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Epithelial–mesenchymal transition or EMT is an extremely dynamic process involved in conversion of epithelial cells into mesenchymal cells, stimulated by an ensemble of signaling pathways, leading to change in cellular morphology, suppression of epithelial characters and acquisition of properties such as enhanced cell motility and invasiveness, reduced cell death by apoptosis, resistance to chemotherapeutic drugs etc. Significantly, EMT has been found to play a crucial role during embryonic development, tissue fibrosis and would healing, as well as during cancer metastasis. Over the years, work from various laboratories have identified a rather large number of transcription factors (TFs) including the master regulators of EMT, with the ability to regulate the EMT process directly. In this review, we put together these EMT TFs and discussed their role in the process. We have also tried to focus on their mechanism of action, their interdependency, and the large regulatory network they form. Subsequently, it has become clear that the composition and structure of the transcriptional regulatory network behind EMT probably varies based upon various physiological and pathological contexts, or even in a cell/tissue type-dependent manner.

Presents Tantra from an ethnographic vantage point, through a series of case studies grounded in diverse settings across contemporary Asia. This is the first collection of essays to approach the topic of Tantric Studies from the vantage point of ethnography and lived religion, moving beyond the centrality of written texts and giving voice to the everyday life and livelihoods of a multitude of Tantric actors. Bringing together a team of international scholars whose contributions range across diverse communities and traditions in South Asia, Southeast Asia, and the Himalayan region, the book connects distant shores of Tantric scholarship and lived Tantric practices. The contributors unpack Tantra's relationship to the body, ritual performance, sexuality, secrecy, power hierarchies, death, magic, and healing, while doing so with vigilant sensitivity to decolonization and the ethics of fieldwork. Through diverse ethnographies of Tantra and attention to lived experiences and life stories, the book challenges normative definitions of Tantra and maps the variety of Tantric traditions, providing comparative perspectives on Tantric societies across regions and religious backgrounds. The accessible tone of the ethnographic case studies makes this an ideal book for undergraduate or graduate audiences working on the topic of Tantra.

PurposeUsing bibliometric, this work aims to evaluate the current status of the body of research on the subject of supply chain resilience (SCR) in developing nations and to provide recommendations for potential lines of inquiry for additional research.Design/methodology/approachThree hundred and thirty-six articles published between 2011 and 2021 were retrieved in Scopus for this bibliometric analysis. This analysis focuses on SCR research conducted in developing countries, highlighting its key authors, countries, institutions, journals, articles and themes.FindingsThis bibliometric review seeks to enrich the discourse on SCR in developing nations through a comprehensive and detailed review of 336 articles covering 138 Journals, 73 countries, 877 authors, 743 organizations and 1,145 author keywords. The United Kingdom, India, and the United States provided a substantial share of the publications. Publication-wise, Hong Kong Polytechnic University and The University of Hong Kong play key roles. The author found that supply chain risk management, sustainability, agile management, artificial intelligence and blockchain are trending topics. Additionally, the author identified eight themes by page rank analysis.Practical implicationsThis study's importance lies primarily in its examination of the current information about SCR in developing countries and significant cluster areas (themes). In the paths, it recommends for further study, which academics may take, and industry professionals should apply in their businesses to create a more resilient and sustainable supply chain.Originality/valueBased on published studies, this study gives exploratory data on SCR in developing countries context. This is first of its kind bibliometric study that focuses on developing countries.

Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) accelerates cardiac contractility. However, the mechanisms by which cMyBP-C phosphorylation increases contractile kinetics have not been fully elucidated. In this study, we tested the hypothesis that phosphorylation of cMyBP-C releases myosin heads from the inhibited super-relaxed state (SRX), thereby determining the fraction of myosin available for contraction. Mice with various alanine (A) or aspartic acid (D) substitutions of the three main phosphorylatable serines of cMyBP-C (serines 273, 282, and 302) were used to address the association between cMyBP-C phosphorylation and SRX. Single-nucleotide turnover in skinned ventricular preparations demonstrated that phosphomimetic cMyBP-C destabilized SRX, whereas phosphoablated cMyBP-C had a stabilizing effect on SRX. Strikingly, phosphorylation at serine 282 site was found to play a critical role in regulating the SRX. Treatment of WT preparations with protein kinase A (PKA) reduced the SRX, whereas, in nonphosphorylatable cMyBP-C preparations, PKA had no detectable effect. Mice with stable SRX exhibited reduced force production. Phosphomimetic cMyBP-C with reduced SRX exhibited increased rates of tension redevelopment and reduced binding to myosin. We also used recombinant myosin subfragment-2 to disrupt the endogenous interaction between cMyBP-C and myosin and observed a significant reduction in the population of SRX myosin. This peptide also increased force generation and rate of tension redevelopment in skinned fibers. Taken together, this study demonstrates that the phosphorylation-dependent interaction between cMyBP-C and myosin is a determinant of the fraction of myosin available for contraction. Furthermore, the binding between cMyBP-C and myosin may be targeted to improve contractile function.

The purpose of this study is to explore the effect of lean practices on performance measures in the automotive industry and identify the lean criteria that can have significant impact on automotive supply chain. The identified lean practices can serve as a template to enhance the performance of a supply chain. The present study offers a multi-criteria decision-making approach to identify the effective performance practices in automotive lean supply chain. The decision-making trial and evaluation laboratory (DEMATEL) was applied on a matrix of observed values and the actual effect of proposed practices was observed. Further it was confirmed with the help of fuzzy-Vlsekriterijumska Optimizacija I Kompromisno Resenje (VIKOR; that means multicriteria optimization and compromise solution, with pronunciation). The criteria which had the most impact are proposed for achieving the future goals of leanness. It was found that among the lean criteria considered, quality management, information management and customer management practices influence the key performance measures more than others. Although DEMATEL and fuzzy-VIKOR were applied for situation leading to setting up of priorities of factors that considered affecting automotive manufacturer, the proposed methodology can be applied in diverse industrial settings. The present study may help decision-makers to device the appropriate strategy in identifying major practices that influence the lean supply chain.

