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Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial
Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous studies have shown that allopurinol has positive effects on several cardiovascular parameters. The ALL-HEART study aimed to determine whether allopurinol therapy improves major cardiovascular outcomes in patients with ischaemic heart disease.
ALL-HEART was a multicentre, prospective, randomised, open-label, blinded-endpoint trial done in 18 regional centres in England and Scotland, with patients recruited from 424 primary care practices. Eligible patients were aged 60 years or older, with ischaemic heart disease but no history of gout. Participants were randomly assigned (1:1), using a central web-based randomisation system accessed via a web-based application or an interactive voice response system, to receive oral allopurinol up-titrated to a dose of 600 mg daily (300 mg daily in participants with moderate renal impairment at baseline) or to continue usual care. The primary outcome was the composite cardiovascular endpoint of non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death. The hazard ratio (allopurinol vs usual care) in a Cox proportional hazards model was assessed for superiority in a modified intention-to-treat analysis (excluding randomly assigned patients later found to have met one of the exclusion criteria). The safety analysis population included all patients in the modified intention-to-treat usual care group and those who took at least one dose of randomised medication in the allopurinol group. This study is registered with the EU Clinical Trials Register, EudraCT 2013-003559-39, and ISRCTN, ISRCTN32017426.
Between Feb 7, 2014, and Oct 2, 2017, 5937 participants were enrolled and then randomly assigned to receive allopurinol or usual care. After exclusion of 216 patients after randomisation, 5721 participants (mean age 72·0 years [SD 6·8], 4321 [75·5%] males, and 5676 [99·2%] white) were included in the modified intention-to-treat population, with 2853 in the allopurinol group and 2868 in the usual care group. Mean follow-up time in the study was 4·8 years (1·5). There was no evidence of a difference between the randomised treatment groups in the rates of the primary endpoint. 314 (11·0%) participants in the allopurinol group (2·47 events per 100 patient-years) and 325 (11·3%) in the usual care group (2·37 events per 100 patient-years) had a primary endpoint (hazard ratio [HR] 1·04 [95% CI 0·89–1·21], p=0·65). 288 (10·1%) participants in the allopurinol group and 303 (10·6%) participants in the usual care group died from any cause (HR 1·02 [95% CI 0·87–1·20], p=0·77).
In this large, randomised clinical trial in patients aged 60 years or older with ischaemic heart disease but no history of gout, there was no difference in the primary outcome of non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death between participants randomised to allopurinol therapy and those randomised to usual care.
UK National Institute for Health and Care Research.
Journal Article
A Catalog of Quasar Properties from SDSS DR7
We present a compilation of properties of the 105,783 quasars in the SDSS Data Release 7 (DR7) quasar catalog. In this value-added product, we compile continuum and emission line measurements around the Halpha, Hbeta, MgII and CIV regions, as well as other quantities such as radio properties, broad absorption line quasar (BALQSO) flags, and disk emitters. We also compile virial black hole mass estimates based on various calibrations. For the fiducial virial mass estimates we use the Vestergaard & Peterson (VP06) calibrations for Hbeta and CIV, and our own calibration for MgII which matches the VP06 Hbeta masses on average. We describe the construction of this catalog, and discuss its limitations. The catalog and its future updates will be made publicly available online.
