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The growing interest in clarifying the controversial situation in the Dark Matter sector has driven the experimental efforts towards new ways to investigate the long-standing DAMA/LIBRA result. Among them, low-temperature calorimeters based on Na-containing scintillating crystals offer the possibility to clarify the nature of the measured signal via particle identification. Here we report the first measurement of Na-containing crystals, based on material different from NaI, i.e. Na\\(_2\\)Mo\\(_2\\)O\\(_7\\) and Na\\(_2\\)W\\(_2\\)O\\(_7\\), pointing out their excellent performance in term of energy resolution, light yield, and particle identification.

The CUPID-Mo experiment is searching for neutrinoless double beta decay in \\(^{100}\\)Mo, evaluating the technology of cryogenic scintillating Li\\(_{2}^{100}\\)MoO\\(_4\\) detectors for CUPID (CUORE Upgrade with Particle ID). CUPID-Mo detectors feature background suppression using a dual-readout scheme with Li\\(_{2}\\)MoO\\(_4\\) crystals complemented by Ge bolometers for light detection. The detection of both heat and scintillation light signals allows the efficient discrimination of \\(\\alpha\\) from \\(\\gamma\\)&\\(\\beta\\) events. In this proceedings, we discuss results from the first 2 months of data taking in spring 2019. In addition to an excellent bolometric performance of 6.7\\(\\,\\)keV (FWHM) at 2615\\(\\,\\)keV and an \\(\\alpha\\) separation of better than 99.9\\% for all detectors, we report on bulk radiopurity for Th and U. Finally, we interpret the accumulated physics data in terms of a limit of \\(T_{1/2}^{0\\nu}\\,> 3\\times10^{23}\\,\\)yr for \\(^{100}\\)Mo and discuss the sensitivity of CUPID-Mo until the expected end of physics data taking in early 2020.

CUPID-Mo is a bolometric experiment to search for neutrinoless double-beta decay (\\(0\\nu\\beta\\beta\\)) of \\(^{100}\\)Mo. In this article, we detail the CUPID-Mo detector concept, assembly, installation in the underground laboratory in Modane in 2018, and provide results from the first datasets. The demonstrator consists of an array of 20 scintillating bolometers comprised of \\(^{100}\\)Mo-enriched 0.2 kg Li\\(_2\\)MoO\\(_4\\) crystals. The detectors are complemented by 20 thin cryogenic Ge bolometers acting as light detectors to distinguish \\(\\alpha\\) from \\(\\gamma\\)/\\(\\beta\\) events by the detection of both heat and scintillation light signals. We observe good detector uniformity, facilitating the operation of a large detector array as well as excellent energy resolution of 5.3 keV (6.5 keV) FWHM at 2615 keV, in calibration (physics) data. Based on the observed energy resolutions and light yields a separation of \\(\\alpha\\) particles at much better than 99.9\\% with equally high acceptance for \\(\\gamma\\)/\\(\\beta\\) events is expected for events in the region of interest for \\(^{100}\\)Mo \\(0\\nu\\beta\\beta\\). We present limits on the crystals' radiopurity (\\(\\leq\\)3 \\(\\mu\\)Bq/kg of \\(^{226}\\)Ra and \\(\\leq\\)2 \\(\\mu\\)Bq/kg of \\(^{232}\\)Th). Based on these initial results we also discuss a sensitivity study for the science reach of the CUPID-Mo experiment, in particular, the ability to set the most stringent half-life limit on the \\(^{100}\\)Mo \\(0\\nu\\beta\\beta\\) decay after half a year of livetime. The achieved results show that CUPID-Mo is a successful demonstrator of the technology - developed in the framework of the LUMINEU project - selected for the CUPID experiment, a proposed follow-up of CUORE, the currently running first tonne-scale cryogenic \\(0\\nu\\beta\\beta\\) experiment.

