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Hypertrophic scars (HTSs) are the result of an abnormal healing process resulting from burns and other severe traumas. The symptoms of that condition include skin irritation, discomfort, and itching. This study aimed to assess the efficacy of fractional carbon dioxide (CO 2 ) laser therapy alone or with triamcinolone or 5-fluorouracil (FU) in the treatment of early post-burn hypertrophic scars (HTSs) that develop during the first 6 months after the injury. A prospective, randomized, single-blind comparative study was conducted on 30 patients aged 16–65 with hypertrophic scars (HTS) resulting from burns. Patients had no prior treatment for their scars. We randomly assigned participants to one of three groups: Group A received fractional CO 2 laser therapy alone, Group B received fractional CO 2 laser therapy with topical 5-fluorouracil, and Group C received fractional CO 2 laser therapy with topical triamcinolone acetonide. All treatment groups showed significant improvements ( p  < 0.05) in overall scar severity and height. Patients in Group C (fractional CO 2 laser + triamcinolone) demonstrated significant improvements in scar pliability, height, and pigmentation ( p  < 0.05). In contrast, patients in Group B (fractional CO 2 laser + 5-FU) showed significant reductions in scar vascularity, pliability, and height following treatment ( p  < 0.05). While all groups reported minor changes in pain and itching, there were no significant differences in these symptoms between Group B and Group C. HTSs of this trial revealed reductions in overall scar surface area and thickness and improvement of pliability and pigmentation; however, there was not statistically significant difference between the effect of 5-fluorouracil and triamcinolone acetonide (TAC), suggesting that neither drug offers better efficacy over the other. Level I, singleblinded randomized control study.

Hypertrophic scars (HTSs) are the result of an abnormal healing process resulting from burns and other severe traumas. The symptoms of that condition include skin irritation, discomfort, and itching. This study aimed to assess the efficacy of fractional carbon dioxide (CO ) laser therapy alone or with triamcinolone or 5-fluorouracil (FU) in the treatment of early post-burn hypertrophic scars (HTSs) that develop during the first 6 months after the injury. A prospective, randomized, single-blind comparative study was conducted on 30 patients aged 16-65 with hypertrophic scars (HTS) resulting from burns. Patients had no prior treatment for their scars. We randomly assigned participants to one of three groups: Group A received fractional CO laser therapy alone, Group B received fractional CO laser therapy with topical 5-fluorouracil, and Group C received fractional CO laser therapy with topical triamcinolone acetonide. All treatment groups showed significant improvements (p < 0.05) in overall scar severity and height. Patients in Group C (fractional CO laser + triamcinolone) demonstrated significant improvements in scar pliability, height, and pigmentation (p < 0.05). In contrast, patients in Group B (fractional CO laser + 5-FU) showed significant reductions in scar vascularity, pliability, and height following treatment (p < 0.05). While all groups reported minor changes in pain and itching, there were no significant differences in these symptoms between Group B and Group C. HTSs of this trial revealed reductions in overall scar surface area and thickness and improvement of pliability and pigmentation; however, there was not statistically significant difference between the effect of 5-fluorouracil and triamcinolone acetonide (TAC), suggesting that neither drug offers better efficacy over the other. Level I, singleblinded randomized control study.

Hydrosalpinx impairs the success of in vitro fertilization (IVF) embryo transfer. Various surgical approaches, such as fluid aspiration or isolation of the affected fallopian tubes, have been used to enhance the outcome. This study was conducted to evaluate and compare the efficacy of laparoscopic tubal disconnection (LTD) and hydroscopic tubal electrocoagulation (HTE) for hydrosalpinx before IVF. After obtaining ethical committee approval, we assessed 112 women who were subfertile due to hydrosalpinx to check their adherence to our selection criteria. Eligible patients were allocated into two groups (LTD vs. HTE). Both groups underwent extensive assessment before the operative procedure. IVF and subsequent embryo transfers were performed in both groups. Live birth and pregnancy rates were evaluated. Patients who underwent LTD prior to IVF embryo transfer had significantly higher live birth (41%), clinical pregnancy (57%), and chemical pregnancy (61%) rates in the LTD group than in the HTE group (12%, 35%, 41%, respectively). However, we could not find a significant difference between the two groups regarding the miscarriage (17% vs. 28%, p=0.33) and multiple pregnancy (14% vs. 12%, p=0.79) rates. No major complications with HTE were observed, except for a case of uterine perforation, whereas two cases of surgical complications occurred in the LTD group. Additionally, we found a significantly shorter operative time and hospital stay (0.5±0.7 days, p=0.012) in the HTE group. LTD may be a more effective approach compared with hysteroscopic tubal electrocoagulation for improving birth and pregnancy rates in patients with IVF and hydrosalpinx.

