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"Simons, John"
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Wild cards III : Jokers Wild
\"The journey into high adventure soars on! Let the secret history of the world be told--of the alien virus that struck Earth after World War II, and of the handful of survivors who found they now possessed superhuman powers. Some were called Aces, endowed with powerful mental and physical prowess. The others were Jokers, tormented by bizarre mind or body disfigurements. Some served humanity. Others wreaked terror. Now, forty years later, under the streets of Manhattan an evil genius unleashes the powers of darkness--and Aces and Jokers alike must fight for their lives. Here, in the third volume of the Wild Cards series, seven of science fiction's most gifted writers take you on a journey of wonder and excitement.Includes stories by:Edward Bryant, Leanne C. Harper, George R. R. Martin, John J. Miller, Lewis Shiner ,Walter Simons, Melinda M. Snodgrass\"-- Provided by publisher.
Obaysch
by
John Simons
in
Hippopotamidae-England-London-History-19th century
,
London Zoo (London, England)-History-19th century
,
Zoo animals-England-London-History-19th century
2019
Obaysch: A Hippopotamus in Victorian London tells the remarkable story of Obaysch the hippopotamus, the first ‘star’ animal to be exhibited in the London Zoo. In 1850, a baby hippopotamus arrived in England, thought to be the first in Europe since the Roman Empire, and almost certainly the first in Britain since prehistoric times. Captured near an island in the White Nile, Obaysch was donated by the viceroy of Egypt in exchange for greyhounds and deerhounds. His arrival in London was greeted with a wave of ‘hippomania’, doubling the number of visitors to the Zoological Gardens almost overnight. Delving into the circumstances of Obaysch’s capture and exhibition, John Simons investigates the phenomenon of ‘star’ animals in Victorian Britain against the backdrop of an expanding British Empire. He shows how the entangled aims of scientific exploration, commercial ambition, and imperial expansion shaped the treatment of exotic animals throughout the nineteenth and early twentieth centuries. Along the way, he uncovers the strange and moving stories of Obaysch and the other hippos who joined him in Europe as the trade in zoo animals grew.
Aces High
by
Martin, George R. R
,
Shiner, Lewis. Pennies from hell
,
Martin, George R. R. Jube
in
Virus diseases Fiction.
,
Extraterrestrial beings Fiction.
,
Human-alien encounters Fiction.
2013
\"It struck in the wake of World War II, a mysterious disease that killed almost 90 percent of those infected. A few of the survivors gained extraordinary powers while others were blighted with severe disabilities. Some of those afflicted chose to use their new abilities to help the human race. But some took a different path. In Aces high, it's the 1980s, but a 1980s both like and unlike our own. Now, after centuries of travel through space, an extraterrestrial being called the Swarm is headed for Earth. Meanwhile, some of the aces given superpowers by the virus are hatching conspiracies to control the human world. These factions are about to collide ... and the fallout could be catastrophic\"--Page 4 of cover.
Sensing the anomeric effect in a solvent-free environment
by
Simons, John P.
,
Cocinero, Emilio J.
,
Vaden, Timothy D.
in
631/45/535
,
631/45/72
,
631/57/2272/2273
2011
The anomeric effect: C2 in the ring
The anomeric effect is a chemical phenomenon that refers to an observed stabilization of six-membered carbohydrate rings when they contain an electronegative substituent at the C1 position of the ring. This stereo-electronic effect influences the three-dimensional shapes of many biological molecules, but its underlying physical origin is still not clear. Cocinero
et al
. use a combination of laser spectroscopy and computational analysis to create a peptidic sensor that can bind the archetypal carbohydrate
D
-galactose in two different anomeric forms. Complexes formed between the truncated peptide motif and isolated
D
-galactose in the gas phase are nearly identical structurally, although the strength of the polarization of their interactions with the peptide differs greatly. These results suggest that it will be important to re-evaluate the influence, and biological effects, of substituents at the C2 position of the six-membered carbohydrate rings.
The anomeric effect is a chemical phenomenon that refers to an observed stabilization of six-membered carbohydrate rings when they contain an electronegative substituent at the C1 position of the ring. This stereoelectronic effect influences the three-dimensional shapes of many biological molecules, but the underlying physical origin is unclear. Here it is shown that complexes formed between a truncated peptide motif and an isolated sugar in the gas phase are nearly identical structurally; however, the strength of the polarization of their interactions with the peptide differs greatly. It will be important to re-evaluate the influence, and biological effects, of substituents at position C2 of the six-membered carbohydrate rings.
