Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
1,921
result(s) for
"Smith, Cynthia"
Sort by:
Hearts unbroken
When Louise Wolfe's boyfriend mocks and disrespects Native people in front of her, she breaks things off and dumps him over e-mail. She'd rather spend her senior year with her family and friends and working on the school newspaper. The editors pair her up with Joey Kairouz, an ambitious new photojournalist, and in no time the paper's staff find themselves with a major story to cover: the school musical director's inclusive approach to casting The Wizard of Oz has been provoking backlash in their mostly white, middle-class Kansas town. As tensions mount at school, so does a romance between Lou and Joey. But 'dating while Native' can be difficult. In trying to protect her own heart, will Lou break Joey's? -- adapted from jacket.
Book
Molecular mechanisms of trigeminal neuralgia: A systematic review
•The pathophysiology of trigeminal neuralgia is unknown.•Abnormal functioning of cellular channels may underlie trigeminal neuralgia.•Numerous potential gene mutations and polymorphisms have been identified.
To conduct a systematic review of the available literature for primary research articles identifying potential gene mutations, polymorphisms and other molecular regulatory mechanisms related to trigeminal neuralgia in order to identify the genetic and molecular models of primary trigeminal neuralgia currently being investigated.
PubMed and Web of Science were systematically searched to identify primary research articles discussing genetic predictors of trigeminal neuralgia and neuropathic pain that were published prior to July 2020. This review was conducted according to PRISMA guidelines.
Out of the 333 articles originally identified, a total of 14 papers were selected for study inclusion. These articles included 5 human studies, 6 mouse studies and 3 rat studies. Four articles investigated sodium channels, 1 investigated a sodium channel and nerve growth factor receptor, 2 investigated potassium channels, 1 investigated calcium channels, 1 investigated the downstream regulatory element antagonist modulator protein, 1 investigated the dynorphin-kappa opioid receptor system, 1 investigated TRPA1, 1 investigated the Nrg1/ErbB3/ErbB2 signaling complex, 1 investigated a serotonin transporter and 1 investigated potassium channels, sodium channels, calcium channels, chloride channels, TRP channels and gap junctions.
Researchers have identified multiple genetic and molecular targets involved with potential pathophysiologies that have a relationship to the creation of trigeminal neuralgia. At this time, there does not seem to be clear causal frontrunner, demonstrating the possibility that genetic predisposition to trigeminal neuralgia may involve multiple genes and/or downstream products, such as ion channels.
Journal Article
Foxfire approach : inspiration for classrooms and beyond
\"This collection of essays by Foxfire practitioners represents the wide range of adaptations by educators of the pedagogical orientation of the Foxfire Magazine and Foxfire Programs for Teachers\"--Back cover.
Book
Age determination of common bottlenose dolphins (Tursiops truncatus) using dental radiography pulp:tooth area ratio measurements
Age is an important parameter to better understand wildlife populations, and is especially relevant for interpreting data for fecundity, health, and survival assessments. Estimating ages for marine mammals presents a particular challenge due to the environment they inhabit: accessibility is limited and, when temporarily restrained for assessment, the window of opportunity for data collection is relatively short. For wild dolphins, researchers have described a variety of age-determination techniques, but the gold-standard relies upon photo-identification to establish individual observational life histories from birth. However, there are few populations with such long-term data sets, therefore alternative techniques for age estimation are required for individual animals without a known birth period. While there are a variety of methods to estimate ages, each involves some combination of drawbacks, including a lack of precision across all ages, weeks-to-months of analysis time, logistical concerns for field applications, and/or novel techniques still in early development and validation. Here, we describe a non-invasive field technique to determine the age of small cetaceans using periapical dental radiography and subsequent measurement of pulp:tooth area ratios. The technique has been successfully applied for bottlenose dolphins briefly restrained during capture-release heath assessments in various locations in the Gulf of Mexico. Based on our comparisons of dental radiography data to life history ages, the pulp:tooth area ratio method can reliably provide same-day estimates for ages of dolphins up to about 10 years old.
Journal Article
Firefly Season
\"Piper feels grateful for visits with her relatives, especially for the time spent with her cousins in Cherokee Nation and Muscogee Nation during summer vacations, fishing on misty mornings and playing on firefly-filled evenings. Piper's family lives a road trip away in Kansas City. So when a neighbor named Sumi moves in next door, Piper is excited to share her stories and seasons with a new friend. The two are inseparable--until Piper's family moves to another city. Their bond overcomes distance, and with time, Piper dreams up a plan to reunite with the people she loves most of all\"--Provided by publisher.
