Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
160
result(s) for
"Singh, Sharad Kumar"
Sort by:
Engineering hydrology : an introduction to processes, analysis, and modeling
This comprehensive engineering textbook offers a thorough overview of all aspects of hydrology and shows how to apply hydrologic principles for effective management of water resources. It presents detailed explanations of scientific principles along with real-world applications and technologies.
Book
Risk factors associated with post-acute sequelae of SARS-CoV-2: an N3C and NIH RECOVER study
Background
More than one-third of individuals experience post-acute sequelae of SARS-CoV-2 infection (PASC, which includes long-COVID). The objective is to identify risk factors associated with PASC/long-COVID diagnosis.
Methods
This was a retrospective case–control study including 31 health systems in the United States from the National COVID Cohort Collaborative (N3C). 8,325 individuals with PASC (defined by the presence of the International Classification of Diseases, version 10 code U09.9 or a long-COVID clinic visit) matched to 41,625 controls within the same health system and COVID index date within ± 45 days of the corresponding case's earliest COVID index date. Measurements of risk factors included demographics, comorbidities, treatment and acute characteristics related to COVID-19. Multivariable logistic regression, random forest, and XGBoost were used to determine the associations between risk factors and PASC.
Results
Among 8,325 individuals with PASC, the majority were > 50 years of age (56.6%), female (62.8%), and non-Hispanic White (68.6%). In logistic regression, middle-age categories (40 to 69 years; OR ranging from 2.32 to 2.58), female sex (OR 1.4, 95% CI 1.33–1.48), hospitalization associated with COVID-19 (OR 3.8, 95% CI 3.05–4.73), long (8–30 days, OR 1.69, 95% CI 1.31–2.17) or extended hospital stay (30 + days, OR 3.38, 95% CI 2.45–4.67), receipt of mechanical ventilation (OR 1.44, 95% CI 1.18–1.74), and several comorbidities including depression (OR 1.50, 95% CI 1.40–1.60), chronic lung disease (OR 1.63, 95% CI 1.53–1.74), and obesity (OR 1.23, 95% CI 1.16–1.3) were associated with increased likelihood of PASC diagnosis or care at a long-COVID clinic. Characteristics associated with a lower likelihood of PASC diagnosis or care at a long-COVID clinic included younger age (18 to 29 years), male sex, non-Hispanic Black race, and comorbidities such as substance abuse, cardiomyopathy, psychosis, and dementia. More doctors per capita in the county of residence was associated with an increased likelihood of PASC diagnosis or care at a long-COVID clinic. Our findings were consistent in sensitivity analyses using a variety of analytic techniques and approaches to select controls.
Conclusions
This national study identified important risk factors for PASC diagnosis such as middle age, severe COVID-19 disease, and specific comorbidities. Further clinical and epidemiological research is needed to better understand underlying mechanisms and the potential role of vaccines and therapeutics in altering PASC course.
Journal Article
Long COVID after SARS-CoV-2 during pregnancy in the United States
Pregnancy alters immune responses and clinical manifestations of COVID-19, but its impact on Long COVID remains uncertain. This study investigated Long COVID risk in individuals with SARS-CoV-2 infection during pregnancy compared to reproductive-age females infected outside of pregnancy. A retrospective analysis of two U.S. databases, the National Patient-Centered Clinical Research Network (PCORnet) and the National COVID Cohort Collaborative (N3C), identified 29,975 pregnant individuals (aged 18–50) with SARS-CoV-2 infection in pregnancy from PCORnet and 42,176 from N3C between March 2020 and June 2023. At 180 days after infection, estimated Long COVID risks for those infected during pregnancy were 16.47 per 100 persons (95% CI, 16.00–16.95) in PCORnet using the PCORnet computational phenotype (CP) model and 4.37 per 100 persons (95% CI, 4.18–4.57) in N3C using the N3C CP model. Compared to matched non-pregnant individuals, the adjusted hazard ratios for Long COVID were 0.86 (95% CI, 0.83–0.90) in PCORnet and 0.70 (95% CI, 0.66–0.74) in N3C. The observed risk factors for Long COVID included Black race/ethnicity, advanced maternal age, first- and second-trimester infection, obesity, and comorbid conditions. While the findings suggest a high incidence of Long COVID among pregnant individuals, their risk was lower than that of matched non-pregnant females.
