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"Spann, Susan"
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Blade of the samurai : a Shinobi mystery
\"Master ninja Hiro Hattori is trying to sleep when he has an unexpected visit from his friend Kazu, a fellow shinobi and member of the same ninja clan working undercover at the shogunate. Kazu says that Saburo, the Shogun's cousin, has been stabbed to death within the walls of the Shogun's palace with Kazu's dagger, and that though he is innocent, he fears he will be blamed for the murder. He begs Hiro's help in escaping the city. But before he can flee, Hiro and Father Mateo, the Jesuit priest under Hiro's protection, are summoned to the palace to aid in the investigation\"-- Provided by publisher.
Book
FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice
Dietary protein restriction is increasingly recognized as a unique approach to improve metabolic health, and there is increasing interest in the mechanisms underlying this beneficial effect. Recent work indicates that the hormone FGF21 mediates the metabolic effects of protein restriction in young mice. Here we demonstrate that protein restriction increases lifespan, reduces frailty, lowers body weight and adiposity, improves physical performance, improves glucose tolerance, and alters various metabolic markers within the serum, liver, and adipose tissue of wildtype male mice. Conversely, mice lacking FGF21 fail to exhibit metabolic responses to protein restriction in early life, and in later life exhibit early onset of age-related weight loss, reduced physical performance, increased frailty, and reduced lifespan. These data demonstrate that protein restriction in aging male mice exerts marked beneficial effects on lifespan and metabolic health and that a single metabolic hormone, FGF21, is essential for the anti-aging effect of this dietary intervention.
The restriction of dietary protein or amino acid intake is well established to extend lifespan in multiple species. Here, the authors show that the endocrine hormone FGF21 is necessary for dietary protein restriction to extend lifespan and improve metabolic health in aged, male mice.
Journal Article
Flask of the drunken master
\"August 1565: When a rival artisan turns up dead outside Ginjiro's brewery, and all the evidence implicates the brewer, master ninja Hiro Hattori and Portuguese Jesuit Father Mateo must find the killer before the magistrate executes Ginjiro and seizes the brewery, leaving his wife and daughter destitute. A missing merchant, a vicious debt collector, and a female moneylender join Ginjiro and the victim's spendthrift son on the suspect list. But with Kyoto on alert in the wake of the shogun's recent death, a rival shinobi on the prowl, and samurai threatening Hiro and Father Mateo at every turn, Ginjiro's life is not the only one in danger. Will Hiro and Father Mateo unravel the clues in time to save Ginjiro's life, or will the shadows gathering over Kyoto consume the detectives as well as the brewer? Flask of the Drunken Master is the latest entry in Susan Spann's thrilling 16th century Japanese mystery series, featuring ninja detective Hiro Hattori and Jesuit Father Mateo\"-- Provided by publisher.
Book
Preferences of Husbands and Wives for Outcomes of Prostate Cancer Screening and Treatment
OBJECTIVE: To explore the preferences of male primary care patients and their spouses for the outcomes of prostate cancer screening and treatment, and quality of life with metastatic prostate cancer. DESIGN: Cross‐sectional design. SETTING: Primary care clinics in Galveston County, Texas. PATIENTS: One hundred sixty‐eight couples in which the husband was a primary care patient and a candidate for prostate cancer screening. MEASUREMENTS AND MAIN RESULTS: Preferences were measured as utilities for treatment outcomes and quality of life with metastatic disease by the time trade‐off method for the husband and the wife individually and then conjointly for the couple. For each health state considered, husbands associated lower utilities for the health states than did their wives. Couples’ utilities fell between those of husbands and wives (all comparisons were significant at P < .01). For partial and complete impotence and mild‐to‐moderate incontinence, the median utility value for the wives was 1.0, indicating that most wives did not associate disutility with their husbands having to experience these treatment complications. CONCLUSIONS: Male primary care patients who are candidates for prostate cancer screening evaluate the outcomes of prostate cancer treatment and life with advanced prostate cancer as being far worse than do their wives. Because the choice between quantity and quality of life is a highly individualistic one, both the patient and his partner should be involved in making decisions about prostate cancer screening.
Journal Article
Duloxetine in the treatment of generalized anxiety disorder
Generalized anxiety disorder (GAD) is a relatively prevalent and disabling condition. Duloxetine, an inhibitor of both serotonin and norepinephrine, was approved by the US FDA in 2007 for the treatment of GAD. Short-term efficacy of duloxetine in dosages of 60-120 mg/day has been established in four double-blind, placebo-controlled trials of 9-10 weeks duration. Duloxetine has also been found to meet rigorous criteria for noninferiority in comparison with venlafaxine in GAD. Duloxetine has shown superiority on measures of functioning and quality of life and, compared with placebo treatment, it reduces painful physical symptoms common in GAD patients. Continuation treatment for acute treatment responders was found to prevent relapse of GAD to a significantly greater degree than placebo. In all acute and long-term trials, duloxetine was well-tolerated. This body of research suggests that duloxetine should be one of the options considered as a first-line treatment for GAD.
