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"Simons, Walton"
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Wild cards III : Jokers Wild
\"The journey into high adventure soars on! Let the secret history of the world be told--of the alien virus that struck Earth after World War II, and of the handful of survivors who found they now possessed superhuman powers. Some were called Aces, endowed with powerful mental and physical prowess. The others were Jokers, tormented by bizarre mind or body disfigurements. Some served humanity. Others wreaked terror. Now, forty years later, under the streets of Manhattan an evil genius unleashes the powers of darkness--and Aces and Jokers alike must fight for their lives. Here, in the third volume of the Wild Cards series, seven of science fiction's most gifted writers take you on a journey of wonder and excitement.Includes stories by:Edward Bryant, Leanne C. Harper, George R. R. Martin, John J. Miller, Lewis Shiner ,Walter Simons, Melinda M. Snodgrass\"-- Provided by publisher.
Book
Cities of ladies : Beguine communities in the medieval Low Countries, 1200-1565
Selected by Choice magazine as an Outstanding Academic Title for 2002
In the early thirteenth century, semireligious communities of women began to form in the cities and towns of the Low Countries. These beguines, as the women came to be known, led lives of contemplation and prayer and earned their livings as laborers or teachers.
In Cities of Ladies , the first history of the beguines to appear in English in fifty years, Walter Simons traces the transformation of informal clusters of single women to large beguinages. These veritable single-sex cities offered lower- and middle-class women an alternative to both marriage and convent life. While the region's expanding urban economies initially valued the communities for their cheap labor supply, severe economic crises by the fourteenth century restricted women's opportunities for work. Church authorities had also grown less tolerant of religious experimentation, hailing as subversive some aspects of beguine mysticism. To Simons, however, such accusations of heresy against the beguines were largely generated from a profound anxiety about their intellectual ambitions and their claims to a chaste life outside the cloister. Under ecclesiastical and economic pressure, beguine communities dwindled in size and influence, surviving only by adopting a posture of restraint and submission to church authorities.
eBook
Ace in the hole
\"Since a strange alien virus created the superhuman beings known as aces and jokers four decades ago, they have struggled for respect and recognition. Now they are key players in a presidential convention torn by hatred and dissent. Assassins stalk the halls of the convention, and one of the candidates plans to use his secret Wild Card power for evil.\"--Page 4 of cover.
Book
Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial
Cholinesterase inhibitors produce small improvements in cognitive and global assessments in Alzheimer's disease. We aimed to determine whether donepezil produces worthwhile improvements in disability, dependency, behavioural and psychological symptoms, carers' psychological wellbeing, or delay in institutionalisation. If so, which patients benefit, from what dose, and for how long?
565 community-resident patients with mild to moderate Alzheimer's disease entered a 12-week run-in period in which they were randomly allocated donepezil (5 mg/day) or placebo. 486 who completed this period were rerandomised to either donepezil (5 or 10 mg/day) or placebo, with double-blind treatment continuing as long as judged appropriate. Primary endpoints were entry to institutional care and progression of disability, defined by loss of either two of four basic, or six of 11 instrumental, activities on the Bristol activities of daily living scale (BADLS). Outcome assessments were sought for all patients and analysed by logrank and multilevel models.
Cognition averaged 0·8 MMSE (mini-mental state examination) points better (95% Cl 0·5–1·2; p<0·0001) and functionality 1·0 BADLS points better (0·5–1·6; p<0·0001) with donepezil over the first 2 years. No significant benefits were seen with donepezil compared with placebo in institutionalisation (42%vs 44% at 3 years; p=0·4) or progression of disability (58%vs 59% at 3 years; p=0·4). The relative risk of entering institutional care in the donepezil group compared with placebo was 0·97 (95% Cl 0·72–1·30; p=0·8); the relative risk of progression of disability or entering institutional care was 0·96 (95% Cl 0·74–1·24; p=0·7). Similarly, no significant differences were seen between donepezil and placebo in behavioural and psychological symptoms, carer psychopathology, formal care costs, unpaid caregiver time, adverse events or deaths, or between 5 mg and 10 mg donepezil.
Donepezil is not cost effective, with benefits below minimally relevant thresholds. More effective treatments than Cholinesterase inhibitors are needed for Alzheimer's disease.
Journal Article
Texas hold'em
\"San Antonio, home of the Alamo, is also host to the nation's top high school jazz competition, and the musicians at Xavier Desmond High are excited to outplay their rivals. They are also jokers, kids with strange abilities and even stranger looks. On top of that, well, they are teenagers, apt for mischief, mishaps, and romantic misunderstandings. Michelle Pond, aka The Amazing Bubbles, thinks that her superhero (and supermom) know-how has prepared her to chaperone the event. But when her students start going wayward, she'll soon discover the true meaning of 'Don't mess with Texas'\"--Dust jacket flap.
BOOK
Aces High
\"It struck in the wake of World War II, a mysterious disease that killed almost 90 percent of those infected. A few of the survivors gained extraordinary powers while others were blighted with severe disabilities. Some of those afflicted chose to use their new abilities to help the human race. But some took a different path. In Aces high, it's the 1980s, but a 1980s both like and unlike our own. Now, after centuries of travel through space, an extraterrestrial being called the Swarm is headed for Earth. Meanwhile, some of the aces given superpowers by the virus are hatching conspiracies to control the human world. These factions are about to collide ... and the fallout could be catastrophic\"--Page 4 of cover.
BOOK