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"St. James, Simone"
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Leveraging Gastrointestinal Organoids for Cancer Treatment
The basal side of these mucosoids interacts with soluble factors through the culture medium and produces mucus, similar to natural conditions. To study the effects of prolonged bacterial infections and their role in carcinogenesis, mucosoid cultures can be integrated into bioreactors or organ-on-a-chip systems that support growth in a perfused microenvironment. The figure also showcases cancer modeling techniques that use Adult Stem Cells (aSCs) combined with advanced genetic manipulation methods to study tumor development and therapeutic strategies. Recent advancements in gene editing technologies, particularly CRISPR/Cas9, have the potential to transform cancer research by providing new tools to study genetic defects in tumors.
Journal Article
Silence for the dead
\"\"Portis House emerged from the fog as we approached, showing itself slowly as a long, low shadow....\" In 1919, Kitty Weekes, pretty, resourceful, and on the run, falsifies her background to obtain a nursing position at Portis House, a remote hospital for soldiers left shell-shocked by the horrors of the Great War. Hiding the shame of their mental instability in what was once a magnificent private estate, the patients suffer from nervous attacks and tormenting dreams. But something more is going on at Portis House-its plaster is crumbling, its plumbing makes eerie noises, and strange breaths of cold waft through the empty rooms. It's known that the former occupants left abruptly, but where did they go? And why do the patients all seem to share the same nightmare, one so horrific that they dare not speak of it? Kitty finds a dangerous ally in Jack Yates, an inmate who may be a war hero, a madman or maybe both. But even as Kitty and Jack create a secret, intimate alliance to uncover the truth, disturbing revelations suggest the presence of powerful spectral forces. And when a medical catastrophe leaves them even more isolated, they must battle the menace on their own, caught in the heart of a mystery that could destroy them both\"-- Provided by publisher.
Book
Wintertime photochemistry of acyl peroxynitrates and ozone in South Korea during the ASIA-AQ campaign
Wintertime photochemical air pollution in East Asia remains poorly constrained despite its impact on regional air quality. Sources and formation pathways of acyl peroxynitrates (PANs) and ozone (O.sub.3 ), key photochemical products, are not well understood, hindering effective mitigation strategies. We investigate PANs and O.sub.3 over South Korea using observations from the ASIA-AQ campaign (February-March 2024). PANs reached 5.5 ppbv, strongly correlating with formaldehyde and particulate matter, indicating active winter photochemistry. Median PANs were higher in the mid-southern peninsula (MS; 990 pptv) and Yellow Sea (1200 pptv) than the Seoul Metropolitan Area (840 pptv). Elevated homologue-to-acetyl peroxynitrate ratios over the MS, with enhanced acryloyl peroxynitrate, acrolein, and ethylene oxide, provided tracers for petrochemical emissions and their impacts. Acetaldehyde contributed 53 %-80 % of PAN production. Ethanol was a major precursor of acetaldehyde (â¼ 50 %). Strong correlations (r.sup.2 0.8) of ethanol and halocarbons indicate industrial and solvent sources under-represented in inventories. Formaldehyde and C.sub.2+ aldehydes contributed â¼ 30 % to ozone production. Low ozone production efficiency ( 10) and radical termination dominated by nitric acid and PANs ( 80 %) indicate VOC-limited conditions. The fractional PANs contribution to NO.sub.x loss increased with decreasing OH reactivity ratio of NO.sub.2 to aldehydes, suggesting spatial increases in ozone production following NO.sub.x reductions. These findings demonstrate that a comprehensive understanding of VOC oxidation, particularly oxygenates from industrial sources, is essential for representing winter photochemistry. PANs measurements provide critical constraints on oxidation processes and their implications for emission control.
Journal Article
The haunting of Maddy Clare
\"In 1920s England, a young woman of limited means and even less experience confronts the ghost of a mysterious serving maid.... Sarah Piper's lonely threadbare existence changes when her temporary agency sends her to assist a ghost hunter. Alistair Gellis--rich, handsome, scarred by World War I, and obsessed by ghosts--has been summoned to investigate the spirit of the nineteen-year-old maid Maddy Clare, who is said to haunt the barn where she committed suicide. Maddy hated men in life, and she will not speak to them in death. But Sarah is unprepared to go alone into a haunted barn looking for the truth. She's even less prepared for the arrival of Alistair's associate, rough, unsettling Matthew Ryder, also a veteran of the trenches, whose scars go deeper than Sarah can reach. Soon, Sarah is caught up in a desperate struggle. For Maddy's ghost is no hoax--she's real, she's angry, and she has powers that defy all reason. Can Sarah and Matthew discover who Maddy was, where she came from, and what is driving her desire for vengeance...before she destroys them all?\"-- Provided by publisher.
