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Increasing amounts of genetic data have led to the development of polygenic risk scores (PRSs) for a variety of diseases. These scores, built from the summary statistics of genome-wide association studies (GWASs), are able to stratify individuals based on their genetic risk of developing various common diseases and could potentially be used to optimize the use of screening and preventative treatments and improve personalized care for patients. Many challenges are yet to be overcome, including PRS validation, healthcare professional and patient education, and healthcare systems integration. Ethical challenges are also present in how this information is used and the current lack of diverse populations with PRSs available. In this review, we discuss the topics above and cover the nature of PRSs, visualization schemes, and how PRSs can be improved. With these tools on the horizon for multiple diseases, scientists, clinicians, health systems, regulatory bodies, and the public should discuss the uses, benefits, and potential risks of PRSs.

In 2016 we have upgraded the COMPASS RICH by novel gaseous photon detectors based on MPGD technology. Four new photon detectors, covering a total active area of 1.5 m 2 , have been installed in order to cope with the challenging efficiency and stability requirements of the COMPASS physics programme. The new detector architecture consists in a hybrid MPGD combination: two layers of THGEMs, the first of which also acts as a reflective photocathode thanks to CsI coating, are coupled to a bulk Micromegas on a pad-segmented anode. These detectors are the first application in an experiment of MPGD-based single photon detectors. Presently, we are further developing the MPGD-based PDs to make them adequate for a setup at the future EIC collider. All aspects of the COMPASS RICH-1 Photon Detectors upgrade are presented: R&D, engineering, mass production, QA and performance; the on-going development for collider application is also presented.

After pioneering gaseous detectors of single photon for RICH applications using CsI solid state photocathodes in MWPCs within the RD26 collaboration and by the constructions for the RICH detector of the COMPASS experiment at CERN SPS, in 2016 we have upgraded COMPASS RICH by novel gaseous photon detectors based on MPGD technology. Four novel photon detectors, covering a total active area of 1.5 m2, have been installed in order to cope with the challenging effciency and stability requirements of the COMPASS physics programme. They are the first application in an experiment of MPGD-based single photon detectors. All aspects of the upgrade are presented, including engineering, mass production, quality assessment and performance. Perspectives for further developments in the field of gaseous single photon detectors are also indicated.

We present the current status of high-energy cosmic-ray physics and gamma-ray astronomy at the Tunka Astrophysical Center (AC). This complex is located in the Tunka Valley, about 50 km from Lake Baikal. Present efforts are focused on the construction of the first stage of the gamma-ray observatory TAIGA - the TAIGA prototype. TAIGA (Tunka Advanced Instrument for cosmic ray physics and Gamma Astronomy) is designed for the study of gamma rays and charged cosmic rays in the energy range 1013 eV–1018 eV. The array includes a network of wide angle timing Cherenkov stations (TAIGA-HiSCORE), each with a FOV = 0.6 sr, plus up to 16 IACTs (FOV - 10∘× 10∘). This part covers an area of 5 km2. Additional muon detectors (TAIGA-Muon), with a total coverage of 2000 m2, are distributed over an area of 1 km2.

The physics motivations and advantages of the new TAIGA (Tunka Advanced Instrument for cosmic ray physics and Gamma Astronomy) detector are presented. TAIGA aims at gamma-ray astronomy at energies from a few TeV to several PeV, as well as cosmic ray physics from 100 TeV to several EeV. For the energy range 30 – 200 TeV the sensitivity of 10 km 2 area TAIGA array for the detection of local sources is expected to be 5 × 10 -14 erg cm -2 sec -1 for 300 h of observations. Reconstruction of the given EAS energy, incoming direction and its core position, based on the timing TAIGA-HiSCORE data, allows one to increase a distance between the IACTs up to 600-1000 m. The low investments together with the high sensitivity for energies ≥ 30-50 TeV make this pioneering technique very attractive for exploring the galactic PeVatrons and cosmic rays. At present the TAIGA first stage has been constructed in Tunka valley, 50 km West from the Lake Baikal. The first experimental results of the TAIGA first stage are presented.

COMPASS is a fixed target experiment at CERN SPS aimed to study hadron structure and spectroscopy. Hadron identification in the momentum range between \\(3\\) and \\(55 GeV/c\\) is provided by a large gaseous Ring Imaging Cherenkov Counter, RICH-1. To cope with the challenges imposed by the new physics program of COMPASS, RICH-1 has been upgraded by replacing four MWPC-based photon detectors with newly developed MPGD-based photon detectors. The architecture of the novel detectors is a hybrid combination of two layers of THGEMs and a Micromegas. The top of the first THGEM is coated with CsI acting as a reflective photo-cathode. The anode is segmented in pads capacitively coupled to the APV-25 based readout. The new hybrid detectors have been commissioned during the 2016 COMPASS data taking and stably operated during the 2017 run. In this paper design, construction, operation and performance aspects of the novel photon detectors for COMPASS RICH-1 are discussed.

The analyzing power, , and the polarization transfer observables , and have been measured in neutron-proton elastic scattering at 260, 318, 386, 472 and 538 MeV for c.m. scattering angles between 64° and 160°. The data were obtained at PSI with a polarized neutron beam and a polarimeter analyzing the transverse polarization of the outgoing proton. They make a significant impact on the knowledge of the Isospin I = 0 nucleon-nucleon scattering.

After pioneering gaseous detectors of single photon for RICH applications using CsI solid state photocathodes in MWPCs within the RD26 collaboration and by the constructions for the RICH detector of the COMPASS experiment at CERN SPS, in 2016 we have upgraded COMPASS RICH by novel gaseous photon detectors based on MPGD technology. Four novel photon detectors, covering a total active area of 1.5~m\\(^2\\), have been installed in order to cope with the challenging efficiency and stability requirements of the COMPASS physics programme. They are the first application in an experiment of MPGD-based single photon detectors. All aspects of the upgrade are presented, including engineering, mass production, quality assessment and performance. Perspectives for further developments in the field of gaseous single photon detectors are also indicated.

After pioneering gaseous detectors of single photon for RICH applications using CsI solid state photocathodes in MWPCs within the RD26 collaboration and by the constructions for the RICH detector of the COMPASS experiment at CERN SPS, in 2016 we have upgraded COMPASS RICH by novel gaseous photon detectors based on MPGD technology. Four novel photon detectors, covering a total active area of 1.5~m\\(^2\\), have been installed in order to cope with the challenging efficiency and stability requirements of the COMPASS physics programme. These detectors are the first application in an experiment of MPGD-based single photon detectors. All aspects of the upgrade are presented, including engineering, mass production, quality assessment and performance. Perspectives for further developments in the field of gaseous single photon detectors are also presented.