Journal Article
The ninja's daughter : a Hiro Hattori novel
\"Autumn, 1565: When an actor's daughter is murdered on the banks of Kyoto's Kamo River, master ninja Hiro Hattori and Portuguese Jesuit Father Mateo are the victim's only hope for justice. As political tensions rise in the wake of the shogun's recent death, and rival warlords threaten war, the Kyoto police forbid an investigation of the killing, to keep the peace--but Hiro has a personal connection to the girl, and must avenge her. The secret investigation leads Hiro and Father Mateo deep into the exclusive world of Kyoto's theater guilds, where they quickly learn that nothing, and no one, is as it seems. With only a mysterious golden coin to guide them, the investigators uncover a forbidden love affair, a missing mask, and a dangerous link to corruption within the Kyoto police department that leaves Hiro and Father Mateo running for their lives\"-- Provided by publisher.
Book
Sex-dependent association of common variants of microcephaly genes with brain structure
Loss-of-function mutations in the genes associated with primary microcephaly (MCPH) reduce human brain size by about two-thirds, without producing gross abnormalities in brain organization or physiology and leaving other organs largely unaffected [Woods CG, et al. (2005) Am J Hum Genet 76:717-728]. There is also evidence suggesting that MCPH genes have evolved rapidly in primates and humans and have been subjected to selection in recent human evolution [Vallender EJ, et al. (2008) Trends Neurosci 31:637-644]. Here, we show that common variants of MCPH genes account for some of the common variation in brain structure in humans, independently of disease status. We investigated the correlations of SNPs from four MCPH genes with brain morphometry phenotypes obtained with MRI. We found significant, sex-specific associations between common, nonexonic, SNPs of the genes CDK5RAP2, MCPH1, and ASPM, with brain volume or cortical surface area in an ethnically homogenous Norwegian discovery sample (n = 287), including patients with mental illness. The most strongly associated SNP findings were replicated in an independent North American sample (n = 656), which included patients with dementia. These results are consistent with the view that common variation in brain structure is associated with genetic variants located in nonexonic, presumably regulatory, regions.
Journal Article
Trial on Mount Koya : a Hiro Hattori novel
\"Master ninja Hiro Hattori and Jesuit Father Mateo head up to Mount Koya, only to find themselves embroiled in yet another mystery, this time in a Shingon Buddhist temple atop one of Japan's most sacred peaks. November, 1565: Master ninja Hiro Hattori and Portuguese Jesuit Father Mateo travel to a Buddhist temple at the summit of Mount Koya, carrying a secret message for an Iga spy posing as a priest on the sacred mountain. When a snowstorm strikes the peak, a killer begins murdering the temple's priests and posing them as Buddhist judges of the afterlife--the Kings of Hell. Hiro and Father Mateo must unravel the mystery before the remaining priests--including Father Mateo--become unwilling members of the killer's grisly council of the dead\"-- Provided by publisher.
Book
Concordance of Couples’ Prostate Cancer Screening Recommendations from a Decision Analysis
Objective:
To determine whether different utilities for prostate cancer screening outcomes for couples, and husbands and wives separately, lead to incongruent screening recommendations.
Methods:
We evaluated survey results of 168 married couples from three family practice centers in Texas, USA. Utilities for eight adverse outcomes of prostate cancer screening and treatment were assessed using the time trade-off method. We assessed utilities separately for each partner and jointly for each couple. Using a previously published decision-analytic model of prostate cancer screening, we input the husband’s age (starting point) and utilities for outcomes from the husband’s, wife’s, and couple’s perspectives (to adjust for quality of life). Both group-level and individualized models were run. We also asked husbands (and wives) if they intended to be screened (or have their husbands screened) for prostate cancer in the future.
Results:
Husbands’ lower tolerance for adverse outcomes (lower utilities) was associated with lower quality-adjusted life expectancy (than their wives) for the choice of screening versus not screening. Depending on the perspective, 48 husbands (28.6%), 89 wives (53.0%), and 58 couples (34.5%) preferred screening in the individual decision-analytic models. Comparing the three perspectives, agreement in model recommendations was greatest between the husbands and the couples (82.1%), intermediate between the wives and couples (63.7%), and lowest between the husbands and wives (55.4%). Using group-aggregated utilities in the decision-analytic model tended to mask the variation in recommended strategies amongst individuals. There was no relationship between screening preferences from the model and the husbands’ and wives’ reported desire for screening, as the majority of subjects wanted screening.
Conclusions:
Discordant health preferences may yield conflicting recommendations for prostate cancer screening. The results have broad implications for informed healthcare decision making for couples.
Journal Article