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Gordon Brown will no doubt love it. The prospect of spamming Tony Blair to online hell has now become a reality. This week Downing Street issued the first public email address for the prime minister. In contrast, Downing Street is keen to emphasise how simple it will be to get in touch with Blair, comparing the system to the smug, but straightforward, offering from the Australian prime minister, John Howard. His site warns that following the automated acknowledgement, \"there will be no further electronic response from the prime minister\", and only a remote chance of a response by Australia Post. Blair's email team is confident that the pounds 11,000 system will stand up to pressure. Downing Street is aware it will have to cope with considerable strain.

The system's creators now want to extend it to enable Downing Street to tighten its grip over Whitehall by ensuring that civil servants \"get a broader feel of wider departmental and government policies, rather than simply their own area or department\". The development of this powerful briefing system has been taken forward by Frank Dobson's former spin doctor, Joe McCrae, with the backing of the Cabinet Office. Some 54,000 civil servants have access to the database, which was based on the Labour party's Excalibur rapid rebuttal system. It is designed primarily to \"help manage and explain new and existing gov ernment policies\" but the system has so far mainly been used by civil servants to email each other. Five years ago it was almost impossible to send a secure email within Whitehall but there were 12.2m messages this February alone. The Cabinet Office paper says it wants to expand the number of civil servants who have desktop access to the network to 300,000. Those involved include the Downing Street strategic communications unit, departmental briefing units, press officers and departmental parliamentary clerks.

The system's creators now want to extend it to enable Downing Street to tighten its grip over Whitehall by ensuring that civil servants \"get a broader feel of wider departmental and government policies, rather than simply their own area or department\". It is designed primarily to \"help manage and explain new and existing government policies\" but the system has so far mainly been used by civil servants to email each other. Five years ago it was almost impossible to send a secure email within Whitehall but there were 12.2m messages this February alone. The Cabinet Office paper says it wants to expand the number of civil servants who have desktop access to the network to 300,000. Those involved include the Downing Street strategic communications unit, departmental briefing units, press officers and departmental parliamentary clerks.

The Mars 2020 mission seeks to conduct a new scientific exploration on the surface of Mars. The Perseverance Rover will be sent to the surface of the Jezero Crater region to study its habitability, search for biosignatures of past life, acquire and cache samples for potential return, and prepare for possible human missions. To enable these objectives, an innovative Sampling and Caching Subsystem (SCS) has been developed and tested to allow the Perseverance Rover to acquire and cache rock core and regolith samples, prepare abraded rock surfaces, and support proximity science instruments. The SCS consists of the Robotic Arm (RA), the Turret and Corer, and the Adaptive Caching Assembly (ACA). These elements reside and interact both inside and outside of the Perseverance Rover to enable surface interactions, sample transfer, and caching. The main body of the Turret consists of the Coring Drill (Corer) with a Launch Abrading Bit initially installed prior to launch. Mounted to the Turret main structure are two proximity science instruments, SHERLOC and PIXL, as well as the Gas Dust Removal Tool (gDRT) and the Facility Contact Sensor (FCS). These work together with the RA to provide the sample acquisition, abraded surface preparation, and proximity science functions. The ACA is a network of assemblies largely inside the front belly of the Rover, which combine to perform the sample handling and caching functions of the mission. The ACA primarily consists of the Bit Carousel, the Sample Handling Assembly (SHA), End Effector (EE), Sample Tubes and their Sample Tube Storage Assembly (STSA), Seals and their Dispenser, Volume, and Tube Assembly (DVT), the Sealing Station, the Vision Station, the Cover Parking Lot, and additional supporting hardware. These components attach to the Caching Component Mounting Deck (CCMD) that is integrated with the Rover interior. This work describes these major elements of the SCS, with an emphasis on the functionality required to perform the set of tasks and interactions required by the subsystem. Key considerations of contamination control and biological cleanliness throughout the development of these hardware elements are also discussed. Additionally, aspects of testing and validating the functionality of the SCS are described. Early prototypes and tests matured the designs over several years and eventually led to the flight hardware and integrated testing in both Earth ambient and Mars-like environments. Multiple unique testbed venues were developed and used to enable testing from low-level mechanism operation through end-to-end sampling and caching interactions with the full subsystem and flight software. Various accomplishments from these testing efforts are highlighted. These past and ongoing tests support the successful preparations of the SCS on its pathway to operations on Mars.

Examining changes in two different retail formats, we show that consumers alter their purchases depending on the retail environment. In both settings, the change in behavior coincides with a reduction in the interpersonal interaction required to complete a transaction. As such, we contend that the format changes reduced a “social friction” that would otherwise inhibit consumers due to an implicit cost associated with ordering certain items in social settings. This paper was accepted by Pradeep Chintagunta, marketing .

2-5A-Dependent RNase L is an endoribonuclease that catalyzes RNA degradation and promotes apoptosis during the innate antiviral response in mammalian cells. Prior studies showed that RNASEL is widely expressed and suggested the presence of mRNA species of different sizes but lacked a characterization of these variants. Using RT-PCR, we show that RNASEL is expressed in all human tissues examined, whereas an alternatively generated spliced variant lacking the third exon (RNASEL del_Ex3) is solely expressed in peripheral blood leukocytes (PBL). Quantitative RT-PCR measurements of RNA from different PBL cell types separated by fluorescence activated cell sorting (FACS) showed that complete RNASEL mRNA levels were significantly elevated in granulocytes compared with all other PBL cell types, whereas expression was lowest in CD8+ T cells. The alternatively spliced RNASEL del_Ex3 transcript was present in all PBL cell types examined but at lower levels than the full-length RNASEL mRNA. The presence of high levels of RNase L protein in granulocytes was confirmed by immunohistochemistry. Our findings are the first to demonstrate the presence of an alternatively spliced RNASEL mRNA and to demonstrate the variable expression of RNase L in different leukocytes. Our results suggest that RNase L plays an important role in granulocytes as an innate immunity enzyme that controls viral infections.

We present three new eclipsing white-dwarf / M-dwarf binary systems discovered during a search for transiting planets around M-dwarfs. Unlike most known eclipsing systems of this type, the optical and infrared emission is dominated by the M-dwarf components, and the systems have optical colors and discovery light curves consistent with being Jupiter-radius transiting planets around early M-dwarfs. We detail the PTF/M-dwarf transiting planet survey, part of the Palomar Transient Factory (PTF). We present a Graphics Processing Unit (GPU)-based box-least-squares search for transits that runs approximately 8X faster than similar algorithms implemented on general purpose systems. For the discovered systems, we decompose low-resolution spectra of the systems into white-dwarf and M-dwarf components, and use radial velocity measurements and cooling models to estimate masses and radii for the white dwarfs. The systems are compact, with periods between 0.35 and 0.45 days and semimajor axes of approximately 2 solar radii (0.01 AU). We use the Robo-AO laser guide star adaptive optics system to tentatively identify one of the objects as a triple system. We also use high-cadence photometry to put an upper limit on the white dwarf radius of 0.025 solar radii (95% confidence) in one of the systems. We estimate that 0.08% (90% confidence) of M-dwarfs are in these short-period, post-common-envelope white-dwarf / M-dwarf binaries where the optical light is dominated by the M-dwarf. Similar eclipsing binary systems can have arbitrarily small eclipse depths in red bands and generate plausible small-planet-transit light curves. As such, these systems are a source of false positives for M-dwarf transiting planet searches. We present several ways to rapidly distinguish these binaries from transiting planet systems.