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"Smith, Sean"
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Adele
Adele touches the hearts of millions of people who love her for her music and share the real and honest emotion she brings to each and every song. In a cynical age, she is a phenomenon. In Adele, bestselling biographer Sean Smith talks to those close to her as he follows her astonishing journey to fame that began on the gritty streets of Tottenham. Through compelling new research and interviews, he reveals that there is far more to Adele than the superstar we all think we know. He uncovers the story of her complex family relationships; the ill-starred love affair between her mother and father; her devastation at the untimely death of her grandfather; and her seemingly unpromising future in a gang-ravaged area of South London. She found salvation at the BRIT School before a series of unhappy love affairs provided the inspiration for her record-breaking albums. He describes how she conquered America and how it all could have been ended by a dramatic vocal injury. Instead, she has made an amazing comeback and found personal happiness in a new relationship and becoming a mum. Intimate and revealing, Adele is the uplifting story of the woman with the most glorious voice in the world.
Book
Current ADC Linker Chemistry
The list of ADCs in the clinic continues to grow, bolstered by the success of first two marketed ADCs: ADCETRIS® and Kadcyla®. Currently, there are 40 ADCs in various phases of clinical development. However, only 34 of these have published their structures. Of the 34 disclosed structures, 24 of them use a linkage to the thiol of cysteines on the monoclonal antibody. The remaining 10 candidates utilize chemistry to surface lysines of the antibody. Due to the inherent heterogeneity of conjugation to the multiple lysines or cysteines found in mAbs, significant research efforts are now being directed toward the production of discrete, homogeneous ADC products, via site-specific conjugation. These site-specific conjugations may involve genetic engineering of the mAb to introduce discrete, available cysteines or non-natural amino acids with an orthogonally-reactive functional group handle such as an aldehyde, ketone, azido, or alkynyl tag. These site-specific approaches not only increase the homogeneity of ADCs but also enable novel bio-orthogonal chemistries that utilize reactive moieties other than thiol or amine. This broadens the diversity of linkers that can be utilized which will lead to better linker design in future generations of ADCs.
Journal Article
Isolated copper–tin atomic interfaces tuning electrocatalytic CO2 conversion
Direct experimental observations of the interface structure can provide vital insights into heterogeneous catalysis. Examples of interface design based on single atom and surface science are, however, extremely rare. Here, we report Cu–Sn single-atom surface alloys, where isolated Sn sites with high surface densities (up to 8%) are anchored on the Cu host, for efficient electrocatalytic CO
2
reduction. The unique geometric and electronic structure of the Cu–Sn surface alloys (Cu
97
Sn
3
and Cu
99
Sn
1
) enables distinct catalytic selectivity from pure Cu
100
and Cu
70
Sn
30
bulk alloy. The Cu
97
Sn
3
catalyst achieves a CO Faradaic efficiency of 98% at a tiny overpotential of 30 mV in an alkaline flow cell, where a high CO current density of 100 mA cm
−2
is obtained at an overpotential of 340 mV. Density functional theory simulation reveals that it is not only the elemental composition that dictates the electrocatalytic reactivity of Cu–Sn alloys; the local coordination environment of atomically dispersed, isolated Cu–Sn bonding plays the most critical role.
The understanding of catalytic reactions at the atomic interface is vital; however, the characterization and mechanism studies of atomically dispersed catalysts remain challenging. Here, the authors demonstrate Cu–Sn surface alloys with isolated Sn atoms on a Cu host to achieve efficient CO
2
to CO conversion.
Journal Article
Rooster's alarm
When a sheep cries \"Cock-a-doodle-doo\" to awaken the other animals, each responds with a surprising sound, while all wonder where the rooster has gone.
BOOK
Unusual synergistic effect in layered Ruddlesden−Popper oxide enables ultrafast hydrogen evolution
Efficient electrocatalysts for hydrogen evolution reaction are key to realize clean hydrogen production through water splitting. As an important family of functional materials, transition metal oxides are generally believed inactive towards hydrogen evolution reaction, although many of them show high activity for oxygen evolution reaction. Here we report the remarkable electrocatalytic activity for hydrogen evolution reaction of a layered metal oxide, Ruddlesden−Popper-type Sr
2
RuO
4
with alternative perovskite layer and rock-salt SrO layer, in an alkaline solution, which is comparable to those of the best electrocatalysts ever reported. By theoretical calculations, such excellent activity is attributed mainly to an unusual synergistic effect in the layered structure, whereby the (001) SrO-terminated surface cleaved in rock-salt layer facilitates a barrier-free water dissociation while the active apical oxygen site in perovskite layer promotes favorable hydrogen adsorption and evolution. Moreover, the activity of such layered oxide can be further improved by electrochemistry-induced activation.
