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رجل النظام البوليسي
بطل الرواية ضابط أمن دولة يدعى (ليو دميدوف) تفتتح الرواية به وهو يطارد أحد خونة الدولة السوفييتية، ويقبض عليه بطريقة إعجازية، إن دميدوف نموذج للمواطن السوفييتي المؤمن بالشيوعية وبالدولة، والذي يتفهم ضرورة القضاء على أعداء الدولة وحمايتها من الاختراق، متزوج من امرأة جميلة تدعى ريزا، مدمن على المنشطات، ويرأس مجموعة من الضباط يبرز بينهم (فاسيلي) الذي يكره ليو ويكرهه ليو بدوره. هذه الحياة سرعان ما تنقلب في ذلك الجو المرعب، المليء بالدسائس، حيث يمكن للإنسان أن ينام وهو موال للدولة ليستيقظ على كشاف يبهر بصره ويأخذه لجلسة تعذيب ومن ثم محاكمة سريعة وإعدام بالرصاص - في الثلاثينات تخلص ستالين من قائد الأمن لأنه كان بطيئا في إجراءاته، واستبدله بالشيطان القزم نيقولاي ييزوف الذي قلص الفترة ما بين القبض على الشخص والتحقيق معه وإعدامه إلى 48 ساعة.
Book
A web-based system for creating, viewing, and editing precursor mass spectrometry ground truth data
Background
Mass spectrometry (MS) uses mass-to-charge ratios of measured particles to decode the identities and quantities of molecules in a sample. Interpretation of raw MS depends upon data processing algorithms that render it human-interpretable. Quantitative MS workflows are complex experimental chains and it is crucial to know the performance and bias of each data processing method as they impact accuracy, coverage, and statistical significance of the result. Creation of the ground truth necessary for quantitatively evaluating MS1-aware algorithms is difficult and tedious task, and better software for creating such datasets would facilitate more extensive evaluation and improvement of MS data processing algorithms.
Results
We present JS-MS 2.0, a software suite that provides a dependency-free, browser-based, one click, cross-platform solution for creating MS1 ground truth. The software retains the first version’s capacity for loading, viewing, and navigating MS1 data in 2- and 3-D, and adds tools for capturing, editing, saving, and viewing isotopic envelope and extracted isotopic chromatogram features. The software can also be used to view and explore the results of feature finding algorithms.
Conclusions
JS-MS 2.0 enables faster creation and inspection of MS1 ground truth data. It is publicly available with an MIT license at github.com/optimusmoose/jsms.
Journal Article
The complete scripts London spy
This gripping, contemporary, emotional thriller from Tom Rob Smith, bestselling author of Child 44 and The Farm, tells the story of a chance romance between two people from very different worlds. Danny - gregarious, hedonistic and romantic - falls in love with the enigmatic and brilliant Alex. Then Alex disappears. When Danny finds Alex's body, he is forced to pursue the truth behind his death. This volume of complete scripts is a brilliant companion to the ratings-winning BBC1 series first shown in November 2015 and set for DVD release in May 2016.
Book
XFlow: An algorithm for extracting ion chromatograms
Mass spectrometry is a fundamental tool for modern proteomics. The increasing availability of mass spectrometry data paired with the increasing sensitivity and fidelity of the instruments necessitates new and more potent analytical methods. To that end, we have created and present XFlow, a feature detection algorithm for extracting ion chromatograms from MS1 LC-MS data. XFlow is a parameter-free procedurally agnostic feature detection algorithm that utilizes the latent properties of ion chromatograms to resolve them from the surrounding noise present in MS1 data. XFlow is designed to function on either profile or centroided data across different resolutions and instruments. This broad applicability lends XFlow strong utility as a one-size-fits-all method for MS1 analysis or target acquisition for MS2. XFlow is written in Java and packaged with JS-MS, an open-source mass spectrometry analysis toolkit.
Journal Article
Fast, axis-agnostic, dynamically summarized storage and retrieval for mass spectrometry data
Mass spectrometry, a popular technique for elucidating the molecular contents of experimental samples, creates data sets comprised of millions of three-dimensional (m/z, retention time, intensity) data points that correspond to the types and quantities of analyzed molecules. Open and commercial MS data formats are arranged by retention time, creating latency when accessing data across multiple m/z. Existing MS storage and retrieval methods have been developed to overcome the limitations of retention time-based data formats, but do not provide certain features such as dynamic summarization and storage and retrieval of point meta-data (such as signal cluster membership), precluding efficient viewing applications and certain data-processing approaches. This manuscript describes MzTree, a spatial database designed to provide real-time storage and retrieval of dynamically summarized standard and augmented MS data with fast performance in both m/z and RT directions. Performance is reported on real data with comparisons against related published retrieval systems.
Journal Article
Scientific Opinion addressing the state of the science on risk assessment of plant protection products for in‐soil organisms
Following a request from EFSA, the Panel on Plant Protection Products and their Residues developed an opinion on the science behind the risk assessment of plant protection products for in‐soil organisms. The current risk assessment scheme is reviewed, taking into account new regulatory frameworks and scientific developments. Proposals are made for specific protection goals for in‐soil organisms being key drivers for relevant ecosystem services in agricultural landscapes such as nutrient cycling, soil structure, pest control and biodiversity. Considering the time‐scales and biological processes related to the dispersal of the majority of in‐soil organisms compared to terrestrial non‐target arthropods living above soil, the Panel proposes that in‐soil environmental risk assessments are made at in‐ and off‐field scale considering field boundary levels. A new testing strategy which takes into account the relevant exposure routes for in‐soil organisms and the potential direct and indirect effects is proposed. In order to address species recovery and long‐term impacts of PPPs, the use of population models is also proposed. This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2017.EN-1164/full
Journal Article
Parent trap
\"As the world's deadliest mom forces Robin to make the ultimate choice between his past and future, Superboy finds himself caught in middle in this volume of Super Sons! In this exciting concluding chapter, Talia al Ghul returns for her son Damian, whom she trained from birth to be an assassin. With the evil in Robin's past finally revealed to Superboy, it might be too much for the Sons' partnership to survive...especially when the boys find out her next victim is one of the most important people in their lives!\"-- Provided by publisher.
Book
JS-MS: a cross-platform, modular javascript viewer for mass spectrometry signals
Background
Despite the ubiquity of mass spectrometry (MS), data processing tools can be surprisingly limited. To date, there is no stand-alone, cross-platform 3-D visualizer for MS data. Available visualization toolkits require large libraries with multiple dependencies and are not well suited for custom MS data processing modules, such as MS storage systems or data processing algorithms.
Results
We present JS-MS, a 3-D, modular JavaScript client application for viewing MS data. JS-MS provides several advantages over existing MS viewers, such as a dependency-free, browser-based, one click, cross-platform install and better navigation interfaces. The client includes a modular Java backend with a novel streaming.mzML parser to demonstrate the API-based serving of MS data to the viewer.
Conclusions
JS-MS enables custom MS data processing and evaluation by providing fast, 3-D visualization using improved navigation without dependencies. JS-MS is publicly available with a GPLv2 license at github.com/optimusmoose/jsms.
Journal Article