Paper
The SDSS-III Baryon Oscillation Spectroscopic Survey: The Quasar Luminosity Function from Data Release Nine
We present a new measurement of the optical Quasar Luminosity Function (QLF), using data from the Sloan Digital Sky Survey-III: Baryon Oscillation Spectroscopic Survey (SDSS-III: BOSS). From the SDSS-III Data Release Nine (DR9), we select a uniform sample of 22,301 i<=21.8 quasars over an area of 2236 sq. deg with confirmed spectroscopic redshifts between 2.2
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The Sloan Digital Sky Survey Quasar Catalog V. Seventh Data Release
We present the fifth edition of the Sloan Digital Sky Survey (SDSS) Quasar Catalog, which is based upon the SDSS Seventh Data Release. The catalog, which contains 105,783 spectroscopically confirmed quasars, represents the conclusion of the SDSS-I and SDSS-II quasar survey. The catalog consists of the SDSS objects that have luminosities larger than M_i = -22.0 (in a cosmology with H_0 = 70 km/s/Mpc Omega_M = 0.3, and Omega_Lambda = 0.7) have at least one emission line with FWHM larger than 1000 km/s or have interesting/complex absorption features, are fainter than i > 15.0 and have highly reliable redshifts. The catalog covers an area of 9380 deg^2. The quasar redshifts range from 0.065 to 5.46, with a median value of 1.49; the catalog includes 1248 quasars at redshifts greater than four, of which 56 are at redshifts greater than five. The catalog contains 9210 quasars with i < 18; slightly over half of the entries have i< 19. For each object the catalog presents positions accurate to better than 0.1\" rms per coordinate, five-band (ugriz) CCD-based photometry with typical accuracy of 0.03 mag, and information on the morphology and selection method. The catalog also contains radio, near-infrared, and X-ray emission properties of the quasars, when available, from other large-area surveys. The calibrated digital spectra cover the wavelength region 3800-9200 Ang. at a spectral resolution R = 2000 the spectra can be retrieved from the SDSS public database using the information provided in the catalog. Over 96% of the objects in the catalog were discovered by the SDSS. We also include a supplemental list of an additional 207 quasars with SDSS spectra whose archive photometric information is incomplete.
Paper
The Sloan Digital Sky Survey Quasar Catalog IV. Fifth Data Release
We present the fourth edition of the Sloan Digital Sky Survey (SDSS) Quasar Catalog. The catalog contains 77,429 objects; this is an increase of over 30,000 entries since the previous edition. The catalog consists of the objects in the SDSS Fifth Data Release that have luminosities larger than M_i = -22.0 (in a cosmology with H_0 = 70 km/s/Mpc, Omega_M = 0.3, and Omega_Lambda = 0.7) have at least one emission line with FWHM larger than 1000 km/s, or have interesting/complex absorption features, are fainter than i=15.0, and have highly reliable redshifts. The area covered by the catalog is 5740 sq. deg. The quasar redshifts range from 0.08 to 5.41, with a median value of 1.48; the catalog includes 891 quasars at redshifts greater than four, of which 36 are at redshifts greater than five. Approximately half of the catalog quasars have i < 19; nearly all have i < 21. For each object the catalog presents positions accurate to better than 0.2 arcsec. rms per coordinate, five-band (ugriz) CCD-based photometry with typical accuracy of 0.03 mag, and information on the morphology and selection method. The catalog also contains basic radio, near-infrared, and X-ray emission properties of the quasars, when available, from other large-area surveys. The calibrated digital spectra cover the wavelength region 3800--9200A at a spectral resolution of ~2000. The spectra can be retrieved from the public database using the information provided in the catalog. The average SDSS colors of quasars as a function of redshift, derived from the catalog entries, are presented in tabular form. Approximately 96% of the objects in the catalog were discovered by the SDSS.
Paper
SDSS J0806+2006 and SDSS J1353+1138: Two New Gravitationally Lensed Quasars from the Sloan Digital Sky Survey
We report the discoveries of two, two-image gravitationally lensed quasars selected from the Sloan Digital Sky Survey: SDSS J0806+2006 at z_s=1.540 and SDSS J1353+1138 at z_s=1.629 with image separations of 1.40\" and 1.41\" respectively. Spectroscopic and optical/near-infrared imaging follow-up observations show that the quasar images have identical redshifts and possess extended objects between the images that are likely to be lens galaxies at z_l~0.6 in SDSS J0806+2006 and z_l~0.3 in SDSS J1353+1138. The field of SDSS J0806+2006 contains several nearby galaxies that may significantly perturb the system, and SDSS J1353+1138 has an extra component near its Einstein ring that is probably a foreground star. Simple mass models with reasonable parameters reproduce the quasar positions and fluxes of both systems.