Hazard and risk assessment of landslides with potentially long run-out is becoming more and more important. Numerical tools exploiting different constitutive models, initial data and numerical solution techniques are important for making the expert’s assessment more objective, even though they cannot substitute for the expert’s understanding of the site-specific conditions and the involved processes. This paper presents a depth-integrated model accounting for pore water pressure dissipation and applications both to real events and problems for which analytical solutions exist. The main ingredients are: (i) The mathematical model, which includes pore pressure dissipation as an additional equation. This makes possible to model flowslide problems with a high mobility at the beginning, the landslide mass coming to rest once pore water pressures dissipate. (ii) The rheological models describing basal friction: Bingham, frictional, Voellmy and cohesive-frictional viscous models. (iii) We have implemented simple erosion laws, providing a comparison between the approaches of Egashira, Hungr and Blanc. (iv) We propose a Lagrangian SPH model to discretize the equations, including pore water pressure information associated to the moving SPH nodes.

Focused ultrasound (FUS) is an emerging noninvasive technology with significant therapeutic potential across various clinical domains. FUS enables precise targeting of tissues using mechanisms like thermoablation, mechanical disruption, and neuromodulation, minimizing damage to surrounding areas. In movement disorders such as essential tremor and Parkinson’s disease, MR-guided FUS thalamotomy has demonstrated substantial tremor reduction and improved quality of life. Psychiatric applications include anterior capsulotomy for treatment-resistant obsessive-compulsive disorder and major depressive disorder, with promising symptom relief and minimal cognitive side effects. FUS also facilitates blood-brain barrier opening for drug delivery in neurological conditions like Alzheimer’s disease. Musculoskeletal applications highlight its efficacy in managing chronic pain from knee osteoarthritis and lumbar facet joint syndrome through precise thermal ablation. Additionally, FUS has shown potential in neuropathic pain management and peripheral nerve stimulation, offering innovative approaches for amputees and cancer survivors. Cognitive and neuromodulatory research underscores its ability to enhance motor function and interhemispheric cortical balance, benefiting stroke and traumatic brain injury rehabilitation. Despite these conditions frequently leading to various kinds of disabilities, no direct exploration of the possible FUS application in rehabilitation is yet available in the literature. All this considered, this review aims to discuss how FUS could be applied in rehabilitation, exploring the current status of knowledge and highlighting future directions.

Rainfall-induced shallow landslides of the flow-type involve different soils, and they often cause huge social and economical disasters, posing threat to life and livelihood all over the world. Due to the frequent large extension of the rainfall events, these landslides can be triggered over large areas (up to tens of square kilometres), and their source areas can be analysed with the aid of distributed, physically based models. Despite the high potential, such models show some limitations related to the adopted simplifying assumptions, the quantity and quality of required data, as well as the use of a quantitative interpretation of the results. A relevant example is provided in this paper referring to catastrophic phenomena involving volcaniclastic soils that frequently occur in southern Italy. Particularly, three physically based models ( SHALSTAB , TRIGRS and TRIGRS-unsaturated ) are used for the analysis of the source areas of huge rainfall-induced shallow landslides occurred in May 1998 inside an area of about 60 km 2 . The application is based on an extensive data set of topographical, geomorphological and hydrogeological features of the affected area, as well as on both stratigraphical settings and mechanical properties of the involved soils. The results obtained from the three models are compared by introducing two indexes aimed at quantifying the “success” and the “error” provided by each model in simulating observed source areas. Advantages and limitations of the adopted models are then discussed for their use in forecasting the rainfall-induced source areas of shallow landslides over large areas.

The purpose of this scoping review was to identify possible chondrotoxic effects caused by drugs usually used for intra-articular injections. PubMed, Scopus, Web of Science and Cochrane were searched. Inclusion criteria required randomized controlled trials written in English that evaluate the toxic effect that damages the cartilage. The literature search resulted in 185 unique articles. 133 full-text articles were screened for inclusion, of which 65 were included. Corticosteroids, with the exception of triamcinolone, along with local anaesthetics, potentially excluding ropivacaine and liposomal bupivacaine, and nonsteroidal anti-inflammatory drugs, exhibited insufficient safety profiles to warrant casual use in clinical settings. Hyaluronic acid, on the other hand, appears to demonstrate safety while also mitigating risks associated with concurrent compounds, thereby facilitating therapeutic combinations. Additionally, there remains a paucity of data regarding platelet-rich plasma, necessitating further evaluation of its potential efficacy and safety. Overall, it seems that results are significantly influenced by the dosage and frequency of injections administered, observed in both human and animal studies.

