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The work focuses on the development of a fluorimetric version of the fingerprint method based on conducting indicator reactions in the presence of a test sample. Observation of these reactions over time provides a more detailed information compared to batch methods, thereby improving sample recognition and enabling quantitative analysis. The proposed indicator reaction utilizes a commercial carbocyanine dye and 4-dimethylaminobenzaldehyde, whose interaction results in a decrease in fluorescence intensity and changes in absorbance over time. Three fluoroquinolones—moxifloxacin, levofloxacin, and ofloxacin—selectively change the signal in concentrations of 1 μM or higher, while other drugs, including different fluoroquinolones, do not interfere with the determination. Ofloxacin was detected in human urine samples at various times post-drug intake. A potential of using the same indicator reaction for sample recognition was demonstrated on examples of apple juices, soil extracts, and meat of varying freshness. Chemometric methods, including linear discriminant analysis, were used for data processing. The method achieved 97% accuracy in discriminating fifteen apple juice samples, 94% accuracy for ten apple juices from 2022 and 2023, 99% accuracy for ten soil samples, and successfully determined the freshness of five meat samples.

In this study we develop a variant of fluorescent sensor array technique based on addition of fluorophores to samples. A correct choice of fluorophores is critical for the successful application of the technique, which calls for the necessity of comparing different discrimination protocols. We used 36 honey samples from different sources to which various fluorophores were added (tris-(2,2′-bipyridyl) dichlororuthenium(II) (Ru(bpy)32+), zinc(II) 8-hydroxyquinoline-5-sulfonate (8-Ox-Zn), and thiazole orange in the presence of two types of deoxyribonucleic acid). The fluorescence spectra were obtained within 400–600 nm and treated by principal component analysis (PCA). No fluorophore allowed for the discrimination of all samples. To evaluate the discrimination performance of fluorophores, we introduced crossing number (CrN) calculated as the number of mutual intersections of confidence ellipses in the PCA scores plots, and relative position (RP) characterized by the pairwise mutual location of group centers and their most distant points. CrN and RP parameters correlated with each other, with total sensitivity (TS) calculated by Mahalanobis distances, and with the overall rating based on all metrics, with coefficients of correlation over 0.7. Most of the considered parameters gave the first place in the discrimination performance to Ru(bpy)32+ fluorophore.

Substitution reactions in carbocyanine dyes are used to determine nucleophilic compounds. The interaction of a chlorine-containing carbocyanine dye with a number of medicinal substances is studied. It is shown that, in the reaction with isoniazid in the presence of a surfactant, this dye selectively changes color from yellow-green to violet. The formation of a product of the substitution of chlorine for isoniazid is proven by chromatography–mass spectrometry. The reaction proceeds in 20 min in the presence of 1 mM cetyltrimethylammonium bromide. The limit of detection for isoniazid in water by the photometric method is 10 μg/mL and in diluted artificial urine using fluorimetry, 0.3 μg/mL. The procedure does not use full-spectrum equipment, which simplifies the determination.

Water quality control employs techniques mostly targeting individual analytes; group detection is also practiced, but the choice of group methods is limited, which supports interest in developing such methods. We have examined the interaction of hypochlorite with a chlorine-containing heptamethine carbocyanine dye in the presence of 30 organic and inorganic model analytes that were found to induce diverse color changes in the system. The main supposed mechanisms are retardation of the dye oxidation with hypochlorite (presumably by scavenging chlorine radicals) and substitution of chlorine atom in the dye by the most nucleophilic analytes (amines, amino acids, proteins, DNA, phenol). The grass-green substitution product is more contrastingly visible against the dark-purple hypochlorite oxidation product of the dye than against the original emerald-green dye. The indicator reaction is monitored photographically for 10–40 min and the images are processed using principal component analysis (PCA) or linear discriminant analysis (LDA), allowing for data convolution for the complex color transitions. Nitrogen compounds are discriminated from the others, and more reactive analytes (tryptophan, cysteine, bovine serum albumin, and DNA) are detected in the presence of less reactive ones in natural water. The system is promising for the development of group assays for dissolved organic matter and the discrimination of water samples.

Objective: a comprehensive theoretical and legal study of the nature of judicial practice. Methods : the methodological basis of the article is postclassical rationality, which allows studying judicial practice in the context of its impact on the public relations regulation and establishing the legal nature of this phenomenon. This determined the integration of methods developed in the legal science (formal legal, comparative legal methods, method of legal modeling) and other humanities (hermeneutical, discursive methods). Results: the article considers judicial practice as an individual legal regulation, i.e. the activities of the authorized judicial bodies of the state aimed at consideration and resolution of legal cases, as well as the creation of individual legal foundations for the lawful behavior of subjects of public relations. The authors proceed from the fact that judicial practice is a unity of cognition, activity, and result, as it actively participates in the construction of legal reality. This leads to the conclusion that judicial practice should be understood dichotomically – as the activity of judges, the result of which is the creation of individual and generalizing legal acts aimed at constructing a legal reality (a specific form of legal communication), and as a material source of law (a set of generalizing legal acts (positions of courts) that have a legal impact on the consciousness and behavior of an indefinite circle of subjects of the same name). Scientific novelty : in the article, for the first time in the Russian legal science, a study of judicial practice is transferred from the level of sectoral analysis to the philosophical-legal level. At the same time, the authors emphasize the interdisciplinary, general humanitarian nature of judicial practice. The analysis and interpretation of judicial practice are carried out at the ontological and axiological levels of legal reality. This allowed identifying the specific role of judicial practice in the legal system as a means of communication between individual and general legal regulation. Practical significance : the main provisions and conclusions of the article can be used in scientific and pedagogical activities when considering the essence and content of judicial practice and its role in the creation and functioning of the Russian legal reality, as well as for improving judicial activity at all levels.

