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Medical dosage calculations for dummies
Most medical dosage calculations are simple, and this guide provides helpful content in an approachable and easy-to-understand format. It give you the practice, confidence, and skills to get a grasp on dosing in the context of real medical conditions.
Book
Fine‐scale population structure of the northern hard clam (Mercenaria mercenaria) revealed by genome‐wide SNP markers
Aquaculture is growing rapidly worldwide, and sustainability is dependent on an understanding of current genetic variation and levels of connectivity among populations. Genetic data are essential to mitigate the genetic and ecological impacts of aquaculture on wild populations and guard against unintended human‐induced loss of intraspecific diversity in aquacultured lines. Impacts of disregarding genetics can include loss of diversity within and between populations and disruption of local adaptation patterns, which can lead to a decrease in fitness. The northern hard clam, Mercenaria mercenaria (Linnaeus, 1758), is an economically valuable aquaculture species along the North American Atlantic and Gulf coasts. Hard clams have a pelagic larval phase that allows for dispersal, but the level of genetic connectivity among geographic areas is not well understood. To better inform the establishment of site‐appropriate aquaculture brood stocks, this study used DArTseq™ genotyping by sequencing to characterize the genetic stock structure of wild clams sampled along the east coast of North America and document genetic diversity within populations. Samples were collected from 15 locations from Prince Edward Island, Canada, to South Carolina, USA. Stringent data filtering resulted in 4960 single nucleotide polymorphisms from 448 individuals. Five genetic breaks separating six genetically distinct populations were identified: Canada, Maine, Massachusetts, Mid‐Atlantic, Chesapeake Bay, and the Carolinas (FST 0.003–0.046; p < 0.0001). This is the first study to assess population genetic structure of this economically important hard clam along a large portion of its native range with high‐resolution genomic markers, enabling identification of previously unrecognized population structure. Results of this study not only broaden insight into the factors shaping the current distribution of M. mercenaria but also reveal the genetic population dynamics of a species with a long pelagic larval dispersal period along the North American Atlantic and Gulf coasts.
Journal Article
Inside countries : subnational research in comparative politics
\"Comparative politics is conventionally seen as the study of politics across countries. Still, the field has a prominent and longstanding tradition of studying politics not across countries but inside them, especially by zooming down to subnational units. Indeed, political science was arguably born subnational: one of the discipline's oldest canonical texts, The Politics, written by Aristotle in the 4th century B.C., offered a typology of political systems based on a comparative study of 158 city constitutions in ancient Greece\"-- Provided by publisher.
Book
Community dynamics under environmental extremes
Ecological restoration is increasingly employed to restore degraded or destroyed ecosystems and evaluation of restoration success requires that natural community dynamics be understood. Wet prairies in the Southeast US have diverse plant communities subject to disturbances including fire, drought, flooding, tropical storms, and freezes. This habitat covers a fraction of its former range and reversing that trend requires ecological restoration; but, long-term data on the dynamics of this system are rare. We analyzed a 12-year plant community composition dataset from a fire-maintained Gulf of Mexico Coastal Plain wet prairie to characterize plant community dynamics and identify indicator species. The site was compared to a nearby wetland mitigation project attempting to restore a wet prairie that had been converted into slash pine (Pinus elliottii) plantation. The reference site had higher species richness, was dominated by Aristida spp., and was stable despite extreme climatic conditions. The restoration site transitioned from dense pine and understory canopy to an open, grassy community, but did not follow a trajectory toward the reference state. Restoration efforts were impeded by woody debris, accumulated duff, soil disturbance from logging, and storm surge from hurricanes. Continued application of prescribed fire and decomposition activity should remove the organic matter and promote establishment of wet prairie species, but on a longer time scale than expected. Although the pine plantation did not return to a typical wet prairie during the study period, the record of community dynamics of the reference wet prairie provides information on the resilience of the habitat type under prescribed fire management, and serves as a reference for restoration efforts and management of this threatened habitat.
