Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
28
result(s) for
"Sparrow, Keith"
Sort by:
Drawing manga weapons, vehicles, and accessories
This how-to guide provides techniques for drawing manga weapons, including a shuriken throwing star and dagger, katana sword, a staff, and an arm plasma cannon.
Book
Impact of Vertebral Fractures and Glucocorticoid Exposure on Height Deficits in Children During Treatment of Leukemia
Abstract
Objective
To assess the effect of vertebral fractures (VF) and glucocorticoid (GC) exposure on height deficits in children during treatment of acute lymphoblastic leukemia (ALL).
Methods
Children with ALL treated without cranial radiation therapy (n = 160; median age, 5.1 years; 58.1% male) were followed prospectively for 6 years. Spinal deformity index (SDI) was used to quantify VF status.
Results
Baseline height z score ± SD was 0.3 ± 1.2. It fell by 0.5 ± 0.4 in the first 6 months for boys and by 0.4 ± 0.4 in the first 12 months for girls (P < 0.01 for both) and then subsequently recovered. The prevalence of VF peaked at 1 year (17.6%). Among those with VF, median SDI rose from 2 [interquartile range (IQR): 1, 7] at baseline to 8 (IQR: 1, 8) at 1 year. A mixed model for repeated measures showed that height z score declined by 0.13 (95% CI: 0.02 to 0.24; P = 0.02) for each 5-unit increase in SDI during the previous 12 months. Every 10 mg/m2 increase in average daily GC dose (prednisone equivalent) in the previous 12 months was associated with a height z score decrement of 0.26 (95% CI: 0.20 to 0.32; P < 0.01).
Conclusions
GC likely plays a major role in the observed height decline during therapy for ALL. Because only a minority of children had VF, fractures could not have contributed significantly to the height deficit in the entire cohort but may have been important among the subset with VF.
This 6-year prospective cohort study shows that vertebral fractures and glucocorticoid exposure are associated with height deficits in children during treatment of acute lymphoblastic leukemia.
Journal Article
Skeletal findings in the first 12 months following initiation of glucocorticoid therapy for pediatric nephrotic syndrome
Summary
Incident vertebral fractures and lumbar spine bone mineral density (BMD) were assessed in the 12 months following glucocorticoid initiation in 65 children with nephrotic syndrome. The incidence of vertebral fractures was low at 12 months (6 %) and most patients demonstrated recovery in BMD Z-scores by this time point.
Introduction
Vertebral fracture (VF) incidence following glucocorticoid (GC) initiation has not been previously reported in pediatric nephrotic syndrome.
Methods
VF was assessed on radiographs (Genant method); lumbar spine bone mineral density (LS BMD) was evaluated by dual-energy X-ray absorptiometry.
Results
Sixty-five children were followed to 12 months post-GC initiation (median age, 5.4 years; range, 2.3–17.9). Three of 54 children with radiographs (6 %; 95 % confidence interval (CI), 2–15 %) had incident VF at 1 year. The mean LS BMD Z-score was below the healthy average at baseline (mean ± standard deviation (SD), −0.5 ± 1.1;
p
= 0.001) and at 3 months (−0.6 ± 1.1;
p
< 0.001), but not at 6 months (−0.3 ± 1.3;
p
= 0.066) or 12 months (−0.3 ± 1.2;
p
= 0.066). Mixed effect modeling showed a significant increase in LS BMD Z-scores between 3 and 12 months (0.22 SD; 95 % CI, 0.08 to 0.36;
p
= 0.003). A subgroup (
N
= 16; 25 %) had LS BMD Z-scores that were ≤−1.0 at 12 months. In these children, each additional 1,000 mg/m
2
of GC received in the first 3 months was associated with a decrease in LS BMD Z-score by 0.39 at 12 months (95 % CI, −0.71 to −0.07;
p
= 0.017).
Conclusions
The incidence of VF at 1 year was low and LS BMD Z-scores improved by 12 months in the majority. Twenty-five percent of children had LS BMD Z-scores ≤−1.0 at 12 months. In these children, LS BMD Z-scores were inversely associated with early GC exposure, despite similar GC exposure compared to the rest of the cohort.
Journal Article
Saturday: Letter: Duchy original
Charlotte Higgins reports John Whittingdale MP's comment that \"Mahler shouldn't have written works that require so many musicians\" - no doubt said tongue in cheek (24 November). But the composer Paul Drayton is ahead of the game in ingeniously reducing scores written for full orchestra.
Newspaper Article
Ultimate strength of welded joints in tubular steel structures
An experimental and theoretical investigation of the strength of welded T-joints has been carried out, and the following tests were conducted:- 17 No. tests for ultimate axial strength (Pu) 17 No. tests for ultimate bending strength (Mu) 71 No. tests for combined axial and bending strength The parameter ranges of the tests were:- brace diameter/chord diameter: 0.42, 0.53, 0.67, 0.77, 1.0 chord diameter/chord thickness: 18, 21, 23, 32 brace thickness/chord thickness: 0.63 - 1.4 All test specimens were steel to BS Grade 43C, with an average nominal yield strength of 350N/mm[sup]2. The interaction between axial and bending strength has been studied experimentally and theoretically and a relationship has been established. Formulae are proposed for calculating the ultimate axial strengths of welded T-joints and the ultimate bending strengths of welded T-joints. Numerical analysis of the experimental test results has been carried out using regression methods. A computer program has been developed to facilitate this task. Design equations have been deduced as a result of the regression analysis. A theoretical study of T-joint stress distribution under axial and bending loads has been carried out using an elastic finite element system called LUSAS, which has been developed at Imperial College, London by Dr. P. Lyons. Results have been plotted using programs developed at Kingston Polytechnic. A review of the twenty existing methods for calculating the ultimate static strengths of welded T, Y. X, K and N-joints in circular hollow steel sections has also been carried out. Calculated loads have been compared with 450 existing test loads, and the results have been analysed statistically. Each formula has been reviewed and discussed and, as a result of the statistical analysis, recommendations for design formulae for K, N and X-joints have been made.
Dissertation