Water may serve as a renewable hydrogen fuel source to replace fossil fuels, although such electrolysis requires highly active catalysts. Here, authors explore Ruddlesden−Popper oxides as hydrogen evolution electrocatalysts that feature an unusual synergistic effect to promote high activity.
Journal Article
Implanting Ni-O-VOx sites into Cu-doped Ni for low-overpotential alkaline hydrogen evolution
Nickel-based catalysts are most commonly used in industrial alkaline water electrolysis. However, it remains a great challenge to address the sluggish reaction kinetics and severe deactivation problems of hydrogen evolution reaction (HER). Here, we show a Cu-doped Ni catalyst implanted with Ni-O-VOx sites (Ni(Cu)VOx) for alkaline HER. The optimal Ni(Cu)VOx electrode exhibits a near-zero onset overpotential and low overpotential of 21 mV to deliver –10 mA cm
−2
, which is comparable to benchmark Pt/C catalyst. Evidence for the formation of Ni-O-VOx sites in Ni(Cu)VOx is established by systematic X-ray absorption spectroscopy studies. The VOx can cause a substantial dampening of Ni lattice and create an enlarged electrochemically active surface area. First-principles calculations support that the Ni-O-VOx sites are superactive and can promote the charge redistribution from Ni to VOx, which greatly weakens the H-adsorption and H
2
release free energy over Ni. This endows the Ni(Cu)VOx electrode high HER activity and long-term durability.
Producing H
2
from water using electricity and earth-abundant elements is necessary for worldwide renewable fuel production, yet most electrocatalysts have sluggish activities or poor stabilities. Here, authors show vanadium oxide modified copper-doped nickel to enable active and durable H
2
evolution.
Journal Article
Houses that can save the world
Featuring nineteen home-building and design strategies that are direct, original and often surprisingly simple, this inspirational sourcebook presents a mix of new technology and time-tested vernacular methods that will change the way we think about 'home'. With strategies and houses that span the globe, including developing regions in Asia, Africa and South America, the book shines a spotlight on everything from wholly new techniques to creative reuse of existing buildings and materials. 00Nothing short of a design revolution is underway as we confront climate change, polluting plastics, global migration, rapidly expanding cities and an ageing population. Part handbook, part manifesto, Houses that Can Save the World shows how architects, designers, engineers, self-builders, artists and others are embracing the new challenges the human race is facing.00Whether you are planning a self-build or are simply looking for ways to make your home more environmentally friendly and efficient, this book is packed with innovative ideas that can help us to make our homes and the world a better place to be.
Book
Modulating Pt-O-Pt atomic clusters with isolated cobalt atoms for enhanced hydrogen evolution catalysis
Platinum is the most efficient catalyst for hydrogen evolution reaction in acidic conditions, but its widespread use has been impeded by scarcity and high cost. Herein, Pt atomic clusters (Pt ACs) containing Pt-O-Pt units were prepared using Co/N co-doped carbon (CoNC) as support. Pt ACs are anchored to single Co atoms on CoNC by forming strong interactions. Pt-ACs/CoNC exhibits only 24 mV overpotential at 10 mA cm
−2
and a high mass activity of 28.6 A mg
−1
at 50 mV, which is more than 6 times higher than commercial Pt/C with any Pt loadings. Spectroscopic measurements and computational modeling reveal the enhanced hydrogen generation activity attributes to the charge redistribution between Pt and O atoms in Pt-O-Pt units, making Pt atoms the main active sites and O linkers the assistants, thus optimizing the proton adsorption and hydrogen desorption. This work opens an avenue to fabricate noble-metal-based ACs stabilized by single-atom catalysts with desired properties for electrocatalysis.
Modulating single-metal sites at the atomic level can boost the intrinsic catalytic activity. Here, the authors describe the design of Pt atomic clusters containing Pt-O-Pt units supported on Co single atoms and N co-doped carbon for enhanced hydrogen evolution catalysis.
Journal Article