Since its initial description 35 years ago as an inducible molecule expressed in cytotoxic and helper T cells, 4-1BB has emerged as a crucial receptor in T-cell-mediated immune functions. Numerous studies have demonstrated the involvement of 4-1BB in infection and tumor immunity. However, the clinical development of 4-1BB agonist antibodies has been impeded by the occurrence of strong adverse events, notably hepatotoxicity, even though these antibodies have exhibited tremendous promise in in vivo tumor models. Efforts are currently underway to develop a new generation of agonist antibodies and recombinant proteins with modified effector functions that can harness the potent T-cell modulation properties of 4-1BB while mitigating adverse effects. In this review, we briefly examine the role of 4-1BB in T-cell biology, explore its clinical applications, and discuss future prospects in the field of 4-1BB agonist immunotherapy. Focus on 4-1BB immunotherapy 4-1BB is a costimulatory T-cell receptor expressed on activated T cells and natural killer cells. Targeting 4-1BB with agonistic antibodies is a promising immuno-oncology approach and has shown potential in preclinical animal models. However, the clinical use of agonistic 4-1BB antibodies for cancer immunotherapy has been hampered by adverse effects and insufficient anti-cancer activity. In this review, the authors provide an overview of the 4-1BB costimulatory pathways in T-cell-mediated cancer immunity and summarize ongoing efforts to develop improved therapies through 4-1BB stimulation. They also explore potential solutions to address the challenges encountered in clinical trials. This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.

Protein-protein interactions (PPIs) and their networks play a central role in all biological processes. Akin to the complete sequencing of genomes and their comparative analysis, complete descriptions of interactomes and their comparative analysis is fundamental to a deeper understanding of biological processes. A first step in such an analysis is to align two or more PPI networks. Here, we introduce an algorithm, IsoRank, for global alignment of multiple PPI networks. The guiding intuition here is that a protein in one PPI network is a good match for a protein in another network if their respective sequences and neighborhood topologies are a good match. We encode this intuition as an eigenvalue problem in a manner analogous to Google's PageRank method. Using IsoRank, we compute a global alignment of the Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, Mus musculus, and Homo sapiens PPI networks. We demonstrate that incorporating PPI data in ortholog prediction results in improvements over existing sequence-only approaches and over predictions from local alignments of the yeast and fly networks. Previous methods have been effective at identifying conserved, localized network patterns across pairs of networks. This work takes the further step of performing a global alignment of multiple PPI networks. It simultaneously uses sequence similarity and network data and, unlike previous approaches, explicitly models the tradeoff inherent in combining them. We expect IsoRank--with its simultaneous handling of node similarity and network similarity--to be applicable across many scientific domains.

PurposeThis paper presents the concerns in agri-food supply chain. Further the research investigates the role of information and communication technology (ICT) in agri-food supply chain and determines the impact of supply chain management (SCM) practices on firm performance.Design/methodology/approachThe theoretical framework was proposed for the study on the basis of existing literature. Data for the study was collected with the help of structured questionnaire from 121 executives and officers of the public food distribution agency. Partial least square (PLS)–structured equation modeling was employed to test the framework and hypotheses.FindingsThe results indicate that ICT and SCM practices (logistics integration and supplier relationships) have a significant relationship. Furthermore, SCM practices (information sharing, supplier relationship and logistics integration) have a significant and positive impact on performance of the organization.Research limitations/implicationsFurther research could be carried out to test the moderation effect of SCM practices between ICT and organizational performance (OP). Extending the research study to the companies operating in other sectors can enhance the external validity of the study and improve the accuracy of parameters examined.Practical implicationsThis study can be of interest to the agri-food industry as well as other industry practitioners interested in improving the performance of the organization from the view of supply chain.Originality/valueThe outcomes of this study have important implications that translate into a series of recommendations for the management of public food distribution as well as other agri-food-based supply chains.

Measurements at the LHC have provided evidence for collective behavior in high-multiplicity proton-lead (pPb) collisions through multiparticle correlation techniques. Yet, no conclusive evidence of jet quenching — the energy loss of high-pT partons as they traverse the medium — has been detected in pPb. This raises the intriguing question: How can a medium described by hydrodynamics, and that significantly modifies the distribution of final-state hadrons, yet has no significant impact on the distribution of high-pT particles? To investigate this, a comprehensive study of differential Fourier coefficients (vn) in particle transverse momentum (pT) and event multiplicity is presented in pPb collisions recorded by the CMS experiment at a nucleon-nucleon centerof- mass energy √sNN = 8.16 TeV. In particular, new measurements of pT-differential multiparticle cumulants using the subevent method probes an extended phase space region up to a high particle pT. Additionally, we compare the results between pPb and PbPb collisions in the same multiplicity window.

Quality management has been widely discussed in the literature, and recent special issues on humanitarian supply chains and relief operations have emphasized the increasing importance of quality management in this key emerging area. In this paper, we provide an extensive literature review in the field of quality management in humanitarian operations and disaster relief management. Our comprehensive review, comprising 61 articles published from 2009 to 2018, leads to the identification of enablers (e.g., transparency, policy framework), challenges (e.g., financial services, identity protection), and theory development approaches, as well as numerous research gaps that must be addressed.