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Sickle cell disease (SCD) and thalassemia are the most common hereditary disorders encountered in Central India. Timely identification of these disorders is critical to reduction in severe clinical manifestations and for identifying disease burden. Present study reports spectrum of hemoglobinopathies among the referred anemia patients to single centre in central India. All individuals referred to the institute from 1st January 2012 to 31st August 2020 for diagnosis were included in the study. Demographic details, clinical and transfusion history were obtained. Hemoglobin electrophoresis or High-Performance Liquid Chromatography (Variant II, Bio-Rad) was performed to identify the type of hemoglobinopathy. Molecular characterization of unknown or rare variants was performed  wherever necessary. During the study period 13,587 individuals were screened. Homozygous beta thalassemia was observed in 0.6% of the patients, whereas SCD was observed in 12% of the patients. Seventy-four individuals have either hereditary persistence of fetal hemoglobin (HPFH) or delta beta thalassemia. More than 50% of SCD patients referred were over the age of 12 years. SCD disease was more common among Pradhan, Gond and Baiga tribes whereas HPFH and delta beta thalassemia was found among Other socially and educationally backward classes. High occurrence of hemoglobinopathies in central India warrants the need of large scale screening in highly prevalent communities for its prevention.

Sickle cell disease has varied clinical symptoms, and patients having high fetal hemoglobin (HbF) have milder symptoms. Various genetic factors are known to modulate the HbF levels. Krüppel-like factor 1 (KLF1) is a transcription factor that regulates the beta-like globin gene expression. Any variation in KLF1 gene may alter the sickle cell disease phenotype. Xmn-I polymorphism is also known to regulate the gamma globin gene expression. Present studies were carried out to investigate the effect of KLF1 gene mutations and Xmn-I polymorphism on the sickle cell disease severity and to ascertain the genotype-phenotype correlation. One hundred and eighteen sickle cell disease patients having a median follow-up of 5 years (3–10 years) were recruited. Clinical details were recorded from their retrospective medical records. Xmn-I polymorphism were analyzed using PCR-RFLP method. Variations in KLF1 gene were identified using Sanger sequencing. Out of 118 patients, 24 had acute chest syndrome and 21 patients had more than 2 pain episodes per year. There were no significant differences in sickle cell disease-related morbidities in male and females barring leg ulcers. A total of 6 polymorphism were observed in KLF1 gene, out of which 3 are novel (c.-304G > C, c.*141A > G and c.*178A > G). No statistically significant association of any of SNPs identified in KLF1 gene or Xmn-I polymorphism was seen with HbF levels as well as the sickle cell disease-related morbidities. No association exists between fetal hemoglobin or sickle cell disease-related morbidities and Xmn-I polymorphism or with SNPs identified in KLF1 gene in the studied cohort.

Sickle cell disease (SCD) and thalassemia are the most common hereditary disorders encountered in Central India. Timely identification of these disorders is critical to reduction in severe clinical manifestations and for identifying disease burden. Present study reports spectrum of hemoglobinopathies among the referred anemia patients to single centre in central India. All individuals referred to the institute from 1st January 2012 to 31st August 2020 for diagnosis were included in the study. Demographic details, clinical and transfusion history were obtained. Hemoglobin electrophoresis or High-Performance Liquid Chromatography (Variant II, Bio-Rad) was performed to identify the type of hemoglobinopathy. Molecular characterization of unknown or rare variants was performed  wherever necessary. During the study period 13,587 individuals were screened. Homozygous beta thalassemia was observed in 0.6% of the patients, whereas SCD was observed in 12% of the patients. Seventy-four individuals have either hereditary persistence of fetal hemoglobin (HPFH) or delta beta thalassemia. More than 50% of SCD patients referred were over the age of 12 years. SCD disease was more common among Pradhan, Gond and Baiga tribes whereas HPFH and delta beta thalassemia was found among Other socially and educationally backward classes. High occurrence of hemoglobinopathies in central India warrants the need of large scale screening in highly prevalent communities for its prevention.

Contains 32 papers from the following seven 2013 Materials Science and Technology (MS&T'13) symposia: Innovative Processing and Synthesis of Ceramics, Glasses and Composites Advances in Ceramic Matrix Composites Advanced Materials for Harsh Environments Advances in Dielectric Materials and Electronic Devices Controlled Synthesis, Processing, and.

The lignite samples collected from Giral lignite field of Barmer basin have been subjected to petrological investigation. The data generated has been discussed to understand the evolution of the paleomires of these lignites. The present study reveals that these low rank C coals are chiefly composed of huminite group macerals, mainly telohuminite and detrohuminite, while liptinite and inertinite group macerals occur in subordinate amounts. Not much variation in the maceral composition from Seam-I to Seam-VIII has been observed. Barmer lignites are characterized by a very high GI （〉10） and moderate TPI indicating topogenous mire in the basin which was permanently flooded. The GI and TPI values and the petrography-based facies critical models indicate that these lignites originated mostly under wet forest swamp to clastic marsh having telmatic to limno-telmatic conditions with a moderate rate of subsidence and a very slow fall in ground water table. Further, the GWI and VI values are suggestive of mesotrophic to rheotrophic hydrological conditions having the dominance of herbaceous to marginal aquatic vegetation. There were spells of periodic drowning of peat especially during the formation of Seam-VII. Moderately high concentration of calcium in these lignites along with the presence of framboidal pyrite indicate enhanced sulphate-reducing bacterial activity present in carbonate and sulphate-rich waters in the basin during peat formation.

