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"Singh, Charan"
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Debt management in India
\"\"Discusses the implications of domestic debt upon consumption, prices and economic growth in India and tests the concept of Ricardian Equivalence using a permanent income approach incorporating Rational Expectations\"--Provided by publisher\"-- Provided by publisher.
Book
Mitochondrial Dysfunction: a Potential Therapeutic Target to Treat Alzheimer’s Disease
Mitochondrial dysfunction plays a very vital role in the pathogenesis of Alzheimer’s disease (AD). Several shreds of evidence have indicated that the mitochondrial function is severely compromised under AD pathogenesis. Most of the recent therapeutic strategies have been conversed to treat AD by pinpointing the pathways involved in the pathophysiology of AD. In AD, mitochondria progressively lose their proper functions that are ultimately responsible for their accumulation and removal via the autophagic process, which is called mitophagy that further worsens the progression of this incapacitating disease. Preclinical and clinical studies have suggested that mitochondrial dysfunction along with mitophagy significantly contributes to the accumulation of amyloid-beta (Aβ) fibrils and hyperphosphorylated tau protein tangles which lead to synaptic dysfunctions and cognitive impairments such as memory loss through reactive oxygen species (ROS)–mediated pathway. The present review is intended to discuss the recent advancements in the frontiers of mitochondrial dysfunction and consequent therapeutic strategies that have been employed to treat AD.
Journal Article
Perspectives on violence and othering in India
\"This volume brings together important and original perspectives from South Asia on the relationship between violence--an increasingly important issue in multicultural societies--and the process of othering. The contributors state that societies create 'others' through deliberate acts of selection over a period of time. The objective of the process of othering is to deny rights and privileges that one sets for one's own group. This volume affirms that central to the understanding of violence in any society is the understanding of othering processes. Violence and nonviolence are influenced by the nature of othering processes as well as the kinds of others in a society. Groups engaged in mutual othering are also the ones that are often involved in violent relationships. Renowned scholars from diverse fields provide multidisciplinary perspectives on violence and othering, discussing the concepts of violence and nonviolence in multicultural societies, communal harmony, constructions of the other, truth commissions, state censorship of 'sensitive' issues, fundamentalism and secularism in multifaith societies, and specific cases from recent violence-prone areas. This volume focuses on the South Asian, and more specifically, the Indian context, but is relevant for researchers seeking to understand these issues anywhere in the world.\"-- Provided by publisher.
Book
Zebrafish an experimental model of Huntington’s disease: molecular aspects, therapeutic targets and current challenges
Huntington disease (HD) is a lethal autosomal dominant neurodegenerative disease whose exact causative mechanism is still unknown. It can transform from one generation to another generation. The CAG triplet expansion on polyglutamine (PolyQ) tract on Huntingtin protein primarily contributes in HD pathogenesis. Apart from this some another molecular mechanisms are also involved in HD pathology such as loss of Brain derived neurotrophic factor in medium spiny neurons, mitochondrial dysfunction, and alterations in synaptic plasticity are briefly discussed in this review. However, several chemicals (3-nitropropionic acid, and Quinolinic acid) and genetic (mHTT-ΔN17-97Q over expression) experimental models are used to explore the exact pathogenic mechanism and finding of new drug targets for the development of novel therapeutic approaches. The zebrafish (
Danio rerio
) is widely used in in-vivo screening of several central nervous system (CNS) diseases such as HD, Alzheimer’s disease (AD), Parkinson’s disease (PD), and in memory deficits. Thus, this makes zebrafish as an excellent animal model for the development of new therapeutic strategies against various CNS disorders. We had reviewed several publications utilizing zebrafish and rodents to explore the disease pathology. Studies suggested that zebrafish genes and their human homologues have conserved functions. Zebrafish advantages and their characteristics over the other experimental animals make it an excellent tool for the disease study. This review explains the possible pathogenic mechanism of HD and also discusses about possible treatment therapies, apart from this we also discussed about possible potential therapeutic targets which will helps in designing of novel therapeutic approaches to overcome the disease progression.
Graphic abstract
Diagrammatic depiction shows prevention of HD pathogenesis through attenuation of various biochemical alterations.
Journal Article
Exploring the genotype-environment interaction of bread wheat in ambient and high-temperature planting conditions: a rigorous investigation
The current study is carried out to find out the stable wheat genotype in ambient and high temperature planting conditions. The objective was to estimate the genotype x environment interactions through various univariates and multivariate techniques. Twenty wheat genotypes were evaluated at Jabalpur, Narmadapuram, and Sagar districts of Madhya Pradesh, India, across cropping years 2019–20 and 2021–21, considering both timely and late planting conditions. The univariate and multivariate stability analysis were performed based on per-plant grain yield and grain filling rate. Our result revealed that environment, genotype, and GEI effects were significant (
P
< 0.001) across all the environments. The wheat genotypes JW3288, L8, and L13 have been discerned as top performers, exhibiting remarkable stability in grain yield per plant. Similarly, for grain filling rate, genotypes L11 and L13 have emerged as superior and consistently stable performers. Notably, the AMMI and GGE models demonstrated superior effectiveness and accuracy compared to the linear regression model. In conclusion, based on thorough univariate and multivariate stability analyses, L13 emerges as the most stable genotype across all environments under both planting conditions. Consequently, L13 holds promise for inclusion in future breeding programs. It's noteworthy that Jabalpur stands out as the most discriminating and representative environment among all the conditions assessed.
