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"Simon Henderson"
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Neprilysin Inhibits Coagulation through Proteolytic Inactivation of Fibrinogen
Neprilysin (NEP) is an endogenous protease that degrades a wide range of peptides including amyloid beta (Aβ), the main pathological component of Alzheimer's disease (AD). We have engineered NEP as a potential therapeutic for AD but found in pre-clinical safety testing that this variant increased prothrombin time (PT) and activated partial thromboplastin time (APTT). The objective of the current study was to investigate the effect of wild type NEP and the engineered variant on coagulation and define the mechanism by which this effect is mediated. PT and APTT were measured in cynomolgus monkeys and rats dosed with a human serum albumin fusion with an engineered variant of NEP (HSA-NEPv) as well as in control plasma spiked with wild type or variant enzyme. The coagulation factor targeted by NEP was determined using in vitro prothrombinase, calibrated automated thrombogram (CAT) and fibrin formation assays as well as N-terminal sequencing of fibrinogen treated with the enzyme. We demonstrate that HSA-NEP wild type and HSA-NEPv unexpectedly impaired coagulation, increasing PT and APTT in plasma samples and abolishing fibrin formation from fibrinogen. This effect was mediated through cleavage of the N-termini of the Aα- and Bβ-chains of fibrinogen thereby significantly impairing initiation of fibrin formation by thrombin. Fibrinogen has therefore been identified for the first time as a substrate for NEP wild type suggesting that the enzyme may have a role in regulating fibrin formation. Reductions in NEP levels observed in AD and cerebral amyloid angiopathy may contribute to neurovascular degeneration observed in these conditions.
Journal Article
Skyward. Volume one, 'My low-G life'
\"One day, gravity on Earth suddenly became a fraction of what it is now. Twenty years later, humanity has adapted to its new low-gravity reality. And to Willa Fowler, who was born just after G-day, it's pretty awesome. You can fly through the air! I mean, sure, you can also die if you jump too high. So you just don't jump too high. And maybe don't get mixed up in your dad's secret plan to bring gravity back that could get you killed... From writer Joe Henderson (showrunner of Fox's Lucifer) and artist Lee Garbett (Lucifer, Loki: Agent of Asgard) comes the story of a young woman's journey to find her place in a world turned upside down.\"--Publisher's description.
Book
Two-Stage Organic Acid Leaching of Industrially Sourced LFP- and NMC-Containing Black Mass
Over the next 5–10 years, the feedstock to lithium-ion battery recycling facilities will shift from Co- and Ni-rich chemistries to lower-value battery chemistries, such as lithium iron phosphate (LFP). Traditional recycling processes use toxic and corrosive inorganic acids for leaching, generating toxic waste streams. The low-value feedstocks will be LFP-rich with contamination from lithium cobalt oxide (LCO) and lithium–nickel–manganese–cobalt oxide (NMC) battery chemistries. Overall, the lower-value feedstock coupled with the need to reduce environmentally damaging waste streams requires the development of robust, green leaching processes capable of selectively targeting the LFP and LCO/NMC battery chemistries. This research concluded that a first-stage oxalic acid leach could selectively extract Al, Li, and P from the industrially sourced LFP-rich black mass. When operating at the optimal conditions (0.5 M oxalic acid, 5% solids, pH 0.8, and an agitation speed of 600 rpm), >99% of the Li and P and >97% of the Al were selectively extracted after 2 h, while Mn, Fe, Cu, Ni, and Co extractions were kept relatively low, namely, at 19%, <3%, <1%, 0%, and 0%. This research also explored a second-stage leach to treat the first-stage leach residue using ascorbic acid, citric acid, and glycine. It was concluded that when leaching with glycine (30 g/L glycine, a temperature of 40 °C, an agitation speed of 600 rpm, and 2% solids at pH 9.6), that >97% of the Co, >77% of the Ni, and 41% of the Mn were extracted, while the co-extraction percentages of Cu, Fe, and Al were <27%, <4%, and <2%.
Journal Article
Organic Acid Leaching of Black Mass with an LFP and NMC Mixed Chemistry
There is an increasing demand for the development of efficient and sustainable battery recycling processes. Currently, many recycling processes rely on toxic inorganic acids to recover materials from high-value battery chemistries such as lithium nickel manganese cobalt oxides (NMCs) and lithium cobalt oxide (LCOs). However, as cell manufacturers seek more cost-effective battery chemistries, the value of the spent battery value chain is increasingly diluted by chemistries such as lithium iron phosphate (LFPs). These cheaper alternatives present a difficulty when recycling, as current recycling processes are geared towards dealing with high-value chemistries; thus, the current processes become less economical. To date, much research is focused on treating a single battery chemistry; however, often, the feed material entering a battery recycling facility is contaminated with other battery chemistries, e.g., LFP feed contaminated with NMC, LCO, or LMOs. This research aims to selectively leach various battery chemistries out of a mixed feed material with the aid of a green organic acid, namely oxalic acid. When operating at the optimal conditions (2% solids, 0.25 M oxalic acid, natural pH around 1.15, 25 °C, 60 min), this research has proven that oxalic acid can be used to selectively dissolve 95.58% and 93.57% of Li and P, respectively, from a mixed LFP-NMC mixed feed, all while only extracting 12.83% of Fe and 8.43% of Mn, with no Co and Ni being detected in solution. Along with the high degree of selectivity, this research has also demonstrated, through varying the pH, that the selectivity of the leaching system can be altered. It was determined that at pH 0.5 the system dissolved both the NMC and LFP chemistries; at a pH of 1.15, the LFP chemistry (Li and P) was selectively targeted. Finally, at a pH of 4, the NMC chemistry (Ni, Co and Mn) was selectively dissolved.