BOOK
Mammalian Phenotype Ontology as a unifying standard for experimental and high-throughput phenotyping data
The Mammalian Phenotype Ontology (MP) is a structured vocabulary for describing mammalian phenotypes and serves as a critical tool for efficient annotation and comprehensive retrieval of phenotype data. Importantly, the ontology contains broad and specific terms, facilitating annotation of data from initial observations or screens and detailed data from subsequent experimental research. Using the ontology structure, data are retrieved inclusively, i.e., data annotated to chosen terms and to terms subordinate in the hierarchy. Thus, searching for “abnormal craniofacial morphology” also returns annotations to “megacephaly” and “microcephaly,” more specific terms in the hierarchy path. The development and refinement of the MP is ongoing, with new terms and modifications to its organization undergoing continuous assessment as users and expert reviewers propose expansions and revisions. A wealth of phenotype data on mouse mutations and variants annotated to the MP already exists in the Mouse Genome Informatics database. These data, along with data curated to the MP by many mouse mutagenesis programs and mouse repositories, provide a platform for comparative analyses and correlative discoveries. The MP provides a standard underpinning to mouse phenotype descriptions for existing and future experimental and large-scale phenotyping projects. In this review we describe the MP as it presently exists, its application to phenotype annotations, the relationship of the MP to other ontologies, and the integration of the MP within large-scale phenotyping projects. Finally we discuss future application of the MP in providing standard descriptors of the phenotype pipeline test results from the International Mouse Phenotype Consortium projects.
Journal Article
Design with the other 90% : cities
Through essays, interviews, and profiles of 60 examples of community-led design, this second book in an ongoing series examines the issues arising from unprecedented urban growth, primarily in the informal settlements of emerging and developing economies, as well as efforts in urban planning, sustainable design, affordable housing, entrepreneurship, nonformal education, communication, food, security, water and sanitation, and public health in these communities.
Book
High site-fidelity in common bottlenose dolphins despite low salinity exposure and associated indicators of compromised health
More than 2,000 common bottlenose dolphins (
Tursiops truncatus
) inhabit the Barataria Bay Estuarine System in Louisiana, USA, a highly productive estuary with variable salinity driven by natural and man-made processes. It was unclear whether dolphins that are long-term residents to specific areas within the basin move in response to fluctuations in salinity, which at times can decline to 0 parts per thousand in portions of the basin. In June 2017, we conducted health assessments and deployed satellite telemetry tags on dolphins in the northern portions of the Barataria Bay Estuarine System Stock area (9 females; 4 males). We analyzed their fine-scale movements relative to modeled salinity trends compared to dolphins tagged near the barrier islands (higher salinity environments) from 2011 to 2017 (37 females; 21 males). Even though we observed different movement patterns among individual dolphins, we found no evidence that tagged dolphins moved coincident with changes in salinity. One tagged dolphin spent at least 35 consecutive days, and 75 days in total, in salinity under 5 parts per thousand. Health assessments took place early in a seasonal period of decreased salinity. Nonetheless, we found an increased prevalence of skin lesions, as well as abnormalities in serum biochemical markers and urine:serum osmolality ratios for dolphins sampled in lower salinity areas. This study provides essential information on the likely behavioral responses of dolphins to changes in salinity (e.g., severe storms or from the proposed Mid-Barataria Sediment Diversion project) and on physiological markers to inform the timing and severity of impacts from low salinity exposure.
Journal Article
Global genetic analysis in mice unveils central role for cilia in congenital heart disease
A forward genetic screen in fetal mice to identify genes involved in congenital heart disease (CHD) reveals that a large proportion of genes associated with CHD are related to cilia and cilia-transduced cell signalling, with potential implications for the human disease.
Cilia defects in congenital heart disease
The identification of genes causing congenital heart disease (CHD) has been challenging, in part because of the difficulty of distinguishing pathogenic mutations from random sequence genetic variability. Cecilia Lo and colleagues have therefore used a large-scale mouse forward genetic screen with chemical mutagenesis to recover mutations causing congenital heart disease. They identify 218 mouse models of the condition and, using whole-exome sequencing, 91 recessive mutations in 61 genes. A larger than expected proportion of these genes was found to be related to cilia and cilia-transduced cell signalling.
Congenital heart disease (CHD) is the most prevalent birth defect, affecting nearly 1% of live births
1
; the incidence of CHD is up to tenfold higher in human fetuses
2
,
3
. A genetic contribution is strongly suggested by the association of CHD with chromosome abnormalities and high recurrence risk
4
. Here we report findings from a recessive forward genetic screen in fetal mice, showing that cilia and cilia-transduced cell signalling have important roles in the pathogenesis of CHD. The cilium is an evolutionarily conserved organelle projecting from the cell surface with essential roles in diverse cellular processes. Using echocardiography, we ultrasound scanned 87,355 chemically mutagenized C57BL/6J fetal mice and recovered 218 CHD mouse models. Whole-exome sequencing identified 91 recessive CHD mutations in 61 genes. This included 34 cilia-related genes, 16 genes involved in cilia-transduced cell signalling, and 10 genes regulating vesicular trafficking, a pathway important for ciliogenesis and cell signalling. Surprisingly, many CHD genes encoded interacting proteins, suggesting that an interactome protein network may provide a larger genomic context for CHD pathogenesis. These findings provide novel insights into the potential Mendelian genetic contribution to CHD in the fetal population, a segment of the human population not well studied. We note that the pathways identified show overlap with CHD candidate genes recovered in CHD patients
5
, suggesting that they may have relevance to the more complex genetics of CHD overall. These CHD mouse models and >8,000 incidental mutations have been sperm archived, creating a rich public resource for human disease modelling.
Journal Article