Objective: Hydrosalpinx impairs the success of in vitro fertilization (IVF) embryo transfer. Various surgical approaches, such as fluid aspiration or isolation of the affected fallopian tubes, have been used to enhance the outcome. This study was conducted to evaluate and compare the efficacy of laparoscopic tubal disconnection (LTD) and hydroscopic tubal electrocoagulation (HTE) for hydrosalpinx before IVF. Materials and Methods: After obtaining ethical committee approval, we assessed 112 women who were subfertile due to hydrosalpinx to check their adherence to our selection criteria. Eligible patients were allocated into two groups (LTD vs. HTE). Both groups underwent extensive assessment before the operative procedure. IVF and subsequent embryo transfers were performed in both groups. Live birth and pregnancy rates were evaluated. Results: Patients who underwent LTD prior to IVF embryo transfer had significantly higher live birth (41%), clinical pregnancy (57%), and chemical pregnancy (61%) rates in the LTD group than in the HTE group (12%, 35%, 41%, respectively). However, we could not find a significant difference between the two groups regarding the miscarriage (17% vs. 28%, p=0.33) and multiple pregnancy (14% vs. 12%, p=0.79) rates. No major complications with HTE were observed, except for a case of uterine perforation, whereas two cases of surgical complications occurred in the LTD group. Additionally, we found a significantly shorter operative time and hospital stay (0.5[+ or -]0.7 days, p=0.012) in the HTE group. Conclusion: LTD may be a more effective approach compared with hysteroscopic tubal electrocoagulation for improving birth and pregnancy rates in patients with IVF and hydrosalpinx. Keywords: Hydrosalpinx, tubal infertility, IVF, embryo transfer, laparoscopy Ama : Hidrosalpinks, in vitro fertilizasyon (IVF) embriyo transferinin basarisini bozar. Sonucu iyilestirmek i in sivi aspirasyonu veya etkilenen fallop t plerinin izolasyonu gibi esitli cerrahi yaklasimlar kullanilmistir. Bu alisma, IVF ncesinde hidrosalpinks i in laparoskopik tubal baglantinin kesilmesinin (LTBK) hidroskopik tubal elektrokoag lasyona (HTE) karsi etkinligini degerlendirmek ve iki y ntemi karsilastirmak i in yapildi. PRECIS: Hysteroscopic tubal electrocoagulation versus laparoscopic tubal disconnection for the management of hydrosalpinx and subsequent pregnancy outcomes: A randomized clinical trial. Gere ve Y ntemler: Etik kurul onayini aldiktan sonra, hidrosalpinks nedeniyle kisir olan 112 kadini, se im kriterlerimize uygunluklarini kontrol etmek i in degerlendirdik. Uygun hastalar 2 gruba ayrildi (LTBK ve HTE). Her iki gruba da operasyon ncesi kapsamli bir degerlendirme yapildi. Her iki grupta da IVF ve ardindan embriyo transferleri yapildi. Canli dogum ve gebelik oranlari degerlendirildi. Bulgular: T p bebek embriyo transferi ncesinde LTBK uygulanan hastalarda, HTE grubuna (sirasiyla %12, %35 ve %41) kiyasla canli dogum (%41), klinik gebelik (%57) ve kimyasal gebelik (%61) oranlari anlamli derecede daha y ksekti. Ancak d s k (%17 vs. %28, p=0,33) ve ogul gebelik (%14 vs. %12, p=0,79) oranlari a isindan 2 grup arasinda anlamli bir fark yoktu. HTE grubunda uterus perforasyonu disinda maj r bir komplikasyon g r lmezken, LTBK grubunda 2 olguda cerrahi komplikasyon meydana geldi. Ayrica HTE grubunda anlamli olarak daha kisa ameliyat s resi ve hastanede kalis s resi (0,5[+ or -]0,7 g n, p=0,012) saptandi. Sonu : Hidrosalpinksli IVF hastalarinda dogum ve gebelik oranlarinin iyilestirilmesinde LTBK HTE'ye g re daha etkili bir yaklasim olabilir. Anahtar Kelimeler: Hidrosalpinks, tubal infertilite, IVF, embriyo transferi, laparoskopi