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"Simon, David"
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Does Early Life Exposure to Cigarette Smoke Permanently Harm Childhood Welfare? Evidence from Cigarette Tax Hikes
Evidence suggests that excise taxes on tobacco improve fetal health. However, it remains unknown if smoke exposure in early life causes lasting harm to children. I find that in utero exposure to a dollar increase in the state cigarette tax causes a 10 percent decrease in sick days from school and a 4.7 percent decrease in having two or more doctor visits. I present additional evidence for decreases in hospitalizations and asthma. This supports the hypothesis that exposure to cigarette smoke in utero and infancy carries significant medium-term costs, and that excise taxes can lead to lasting intergenerational improvements in well-being.
Journal Article
Gender differential in low psychological health and low subjective well-being among older adults in India: With special focus on childless older adults
Gender and health are two factors that shape the quality of life in old age. Previous available literature established an associaton between various demographic and socio-economic factors with the health and well-being of older adults in India; however, the influence of childless aged is neglected. Therefore, the study examined the gender differential in psychological health and subjective well-being among older adults, focusing on childless older adults.
This study utilized data from Building a Knowledge Base on Population Aging in India (BKPAI). Psychological health and subjective well-being were examined for 9541 older adults aged 60 years & above. Descriptive statistics and bivariate analysis were used to find the preliminary results. Further, multivariate analysis has been done to fulfill the objective of the study.
Around one-fifth (21.2%) of the men reported low psychological health, whereas around one-fourth (25.5%) of the women reported low psychological health. Further, around 24 per cent of men and 29 per cent of women reported low subjective well-being. Results found that low psychological well-being (OR = 1.87, C.I. = 1.16-3.01), as well as low subjective well-being (OR = 1.78, C.I. = 1.15-2.76), was higher in childless older women than in childless older men. Higher education, community involvement, good self-rated health, richest wealth quintile, and residing in urban areas significantly decrease the odds of low subjective well-being and low psychological well-being among older adults.
There is a need to improve older adults' psychological health and subjective well-being through expanded welfare provisions, especially for childless older adults. Moreover, there is an immediate requirement to cater to the needs of poor and uneducated older adults.
Journal Article
Rethinking sustainable cities : accessible, green and fair
\"Sustainable urbanisation has moved to the forefront of global debate, research and policy agendas over recent years. This compact book is designed to make a signal contribution to the sustainable urbanisation agenda through authoritative interventions contextualising, assessing and explaining clearly the relevance and importance of three central characteristics of sustainable towns and cities everywhere, namely that they should be accessible, green and fair\"--Provided by publisher.
Book
Co-Productive Tools for Transcending the Divide: Building Urban–Rural Partnerships in the Spirit of the New Leipzig Charter
The outdated and discredited notion of a binary urban–rural divide remains stubbornly widely used. However, it both sets up and reflects oppositional politics and processes between the two supposedly mutually exclusive categories of space and place, which hamper urban–rural partnerships. Empirical reality on the ground is far more complex. Just as more appropriate conceptualisations and approaches have evolved, so new research methods and tools have been developed to overcome the different institutional barriers and stakeholder priorities in the face of contemporary real-world complexities and the urgency of tackling the ‘wicked’ challenges of sustainability, which also underpin the New Leipzig Charter. The focus here is on co-production and related methods, which can be considered as representing the top-most rungs of Arnstein’s (1969) Ladder of Participation. The relevance and application of these methods are exemplified from the work of Mistra Urban Futures in relation to transcending conventional European urban–rural divisions and forming partnerships, with due attention to problems and limitations. Such methods have considerable potential, including for addressing unequal power relations, but are time-consuming and require careful adaptation to each situation.
Journal Article
Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model
Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson’s disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic PD. This α-synucleinopathy leads to mitochondrial dysfunction, which may drive dopaminergic neurodegeneration. PARKIN and PINK1, mutated in autosomal recessive PD, regulate the preferential autophagic clearance of dysfunctional mitochondria (“mitophagy”) by inducing ubiquitylation of mitochondrial proteins, a process counteracted by deubiquitylation via USP30. Here we show that loss of USP30 in
Usp30
knockout mice protects against behavioral deficits and leads to increased mitophagy, decreased phospho-S129 αSyn, and attenuation of SN dopaminergic neuronal loss induced by αSyn. These observations were recapitulated with a potent, selective, brain-penetrant USP30 inhibitor, MTX115325, with good drug-like properties. These data strongly support further study of USP30 inhibition as a potential disease-modifying therapy for PD.
USP30 has been proposed to regulate mitophagy, a relevant Parkinson’s disease mechanism. Here, the authors show that
Usp30
knockout mice and USP30 inhibitors like MTX115325 demonstrate neuroprotective responses in an alpha-synuclein mouse model of Parkinson’s disease.
Journal Article
Patient data ownership: who owns your health?
Abstract
This article answers two questions from the perspective of United Kingdom law and policy: (i) is health information property? and (ii) should it be? We argue that special features of health information make it unsuitable for conferral of property rights without an extensive system of data-specific rules, like those that govern intellectual property. Additionally, we argue that even if an extensive set of rules were developed, the advantages of a property framework to govern health information would be slight: propertization is unlikely to enhance patient self-determination, increase market efficiency, provide patients a foothold in the data economy, clarify legal uses of information, or encourage data-driven innovation. The better approach is to rely less, not more, on property. We recommend a regulatory model with four signature features: (i) substantial protection for personal health data similar to the GDPR with transparent limits on how, when, and by whom patient data can be accessed, used, and transmitted; (ii) input from relevant stakeholders; (iii) interoperability; and (iv) greater research into a health-data service, rather than goods, model.
Journal Article