The anomeric effect is a chemical phenomenon
1
,
2
,
3
,
4
,
5
,
6
,
7
,
8
,
9
that refers to an observed stabilization
10
of six-membered carbohydrate rings when they contain an electronegative substituent at the C1 position of the ring. This stereoelectronic effect influences the three-dimensional shapes of many biological molecules. It can be manifested not only in this classical manner involving interaction of the endocyclic oxygen atom (O5) found in such sugars with the C1 substituent (endo-anomeric effect) but also through a corresponding interaction of the electronegative exocyclic substituent with O5 (exo-anomeric effect). However, the underlying physical origin(s) of this phenomenon is still not clear
1
,
3
,
4
,
11
,
12
,
13
,
14
. Here we show, using a combination of laser spectroscopy and computational analysis, that a truncated peptide motif can engage the two anomers of an isolated sugar in the gas phase, an environment lacking extraneous factors which could confound the analysis. (Anomers are isomers that differ in the orientation of the substituent at C1.) Complexes formed between the peptide and the α- or β-anomers of
d
-galactose are nearly identical structurally; however, the strength of the polarization of their interactions with the peptide differs greatly. Natural bond order calculations support this observation, and together they reveal the dominance of the exo- over the endo-anomeric effect. As interactions between oxygen atoms at positions C1 and C2 (O1 and O2, respectively) on the pyranose ring can alter the exo/endo ratio of a carbohydrate, our results suggest that it will be important to re-evaluate the influence, and biological effects, of substituents at position C2 in sugars.
Journal Article
The further adventures of Red Sonja
\"She lived in a savage world in an uncivilized age - a world ruled by men and governed by the sword. The[y] called her... Red Sonja - for her flame red hair, and for the smoldering fire of her pride, which gave her sword-arm a strength that few men could match, and none had ever defeated. This collection contains a variety of issues from the original Marvel Comics series 'The Savage Sword of Conan,' as well as Sonja Tales from 'Kull and the Barbarians,' with each page re-mastered for this volume. Also included is a gallery of pin-ups by Frank Thorne, Howard Chaykin, and more. These tales are where it all began, and set the stage for the current Red Sonja series from Dynamite Entertainment\"--back cover.
How the King of Beasts Became a Republican
2020
This essay examines the way in which the lion who lived first at Versailles and then in Le Jardin des Plantes in Paris was depicted in a range of texts. It shows how the lion was central to debates about science, Revolution, and the function of zoos.
Journal Article
The management of mobile bearing dislocation in the Oxford lateral unicompartmental knee replacement
by
Price, A. J.
,
Jackson, W. F. M.
,
Dodd, C. A. F.
in
Arthroplasty, Replacement, Knee - methods
,
arthroscopy
,
Bearings
2011
This article describes a technique to manage dislocations of mobile bearing lateral unicompartmental knee replacements. When dislocations occur, the bearing usually subluxes medially over the medial wall of the tibial component into the intercondylar notch. By positioning small fragment screws with their heads above the vertical wall, thereby increasing the height of the wall, subsequent dislocations can be prevented. Seven cases treated in this manner are reported, of which one of the seven has redislocated. In the remaining six, their clinical outcomes are comparable to the outcomes of those without dislocations.
Level of evidence
Retrospective case series, Level IV.
Journal Article
Isolation of novel virus-like sequences associated with human hepatitis
by
Schlauder, George G.
,
Mushahwar, Isa K.
,
Leary, Thomas P.
in
Adult
,
Africa, Eastern - epidemiology
,
Africa, Western - epidemiology
1995
Two viruses, GB virus A (GBV-A) and GB virus B (GBV-B), were recently identified in the GB hepatitis agent. Human sera containing antibodies that recognize GBV-A and/or GBV-B recombinant proteins were subjected to polymerase chain reaction studies with degenerate oligonucleotides capable of amplifying a segment of the putative helicase genes from GBV-A, GBV-B or hepatitis C virus. Novel sequences related to members of the
Flaviviridae
were identified in sera from 12 individuals including 4 individuals with hepatitis. The limited nucleotide sequence identity between GBV-A, GBV-B and HCV sequences suggests that a novel virus, tentatively named GB virus C, may be responsible for some cases of non-A, non-B, non-C, non-D, non-E hepatitis.
Journal Article