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The methodology of the functioning of the adaptive management system of a LEM is based on modeling technologies, system, process, marketing and institutional approaches, methods of marketing, economic and content analysis, SWOT analysis, as well as methods of strategic, operational and category management. According to the federal law No. 61-FL \"On Medicine Circulation\" dated April 12, 2010, the List of Vital and Essential Medicines is an annually approved by the Government of the Russian Federation list of medicines, which provides for priority health needs for the prevention and treatment of diseases, including those prevailing in the structure of morbidity in the Russian Federation. The management of the attributes of medicine as a product consists of ensuring its competitiveness, managing assortment, developing new medicines and recommendations concerning production, packaging and price. [...]it is related to decisions concerning medicines that should be promptly included or excluded from a LEM. A specific feature of the formation of a LEM is the lack of the possibility (due to the existence of an institutional standard) to fully influence the list of essential products. Since the main criteria for the effectiveness of adaptive systems are the criteria for maintaining economic stability and ensuring the competitiveness of an organization, preventive measures aimed to determine the financial burden on the activities of a pharmacy when medicine is included in its LEM is of vital importance from the point of view of the methodological basis for forming an adaptive management system for a LEM1, 19 - 20.