Explore the vast range of titles available.

CCAT-prime is a new 6 m crossed Dragone telescope designed to characterize the cosmic microwave background (CMB) polarization and foregrounds, measure the Sunyaev–Zel’dovich effects of galaxy clusters, map the [CII] emission intensity from the epoch of reionization (EoR), and monitor accretion luminosity over multiyear timescales of hundreds of protostars in the Milky Way. CCAT-prime will make observations from a 5600-m-altitude site on Cerro Chajnantor in the Atacama Desert of northern Chile. The novel optical design of the telescope combined with high-surface-accuracy ( < 10 μ m) mirrors and the exceptional atmospheric conditions of the site will enable sensitive broadband, polarimetric, and spectroscopic surveys at sub-millimeter to millimeter wavelengths. Prime-Cam, the first light instrument for CCAT-prime, consists of a 1.8-m-diameter cryostat that can house seven individual instrument modules. Each instrument module, optimized for a specific science goal, will use state-of-the-art kinetic inductance detector (KID) arrays operated at ∼ 100 mK and Fabry–Perot interferometers (FPI) for the EoR science. Prime-Cam will be commissioned with staged deployments to populate the seven instrument modules. The full instrument will consist of 60,000 polarimetric KIDs at a combination of 220/280/350/410 GHz, 31,000 KIDS at 250/360 GHz coupled with FPIs, and 21,000 polarimetric KIDs at 850 GHz. Prime-Cam is currently being built, and the CCAT-prime telescope is designed and under construction by Vertex Antennentechnik GmbH to achieve first light in 2021. CCAT-prime is also a potential telescope platform for the future CMB Stage IV observations.

The epoch of reionization spectrometer (EoR-Spec) is an instrument module for the Prime-Cam receiver of the 6-m aperture CCAT-prime Telescope at 5600 m in Chile. EoR-Spec will perform 158 μ m [CII] line intensity mapping of star-forming regions at redshifts between 3.5 and 8 (420–210 GHz), tracing the evolution of structure during early galaxy formation. At lower redshifts, EoR-Spec will observe galaxies near the period of peak star formation—when most stars in today’s universe were formed. At higher redshifts, EoR-Spec will trace the late stages of reionization, the early stages of galaxy assembly, and the formation of large-scale, three-dimensional clustering of star-forming galaxies. To achieve its science goals, EoR-Spec will utilize CCAT-prime’s exceptionally low water vapor site, large field of view ( ∼ 5 ∘ at 210 GHz), and narrow beam widths ( ∼ 1 arcminute at 210 GHz). EoR-Spec will be outfitted with a cryogenic, metamaterial, silicon substrate-based Fabry–Perot interferometer operating at a resolving power ( λ / Δ λ ) of 100. Monolithic dichroic arrays of cryogenic, feedhorn-coupled transition edge sensor bolometers provide approximately 6000 detectors, which are read out using a frequency division multiplexing system based on microwave SQUIDs. The novel design allows the measurement of the [CII] line at two redshifts simultaneously using dichroic pixels and two orders of the Fabry–Perot. Here we present the design and science goals of EoR-Spec, with emphasis on the spectrometer, detector array, and readout designs.

Based on far-infrared spectroscopy of a small sample of nearbyinfrared-bright and ultraluminous infrared galaxies (ULIRGs) with theISO Long Wavelength Spectrometer we find adramatic progression in ionic/atomic fine-structure emission line andmolecular/atomic absorption line characteristics in these galaxiesextending from strong [O III]52,88 km and [N III]57 km lineemission to detection of only faint [C II]158 km line emissionfrom gas in photodissociation regions in the ULIRGs. The molecularabsorption spectra show varying excitation as well, extending fromgalaxies in which the molecular population mainly occupies the groundstate to galaxies in which there is significant population in higherlevels. In the case of the prototypical ULIRG, the merger galaxy Arp220, the spectrum is dominated by absorption lines of OH, H sub(2)O, CH,and [O I]. Low [O III]88 km line flux relative to the integratedfar-infrared flux correlates with low excitation and does not appear tobe due to far-infrared extinction or to density effects. A progressiontoward soft radiation fields or very dusty H II regions may explainthese effects.

