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"Sperling, David"
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Budget Impact of Shifting the Treatment Setting of Unresectable Liver Metastases Associated with Primary Colorectal Cancer Using Y-90 Resin Microspheres from the Outpatient Hospital to the Office-Based Laboratory
2025
In the wake of ever-increasing health care costs, solutions are sought to make health care more affordable, such as moving hospital outpatient procedures to office-based laboratory (OBL) settings. A budget impact model was constructed to estimate the health plan cost benefit of moving 50% of yttrium-90 resin microspheres (Y-90) selective internal radiation therapy (SIRT) procedures for unresectable liver metastases associated with primary colorectal cancer (CRC) from a traditional hospital outpatient setting (HOPPS) to an OBL setting.
The eligible population was estimated using an incidence-based approach for a hypothetical health plan with 1 million covered lives. Modeled costs were based on 2024 Medicare reimbursement rates. Three treatment scenarios were considered: 1) base case HOPPS, 2) hybrid (HOPPS/OBL), and 3) OBL settings. Budget impacts were estimated as the differences in annual total cost of treatment after switching 50% of Y-90 SIRTs from HOPPS to the hybrid (HOPPS/OBL) or OBL setting. Per-member-per-month (PMPM) budget impacts were also calculated. Sensitivity analyses were conducted by varying the proportions of patients shifting settings and the treatment setting they were shifting into.
Annually, 28 patients were estimated to have metastatic CRC and unresectable liver metastases in a health plan of 1 million members. Average estimated per-patient cost savings would be $8,791 by switching one patient to a hybrid setting and $17,697 for a patient switched to the OBL. Switching 50% of eligible procedures resulted in PMPM cost benefits to the plan of $0.0102 for hybrid setting and $0.0206 for OBL. In sensitivity analyses, annual cost savings for the health plan were affected by both the proportion of patients shifted and the setting they were shifted into.
Shifting a percentage of the treatment of unresectable liver metastases with Y-90 SIRT to the OBL setting results in modest cost benefits for US health plans.
Journal Article
The Hallel Psalms (Psalms 113–118)
2024
Psalms 113–118 form the Jewish liturgical Unit known as Hallel. The present contribution is a close philological study of these Hallel Psalms, which builds upon the observation by Franz Delitzsch (1813–1890) that verbal similarity between psalms was central to the arrangement of most of the Psalter. This is particularly true of the Hallel Psalms, as this study attempts to show. The comparative philological method employed here, which stresses semantic comparison among the Semitic languages rather than etymology, I owe to my lamented teacher Moshe Held (1924–1964). Inasmuch as the Book of Psalms is part of the literature of the ancient Near East, regular reference is made to that literature, especially to the literature of ancient Mesopotamia.
Journal Article
Fabricating (Other) Computations: Digital Fabrication and Technological Appropriation in Latin America
by
Scheeren, Rodrigo
,
Herrera, Pablo C.
,
Sperling, David M.
in
21st century
,
Architecture
,
Culture
2020
This paper introduces and examines the latest and current background of digital fabrication in the context of Latin American architecture and presents updated information from the Homo Faber: Digital Fabrication in Latin America Project, which focuses on laboratories exploring the application of manufacturing technologies in architectural experiments and design objects. The results point to a context including several dynamics involving the emergence of digital craft in communities, the redesign of standard building components, the creation of mobile laboratories, experiments connecting low and high technologies, hacking practices, as well as bottom-up strategies to implement these technologies in the industry. The overall conclusion is that technology transfer and technological appropriation processes are still being carried out in the region.
Journal Article
Minimally Invasive Treatment Options for Hepatic Uveal Melanoma Metastases
2023
Uveal melanoma is one of the most common primary intraocular malignancies that accounts for about 85% of all ocular melanomas. The pathophysiology of uveal melanoma is distinct from cutaneous melanoma and has separate tumor profiles. The management of uveal melanoma is largely dependent on the presence of metastases, which confers a poor prognosis with a one-year survival reaching only 15%. Although a better understanding of tumor biology has led to the development of novel pharmacologic agents, there is increasing demand for minimally invasive management of hepatic uveal melanoma metastases. Multiple studies have already summarized the systemic therapeutic options available for metastatic uveal melanoma. This review covers the current research for the most prevalent locoregional treatment options for metastatic uveal melanoma including percutaneous hepatic perfusion, immunoembolization, chemoembolization, thermal ablation, and radioembolization.
Journal Article
Transjugular Intrahepatic Portosystemic Shunt (TIPS) Check and Revision in a Freestanding Outpatient Facility: Safety and Efficacy
2024
Aim This study aims to evaluate the safety and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) check and revision procedures performed in a freestanding interventional radiology (IR) outpatient facility. Methodology A total of 40 patients (male 31:female 9, median age 60 years old) underwent a TIPS check and/or revision at a freestanding IR outpatient facility between 2009 and 2017. Procedures were performed using a mobile C-arm unit under intravenous (IV) moderate sedation, with the patient discharged home on the same day. The decision to perform a TIPS check was based on abnormal surveillance ultrasound findings or the recurrence of portal hypertension symptoms. TIPS were revised if the patient was found to have angiographic stenosis, elevated portosystemic gradients, or recurrent symptoms. TIPS were revised with balloon angioplasty and/or bare metal stent placement. Results Revision was attempted in 34 cases, and 6 were found to not require a revision. The average time to revision was 19 months (range 0.6-99 months). Of the 40 patients, 24 (60%) underwent a TIPS check and/or revision due to findings from surveillance ultrasound, while 16 (40%) underwent a check or revision due to a recurrence of symptoms. Of the 34 TIPS revisions, 28 (83%) involved angioplasty alone, 5 (15%) were stent-assisted, and 1 failed due to unsuccessful cannulation. The overall technical success rate for performing the revisions was 94% (32/34). The one-year patency rate was approximately 57%. The mean fluoroscopy time was 16.1 minutes (range: 3.7-52.5 minutes). Post-procedural recovery time was minimal, averaging one to two hours. No major complications were observed (0%, 0/40). One patient (2.5%, 1/40) experienced a minor complication (access site hematoma), and two patients were hospitalized within 30 days for reasons unrelated to the procedure. Conclusions TIPS revision can be performed successfully and safely in an outpatient facility.