The influence of pregnancy on Long COVID is not well understood. Here, the authors use electronic health record data from the United States to compare the incidence of Long COVID in females after infection in pregnancy with matched non-pregnant females of reproductive age.
Journal Article
Biodegradation of Cellulosic Wastes and Deinking of Colored Paper with Isolated Novel Cellulolytic Bacteria
Biofuels are the cheapest source of energy, and the continuous decline of traditional sources of energy with the increasing population leads to looking for alternatives to reduce the consumption of traditional sources of energy. Bioethanol production from lignocellulosic wastes and cellulosic wastes is not a new approach for fuel production but a cheap and accessible way for the production of fuel. Bacillus is one of the major species that can act as a source of diversified enzymes. In this study, it was emphasized on screening and isolation of a novel, characterization, and best catalytic action on both celluloses and proteins in the presence of different carbon and nitrogen sources. It was observed the effective catalytic breakdown of cellulose with the crude enzyme to glucose allowed fur for fermentation with Saccharomyces, ultimately leading to the generation of alcohol. The study aims to isolate the microbes that can produce cellulases and enzymes and could be used for biodegradation to produce ethanol in the reaction. The maximum enzyme activity was achieved at 3.112 UI with optimized pH and temperature, and the maximum conversion of sugars into alcohol was about 70% in the newspaper, cartons, colored paper, and disposable paper cups. An essential observation was the decolorization of the origami craft paper within 24 hours. The study was involved in enhancing the maximum Enzyme activity of cellulases from different cellulosic raw materials. Hence, it was achieved by JCB strain, optimization of pH, temperature, and acids for the biodegradation. The presence of peaks at 3200 and 2900 was a confirmation of ethanol bonds in the biodegradation reaction mixtures.
Journal Article
Determinants of Indian physicians' satisfaction & dissatisfaction from their job
Physicians' satisfaction/dissatisfaction from their job is an important factor associated with health service that deals with human life. This study was conducted to ascertain overall level and proportion of physicians' satisfaction from their job as well as to identify those components that influenced it.
A comprehensive customized questionnaire was used with Section A to assess demographic profile of physicians and Section B to assess satisfaction. Response to each question was devised using Likert scale. Likert scale responses were converted to normal scale so that statistical procedures could be naturally developed. A total of 170 physicians were selected using multistage sampling. Questionnaire was administered on one to one basis to avoid non-response. Precise and contextualized descriptive and inferential statistical procedures were used for analysis.
Of the 140 physicians, 103 (74%) were satisfied from their job with average score of 19.15 ± 11.46 while 37 (26%) were dissatisfied with average score -09.27 ± 06.30. Nine out of 15 components were found significant (P<0.05).
Comparative assessment of the present results with those of other studies revealed that satisfaction percentage of Indian physicians and those of the developed countries were almost the same. Perhaps, magnitude of satisfaction level (average score) of the Indian physicians were towards the lower side. Nine determinants, identified in this study can be used safely to assess any professionals' satisfaction.
Journal Article
Dynamic network analysis of a target defense differential game with limited observations
In this paper, we study a Target-Attacker-Defender (TAD) differential game involving one attacker, one target and multiple defenders. We consider two variations where (a) the attacker and the target have unlimited observation range and the defenders are visibility constrained (b) only the attacker has unlimited observation range and the remaining players are visibility constrained. We model the players' interactions as a dynamic game with asymmetric information. Here, the visibility constraints of the players induce a visibility network which encapsulates the visibility information during the evolution of the game. Based on this observation, we introduce network adapted feedback or implementable strategies for visibility constrained players. Using inverse game theory approach we obtain network adapted feedback Nash equilibrium strategies. We introduce a consistency criterion for selecting a subset (or refinement) of network adapted feedback Nash strategies, and provide an optimization based approach for computing them. Finally, we illustrate our results with numerical experiments.
Paper