Paper
SDSSJ102111.02+491330.4: A Newly Discovered Gravitationally Lensed Quasar
We report follow-up observations of two gravitational lens candidates identified in the Sloan Digital Sky Survey (SDSS) dataset. We have confirmed that SDSS J102111.02+491330.4 is a previously unknown gravitationally lensed quasar. This lens system exhibits two images of a \\(z = 1.72\\) quasar, with an image separation of \\(1{\\farcs}14 \\pm 0.04\\). Optical and near-IR imaging of the system reveals the presence of the lensing galaxy between the two quasar images. Observations of SDSS J112012.12+671116.0 indicate that it is more likely a binary quasar than a gravitational lens. This system has two quasars at a redshift of \\(z = 1.49\\), with an angular separation of \\(1{\\farcs}49 \\pm 0.02\\). However, the two quasars have markedly different SEDs and no lens galaxy is apparent in optical and near-IR images of this system. We also present a list of 31 SDSS lens candidates which follow-up observations have confirmed are \\textit{not} gravitational lenses.
Paper
A Survey of z>5.7 Quasars in the Sloan Digital Sky Survey IV: Discovery of Seven Additional Quasars
We present the discovery of seven quasars at z>5.7, selected from ~2000 deg^2 of multicolor imaging data of the Sloan Digital Sky Survey (SDSS). The new quasars have redshifts z from 5.79 to 6.13. Five are selected as part of a complete flux-limited sample in the SDSS Northern Galactic Cap; two have larger photometric errors and are not part of the complete sample. One of the new quasars, SDSS J1335+3533 (z=5.93), exhibits no emission lines; the 3-sigma limit on the rest-frame equivalent width of Ly alpha+NV line is 5 A. It is the highest redshift lineless quasar known, and could be a gravitational lensed galaxy, a BL Lac object or a new type of quasar. Two new z>6 quasars, SDSS 1250+3130 (z=6.13) and SDSS J1137+3549 (z=6.01), show deep Gunn-Peterson absorption gaps in Ly alpha. These gaps are narrower the complete Gunn-Peterson absorption troughs observed among quasars at z>6.2 and do not have complete Ly beta absorption.
Paper
SDSS J092455.87+021924.9: an Interesting Gravitationally Lensed Quasar from the Sloan Digital Sky Survey
We report the discovery of a new gravitationally lensed quasar from the Sloan Digital Sky Survey, SDSS J092455.87+021924.9 (SDSS J0924+0219). This object was selected from among known SDSS quasars by an algorithm that was designed to select another known SDSS lensed quasar (SDSS 1226-0006A,B). Five separate components, three of which are unresolved, are identified in photometric follow-up observations obtained with the Magellan Consortium's 6.5m Walter Baade telescope at Las Campanas Observatory. Two of the unresolved components (designated A and B) are confirmed to be quasars with z=1.524; the velocity difference is less than 100 km sec^{-1} according to spectra taken with the W. M. Keck Observatory's Keck II telescope on Mauna Kea. A third stellar component, designated C, has the colors of a quasar with redshift similar to components A and B. The maximum separation of the point sources is 1.78\". The other two sources, designated G and D, are resolved. Component G appears to be the best candidate for the lensing galaxy. Although component D is near the expected position of the fourth lensed component in a four image lens system, its properties are not consistent with being the image of a quasar at z~1.5. Nevertheless, the identical redshifts of components A and B and the presence of component C strongly suggest that this object is a gravitational lens. Our observations support the idea that a foreground object reddens the fourth lensed component and that another unmodeled effect (such as micro- or milli-lensing) demagnificates it, but we cannot rule out the possibility that SDSS0924+0219 is an example of the relatively rare class of ``three component'' lens systems.
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