Explore the vast range of titles available.

IntroductionThere is a huge resource gap in mental health service provision & service utilisation in LAMIC including Pakistan. SOUL Programme has been established in the City of Larkana, on charitable donations, which utilises principles of home-based outreach and produces clinical and functional outcomes.ObjectivesSOUL programme focuses on collaborative working with patients & families. The objectives include recognition, treatment, family education & psychosocial support to maximize clinical, functional & occupational outcomes.MethodsSingle cohort intervention (patients recruited on continual basis over time) with innovative service structure and culturally relevant open label intervention design developed with local academic psychiatric unit in Larkano, Pakistan. Training was provided to local mental health professionals on diagnosis, delivering care & use of recognized clinical outcome measures.ResultsWe have recruited a cohort of 160 patients on continual basis over time. Our analysis show a higher BPRS and lower GAF ratings for men in comparison to female cohort at the baseline. Our Ten year follow up has demonstrated statistically significant clinical / functional improvement on BPRS, CGI & GAF measures. The mean differences recorded for the individual measures after 12 months were BPRS, CGI-I and GAF and were all statistically significant. Innovative home-based community mental health intervention shows significant improvements in clinical and functional outcomes (with good effect size).ConclusionsSOUL Programme is a highly effective and cost-efficient intervention model for treatment of schizophrenia in a developing country setting. Our 10 year follow up study confirms the feasibility of this intervention model through close working with families of our patients.DisclosureNo significant relationships.

The LHCb experiment has been taking data at the Large Hadron Collider (LHC) at CERN since the end of 2009. One of its key detector components is the Ring-Imaging Cherenkov (RICH) system. This provides charged particle identification over a wide momentum range, from 2–100 GeV/ c . The operation and control, software, and online monitoring of the RICH system are described. The particle identification performance is presented, as measured using data from the LHC. Excellent separation of hadronic particle types ( π , K, p) is achieved.

IntroductionPsychiatric services in LEDCs face a tripartite challenge: (i) limited financial capital; (ii) scarcity of professionals; (iii) restrictive health beliefs. Inevitably, services developed for the first-world are ill-suited here. Psychiatric services must be designed from the ground up: inspired by but not a replica of best practices in the developed world. The SOUL project in Larkana, Pakistan provides home based assessment by a psychiatrist and fortnightly treatment by a mobile nursing team for schizophrenic patients. Psychoeducation of carers and the community as well as facilitation of work for patients are core aims. This mixed-methods study evaluates the experiences of primary stakeholders - patients and their carers.Objectives1.Are patients and carers satisfied with the care received? 2.Has SOUL been successful in changing health beliefs? 3.How could the programme be improved?MethodsThe principal investigator accompanied the team for 4-weeks. Purposive sampling was employed. Satisfaction was assessed quantitatively using the likert based PSQ-18 questionnaire. Thereafter, qualitative data was gathered using semi-structured interviews and analysed using a grounded theory approach. A total of 27 interviews were conducted before data saturation.Results100% of interviewees answered ’Satisfied’ or ’Very’ Satisfied to all elements of the PSQ-18. Above all, stakeholders valued that treatment was free and highly accessible (home visits), promoting treatment adherence. They felt psychoeducation events significantly reduced community stigma and made families more likely to seek psychiatrists over faith healers. Provision of respite care was suggested as a future improvement.ConclusionsSOUL is highly valued by stakeholders and offers an excellent example of LEDC psychiatric care.DisclosureNo significant relationships.

Royal Jelly (RJ) is product from bees that is used to feed larvae in the hive as well as a main nutritional source for the queen honey bee. It has various important biological activities including as an antioxidant, immunomodulatory, anti-inflammatory, antimicrobial, cholesterol-lowering, and growth promoter activities and has the ability for inhibition of certain enzymatic degradation. It can be used for the improvement of growth performance, gut health and quality and safety of animal products in poultry due to its antioxidant and immune modulating properties. The antioxidant activity of RJ is mainly due to the presence of polyphenolic compounds. It is an excellent source of B and C vitamins and folic acid. The mineral profile of RJ is useful as it contains major macro and micro minerals. Studies conducted on supplementation with RJ in poultry diets have shown a significant increase in body weight, egg production, and immune levels and is especially useful in organic production. Supplementation of RJ at the level of 10 and 15 mg/kg in layer diets positively influenced egg weight (by 5.0% and 4.8% respectively), egg production (10.5% and 11.0% respectively), weight gain of hens (7.0% and 6.5% respectively) and yolk pigmentation (9.5% and 9.7% respectively). Total leukocyte and erythrocyte counts in the diet containing 200 mg/kg RJ were significantly higher than the diet contained 100 mg/kg or the unsupplemented control group. However, the heterophil/lymphocyte ratio and heterophil percent were reduced in RJ-fed groups. Supplementing poultry diets with RJ offers an opportunity to maximise profit from safe and high quality poultry production.

