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"Song, Li-Gang"
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Association of PON1, P2Y12 and COX1 with Recurrent Ischemic Events in Patients with Extracranial or Intracranial Stenting
Short-term combined use of clopidogrel and aspirin improves cerebrovascular outcomes in patients with symptomatic extracranial or intracranial stenosis. Antiplatelet non-responsiveness is related to recurrent ischemic events, but the culprit genetic variants responsible for the non-responsiveness have not been well studied. We aimed to identify the genetic variants associated with poor clinical outcomes.
Patients with symptomatic extracranial or intracranial stenosis scheduled for stenting and receiving dual antiplatelets (clopidogrel 75 mg and aspirin 100 mg daily) for at least 5 days before intervention were enrolled. Ischemic events including recurrent transient ischemic attack, stroke, myocardial infarction, and vascular-related mortality within 12 months follow-up were recorded. We examined the influence of genetic polymorphisms on treatment outcome in our patients.
A total of 268 patients were enrolled into our study and ischemic events were observed in 39 patients. For rs662 of paraoxonase 1 (PON1), allele C was associated with an increased risk of ischemic events (OR = 1.64, 95%CI = 1.03-2.62, P = 0.029). The A-allele carriers of rs2046934 of P2Y12 had a significant association with adverse events (OR = 2.01, 95%CI = 1.10-3.67, P = 0.041). The variant T-allele of cyclooxygenase-1 (COX1) rs1330344 significantly increased the risk of recurrent clinical events (OR = 1.85, 95%CI = 1.12-3.03, P = 0.017). The other single nucleotide polymorphism (SNP) had no association with ischemic events.
PON1, P2Y12 and COX1 polymorphisms were associated with poorer vascular outcomes. Testing for these polymorphisms may be valuable in the identification of patients at risk for recurrent ischemic events.
Journal Article
A non-probabilistic reliability-based topology optimization of continuum structures using evolutionary topology optimization method
This paper considers a non-probabilistic reliability topology optimization method of continuum structures under uncertainty. To do this, we first propose an evolutionary topology optimization algorithm that represents the smooth boundary using a level set function updated by the nodal sensitivity numbers. Next, we propose a two-step search-based structural non-probabilistic reliability analysis method to improve convergence performance and computational efficiency while ensuring the accuracy of the structural non-probabilistic reliability analysis for highly nonlinear problems. Combining the proposed evolutionary topology optimization method and the two-step search-based non-probabilistic reliability analysis method, an algorithm for solving the topology optimization problem of continuum structures formulated with volume minimization under reliability constraints expressed as displacements is constructed, and the accuracy and effectiveness of the proposed method are verified through numerical calculation for typical problems. Numerical results show that the proposed non-probabilistic reliability topology optimization method based on the level set model is an effective method to solve efficiently the reliability topology optimization problem of continuum structures with smooth representation of the boundary shape.
Journal Article
串联病变是急性基底动脉闭塞血管内治疗预后不良的危险因素:单中心队列研究
目的 探讨串联病变对急性基底动脉闭塞患者血管内治疗预后的预测价值.方法 纳入2012年1月至2018年7月共187例急性基底动脉闭塞患者(包括串联病变25例、非串联病变162例),均行血管内治疗,术前采用后循环Alberta脑卒中计划早期CT评分(pc-ASPECTS)和脑桥-中脑指数(PMI)评价脑梗死范围,后交通评分和美国介入和治疗性神经放射学学会/美国介入放射学学会(ASITN/SIR)分级评价基底动脉闭塞后后循环侧支代偿.主要预后指标为术后即刻血管再通率以及治疗后90 d功能独立性和预后,主要安全终点为术后7d内颅内出血和症状性颅内出血发生率以及治疗后90 d病死率.结果 串联病变组患者病变主要位于基底动脉起始部(包括椎动脉颅内段)和远端(P=0.000)、合并颅内动脉狭窄比例较低(P=0.000).25例串联病变患者中21例采取Dirty-road路径、4例采取Clean-road路径,支架取栓(P=0.030)和术中静脉注射替罗非班(P=0.028)比例更低,支架植入比例更高(P=0.005),术后即刻血管再通率更低(P=0.001),治疗后90 d病死率更高(P=0.002).单因素和多因素Logistic回归分析显示,串联病变是急性基底动脉闭塞术后即刻血管再通率较低(OR=0.050,95％CI:0.010～ 0.530;P=0.012)和治疗后90 d病死率较高(OR=17.320,95％CI:2.700 ～ 111.040;P=0.003)的危险因素.结论 串联病变是急性基底动脉闭塞患者血管内治疗后预后不良的危险因素.
