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"Smith, Christopher"
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Dancing revolution : bodies, space, and sound in American cultural history
\"Smith's project reconfigures the understanding of public space as a site for symbolic contestation of social and political control by investigating historical moments of participatory vernacular dance. Smith focuses extensively on public venues, such as the street, dance hall, and theater, in order to analyze the ways in which participatory public dance--street dance--functioned as a tool for contesting, constructing, or reinventing social order. Utilizing individual case studies that include, in part, the God-intoxicated public demonstrations of the First Great Awakening; the Creolized antebellum theatrical and festival dance of cities as diverse as New Orleans, Albany, and Bristol; the modernism, primitivism, and racial integration of 20th century African American popular dance; and the social role of dance in contemporary transgressive communities, Smith's project spans centuries, geographies, and cultural identities. Smith contends that highly diverse groups from across a very wide span of political and cultural identities have struck upon street dance as an effective and empowering rhetorical strategy. Smith analyzes the particularly explosive contestation of gender, sexuality, race, class, and community identity that occurs when these participatory public dances occur\"-- Provided by publisher.
Book
Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to phenotypic diversity in multicellular organisms. Alternative splicing generates multiple transcripts from a single gene, enriching the diversity of proteins and phenotypic traits. It is well established that alternative splicing contributes to key innovations over long evolutionary timescales, such as brain development in bilaterians. However, recent developments in long-read sequencing and the generation of high-quality genome assemblies for diverse organisms has facilitated comparisons of splicing profiles between closely related species, providing insights into how alternative splicing evolves over shorter timescales. Although most splicing variants are probably non-functional, alternative splicing is nonetheless emerging as a dynamic, evolutionarily labile process that can facilitate adaptation and contribute to species divergence.In this Perspective, the authors discuss how regulated alternative splicing can generate phenotypic diversity and outline emerging evidence that alternative splicing contributes to adaptation and species divergence.
Journal Article
On the fermionic couplings of axionic dark matter
In the non-relativistic limit, two types of dark matter axion interactions with fermions are thought to dominate: one is induced by the spatial gradient of the axion field and called the axion wind, and the other by the time-derivative of the axion field, generating axioelectric effects. By generalizing Schiff theorem, it is demonstrated that this latter operator is actually strongly screened. For a neutral fermion, it can be entirely rotated away and is unobservable. For charged fermions, the only effect that can peek through the screening is an axion-induced electric dipole moment (EDM). These EDMs are not related to the axion coupling to gluons, represent a prediction of the Dirac theory analogous to the
g
=
2
magnetic moments, are not further screened by the original Schiff theorem, and are ultimately responsible for inducing the usual axioelectric ionization. The two main phenomenological consequences are then that first the axion-induced nucleon EDM could be significantly larger than expected from the axion gluonic coupling, and second, that the electron EDM could also become available, and could actually be highly sensitive to relic axions.
Journal Article
Adobe Creative Cloud all-in-one for dummies
Adobe Creative Cloud is the most popular suite of tools among creative professionals, and a valuable resource you can use to fulfill all of your design goals. Ready to get started? The only book on the market of its kind, Adobe Creative Cloud All-in-One For Dummies is written by designers for designers. It will provide you with expert instruction that spans seven mini-books, with helpful information that can grant insight regardless of your current level of knowledge.
Book
Intron retention as a component of regulated gene expression programs
Intron retention has long been an exemplar of regulated splicing with case studies of individual events serving as models that provided key mechanistic insights into the process of splicing control. In organisms such as plants and budding yeast, intron retention is well understood as a major mechanism of gene expression regulation. In contrast, in mammalian systems, the extent and functional significance of intron retention have, until recently, remained greatly underappreciated. Technical challenges to the global detection and quantitation of transcripts with retained introns have often led to intron retention being overlooked or dismissed as “noise”. Now, however, with the wealth of information available from high-throughput deep sequencing, combined with focused computational and statistical analyses, we are able to distinguish clear intron retention patterns in various physiological and pathological contexts. Several recent studies have demonstrated intron retention as a central component of gene expression programs during normal development as well as in response to stress and disease. Furthermore, these studies revealed various ways in which intron retention regulates protein isoform production, RNA stability and translation efficiency, and rapid induction of expression via post-transcriptional splicing of retained introns. In this review, we highlight critical findings from these transcriptomic studies and discuss commonalties in the patterns prevalent in intron retention networks at the functional and regulatory levels.