Journal Article
Sidelined
In 1968, noted sociologist Harry Edwards established the Olympic Project for Human Rights, calling for a boycott of that year's games in Mexico City as a demonstration against racial discrimination in the United States and around the world. Though the boycott never materialized, Edwards's ideas struck a chord with athletes and incited African American Olympians Tommie Smith and John Carlos to protest by raising their black-gloved fists on the podium after receiving their medals.Sidelineddraws upon a wide range of historical materials and more than forty oral histories with athletes and administrators to explore how the black athletic revolt used professional and college sports to promote the struggle for civil rights in the late 1960s. Author Simon Henderson argues that, contrary to popular perception, sports reinforced the status quo since they relegated black citizens to stereotypical roles in society. By examining activists' successes and failures in promoting racial equality on one of the most public stages in the world, Henderson sheds new light on an often-overlooked subject and gives voice to those who fought for civil rights both on the field and off.
eBook
Evaluation of the Removal of PVDF Using ToF-SIMS: Comparing Dihydrolevoglucosenone and Pyrolysis as Pretreatments for Cathode Materials of Lithium-Ion Batteries
Effective and environmentally benign removal of polyvinylidene fluoride (PVDF) binders from spent battery electrodes remains a critical hurdle in sustainable recycling, primarily due to issues related to the mitigation of fluorinated compound emissions. This work evaluates PVDF binder removal from cathode active material using either a green solvent-based dissolution process or pyrolysis, analyzed by time-of-flight secondary ion mass spectrometry (ToF-SIMS). The solvent pretreatment involved mixing dihydrolevoglucosenone (Cyrene™) with PVDF-coated NMC811 at 100 °C, followed by hot filtration to separate the Cyrene-PVDF solution. Pyrolysis was conducted at 800 °C under an argon atmosphere. Positive ToF-SIMS spectra for Cyrene showed characteristic peaks at ketene (42 m/z) and 1,3-dioxole (86 m/z), along with intense C2H3O+, C3H3O+, C4H7+, and C3H5O+ peaks. The characteristic peaks used to identify PVDF were C3H2F5+ (133 m/z), C3H2F3+ (95 m/z), and C3HF4+ (113 m/z). Both processes resulted in PVDF removal, with pyrolysis demonstrating higher effectiveness. Particle agglomeration was observed in both pretreated NMC811 samples, however agglomeration was more pronounced with Cyrene pretreatment due to PVDF redeposition. Following pyrolysis, PVDF was transformed into a defluorinated carbonaceous material.
Journal Article
\There Is Nothing Funny in This World About Rioting in Harlem\: Reactions to Bill Cosby as Reflections on the State of the Black Freedom Struggle
Reactions to Bill Cosby's comedy and his political views show the way in which many have failed to clearly distinguish between these two strands of his connection to the freedom struggle. This has been complicated by Cosby's projection of some of his political ideals through his comedy while he chose to neglect others. The militant and radical words of Cosby in Playboy in 1969, his endorsement of civil rights causes, help for the under-privileged, and critique of systemic racism contrasted with the color-blind worldview projected by his comic creations. His more recent message of Black self-determination and community action that has links to conservative thought exists alongside repeats of The Cosby Show and the associated projection of a color-blind world symbolically led by Barack Obama. Such duality and visibility has so often made Cosby a reference point for the position of Blacks in America in the years since the civil rights movement.
Journal Article
Students take the lead for learning in practice: A process for building self-efficacy into undergraduate nursing education
To prepare graduate nurses for practice, the curriculum and pedagogy need to facilitate student engagement, active learning and the development of self-efficacy. This pilot project describes and explores an initiative, the Check-in and Check-out process, that aims to engage students as active partners in their learning and teaching in their clinical preparation for practice. Three interdependent elements make up the process: a check-in (briefing) part; a clinical practice part, which supports students as they engage in their learning and practise clinical skills; and a check-out (debriefing) part. A student evaluation of this initiative confirmed the value of the process, which has subsequently been embedded in the preparation for practice and work-integrated learning courses in the undergraduate nursing programs at the participating university. The introduction of a singular learning process provides consistency in the learning approach used across clinical learning spaces, irrespective of their location or focus. A consistent learning process—including a common language that easily transfers across all clinical courses and clinical settings—arguably enhances the students’ learning experience, helps them to actively manage their preparation for clinical practice and to develop self-efficacy.
•The curriculum needs to be structured to foster inquiry by nursing students.•Enhanced inquiry can improve students' understanding because they identify knowledge gaps.•A single, consistent learning process might build student self-efficacy in various clinical learning spaces.
Journal Article
'Nasty Demonstrations by Negroes': The Place of the Smith-Carlos Podium Salute in the Civil Rights Movement
When Tommy Smith and John Carlos bowed their heads and raised a fist as the \"Star-Spangled Banner\" began to play, they changed the Olympic landscape forever. Their actions became a touchstone for all future political protests at the Games. Henderson dissects the myriad ways in which the podium salute provided a unique encapsulation of the state of the civil rights movement in 1968. The protest communicated many messages that had been heard throughout the 1960s.
Journal Article