Journal Article
Altered Fecal Microbiome Years after Traumatic Brain Injury
Patients with chronic traumatic brain injury (TBI) requiring long-term, permanent care suffer a myriad of clinical symptoms (i.e., impaired cognition, fatigue, and other conditions) that persist for years beyond the acute brain injury. In addition to these comorbid clinical symptoms, chronic TBI patients exhibit altered amino acid and hormonal profiles with distinct cytokine patterns suggesting chronic inflammation. This metabolic link suggests a role of the gut-brain axis in chronic TBI. Thus, we utilized a two-site trial to investigate the role of the gut-brain axis in comorbidities of chronic TBI. The fecal microbiome profile of 22 moderate/severe TBI patients residing in permanent care facilities in Texas and California was compared to 18 healthy age-matched control subjects working within the participating facilities. Each fecal microbiome was characterized by 16S(V4) ribosomal RNA (rRNA) gene sequencing and metagenomic genome sequencing approaches followed by confirmatory full 16S rRNA gene sequencing or focused tuf gene speciation and specific quantitative polymerase chain reaction evaluation of selected genera or species. The average chronic TBI patient fecal microbiome structure was significantly different compared to the control cohort, and these differences persisted after group stratification analysis to identify any unexpected confounders. Notably, the fecal microbiome of the chronic TBI cohort had absent or reduced Prevotella spp. and Bacteroidies spp. Conversely, bacteria in the Ruminococcaceae family were higher in abundance in TBI compared to control profiles. Previously reported hypoaminoacidemia, including significantly reduced levels of l-tryptophan, l-sarcosine, ß-alanine, and alanine, positively correlated with the reduced levels of Prevotella spp. in the TBI cohort samples compared to controls. Although the sequelae of gut-brain axis disruption after TBI is not fully understood, characterizing TBI-related alterations in the fecal microbiome may provide biomarkers and therapeutic targets to address patient morbidity.
Journal Article
Management of Type 1 Diabetes with Advanced Technology
[LANGUAGE= \"English\"] The understanding and treatment of type 1 diabetes (T1D) is advancing with technological advances. The discovery of insulin in 1921 revolutionized diabetes treatment and paved the way for the development of insulin pumps (IP) continuous glucose monitors (CGMs) and artificial pancreas (AP) systems, which have significantly improved diabetes management. IP provides continuous insulin delivery, offering benefits, such as adaptability, precise dosing, and improved glycemic control. The CGMs enable real-time glucose monitoring, leading to enhanced glycemic management and reduced hypoglycemia risk. The AP systems combine CGM and IP technologies to automate insulin delivery, resulting in improved outcomes and potential dual hormone systems using insulin and glucagon. Despite the potential of these technologies, challenges exist in utilizing them in India, including cost, insurance coverage, availability, awareness, healthcare infrastructure, trained professionals, cultural barriers, and data management issues. However, ongoing research and advanced research utilizing cutting-edge technologies offer hope for new therapies and ultimately a cure for T1D.
Journal Article
Substance Abuse of Parents and Emotional Wounds among Their Broods
Substance abuse by parents inflicts enduring emotional wounds on their children, with repercussions
stretching across family, society, and individual well-being. The profound impact of parental substance
abuse on children manifests primarily as aggression but conceals a spectrum of potential behavioral disorders.
Factors contributing to this aggression include neglect, strained mother-child relationships, impaired
parenting, family conflicts, stress, physical abuse, and poor ego development. If these emotional struggles
are not addressed, they can potentially lead to delinquent behavior, conduct disorders, and substance
abuse in the future. To mitigate mental health risks in children and adolescents, preventive measures should
be implemented. These measures include educating parents, providing family therapy, developing healthy
coping mechanisms, offering school-based mental health services, and promoting open communication.
Addressing these vulnerable children’s intricate emotional challenges and ensuring their emotional wellbeing
and future success require a collaborative effort involving parents, educators, society, and government
working together in coordination.
Journal Article
Comparison of breastfeeding, music therapy, and oral sucrose's impact on pain relief among infants during pentavalent vaccination
BACKGROUND: Vaccination is a quick, safe, and effective way to avoid contracting hazardous diseases, but it often causes pain and discomfort. Various pharmacological and non-pharmacological pain management techniques are used to treat pain. This study aimed to compare the effectiveness of breastfeeding, musical therapy, and oral sucrose in infant's pain relief during pentavalent vaccination. MATERIALS AND METHODS: A quasi-experimental posttest-only research design was used. A total of 150 infants were enrolled using the purposive sampling technique (50 in the breastfeeding, 50 in the musical therapy, and 50 in the oral sucrose groups) coming for the first, second, and third doses of pentavalent vaccination. The data were collected using observation and the Neonatal Infant Pain Scale (NIPS). The results were calculated by descriptive and inferential statistics. RESULTS: The study revealed that half of the infants in the breastfeeding group felt severe pain, whereas the majority of infants in the musical therapy and oral sucrose groups felt severe pain during pentavalent vaccination. The median pain score in breastfeeding, musical therapy, and oral sucrose was 4.50, 6, and 7, respectively. Breastfeeding was significantly different from both musical therapy and oral sucrose in terms of pain scores. However, no significant difference was observed between musical therapy and oral sucrose. Overall, the results indicate that breastfeeding had a distinct impact on pain relief during pentavalent vaccination compared with the other interventions, while musical therapy and oral sucrose did not differ significantly in their effectiveness. CONCLUSION: The study concluded that breastfeeding is a safe, reliable, cost-effective, and easily accessible method to relieve an infant's pain during pentavalent vaccination. It is a simple method to alleviate pain among infants during vaccination.
Journal Article