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This systematic review synthesizes evidence on biomarker responses to physiological loads in professional male team sport athletes, providing insights into induced fatigue states. Structured searches across major databases yielded 28 studies examining various biomarkers in elite team sport players. Studies evaluated muscle damage markers, anabolic/catabolic hormones reflecting metabolic strain, inflammatory markers indicating immune activity and tissue damage, immunological markers tied to infection risk, and oxidative stress markers showing redox imbalances from excessive physiological load. Responses were examined in official matches and training across competitive seasons. The evidence shows that professional team sports induce significant alterations in all studied biomarkers, reflecting measurable physiological strain, muscle damage, oxidative stress, inflammation, and immunosuppression during intensive exercise. These effects tend to be larger and more prolonged after official matches compared to training. Reported recovery time courses range from 24-h to several days post-exercise. Monitoring biomarkers enables quantifying cumulative fatigue and physiological adaptations to training/competition loads, helping to optimize performance while mitigating injury and overtraining. Key biomarkers include creatine kinase, testosterone, cortisol, testosterone/cortisol ratio, salivary immunoglobulin-A, and markers of inflammation and oxidative stress. Further research should extend biomarker monitoring to cover psychological stress and affective states alongside physiological metrics for deeper insight into athlete wellness and readiness.

This paper shows wind speed measurements from the TASEC-Lab experiment in a stratospheric balloon mission. The mission was launched in July 2021 from León (Spain) aerodrome. Measurements of horizontal wind speed in relation to the balloon gondola were successfully carried out with a cup anemometer. According to the available literature, this is the first time a cup anemometer has been used in a stratospheric balloon mission. The results indicate the need to consider the horizontal wind speed from the balloon ascent phase for thermal calculations of the mission.

Although there is a wide range of validated devices to measure vertical jump height, the degree of interchangeability among them is currently unknown. Aims: The purpose of this study was to examine the concurrent validity and reliability of multiple devices to measure jump height in men’s handball players. Methods: Sixteen players (age = 24.0 ± 3.7 years old) performed three types of jumps (n= 144—squat jump (SJ), countermovement jump (CMJ) and Abalakov jump (ABK)) on a contact platform (CHRONOJUMP®) while simultaneously being measured with two inertial devices (WIMU® and VERT®) and recorded with a high-speed camera. Vertical jump height was analyzed according to each type of jump. Results: The t-test showed statistically significant differences (p = 0.001) between the contact platform (reference standard) and the rest of the tools that tended to overestimate jump height in all jumps. SJ and CMJ proved to be the jump tests with the most stable reliability values in all devices (ICC: 0.92–0.98), except in the comparison with VERT®. Conclusions: Although all the analyzed devices proved to be valid and reliable in previous studies, they are not interchangeable. Therefore, it is suggested to always use the same type of device to evaluate vertical height jump.

The risk of spread of African swine fever virus (ASFV) from Russia and Caucasian areas to several EU countries has recently emerged, making it imperative to improve our knowledge and defensive tools against this important pathogen. The ASFV genome encodes many genes which are not essential for virus replication but are known to control host immune evasion, such as NFκB and the NFAT regulator A238L, the apoptosis inhibitor A224L, the MHC-I antigen presenting modulator EP153R, and the A276R gene, involved in modulating type I IFN. These genes are hypothesized to be involved in virulence of the genotype I parental ASFV NH/P68. We here describe the generation of putative live attenuated vaccines (LAV) prototypes by constructing recombinant NH/P68 viruses lacking these specific genes and containing specific markers.

The use of inertial devices in sport has become increasingly common. The aim of this study was to examine the validity and reliability of multiple devices for measuring jump height in volleyball. The search was carried out in four databases (PubMed, Scopus, Web of Sciences and SPORTDiscus) using keywords and Boolean operators. Twenty-one studies were selected that met the established selection criteria. The studies focused on determining the validity and reliability of IMUs (52.38%), on controlling and quantifying external load (28.57%) and on describing differences between playing positions (19.05%). Indoor volleyball was the modality in which IMUs have been used the most. The most evaluated population was elite, adult and senior athletes. The IMUs were used both in training and in competition, evaluating mainly the amount of jump, the height of the jumps and some biomechanical aspects. Criteria and good validity values for jump counting are established. The reliability of the devices and the evidence is contradictory. IMUs are devices used in volleyball to count and measure vertical displacements and/or compare these measurements with the playing position, training or to determine the external load of the athletes. It has good validity measures, although inter-measurement reliability needs to be improved. Further studies are suggested to position IMUs as measuring instruments to analyze jumping and sport performance of players and teams.