The shallow deposits of unsaturated pyroclastic soils covering the slopes in the Campania region (southern Italy) are systematically affected by various rainfall-induced slope instabilities. The type and triggering of these instabilities depend on several factors, among which in situ soil suction—as an initial condition—and rainfall—as a boundary condition—play a fundamental role. Based on the available database—which includes a comprehensive catalogue of historical data, in situ soil suction measurements and soil laboratory tests along with the results of geomechanical analyses—this paper discusses the relationships among in situ soil suction and rainfall conditions and induced slope instability types. The goal is to reach a better understanding of past events and gain further insight into the analysis and forecasting of future events. In particular, the paper outlines how the season strongly affects the spatial distribution and the type of slope instability likely to develop. For example, erosion phenomena essentially occur at the end of the dry season and originate hyperconcentrated flows while first-time shallow slides prevail in the rainy season and later propagate as debris flows or as debris avalanches.

Background: Percutaneous electrolysis (PE) is a minimally invasive procedure that utilizes galvanic current delivered through a needle. PE is increasingly employed for musculoskeletal disorders, despite the scarcity of scientific evidence supporting its use. The aim of this systematic review is to synthesize the existing evidence and explore the applications of PE in rehabilitation. Methods: In line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search was conducted across the PubMed, Web of Science, Scopus, and PEDro databases from inception to July 2025. The search strategy employed the term “Percutaneous Electrolysis” without applying additional filters or time restrictions, ensuring a comprehensive search. Cited references from screened articles were also evaluated for potential inclusion. Studies were included if they met the following criteria: peer-reviewed articles, intervention-based research, relevance to the topic, and publication in English. Results: Of the 181 papers retrieved, 143 were excluded for various reasons, leaving 38 studies. The evidence suggests that PE appears effective in reducing pain and improving function, particularly when combined with exercises such as eccentric training or stretching, though inconsistencies in protocols and patient characteristics, along with unclear mechanisms, show that it warrants further investigation. Conclusions: In conclusion, while PE emerges as a promising therapeutic strategy for musculoskeletal disorders, its full integration into rehabilitation practice necessitates further rigorous research to standardize treatment protocols, elucidate the underlying mechanism, and validate its cost-effectiveness. These steps are essential to establish PE as a robust and evidence-based option within the field of rehabilitation.

Telerehabilitation is an effective, accessible addition or alternative to conventional rehabilitation for fracture management, especially in older adults after hip fractures, leveraging video visits, mHealth apps, virtual reality (VR), and wearable sensors to deliver exercise, education, and monitoring at home with high satisfaction and adherence. Across non-surgical and surgical contexts, telemedicine shows feasibility and cost benefits, with mixed superiority but consistent non-inferiority for functional outcomes versus in-person care. In hip fracture populations, randomized and non-randomized studies indicate improvements in functional independence measure (FIM), Timed Up and Go test (TUG), Activities of Daily Living/Instrumental Activities of Daily Living (ADLs/IADLs), and quality of life, with some evidence for reduced anxiety and depression, while effects on mobility, pain, and adverse events remain uncertain overall. In patients with upper-limb fractures, telerehabilitation appears to improve function and pain, though strength gains may lag compared with in-person therapy in some trials; adjuncts like motor imagery and virtual reality may enhance outcomes and motivation. Application is facilitated by user-friendly platforms, caregiver involvement, and simple modalities such as structured phone follow-up. Limitations include small samples, heterogeneous protocols, scarce long-term data, and a predominance of non-inferiority or complementary designs, warranting larger, definitive trials. This technology can lead to improved patient management at home, effortlessly verifying treatment compliance, efficacy, and safety, while simultaneously reducing the need for hospitalization, promoting a more peaceful recovery. Here, we have undertaken a narrative review of the medical–scientific literature in this field.