Book
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity
The authors developed small-molecule inhibitors of STOML3 oligomerization, a membrane protein that interacts with mechanosensitive ion channels, such as Piezo2. One of these molecules was effective in silencing touch receptors and reversed touch-evoked pain associated with nerve injury or diabetic neuropathy.
The skin is equipped with specialized mechanoreceptors that allow the perception of the slightest brush. Indeed, some mechanoreceptors can detect even nanometer-scale movements. Movement is transformed into electrical signals via the gating of mechanically activated ion channels at sensory endings in the skin. The sensitivity of Piezo mechanically gated ion channels is controlled by stomatin-like protein-3 (STOML3), which is required for normal mechanoreceptor function. Here we identify small-molecule inhibitors of STOML3 oligomerization that reversibly reduce the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors
in vivo
. STOML3 inhibitors in the skin also reversibly attenuate fine touch perception in normal mice. Under pathophysiological conditions following nerve injury or diabetic neuropathy, the slightest touch can produce pain, and here STOML3 inhibitors can reverse mechanical hypersensitivity. Thus, small molecules applied locally to the skin can be used to modulate touch and may represent peripherally available drugs to treat tactile-driven pain following neuropathy.
Journal Article
Lost among the living
\"England, 1921. Three years after her husband, Alex, disappeared, shot down over Germany, Jo Manders still mourns his loss. Working as a paid companion to Alex's wealthy, condescending aunt, Dottie Forsyth, Jo travels to the family's estate in the Sussex countryside. But there is much she never knew about her husband's origins...and the revelation of a mysterious death in the Forsyths' past is just the beginning... All is not well at Wych Elm House. Dottie's husband is distant, and her son was grievously injured in the war. Footsteps follow Jo down empty halls, and items in her bedroom are eerily rearranged. The locals say the family is cursed, and that a ghost in the woods has never rested. And when Jo discovers her husband's darkest secrets, she wonders if she ever really knew him. Isolated in a place of deception and grief, she must find the truth or lose herself forever. And then a familiar stranger arrives at Wych Elm House... \"-- Provided by publisher.
Book
Insights on ozone formation sensitivity in Southeast and East Asian megacities during ASIA-AQ
Controlling ozone (O3) in rapidly urbanizing megacities in Southeast and East Asia remains a challenge. O3 is a secondary pollutant formed through nonlinear photochemical reactions with its precursors: nitrogen oxides (NOx) and volatile organic compounds (VOCs). Observation-based quantification of precursor sensitivity remains scarce, limiting actionable O3 control. To address this, we leverage airborne observations from the NASA DC-8 during the ASIA-AQ campaign conducted in February and March 2024 across four Asian megacities: Metro Manila, the Seoul Metropolitan Area, the Tainan–Kaohsiung Metropolitan Area, and the Bangkok Metropolitan Region. These extensive measurements of various trace gases were used to constrain a zero-dimensional box model and estimate the net production rates of Ox (POx, Ox = O3 + NO2). Precursor sensitivity regimes were characterized for each megacity by generating isopleths of POx across varying levels of NOx and VOCs. The analysis revealed that Manila and Tainan–Kaohsiung exhibited predominantly NOx-sensitive conditions, favoring NOx reduction as an effective O3 mitigation strategy, while Bangkok showed a more mixed sensitivity, suggesting combined NOx and VOC reductions. In contrast, Seoul exhibited a primarily VOC-sensitive regime associated with its higher NOx conditions relative to the other cities, underscoring the importance of VOC-focused strategies. In addition, to quantitatively assess sensitivity transitions, we computed orthogonal distances from the isopleth transition boundaries for all four study areas. Diurnal analyses of these distances revealed a shift from more VOC-sensitive conditions in the morning toward more NOx-sensitive regimes in the afternoon. These findings provide critical insights for formulating effective, city-specific O3 control policies in urban environments.
Journal Article