Clinical measurement. To investigate the characteristics of wrist motion (area, axis, and location) during activities of daily living (ADL) using electrogoniometry. A sample of 83 normal volunteers performed the Sollerman hand function test (SHFT) with a flexible biaxial electrogoniometer applied to their wrists. This technique is accurate and reliable and has been used before for assessment of wrist circumduction in normal volunteers. A software package was used to overlay an ellipse of best fit around the 2-dimensional trace of the electrogoniometer mathematically computing the area, location, and axis angle of the ellipse. Most ADL could be completed within 20% of the total area of circumduction (3686°° ± 1575°°) of a normal wrist. An oblique plane in radial extension and ulnar flexion (dart-throwing motion plane) was used for rotation (−14° ± 32°) and power grip tasks (−29° ± 25°) during ADL; however, precision tasks (4° ± 28°), like writing, were performed more often in the flexion extension plane. In the dominant hand, only 2 power tasks were located in flexion region (cutting play dough [ulnar] and pouring carton [radial]), precision tasks were located centrally, and rotation and other power tasks were located in extension region. This study has identified that wrist motion during the ADL requires varying degrees of movement in oblique planes. Using electrogoniometry, we could visualize the area, location, and plane of motion during ADL. This could assist future researchers to compare procedures leading to loss of motion in specific quadrants of wrist motion and its impact on patient's ability in performing particular ADL. It could guide hand therapists to specifically focus on retraining the ADL that may be affected when wrist range of motion is lost after injury. Diagnostic level III.

Mand-Raigarh coalfield is one of the largest coalfields in the Mahanadi basin. The Geological Survey of India carried out initial study primarily on exploration. However, detailed petrographic and geochemical characters of the coals have not been done so far. This investigation is an attempt for petrographic and geochemical appraisal of the coals. Moreover, effort is also made for possible interpretation on development of coal facies. The results drawn from 30 composite coal samples suggest coals are rich in vitrinite, with collotelinite as the dominant maceral while liptinite macerals register low concentration. Dominant mineral assemblages found were clay minerals, pyrite was recorded as disseminated, framboidal and euhedral forms, carbonates recorded were mainly siderites. The vitrinite reflectance random （VRo） mean values range from 0.44 % to 0.56 %, and the rank of coal is suggested as high volatile ＇B＇ to ＇A＇ sub- bituminous in rank. The rock-eval pyrolysis reveal TOC content varying from 37 % to 68.83 %, while low hydrocarbon generating potential is evident from low $2 and Tmax values. The Hydrogen Index （HI） versus Oxygen Index （OI） plot reveal that the samples belong to Kerogen type--II-III with input dominantly from terrestrial source, some samples also fall in Kerogen type--II domain indicating lacustrine input. Vitrinite reflectance result indicate that the samples are immature and approaching oil window, which is in agreement with data of the Rock-Eval parameters. The gelification index （GI） and tissue preservation index （TPI） indicate that the coal developed in a telematic set up with high tree density. The ground water index （GWI） and vegetation index （VI） demonstrate that the peat developed as an ombrogenous bog.

This volume contains 20 manuscripts presented during the Materials Science & Technology 2017 Conference (MS&T'17), held October 8-12, 2017 at the David L. Lawrence Convention Center, Pittsburgh, PA. Papers from the following symposia are included in this volume: * 9th International Symposium on Green and Sustainable Technologies for Materials Manufacturing and Processing * Advances in Dielectric Materials and Electronic Devices * Construction and Building Materials for a Better Environment * Innovative Processing and Synthesis of Ceramics, Glasses and Composites * Materials Issues in Nuclear Waste Management in the 21st Century * Materials Development for Nuclear Applications and Extreme Environments * Materials for Nuclear Energy Applications * Nanotechnology for Energy, Healthcare andIndustry * Processing and Performance of Materials Using Microwaves, Electric and Magnetic Fields, Ultrasound, Lasers, and Mechanical Work – Rustum Roy Symposium These symposia provided a forum for scientists, engineers, and technologists to discuss and exchange state-of-the-art ideas, information, and technology on advanced methods and approaches for processing, synthesis, characterization, and applications of ceramics, glasses, and composites. Each manuscript was peer-reviewed using The American Ceramic Society's review process. The editors wish to extend their gratitude and appreciation to their symposium co-organizers, to all of the authors for their valuable submissions, to all the participants and session chairs for their time and effort, and to all the reviewers for their comments and suggestions. We hope that this volume will serve as a useful reference for the professionals working in the field of materials science.

This volume contains 40 papers from the following 10 Materials Science and Technology (MS&T'14) symposia: * Rustum Roy Memorial Symposium: Processing and Performance of Materials Using Microwaves, Electric and Magnetic Fields, Ultrasound, Lasers, and Mechanical Work * Advances in Dielectric Materials and Electronic Devices * Innovative Processing and Synthesis of Ceramics, Glasses and Composites * Advances in Ceramic Matrix Composites * Sintering and Related Powder Processing Science and Technology * Advanced Materials for Harsh Environments * Thermal Protection Materials and Systems * Advanced Solution Based Processing for Ceramic Materials * Controlled Synthesis, Processing, and Applications of Structure and Functional Nanomaterials * Surface Protection for Enhanced Materials Performance