Subject of Research. The paper considers physical processes occurring in sensory elements of angular rate and apparent acceleration measuring devices, such as hemispherical resonator gyro and pendulum accelerometer. Inertial masses of the studied sensory elements are made of KU-1 quartz glass. Method. Actual engineering drawings of the sensory elements are converted into a specialized 3D environment to simulate the performance of devices under different input effects, that is impossible with real devices. Moreover, traditional mathematical modeling approach, that involves such software packages as Matlab, does not provide a complete picture. Main Results. Visual information on the nature of motion of inertial masses was obtained using the results of 3D modeling, making it possible to improve and correct the known mathematical models of devices for subsequent Matlab analysis with closed control loop, since the studied gyro and accelerometer are compensation type devices with positive and negative feedback, respectively. Resonant frequencies of the considered devices were calculated as well. Practical Relevance. Considering the accelerometer, the obtained information on resonant frequencies made it possible to calculate band pass filters in order to suppress reactions to disturbances at these frequencies in the device pass band, and for the hemispherical resonator gyro it provides the possibility to define more precisely the resonator working frequency of oscillations.

Inelastic nuclear interaction probability of 400 GeV/c protons interacting with bent silicon crystals was investigated, in particular for both types of crystals installed at the CERN Large Hadron Collider for beam collimation purposes. In comparison to amorphous scattering interaction, in planar channeling this probability is ∼36% for the quasi-mosaic type (planes (111)), and ∼27% for the strip type (planes (110)). Moreover, the absolute inelastic nuclear interaction probability in the axial channeling orientation, along the ⟨110⟩ axis, was estimated for the first time, finding a value of 0.6% for a crystal 2 mm long along the beam direction, with a bending angle of 55 μrad. This value is more than two times lower with respect to the planar channeling orientation of the same crystal, and increases with the vertical angular misalignment. Finally, the correlation between the inelastic nuclear interaction probability in the planar channeling and the silicon crystal curvature is reported.

Objective : to study the socio-cultural and legal nature of the corruption phenomenon in a discursive and communicative context. Methods : the methodological basis of the article is the synthesis of the discursive and communicative theory of J. Habermas and W. Krawietz’s integrative theory of legal reality, focusing on the interdisciplinary study of corruption as an interdisciplinary category, taking into account not only objective, but also subjective components. This determined the choice of research methods (comparative, hermeneutic, and discursive methods). Results : corruption as a phenomenon and the interdisciplinary category reflecting it is determined by social, cultural and psychological factors of the legal reality development. Acting as a complex legal archetype, it defines the value attitudes of consciousness and behavior of the legal communication participants, orienting them to carry out actions aimed at satisfying individual (less often group and social) interests, even if they contradict the law. Corrupt behavior is perceived by a large part of the Russian society as a model of hierarchical interaction of the legal communication subjects, the purpose of which, according to the addressee, is to increase the effectiveness of the addressee’s activities. In addition, corruption is becoming an informal means of “liberation” from the legal requirements, rigid and unfair, according to some representatives of the society. In these conditions, the success of the institutional fight against corruption can be achieved only if this fight involves not only improvement of anti-corruption legislation, but also countering shadow norms, creating a system of anti-incentives for corrupt behavior, including ideologically, through the formation of value attitudes of citizens to reject corrupt practices as unpatriotic and harmful to the rule of law and the legal culture of the society as a whole. Scientific novelty : for the first time in Russian jurisprudence, a study of the category of corruption in the communicative and discursive aspect was conducted. Practical significance : the main provisions and conclusions of the article can be used in scientific and pedagogical activities when considering the issues of the essence and content of the Russian legal reality, in the anti-corruption activities of state and municipal bodies, as well as in anti-corruption education.

Crystalline undulators with periodically deformed crystallographic planes offer coherent electromagnetic fields on the order of 1000 T and provide undulator period L in submillimeter range. We present an idea for creation of a crystalline undulator and report its realization. One face of a silicon crystal was given periodic microscratches (grooves) by means of a diamond blade, with a period ranging from 0.1 to 0.5 mm in different samples. The x-ray tests of the crystal deformation have shown that a sinusoidal-like shape of crystalline planes goes through the bulk of the crystals. This opens up the possibility for experiments with high-energy particles channeled in the crystalline undulator, a new compact source of radiation. The first experiments on photon emission in the crystal undulator are in preparation at IHEP (Protvino) with 2–15 GeV positrons and at LNF (Frascati) with 500–800 MeV positrons, aiming to produce undulator photons in the range of 50–500 keV. The results of Monte Carlo simulations for the planned experiments are presented as well.

Objective: to comprehensively study the borrowings of law as a means of improving the national legal system. Great attention is paid to the classification of legal borrowings and the specifics of these processes in modern Russia.Methods: the methodological basis of the research is the synthesis of classical and post-classical ideological paradigms, which determined the choice of specific research methods: formal-legal, comparative, method of legal modeling, hermeneutic, discursive.Results: the article studies the legal category of “borrowings of law”. Based on the study of content, focus and methods of law borrowings, their classification (reception of law, legal dialogue, legal acculturation, legal transfer, legal expansion) is proposed. The author’s interpretation of these concepts and their role in improving the national legal system is given. Special attention is paid to the nature and significance of law borrowings in Russia. The conclusion is made that the effective legal system development is possible only under the combination of legal borrowings and national legal values. Scientific novelty: for the first time, the article analyzes the essence and content of law borrowings from post-classical viewpoint, their classification is given, defines their role in the legal development of modern Russia.Practical significance: the main provisions and conclusions of the article can be used in scientific and educational activities when considering the essence and content of legal development.