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Purpose Accumulation of visceral, but not subcutaneous, adipose tissue is highly associated with metabolic disease. Inflammation inciting from adipose tissue is commonly associated with metabolic disease risk and comorbidities. However, constituents of the immune system, lymph nodes, embedded within these adipose depots remain under-investigated. We hypothesize that, lymph nodes are inherently distinct and differentially respond to diet-induced obesity much like the adipose depots they reside in. Methods Adipose tissue and lymph nodes were collected from the visceral and inguinal depots of male mice fed 13 weeks of standard CHOW or high fat diet (HFD). Immune cells were isolated from tissues, counted and characterized by flow cytometry or plated for proliferative capacity following Concanavalin A stimulation. Lymph node size and fibrosis area were also characterized. Results In HFD fed mice visceral adipose tissue accumulation was associated with significant enlargement of the lymph node encased within. The subcutaneous lymph node did not change. Compared with mice fed CHOW for 13 weeks, mice fed HFD had a decline in immune cell populations and immune cell proliferative ability, as well as, exacerbated fibrosis accumulation, within the visceral, but not subcutaneous, lymph node. Conclusions Obesity-induced chronic low-grade inflammation is associated with impaired immunity and increased susceptibility to disease. Excessive visceral adiposity and associated inflammation driven by diet likely leads to obesity-induced immune suppression by way of lymph node/lymphatic system pathophysiology.

The Mu2e experiment at Fermilab will search for the neutrinoless μ−→e− conversion in the field of an aluminum nucleus. The Mu2e data-taking plan assumes two running periods, Run I and Run II, separated by an approximately two-year-long shutdown. This paper presents an estimate of the expected Mu2e Run I search sensitivity and includes a detailed discussion of the background sources, uncertainties of their prediction, analysis procedures, and the optimization of the experimental sensitivity. The expected Run I 5σ discovery sensitivity is Rμe=1.2×10−15, with a total expected background of 0.11±0.03 events. In the absence of a signal, the expected upper limit is Rμe<6.2×10−16 at 90% CL. This represents a three order of magnitude improvement over the current experimental limit of Rμe<7×10−13 at 90% CL set by the SINDRUM II experiment.

In hot weather, it is a common practice to cool concrete-particularly for mass concrete applications-to prevent thermal cracking and durability problems. An increasingly popular method of cooling is through direct injection of liquid nitrogen (LN^sub 2^) into the drums of concrete trucks. During an investigation of the effects of LN^sub 2^ on concrete properties, it was observed that the practice has unexpected impacts on concrete slump and setting time. While it is known that increasing temperature decreases slump for concrete with given mixture proportions, it is surprising that concrete cooled with LN^sub 2^ has low slump similar to that of a hot mixture, a phenomenon that is not affected by the time at which the concrete is cooled. The initial setting time, however, is actually longer than predicted when there is a significant delay in LN^sub 2^ cooling. [PUBLICATION ABSTRACT]

The Mu2e experiment at Fermilab will search for the neutrinoless μ−→e− conversion in the field of an aluminum nucleus. The Mu2e data-taking plan assumes two running periods, Run I and Run II, separated by an approximately two-year-long shutdown. This paper presents an estimate of the expected Mu2e Run I search sensitivity and includes a detailed discussion of the background sources, uncertainties of their prediction, analysis procedures, and the optimization of the experimental sensitivity. The expected Run I 5σ discovery sensitivity is Rμe=1.2×10−15, with a total expected background of 0.11±0.03 events. In the absence of a signal, the expected upper limit is Rμe<6.2×10−16 at 90% CL. This represents a three order of magnitude improvement over the current experimental limit of Rμe<7×10−13 at 90% CL set by the SINDRUM II experiment.

The Cosmic-Ray Veto detector for the muon-to-electron conversion experiment at Fermilab consists of four plastic scintillating counter layers read out by silicon photo-multipliers through embedded wavelength-shifting fibers. In order to increase the light yield in the most critical regions of the Cosmic-Ray Veto detector for improved background rejection, a 1.8 mm diameter fiber is being used in many of the detector's critical modules instead of the previously planned 1.4 mm diameter fiber. This paper reports the testing procedure and light properties of thirty-four 1.8 mm fiber spools, with measurements performed using a custom-built scanner. We compare these new results with previously published data from the 1.4 mm diameter fiber used for regions of the cosmic-ray veto where the increased light yield is not required. In addition, measurements of fiber aging were performed.

The Heavy Photon Search experiment (HPS) at the Thomas Jefferson National Accelerator Facility searches for electro-produced dark photons. We report results from the 2016 Engineering Run consisting of 10608/nb of data for both the prompt and displaced vertex searches. A search for a prompt resonance in the \\(e^+e^-\\) invariant mass distribution between 39 and 179 MeV showed no evidence of dark photons above the large QED background, limiting the coupling of ^2 10^-5, in agreement with previous searches. The search for displaced vertices showed no evidence of excess signal over background in the masses between 60 and 150 MeV, but had insufficient luminosity to limit canonical heavy photon production. This is the first displaced vertex search result published by HPS. HPS has taken high-luminosity data runs in 2019 and 2021 that will explore new dark photon phase space.

Real exchange-rate changes affect bonds differently from stocks. Bonds, having relatively fixed income streams, reflect only an interest-rate effect; stocks reflect a conjunction of interest-rate and cash-flow effects. If exchange rate changes contain information about future interest rates and cash flows over more than one period, then using short horizons may not fully capture exchange exposure, which may explain why prior empirical studies have failed to find an association between stock returns and exchange rates. Using long-horizon returns and long-horizon exchange-rate changes as we do provides a clearer picture of exchange exposure.

In this ecological study we show that the particular curvilinear formulation of the relationship between density and the failing rate of organizations proposed by Hannan and Freeman does not hold for the California wine industry between 1940 and 1985. We demonstrate instead that an alternative model focusing on prior foundings and prior failings gives a superior account of the failing rate in this population. We argue that Hannan and Freeman's density-dependent model of organizational mortality systematically overstates the negative effects of illegitimacy on business organizations. We argue further that their model underestimates business organizations' ability to avoid elimination by migrating to neighboring niches and by enlarging their initial niche.

A digital data acquisition system (DDAS) has been implemented for the Low Energy Neutron Detector Array (LENDA). LENDA is an array of 24 BC-408 plastic-scintillator bars designed to measure low-energy neutrons with kinetic energies in the range of 100 keV to 10 MeV from (p,n)-type charge-exchange reactions. Compared to the previous data acquisition (DAQ) system for LENDA, DDAS offers the possibility to lower the neutron detection threshold, increase the overall neutron-detection efficiency, decrease the dead time of the system, and allow for easy expansion of the array. The system utilized in this work was XIA's Digital Gamma Finder Pixie-16 250 MHz digitizers. A detector-limited timing resolution of 400 ps was achieved for a single LENDA bar. Using DDAS, the neutron detection threshold of the system was reduced compared to the previous analog system, now reaching below 100 keV. The new DAQ system was successfully used in a recent charge-exchange experiment using the \\(^16\\)C(p,n) reaction at the National Superconducting Cyclotron Laboratory (NSCL).