A bstract An angular analysis of the B 0 → K *0 (→ K + π − ) μ + μ − decay is presented. The dataset corresponds to an integrated luminosity of 3.0 fb −1 of pp collision data collected at the LHCb experiment. The complete angular information from the decay is used to determine CP -averaged observables and CP asymmetries, taking account of possible contamination from decays with the K + π − system in an S-wave configuration. The angular observables and their correlations are reported in bins of q 2 , the invariant mass squared of the dimuon system. The observables are determined both from an unbinned maximum likelihood fit and by using the principal moments of the angular distribution. In addition, by fitting for q 2 -dependent decay amplitudes in the region 1.1 < q 2 < 6.0 GeV 2 / c 4 , the zero-crossing points of several angular observables are computed. A global fit is performed to the complete set of CP -averaged observables obtained from the maximum likelihood fit. This fit indicates differences with predictions based on the Standard Model at the level of 3.4 standard deviations. These differences could be explained by contributions from physics beyond the Standard Model, or by an unexpectedly large hadronic effect that is not accounted for in the Standard Model predictions.

A bstract The isospin asymmetries of B → Kμ + μ − and B → K * μ + μ − decays and the partial branching fractions of the B 0 → K 0 μ + μ − , B + → K + μ + μ − and B + → K *+ μ + μ − decays are measured as functions of the dimuon mass squared, q 2 . The data used correspond to an integrated luminosity of 3 fb −1 from proton-proton collisions collected with the LHCb detector at centre-of-mass energies of 7 TeV and 8 TeV in 2011 and 2012, respectively. The isospin asymmetries are both consistent with the Standard Model expectations. The three measured branching fractions favour lower values than their respective theoretical predictions, however they are all individually consistent with the Standard Model.

A bstract Production cross-sections of prompt charm mesons are measured with the first data from pp collisions at the LHC at a centre-of-mass energy of 13 TeV. The data sample corresponds to an integrated luminosity of 4.98 ± 0.19 pb −1 collected by the LHCb experiment. The production cross-sections of D 0 , D + , D s + , and D *+ mesons are measured in bins of charm meson transverse momentum, p T , and rapidity, y , and cover the range 0 < p T < 15GeV/c and 2.0 < y < 4.5. The inclusive cross-sections for the four mesons, including charge conjugation, within the range of 1 < p T < 8 GeV/c are found to be σ pp → D 0 X = 2460 ± 3 ± 130 μ b σ pp → D + X = 1000 ± 3 ± 110 μ b σ pp → D s + X = 460 ± 13 ± 100 μ b σ pp → D ∗ + X = 880 ± 5 ± 140 μ b where the uncertainties are due to statistical and systematic uncertainties, respectively.

A bstract An angular analysis and a measurement of the differential branching fraction of the decay B s 0  →  ϕμ + μ − are presented, using data corresponding to an integrated luminosity of 3 . 0 fb −1 of pp collisions recorded by the LHCb experiment at s = 7 and 8 TeV. Measurements are reported as a function of q 2 , the square of the dimuon invariant mass and results of the angular analysis are found to be consistent with the Standard Model. In the range 1 < q 2 < 6 GeV 2 /c 4 , where precise theoretical calculations are available, the differential branching fraction is found to be more than 3 σ below the Standard Model predictions.

In the Standard Model of particle physics, the strength of the couplings of the b quark to the u and c quarks, | V ub | and | V cb |, are governed by the coupling of the quarks to the Higgs boson. Using data from the LHCb experiment at the Large Hadron Collider, the probability for the Λ b 0 baryon to decay into the p final state relative to the final state is measured. Combined with theoretical calculations of the strong interaction and a previously measured value of | V cb |, the first | V ub | measurement to use a baryonic decay is performed. This measurement is consistent with previous determinations of | V ub | using B meson decays to specific final states and confirms the existing incompatibility with those using an inclusive sample of final states. The accurate determination of quark mixing parameters is essential for the understanding of the Standard Model. The LHCb collaboration now reports the coupling strength of the b quark to the u quark through the measurement of a baryonic decay mode.

A bstract The differential branching fraction of the rare decay Λ b 0  →  Λμ + μ − is measured as a function of q 2 , the square of the dimuon invariant mass. The analysis is performed using proton-proton collision data, corresponding to an integrated luminosity of 3 . 0 fb −1 , collected by the LHCb experiment. Evidence of signal is observed in the q 2 region below the square of the J/ψ mass. Integrating over 15 < q 2 < 20 GeV 2 /c 4 the differential branching fraction is measured as d ℬ Λ b 0 → Λ μ + μ − / d q 2 = 1.18 − 0.08 + 0.09 ± 0.03 ± 0.27 × 10 − 7 GeV 2 / c 4 − 1 , where the uncertainties are statistical, systematic and due to the normalisation mode, Λ b 0  →  J / ψΛ , respectively. In the q 2 intervals where the signal is observed, angular distributions are studied and the forward-backward asymmetries in the dimuon ( A FB ℓ ) and hadron ( A FB h ) systems are measured for the first time. In the range 15 < q 2 < 20 GeV 2 /c 4 they are found to be A F B ℓ = − 0.05 ± 0.09 stat ± 0.03 syst and A F B h = − 0.29 ± 0.07 stat ± 0.03 syst .