Background Androgen Deprivation Therapy (ADT) for prostate cancer causes significant adverse effects including muscle wasting, bone density reduction, increased fatigue, and psychological distress. Despite growing evidence supporting exercise as an effective countermeasure, standardized evidence-based protocols for this population remain underdeveloped in clinical practice. Exercise is beneficial for managing cancer-related side effects, and general exercise guidelines for cancer survivors are available, but tailoring of exercise interventions may be more effective in those with treatment-specific complications. Methods/design This randomized controlled trial with two parallel arms compares a 24-week supervised progressive resistance training program (SPoRT-PCa-ADT) with a control group receiving personalized home-based training following initial assessment and weekly telephone follow-up. The SPoRT-PCa-ADT Program utilizes velocity-based training methodology, progressing through three distinct phases (adaptation, development, maintenance) with intensity corresponding to 60% 1RM (mean propulsive velocity 0.92 m/s) and a 10% velocity loss threshold. The exercise protocol focuses primarily on squat movement patterns with real-time velocity feedback and incorporates daily readiness assessment to accommodate treatment-related fatigue fluctuations. Control group participants receive structured written instructions for home-based resistance training including warm-up and three effective sets of 12 repetitions of box squats, to be performed two to three times per week on non-consecutive days, with weekly telephone monitoring. The comprehensive assessment protocol includes progressive loading tests, vertical jump assessment, isometric strength measurement, and patient-reported outcomes measuring fatigue, quality of life, psychological distress, urinary function, and sleep quality. Assessments occur at baseline, midpoint (patient-reported outcomes only), and post-intervention, with additional biomarker collection. Discussion To our knowledge, this will be the first study to implement a standardized velocity-based training protocol specifically developed for prostate cancer patients receiving ADT. The supervised program is delivered by exercise physiologists in a specialized sports center setting with consistent medical oversight, facilitating integration within cancer care pathways while ensuring exercise quality and safety. This detailed randomized controlled trial protocol provides clinicians with a standardized yet adaptable framework for exercise prescription in PCa-ADT patients, bridging the gap between evidence-based exercise principles and clinical implementation. Trial registration ClinicalTrials.gov (NCT07064811, protocol version: 1.0, date registered:15 July 2025).

African swine fever (ASF) is a complex infectious disease of swine that constitutes devastating impacts on animal health and the world economy. Here, we investigated the evolutionary epidemiology of ASF virus (ASFV) in Eurasia and Africa using the concatenated gene sequences of the viral protein 72 and the central variable region of isolates collected between 1960 and 2015. We used Bayesian phylodynamic models to reconstruct the evolutionary history of the virus, to identify virus population demographics and to quantify dispersal patterns between host species. Results suggest that ASFV exhibited a significantly high evolutionary rate and population growth through time since its divergence in the 18th century from East Africa, with no signs of decline till recent years. This increase corresponds to the growing pig trade activities between continents during the 19th century, and may be attributed to an evolutionary drift that resulted from either continuous circulation or maintenance of the virus within Africa and Eurasia. Furthermore, results implicate wild suids as the ancestral host species (root state posterior probability = 0.87) for ASFV in the early 1700s in Africa. Moreover, results indicate the transmission cycle between wild suids and pigs is an important cycle for ASFV spread and maintenance in pig populations, while ticks are an important natural reservoir that can facilitate ASFV spread and maintenance in wild swine populations. We illustrated the prospects of phylodynamic methods in improving risk-based surveillance, support of effective animal health policies, and epidemic preparedness in countries at high risk of ASFV incursion.

