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"Srinath"
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Comparative assessment of cognitive impairment and oxidative stress markers among vitamin D insufficient elderly patients with and without type 2 diabetes mellitus (T2DM)
Disorders of mental health are known to affect cognitive functions, hence called as cognitive disorders. Impaired glucose metabolism, insulin resistance, vitamin-D deficiency and oxidative stress are some of the key early events reported to be involved in the pathogenesis of most common cognitive disorders, which include Alzheimer's disease. Type-2 diabetes mellitus (T2DM) is one of the known contributing factors of cognitive impairment and dementia.
A cross sectional study was carried out in 145 subjects, who were assessed for cognitive function by modified mini mental status examination (3MS). In addition, measurement of fasting blood sugar (FBS), fasting insulin, HbA1c, lipid profile, vitamin D and oxidative markers was performed. Participants were divided into different groups based on (a) vitamin D insufficiency and sufficiency; (b) diabetic and non-diabetic with and without cognitive impairment.
The study included a total of 145 subjects; 51 males and 94 females and the mean age was 68.24±9.70 years. Among diabetics with vitamin D insufficiency, 35 subjects (71.43%) had cognitive impairment, but, among non-diabetics with vitamin D insufficiency, 27 subjects (62.79%) had cognitive impairment. Chi square test showed no significant association between diabetes, vitamin D insufficiency and cognitive impairment. Glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels were non-significantly lower in cognition-impaired subjects, when compared to cognition normal subjects in diabetics with vitamin D insufficiency.
Our study showed that cognitive impairment is more predominant in individuals with diabetes. However, our study did not find any significant relationship between T2DM, vitamin D deficiency, cognitive impairment, and oxidative stress. A significant association was found only with GPx and 3MSE score in vitamin D insufficient non-diabetics.
Journal Article
War and peace in modern India
\"A highly researched account of security strategy in the early years of Indian independence, this book analyses conflicts pertaining to princely states and their integration within India, and to disputes with other nations, namely, Pakistan and China.\"--Provided by publisher.
Book
Food in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems
Unhealthy diets pose a greater risk to morbidity and mortality than does unsafe sex, and alcohol, drug, and tobacco use combined. Because much of the world's population is inadequately nourished and many environmental systems and processes are pushed beyond safe boundaries by food production, a global transformation of the food system is urgently needed. More than 820 million people have insufficient food and many more consume an unhealthy diet that contributes to premature death and morbidity. [...]global food production is the largest pressure caused by humans on Earth, threatening local ecosystems and the stability of the Earth system. With food production causing major global environmental risks, sustainable food production needs to operate within the safe operating space for food systems at all scales on Earth. [...]sustainable food production for about 10 billion people should use no additional land, safeguard existing biodiversity, reduce consumptive water use and manage water responsibly, substantially reduce nitrogen and phosphorus pollution, produce zero carbon dioxide emissions, and cause no further increase in methane and nitrous oxide emissions. Because food systems are a major driver of poor health and environmental degradation, global efforts are urgently needed to collectively transform diets and food production.
Journal Article
India's war : World War II and the making of modern South Asia
\"Between 1939 and 1945 India underwent irreversible change when Indians suddenly found themselves fighting in World War II, and the author paints a picture of battles abroad and life on the home front, arguing that the war is crucial to explaining why colonial rule ended in South Asia,\"--NoveList.
Book
Noncommunicable Diseases
Cardiovascular disease, cancer, chronic pulmonary disease, and diabetes are conditions that, to a large extent, do not result directly from infection. The toll from these noncommunicable diseases is the subject of this review in the Global Health series.
The United Nations has held only two meetings of heads of state on a health-related issue. The first, in 2001, was on human immunodeficiency virus infection and the acquired immunodeficiency syndrome. The second, in September 2011, was on noncommunicable diseases. Although noncommunicable diseases were ignored during the framing of the Millennium Development Goals in 2000, their leading and growing contribution to preventable deaths and disability across the globe has compelled policymakers to pay attention and initiate action. The United Nations and the World Health Organization (WHO) have called for a 25% reduction by 2025 in mortality from noncommunicable diseases among . . .
Journal Article
Fierce enigmas : a history of the United States in South Asia
\"South Asia looms large in American foreign policy. Over the past two decades, we have spent billions of dollars and thousands of human lives in the region, to seemingly little effect. As Srinath Raghavan reveals in Fierce Enigmas, this should not surprise us. For 230 years, America's engagement with India, Afghanistan, and Pakistan has been characterized by short-term thinking and unintended consequences. Beginning with American traders in India in the eighteenth century, the region has become a locus for American efforts-secular and religious-to remake the world in its image\"-- Publisher's description.
Book
Global Burden of Disease Study 2015 provides GPS for global health 2030
The latest estimates and analyses from the Global Burden of Disease Study 2015 (GBD 2015)1-7 provide a vital link between the Millennium Development Goals (MDGs) and the Sustainable Development Goals (SDGs) for 2016-30. The GBD 2015 investigators report global and national trends in various health metrics, from 1990 to 2015, and their association with levels of national development measured through a Socio-demographic Index (SDI), and profile epidemiological and health transitions across the world. GBD 2015 also measures progress on specific MDG-related indicators and non-MDG-related indicators that are included in the SDGs.1-7
Journal Article
Indira Gandhi and the years that transformed India
Indira Gandhi's ascent as prime minister of India in 1966 was entirely unforeseen. But she soon emerged as one of the most powerful political leaders of her times, who transformed the world's largest democracy. She served as prime minister for a remarkable fifteen years, leaving behind a complex and deeply controversial legacy. In this fascinating account, Srinath Raghavan tells the story of Indira Gandhi's political career and the momentous changes that India experienced under her leadership.
BOOK
Gas Turbine Heat Transfer and Cooling Technology
A comprehensive reference for engineers and researchers, this second edition focuses on gas turbine heat transfer issues and their associated cooling technologies for aircraft and land-based gas turbines. It provides information on state-of-the-art cooling technologies such as advanced turbine blade film cooling and internal cooling schemes.
eBook