Journal Article
Gunpowder & embers
\"Thirty years ago, the world ended. Giant electrovoric ants and pterodons came through a rift in space-time, millions of humans died, and that was that. Thirty years later, humanity has rebuilt . . . to an extent. Without electricity, human ingenuity has provided some creative solutions, but most folks survive at the subsistence level, farming to keep themselves and their families fed. Chuck Gibson never thought he'd have to leave his family's farm. The simple life of a rancher was enough for him. A dying stranger proved him wrong. Now, he's on the road of destiny, accompanied by a mystic warrior monk, a beautiful dragon tamer, a runaway cultist, and a mysterious drunken lecher, all of them searching for the key to reclaiming humanity's future and past. Each of them carrying a single spark of hope. But will that hope be enough to light the beacons of freedom once again? Or will they face the next century in bondage to the last century's technology?\"-- Provided by publisher.
Book
Climate and air-quality benefits of a realistic phase-out of fossil fuels
The combustion of fossil fuels produces emissions of the long-lived greenhouse gas carbon dioxide and of short-lived pollutants, including sulfur dioxide, that contribute to the formation of atmospheric aerosols
1
. Atmospheric aerosols can cool the climate, masking some of the warming effect that results from the emission of greenhouse gases
1
. However, aerosol particulates are highly toxic when inhaled, leading to millions of premature deaths per year
2
,
3
. The phasing out of unabated fossil-fuel combustion will therefore provide health benefits, but will also reduce the extent to which the warming induced by greenhouse gases is masked by aerosols. Because aerosol levels respond much more rapidly to changes in emissions relative to carbon dioxide, large near-term increases in the magnitude and rate of climate warming are predicted in many idealized studies that typically assume an instantaneous removal of all anthropogenic or fossil-fuel-related emissions
1
,
4
–
9
. Here we show that more realistic modelling scenarios do not produce a substantial near-term increase in either the magnitude or the rate of warming, and in fact can lead to a decrease in warming rates within two decades of the start of the fossil-fuel phase-out. Accounting for the time required to transform power generation, industry and transportation leads to gradually increasing and largely offsetting climate impacts of carbon dioxide and sulfur dioxide, with the rate of warming further slowed by reductions in fossil-methane emissions. Our results indicate that even the most aggressive plausible transition to a clean-energy society provides benefits for climate change mitigation and air quality at essentially all decadal to centennial timescales.
Scenarios that model a realistic phase-out of fossil fuels find no substantial near-term increase in the rate of warming, and suggest benefits for climate change mitigation and air quality at essentially all timescales.
Journal Article
Genome-Wide Association between Branch Point Properties and Alternative Splicing
The branch point (BP) is one of the three obligatory signals required for pre-mRNA splicing. In mammals, the degeneracy of the motif combined with the lack of a large set of experimentally verified BPs complicates the task of modeling it in silico, and therefore of predicting the location of natural BPs. Consequently, BPs have been disregarded in a considerable fraction of the genome-wide studies on the regulation of splicing in mammals. We present a new computational approach for mammalian BP prediction. Using sequence conservation and positional bias we obtained a set of motifs with good agreement with U2 snRNA binding stability. Using a Support Vector Machine algorithm, we created a model complemented with polypyrimidine tract features, which considerably improves the prediction accuracy over previously published methods. Applying our algorithm to human introns, we show that BP position is highly dependent on the presence of AG dinucleotides in the 3' end of introns, with distance to the 3' splice site and BP strength strongly correlating with alternative splicing. Furthermore, experimental BP mapping for five exons preceded by long AG-dinucleotide exclusion zones revealed that, for a given intron, more than one BP can be chosen throughout the course of splicing. Finally, the comparison between exons of different evolutionary ages and pseudo exons suggests a key role of the BP in the pathway of exon creation in human. Our computational and experimental analyses suggest that BP recognition is more flexible than previously assumed, and it appears highly dependent on the presence of downstream polypyrimidine tracts. The reported association between BP features and the splicing outcome suggests that this, so far disregarded but yet crucial, element buries information that can complement current acceptor site models.
Journal Article