Journal Article
Leveraging Positive Psychology within a School District
2020
The purpose of this qualitative narrative case study was to describe the components of positive psychology within a Mid-Missouri school district. There is an insufficient amount of research that is focused on positive psychology in schools that link strengths- based methods to reach maximum achievement levels set by state standards. This study took a closer look at the developmental nature of positive psychology, and the impact it can have on outcomes that matter most to educators. It will add to the educational knowledge base by investigating the strengths of our educators and how that has an impact on workforce engagement. This study encompassed the advantages of investing in human capital through a strengths-based approach which leverages motivation found in positive psychology. This framework leads to the following components of Seligman (2011)’s PERMA Model: (a) Positive Emotion, (b) Engagement, (c) Relationships, (d) Meaning, and (e) Accomplishments. Through interviews, the researcher was able to discover themes aligning with positive psychology. The findings exposed the implementation of all five of Seligman (2011)’s PERMA Model, with an emphasis on relationships and engagement, in order to invest in human capital to leverage strengths- based approaches to maximize teaching and learning.
Dissertation
Fabricating Computaciones: Fabricacion Digital y Apropiacion Tecnologica en America Latina
2020
This paper introduces and examines the latest and current background of digital fabrication in the context of Latin American architecture and presents updated information from the Homo Faber: Digital Fabrication in Latin America Project, which focuses on laboratories exploring the application of manufacturing technologies in architectural experiments and design objects. The results point to a context including several dynamics involving the emergence of digital craft in communities, the redesign of standard building components, the creation of mobile laboratories, experiments connecting low and high technologies, hacking practices, as well as bottom-up strategies to implement these technologies in the industry. The overall conclusion is that technology transfer and technological appropriation processes are still being carried out in the region.
Journal Article
Fabricating (Other) Computations: Digital Fabrication and Technological Appropriation in Latin America
by
Rodrigo Scheeren
,
David Sperling
,
Pablo C. Herrera Polo
in
architectural design
,
design practice
,
digital fabrication
2020
This paper introduces and examines the latest and current background of digital fabrication in the context of Latin American architecture and presents updated information from the Homo Faber: Digital Fabrication in Latin America Project, which focuses on laboratories exploring the application of manufacturing technologies in architectural experiments and design objects. The results point to a context including several dynamics involving the emergence of digital craft in communities, the redesign of standard building components, the creation of mobile laboratories, experiments connecting low and high technologies, hacking practices, as well as bottom-up strategies to implement these technologies in the industry. The overall conclusion is that technology transfer and technological appropriation processes are still being carried out in the region.
Journal Article
Creative Power: Viktor Lowenfeld as a Jewish Refugee in the Jim Crow South
2019
This thesis explores the historical alliance between Jewish refugees, fleeing from Nazioccupied Europe, and African American art students in the Jim Crow South. Told largely from the perspective of an Austrian-Jewish art educator, Viktor Lowenfeld, and his two most celebrated students, John T. Biggers and Samella Lewis, this thesis examines how a complex culture of shared empathy emerged in the most unlikely of places in order to create politically radical works of art which challenged antisemitism and racism. Lowenfeld’s qualities as an artist were anathema to fascist ideologies which vilified Jewish intellectualism and modernist art expression, and his experiences in Vienna teaching art to the blind, considered “degenerates” by promoters of Nazism, marked the beginning of his politically subversive career. Fleeing in 1938 and finding employment at the Hampton Institute in Virginia, Lowenfeld continued to encourage political resistance through the production of art, this time within the spaces of a historically Black institution. The artistry that developed at the Hampton Institute allowed processes of identity affirmation and reclamation to occur. As Lowenfeld relied on his experiences of persecution to relate to students, he effectively strengthened and weaponized his Jewish identity, while his students used creative expression to redefine their own aesthetic and cultural heritages. This thesis reimagines the dynamic between Jewish and African American activists to include artistic, pedagogical and transnational frameworks. It challenges scholarship that colors this historical alliance with excessive pessimism, while still recognizing the strains of tension within as exemplified by Lowenfeld’s relationship with Biggers and Lewis. Furthermore, it works in opposition to myths that Jews’ participation in rising Civil Rights rhetoric and interests were motivated by desires to shed their Jewish identities and become mainstream members of white society, as the narrative instead demonstrates a reinforcement of Jewishness in Lowenfeld.
Dissertation
Miriam, Aaron and Moses: Sibling Rivalry
1999
According to Numbers 26:57—59, Miriam and Aaron are the siblings of Moses. In the pericope studied here (Num 11:35—16:16) Moses is challenged by Miriam and Aaron both with regard to his marital choice and to his superior prophetic status. The present article attempts to explicate some of the philological and thematic difficulties in the text. In the light of the archaeological data currently available, which demonstrate that none of the narrative of the Torah is historical, the study suggests that Num 11:35—16:16 is addressed to a Jewish audience of the Achaemenid Persian period; a period in which a written Torah, an innovation, was in competition with oral prophecy, an older traditional form of divine revelation. By composing a tale in which YHWH himself affirmed the superiority of his communications to Moses over his communications to other prophets, the author of the pericope was, in fact, claiming that Scripture, which contained the divine word in its clearest form, was far more reliable than prophecy orally delivered.
Journal Article