Although it has been found that soccer produces limb imbalance, it has not been rigorously determined how to evaluate it in soccer players or which low-cost tests are the most effective for its analysis. Therefore, the objective of this systematic review was to identify and examine the evidence and evaluations of limb imbalance produced in professional soccer players. A systematic search was conducted in three databases (PubMed, Web of Sciences, and Scopus) to identify relevant studies published before 23 May 2022. Of the 2364 studies identified initially, only 12 articles were included in the systematic review. The results revealed that injury risks can be detected in professional soccer players through the YBT (Y Balance Test). The PSLR (Passive Straight Leg Raise) test, as well as the evaluation of the ROM (range of motion) in movements of adduction and internal hip rotation, seem to be two reliable tests to detect imbalances in the flexibility of the extremities. The FMS (Functional Motion Screen) test is inversely related to the performance in jump tests; thus, its combination can help to detect asymmetries in power generation. Finally, strength assessment tests in soccer players can negatively alter the flexibility values of agonist/antagonist muscles. Therefore, it is advisable to monitor both strength and flexibility tests synergistically to obtain a comprehensive evaluation.

Food addiction (FA) is an emerging psychiatric condition that presents behavioral and neurobiological similarities with other addictions, and its early identification is essential to prevent the development of more severe disorders. The aim of the present study was to determine the ability of anthropometric measures, eating habits, symptoms related to eating disorders (ED), and lifestyle features to predict the symptoms of food addiction. Methodology: A cross-sectional study was conducted in a sample of 702 university students (77.3% women; age: 22 ± 6 years). The Food Frequency Questionnaire (FFQ), the Yale Food Addiction Scale 2.0 (YFAS 2.0), the Eating Attitudes Test (EAT-26), anthropometric measurements, and a set of self-report questions on substance use, physical activity level, and other questions were administered. A total of 6.4% of participants presented symptoms compatible with food addiction, and 8.1% were at risk for ED. Additionally, 26.5% reported daily smoking, 70.6% consumed alcohol, 2.9% used illicit drugs, and 29.4% took medication; 35.3% did not engage in physical activity. Individuals with food addiction had higher BMI (p = 0.010), waist circumference (p = 0.001), and body fat (p < 0.001) values, and a higher risk of eating disorders (p = 0.010) compared to those without this condition. In the multivariate logistic model, non-dairy beverage consumption (such as coffee or alcohol), vitamin D deficiency, and waist circumference predicted food addiction symptoms (R2Nagelkerke = 0.349). Indeed, the machine learning approaches confirmed the influence of these variables. Conclusions: The prediction models allowed an accurate prediction of FA in the university students; moreover, the individualized approach improved the identification of people with FA, involving complex dimensions of eating behavior, body composition, and potential nutritional deficits not previously studied.

African swine fever (ASF) is a contagious viral disease of pigs and wild boar that poses a major threat to the global swine industry. The genotype II African swine fever virus (ASFV) entered the European Union (EU) in 2014 and since then fourteen countries have been affected, Italy and North Macedonia being the last in 2022. While whole genome sequencing remains the gold standard for the identification of new genetic markers, sequencing of multiple loci with significant variations could be used as a rapid and cost-effective alternative to track outbreaks and study disease evolution in endemic areas. To further our understanding of the epidemiology and spread of ASFV in Europe, 382 isolates collected during 2007 to 2022 were sequenced. The study was initially performed by sequencing the central variable region (CVR), the intergenic region (IGR) between the and genes and the and genes. For further discrimination, two new PCRs were designed to amplify the IGR between the and genes of the multigene family 505 (MGF505) and the IGR between the and genes. The sequences obtained were compared with genotype II isolates from Europe and Asia. The combination of the results obtained by sequencing these variable regions allowed to differentiate the European II-ASFV genotypes into 24 different groups. In addition, the SNP identified in the IGR - region, not previously described, grouped the viruses from North Macedonia that caused the 2022 outbreaks with viruses from Romania, Bulgaria, Serbia and Greece, differentiating from other genotype II isolates present in Europe and Asia. Furthermore, tandem repeat sequence (TRS) within the - genes of the multigene family 505 (MGF505) revealed eight different variants circulating. These findings describe a new multi-gene approach sequencing method that can be used in routine genotyping to determine the origin of new introductions in ASF-free areas and track infection dynamics in endemic areas.