Journal Article
Batman : the Court of Owls saga
\"Hidden for years, a secret organization known as the Court of Owls suddenly surfaces in Gotham City. But why? As Batman begins to unravel the deadly mystery, he discovers a conspiracy going back to his youth and beyond to the origins of the city he's sworn to protect. Could the Court of Owls, once thought to be nothing more than an urban myth, be behind the never-ending crime and corruption in Gotham? Or is Bruce Wayne losing his grip on sanity and falling prey to the pressures of being Batman?\"-- Provided by publisher.
BOOK
The influence of environmental gradients on individual behaviour
The expression of individual behaviour as a function of environmental variation (behavioural plasticity) is recognized as a means for animals to modify their phenotypes in response to changing conditions. Plasticity has been studied extensively in recent years, leading to an accumulation of evidence for behavioural plasticity within natural populations. Despite the recent attention given to studying individual variation in behavioural plasticity, there is still a lack of consensus regarding its causes and constraints. One pressing question related to this is whether individual plasticity carries over across temporal and environmental gradients. That is, are some individuals more plastic (responsive) than others in general? Here, we examined the influence of temporal and environmental gradients on individual behavioural responses in a marine gastropod, Littoraria irrorata. We measured individual boldness repeatedly over time and in response to tidal cycle (high vs. low, an index of risk) and daily temperature fluctuations (known to affect metabolism), in a controlled field experiment. On average, boldness increased from high to low tide and with increasing temperature but decreased marginally over time. Individuals also differed in their responses to variation in tide and temperature, but not over time. Those which were relatively bold at high tide (when predation risk is greater) were similarly bold at low tide, whereas shy individuals became much more “bold” at low tide. Most notably, individuals that were more responsive to tide (and thus risk) were also more responsive to temperature changes, indicating that plasticity was correlated across contexts (r = 0.57) and that bolder individuals were least plastic overall. This study provides a rare and possibly first example of consistency of individual behavioural plasticity across contexts, suggesting underlying physiology as a common mechanism, and raises the possibility of correlational selection on plasticity. This paper examines the consistency of individual behavioural plasticity, across environmental gradients. The author's results contribute significantly to the literature on the causes and consequences of individual behaviour by providing the first empirical evidence of domain‐general behavioural plasticity and by raising the possibility that individual plasticity may be under correlational selection.
Journal Article
Climate Change Impacts on Water Use in Horticulture
The evidence for anthropogenic global climate change is strong, and the projected climate changes could greatly impact horticultural production. For horticulture, two of the biggest concerns are related to the scarcity of water for crop production and the potential for increased evapotranspiration (ET). While ET is known to increase with air temperature, it is also known to decrease with increasing humidity and atmospheric CO2 concentration. Considering all of these factors and a plausible climate projection, this paper demonstrates that ET may increase or decrease depending on the magnitude of atmospheric changes including wind speed. On the other hand, the evidence is still strong that water resources will become less reliable in many regions where horticultural crops are grown.
Journal Article
Evapotranspiration Estimate over an Almond Orchard Using Landsat Satellite Observations
California growers face challenges with water shortages and there is a strong need to use the least amount of water while optimizing yield. Timely information on evapotranspiration (ET), a dominant component of crop consumptive water use, is critical for growers to tailor irrigation management based on in-field spatial variability and in-season variations. We evaluated the performance of a remote sensing-based approach, Mapping Evapotranspiration at high Resolution with Internalized Calibration (METRIC), in mapping ET over an almond orchard in California, driven by Landsat satellite observations. Reference ET from a network of weather stations over well-watered grass (ETo) was used for the internal calibration and for deriving ET at daily and extended time period, instead of alfalfa based reference evapotranspiration (ETr). Our study showed that METRIC daily ET estimates during Landsat overpass dates agreed well with the field measurements. During 2009–2012, a root mean square error (RMSE) of 0.53 mm/day and a coefficient of determination (R2) of 0.87 were found between METRIC versus observed daily ET. Monthly ET estimates had a higher accuracy, with a RMSE of 12.08 mm/month, a R2 of 0.90, and a relatively small relative mean difference (RMD) of 9.68% during 2009–2012 growing seasons. Net radiation and Normalized Difference Vegetation Index (NDVI) from remote sensing observations were highly correlated with spatial and temporal ET estimates. An empirical model was developed to estimate daily ET using NDVI, net radiation (Rn), and vapor pressure deficit (VPD). The validation showed that the accuracy of this easy-to-use empirical method was slightly lower than that of METRIC but still reasonable, with a RMSE of 0.71 mm/day when compared to ground measurements. The remote sensing based ET estimate will support a variety of State and local interests in water use and irrigation management, for both planning and regulatory/compliance purposes, and it provides the farmers observation-based guidance for site-specific and time-sensitive irrigation management.