Background Electrocardiogram (ECG) signal conditioning is a vital step in the ECG signal processing chain that ensures effective noise removal and accurate feature extraction. Objective This study evaluates the performance of the FDA 510 (k) cleared HeartKey Signal Conditioning and QRS peak detection algorithms on a range of annotated public and proprietary ECG databases (HeartKey is a UK Registered Trademark of B‐Secur Ltd). Methods Seven hundred fifty‐one raw ECG files from a broad range of use cases were individually passed through the HeartKey signal processing engine. The algorithms include several advanced filtering steps to enable significant noise removal and accurate identification of the QRS complex. QRS detection statistics were generated against the annotated ECG files. Results HeartKey displayed robust performance across 14 ECG databases (seven public, seven proprietary), covering a range of healthy and unhealthy patient data, wet and dry electrode types, various lead configurations, hardware sources, and stationary/ambulatory recordings from clinical and non‐clinical settings. Over the NSR, MIT‐BIH, AHA, and MIT‐AF public databases, average QRS Se and PPV values of 98.90% and 99.08% were achieved. Adaptable performance (Se 93.26%, PPV 90.53%) was similarly observed on the challenging NST database. Crucially, HeartKey's performance effectively translated to the dry electrode space, with an average QRS Se of 99.22% and PPV of 99.00% observed over eight dry electrode databases representing various use cases, including two challenging motion‐based collection protocols. Conclusion HeartKey demonstrated robust signal conditioning and QRS detection performance across the broad range of tested ECG signals. It should be emphasized that in no way have the algorithms been altered or trained to optimize performance on a given database, meaning that HeartKey is potentially a universal solution capable of maintaining a high level of performance across a broad range of clinical and everyday use cases. A universal ECG signal processing engine with highly effective noise removal and accurate QRS detection capability enables the acquisition of medical‐grade ECG data on a wide range of ECG‐functionalized devices.

Why should Bloomingdale Township have its own road and bridge department when DuPage County already has a transportation section? And why should it have an assessor's office when county government takes care of that too? Rosie Fitzpatrick runs down the list of township services and asks: Why should Bloomingdale taxpayers send $4.4 million in property taxes to a government entity that, in her estimation, does not need to exist? As the DuPage County co-chair of a group called STOP--Send Township Officials Packing--Fitzpatrick is at the center of a lawsuit that could make it easier for counties throughout the state to dissolve their township governments. She hopes to get just such a referendum proposal onto the November ballot in DuPage. A decision on the suit could come some time after June 3.

The investigation into Dorothy Jewula's homicide centered on one of her employees Friday, the day after her body was discovered in the trunk of her car in a DeKalb parking lot. Police said they had detained a cook who worked at Jewula's Roosevelt Road Kentucky Fried Chicken in Westchester. The cook, a 19-year-old Broadview man, is believed to have been the last person to see Jewula alive, said Westchester Police Lt. Sam Pulia. He called the cook a \"material witness,\" as opposed to a suspect.

But with the grinding of a backhoe early Monday, the graves of Sarah and Emmett Dickerson were the first to be unearthed at Allerton Ridge Cemetery to make way for a planned commercial development. And even as a minister murmured prayers over their newly opened graves, village Trustee Richard Tross was heading to court, hoping to block the disinterments. A federal judge will hear his petition Tuesday morning. At issue are permits that were just obtained to move the remains of 61 people during the next two months. Ultimately, landowner Richard Heil plans to move more than 170 graves to a smaller site on the property, so he can build a 51-acre commercial development on the remaining cemetery land.

Malignant biliary obstruction is a common problem that is regarded as having a poor prognosis and is usually managed with palliation. Our aim was to investigate the survival of 182 consecutive subjects with malignant biliary obstruction where management was palliative with an [corrected] endoscopically placed biliary stent. We undertook a retrospective longitudinal study with date of death or confirmed survival of at least 23 months, as the primary end point. Diagnosis and blood indices from the 24 hr prior to first ERCP were obtained from hospital records. Of the 182 eligible subjects follow-up of date of death or confirmed survival of at least 23 months was obtained in 181 (99.5%). Of these 181 patients, 37 (20.4%) survived for more than one year. Histological confirmation was obtained in 47 of 182 subjects (25.8%). Increased age at first ERCP predicted increased survival (P < 0.05). In conclusion, in patients with malignant biliary obstruction, where management was endoscopic and palliative, 20.4% survived for more than one year with increased age at diagnosis being the only significant predictive marker.

Great uncertainty exists about the benefit of detecting breast cancer by mammography in women under 50 years of age. We have reviewed the survival of patients aged 49 years or less whose cancers were detected by mammography alone. 117 women under the age of 50 years were diagnosed with breast cancer between 1978 and 1991 based only on an abnormal mammogram. Ductal carcinoma in-situ (DCIS) was found in 47 (40%) of these women, whilst 70 (60%) had infiltrating ductal or infiltrating lobular carcinomas. During the same interval, 928 women in this age group presented with palpable breast cancer. DCIS was diagnosed in 82 (9%) of these women, whilst 846 (91%) had infiltrating carcinoma. Among the infiltrating cancers detected by mammography alone, 50% were stage I, whilst only 30% of the women with palpable cancers were stage I. Five-year survival for all mammographically detected cancer patients was 95%, whereas for women with palpable cancers the survival was 74% (p<0·00005). If DCIS is not included, the corresponding survivals are 91% for mammographically detected infiltrating cancers and 72% for palpable infiltrating cancers. Only 1 woman who died among those with palpable cancer had had a mammogram before diagnosis. Our data contradict the suggestion that women under 50 are put at a survival disadvantage by undergoing mammography. We believe that investigators who have reported negative results in this age group must examine other causes for their results.