Journal Article
急性进展性大血管闭塞性卒中的病理生理学机制、临床分型与治疗策略
急性进展性大血管闭塞性卒中是特殊类型的急性大血管闭塞性缺血性卒中,通过充分的病史询问、详细的影像学评估和适宜的个体化治疗,可以获得较好预后.本文综述急性进展性大血管闭塞性卒中区别于其他病因缺血性卒中的病理生理学机制、临床特点和分型及治疗策略.
Journal Article
Reliability and Validity of the Repeatable Battery for Assessment of Neuropsychological Status Scale in Evaluation of Vascular Cognitive Impairment in Elderly Han Population
Vascular cognitive impairment (VCI) and Alzheimer's disease are the most common cognitive impairment diseases in the elderly. This study aimed to apply the Repeatable Battery for Assessment of Neuropsychological Status (RBANS) scale to evaluate VCI in elderly patients and analyze its reliability and validity.
We enrolled 278 VCI patients admitted to our hospital, from June 2017 to June 2018. The basic clinical information of each patient was documented, and the Mini-Mental State Examination (MMSE) and the RBANS scales were suggested to complete.
We found significant correlations between the RBANS total score and age, diabetes, hypertension, coronary heart disease and years of education. The internal consistency of the RBANS scale Cronbach αsuggested a good agreement with the total score and the single score at two time points. Moreover, the RBANS total score and the score of each dimension in the RBANS scale were positively correlated with the MMSE immediate memory, calculation ability, delayed memory, commanding ability, reading comprehension ability, command execution, sentence making, and pattern duplicating ability.
In conclusion, the RBANS has good reliability and validity for the assessment of cognitive dysfunction in elderly VCI patients. It can be used as a routine clinical and research tool, for the simplicity in operation and superior acceptance.
Journal Article
OsSET1, a novel SET‐domain‐containing gene from rice
A novel SET‐domain‐containing gene OsSET1 was isolated from rice (Oryza sativa L.). Its deduced protein consists of 895 amino acids. OsSET1 has a high degree of structure similarity to other SET‐domain‐containing genes such as CLF in higher plants and E(z) in animals. RT‐PCR showed that the gene expresses throughout the entire plant. A transient expression assay in onion epidermis revealed that the OsSET1 protein is localized in nuclei. Over‐expression of the SET domain of OsSET1 in Arabidopsis resulted in altered shoot development at seedling stages.
Journal Article
Application of Keyhole Microneurosurgery in China
INTRODUCTIONMicroneurosurgery made its debut in the early 1960s. It became popular in the medical field and became a primary operation method in neurosurgery since it improved the efficacy of neurosurgery with a less surgery-related injury. Over the past five decades, the accumulation of experience of microsurgery, improvement of microsurgery techniques, refined micro-instruments, and advanced preoperative diagnostic imaging allowed the evolution of microneurosurgery techniques and further reduced surgery-related trauma.
Journal Article
Market-based control strategy for long-span structures considering the multi-time delay issue
To solve the different time delays that exist in the control device installed on spatial structures, in this study, discrete analysis using a 2N precise algorithm was selected to solve the multi-time-delay issue for long-span structures based on the market-based control （MBC） method. The concept of interval mixed energy was introduced from computational structural mechanics and optimal control research areas, and it translates the design of the MBC multi-time-delay controller into a solution for the segment matrix. This approach transforms the serial algorithm in time to parallel computing in space, greatly improving the solving efficiency and numerical stability. The designed controller is able to consider the issue of time delay with a linear controlling force combination and is especially effective for large time-delay conditions. A numerical example of a long-span structure was selected to demonstrate the effectiveness of the presented controller, and the time delay was found to have a significant impact on the results.
Journal Article
Molecular analysis of early rice stamen development using organ-specific gene expression profiling
Elucidating the regulatory mechanisms of plant organ formation is an important component of plant developmental biology and will be useful for crop improvement applications. Plant organ formation, or organogenesis, occurs when a group of primordial cells differentiates into an organ, through a well-orchestrated series of events, with a given shape, structure and function. Research over the past two decades has elucidated the molecular mechanisms of organ identity and dorsalventral axis determinations. However, little is known about the molecular mechanisms underlying the successive processes. To develop an effective approach for studying organ formation at the molecular level, we generated organ-specific gene expression profiles (GEPs) reflecting early development in rice stamen. In this study, we demonstrated that the GEPs are highly correlated with early stamen development, suggesting that this analysis is useful for dissecting stamen development regulation. Based on the molecular and morphological correlation, we found that over 26 genes, that were preferentially up-regulated during early stamen development, may participate in stamen development regulation. In addition, we found that differentially expressed genes during early stamen development are clustered into two clades, suggesting that stamen development may comprise of two distinct phases of pattern formation and cellular differentiation. Moreover, the organ-specific quantitative changes in gene expression levels may play a critical role for regulating plant organ formation.
Journal Article