos rupestres that differ in their desiccation tolerance. Campos rupestres is an ecoregion characterized by particular vegetation growing on rocky substrates that occurs along mountains in central/south‐eastern Brazil, above 900 m a.s.l. It is considered a Neotropical hotspot and the main centre of diversity for DT vascular plants and the Velloziaceae. Here, we tested whether carbon assimilation rates, functional traits and species habitats corroborate the hypothesized trade‐off between productivity and desiccation tolerance. All species showed similar photosynthetic rates during the wet season; in the dry season, only DT species showed drastic decrease in their metabolism. Non‐desiccation‐tolerant (NT) species are larger than DT ones (i.e. greater maximum plant height; stem volume). Relative canopy area and stem dry‐matter content were lower in DT compared to NT, while leaf phosphorous concentration was higher in DT. The remaining morphofunctional traits evaluated did not vary between these groups. DT species occupied mainly exposed rock soils, while NT species occurred in deep, sandy soil habitats. Our results support the hypothesis of a trade‐off between desiccation tolerance and productivity in angiosperms and suggest that DT strategy may only evolve and persist in habitats where severe growth limitations due to drought limit competition from more productive species. Lay Summary

The physiological demands of soccer challenge the entire spectrum of the response capacity of the biological systems and fitness requirements of the players. In this review we examined variations and evolutionary trends in body composition, neuromuscular and endurance-related parameters, as well as in game-related physical parameters of professional players. Further, we explore aspects relevant for training monitoring and we reference how different training stimulus and situational variables ( e.g ., competition exposure) affect the physiological and performance parameters of players. Generally, improvements of small magnitude in non- (non-CMJ) and countermovement-based jumps (CMJ Based ) and in the sprint acceleration (ACC Phase ) and maximal velocity phase (MV Phase ) are observed from start of preparation phase (PPS) to beginning of competition phase (BCP). A greater magnitude of increases is observed in physiological and endurance performance measures within this period; moderate magnitude in sub-maximal intensity exercise (velocity at fixed blood lactate concentrations; V 2–4mmol/l ) and large magnitude in VO 2max , maximal aerobic speed (MAS) and intense intermittent exercise performance (IE). In the middle of competition phase (MCP), small (CMJ Based and ACC Phase ), moderate (non-CMJ; MV Phase ; VO 2max ; sub-maximal exercise) and large (MAS and IE) improvements were observed compared to PPS. In the end of competition period (ECP), CMJ Based and MV Phase improve to a small extent with non-CMJ, and ACC Phase, VO 2max , MAS, sub-maximal intensity exercise and IE revealing moderate increments compared to PPS. Although less investigated, there are generally observed alterations of trivial magnitude in neuromuscular and endurance-related parameters between in-season assessments; only substantial alterations are examined for IE and sub-maximal exercise performance (decrease and increase of small magnitude, respectively) from BCP to MCP and in VO 2max and IE (decrements of small magnitude) from MCP to ECP. Match performance may vary during the season. Although, the variability between studies is clear for TD, VHSR and sprint, all the studies observed substantial increments in HSR between MCP and ECP. Finally, studies examining evolutionary trends by means of exercise and competition performance measures suggests of a heightened importance of neuromuscular factors. In conclusion, during the preseason players “recover” body composition profile and neuromuscular and endurance competitive capacity. Within in-season, and more robustly towards ECP, alterations in neuromuscular performance seem to be force-velocity dependent, and in some cases, physiological determinants and endurance performance may be compromised when considering other in-season moments. Importantly, there is a substantial variability in team responses that can be observed during in-season. Consequently, this informs on the need to both provide a regular training stimulus and adequate monitorization throughout the season.

Studies have separately compared the association of age with blood pressure variability (BPV) or pulse wave velocity (PWV). We aimed to establish the association between age and metrics of short-term BPV and PWV in the same sample. 508 under 60 years (< 60) and 141 in their sixties (≥ 60) measured blood pressure (OBP), and PWV using the oscillometric technique (br-PWV). They recorded an ambulatory BP monitoring (ABPM) to obtain variables for systolic (SBPV) and diastolic BPV (DBPV). We also estimated PWV using formulas. We calculated the Pearson correlation coefficient (r) and determination coefficient (R 2 ) of all parameters with age. The correlation between age and PWV was very strong (br-PWV; r = 0.901; p < 0.001). It was poor for SBPV, 24-h weighted SD r = 0.492; p < 0.001, and not significant for DBPV, 24-h weighted SD r = 0.220; p < 0.001. The correlation and determination values were generally better in the group comprising ≥ 60-years, with R 2 values robust for PWV (br-PWV = 0.812) weaker for SBPV (24-h weighted SD = 0.243) and deemed irrelevant for DBPV (24-h weighted SD = 0.048). Our study shows that PWV metrics are firmly and significantly more influenced by age than short-term BPV.

Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with varied prognosis, chronic course, and duration of illness with reduced quality of life. One factor that significantly contributes to the relevant disease burden of MDD is the heterogeneous treatment response patients experience with current treatment options. A variety of experimental protocols in humans and animals have highlighted that inflammation and neuroinflammation are relevant biological factors that interact with external stimuli and neurophysiological mechanisms, and can trigger MDD. It is well established that exercise is efficacious in treating mild to moderate depression with response rates comparable to mainstream therapies such as antidepressant medication and cognitive behavioral therapy. Several studies have shown that physical exercise is beneficial for a range of chronic diseases. Indeed, physical exercise can promote molecular changes that swerve a chronic pro-inflammatory state to an anti-inflammatory state in both periphery and central nervous system. The changes caused by physical exercise include an increase in PGC1α gene expression, a transcriptional co-activator involved in reducing the synthesis and releasing of pro-inflammatory cytokines, and an increase in anti-inflammatory cytokines. PGC1α changes the metabolism of kynurenine towards, and, in turn, it reduces glutamatergic neurotoxicity. Moreover, some studies have shown that physical exercise promotes alterations in the circuitry of monoaminergic neurotransmission, at least in some aspects, through the effects on the release of proinflammatory cytokines. This review will highlight the effects of physical exercise as therapy and its relation with the biological mechanisms involved in the pathophysiology of MDD, with particular emphasis in the interactions among physical exercise, hypothalamic-pituitary-adrenal (HPA) axis, neuroinflammation, and with the neurotransmitters underlying the main brain circuits involved in the MDD.

Background Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation is a rare autosomal dominant disease caused by mutations in KIF11 which disrupt EG5 protein function, impacting the development and maintenance of retinal and lymphatic structures due to its expression in the retinal photoreceptor cilia. The primary ocular finding in MCLMR is chorioretinopathy. Additional features can include microphthalmia, angle-closure glaucoma, persistent hyperplastic primary vitreous, cataract, pseudo-coloboma, persistent hyaloid artery, and myopic or hypermetropic astigmatism. The appearance of the chorioretinal lesions as white to pinkish, round, non-elevated atrophic areas devoid of blood vessels resembles the lacunae in Aicardy syndrome. Due to the lack of systematic description of the lesions and significant phenotypical variability, there is an impending need for a detailed report of each case. Case presentation A child with microcephaly detected in the third trimester of gestation began her following in the ophthalmology department due to a non-visually significant cataract. Shortly after, she developed nystagmus and large-angle alternating esotropia with cross-fixation. Her fundus initially showed a pallid optic disc and pigmentary changes, developing thereafter retinal lacunae and a retinal fold. Her differential diagnosis accompanied the dynamic changes in her fundus, which included congenital infections, Leber´s Congenital Amaurosis and Aicardy syndrome. At 19 months old, genetic testing identified a heterozygous mutation (c.1159 C > T, p.Arg387*) in the KIF11 gene. The patient underwent bilateral medial rectus muscle recession surgery at 2 years old for persistent esotropia, with significant improvement. Refraction revealed a hyperopic astigmatism in both eyes (+ 0.25 -2.50 × 180 OD and + 0.75 -2.00 × 170 OS). She continues to require right eye patching for 2 hours daily. Conclusions This case report expands the phenotypic spectrum of MCLMR by demonstrating a unique combination of retinal features which sheds new light on differential diagnosis from Aicardy syndrome. Our findings emphasize the significant phenotypic variability associated with MCLMR, particularly regarding ocular involvement. This underscores the importance of detailed clinical evaluation and comprehensive reporting of cases to improve our understanding of the disease spectrum and genotype-phenotype correlations.

Ticks are hematophagous ectoparasites that transmit pathogens and inflict significant economic losses on the cattle industry. Remarkably, they can survive extended periods of starvation in the absence of a host. The primary objective of this study was to investigate the metabolic adaptations that enable the tick Rhipicephalus microplus to endure starvation using the BME26 cell line as a model system. To simulate nutrient deprivation, cells were subjected to starvation conditions by replacing the L-15 culture medium with phosphate-buffered saline (PBS). Our findings show that these tick cells can endure experimental starvation for up to 48 h. The assessment of glycogen levels in starved cells shows a significant decrease, at both the 24 h and 48 h marks. Additionally, upregulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression, along with downregulation of hexokinase (HK) and pyruvate kinase (PK) gene expression, indicated that BME26 cells would prioritize the gluconeogenic pathway over the glycolytic pathway under starvation conditions. Moreover, the transcriptional levels of autophagy-related genes (ATG) were upregulated in response to starvation. Taken together, our findings suggest a potential role for autophagy in supplying substrates for the gluconeogenic pathway in nutrient-deprived tick cells. This work contributes to the understanding of metabolic regulation in R. microplus ticks and offers valuable insights for tick control strategies.

This article examines how the integration of ChatGPT, Python, and Microsoft Excel can significantly enhance the productivity of medical librarians. These tools provide a powerful framework for automating tasks, processing large datasets, and generating actionable insights. ChatGPT, with its advanced natural language processing, helps automate Python script generation and improve data processing in Excel, streamlining workflows and enabling more precise service delivery. Practical applications demonstrate improvements in information retrieval, data management, and research support. The results show that, despite some integration challenges, these technologies have the potential to greatly elevate the efficiency and effectiveness of librarians in managing healthcare data.