Journal Article
Practical utilization of recombinant AAV vector reference standards: focus on vector genomes titration by free ITR qPCR
Clinical trials using recombinant adeno-associated virus (rAAV) vectors have demonstrated efficacy and a good safety profile. Although the field is advancing quickly, vector analytics and harmonization of dosage units are still a limitation for commercialization. AAV reference standard materials (RSMs) can help ensure product safety by controlling the consistency of assays used to characterize rAAV stocks. The most widely utilized unit of vector dosing is based on the encapsidated vector genome. Quantitative polymerase chain reaction (qPCR) is now the most common method to titer vector genomes (vg); however, significant inter- and intralaboratory variations have been documented using this technique. Here, RSMs and rAAV stocks were titered on the basis of an inverted terminal repeats (ITRs) sequence-specific qPCR and we found an artificial increase in vg titers using a widely utilized approach. The PCR error was introduced by using single-cut linearized plasmid as the standard curve. This bias was eliminated using plasmid standards linearized just outside the ITR region on each end to facilitate the melting of the palindromic ITR sequences during PCR. This new \"Free-ITR\" qPCR delivers vg titers that are consistent with titers obtained with transgene-specific qPCR and could be used to normalize in-house product-specific AAV vector standards and controls to the rAAV RSMs. The free-ITR method, including well-characterized controls, will help to calibrate doses to compare preclinical and clinical data in the field.
Journal Article
Impacts of climate change and rising atmospheric CO2 on future projected reference evapotranspiration in Emilia-Romagna (Italy)
The continuous increase of atmospheric CO2 content mainly due to anthropogenic CO2 emissions is causing a rise in temperature on earth, altering the hydrological and meteorological processes and affecting crop physiology. Evapotranspiration is an important component of the hydrological cycle. Thus, understanding the change in evapotranspiration due to global warming is essential for better water resources planning and management and agricultural production. In this study, the effect of climate change with a focus on the combined effect of temperature and elevated CO2 concentrations on reference evapotranspiration (ETo) was evaluated using the Penman–Monteith equation. A EURO-CORDEX regional climate model (RCM) ensemble was used to estimate ETo in five locations in the Emilia-Romagna region (Northern Italy) during the period 2021–2050. Then, its projected changes in response to different CO2 concentrations (i.e., 372 ppm and 550 ppm) under two Representative Concentration Pathways (RCP) scenarios (i.e., RCP4.5 and RCP8.5) were analyzed. Simulation results with both scenarios, without increasing CO2 levels (372 ppm), showed that the annual and summertime ETo for all locations increased by an average of 4 to 5.4% with regard to the reference period 1981–2005, for an increase of air temperature by 1 to 1.5 °C. When the effect of elevated CO2 levels (550 ppm) was also considered in combination with projected changes in temperature, changes in both annual and summer ETo demand for all locations varied from − 1.1 to 2.2% during the 2021–2050 period with regard to the reference period 1981–2005. This shows that higher CO2 levels moderated the increase in ETo that accompanies an increase in air temperature.
Journal Article