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Resolving land disputes in East Asia : exploring the limits of law
\"Economic development and mass urbanization have unleashed unprecedented levels of land disputes in East Asia. In China and Vietnam especially, courts and other legal institutions struggle to find lasting solutions. It is against this background of legal failure that this book brings together leading scholars to understand how state agencies, land users and land developers imaginatively engage with each other to resolve disputes. Drawing on empirically rich case studies, contributors explore the limits of law and legal institutions in resolving land disputes and reveal insights into how key actors in East Asia understand land disputes. Their studies reveal promising dispute resolution practices and point to the likely ways that states will deal with land disputes in the future\"-- Provided by publisher.
Book
Desmoglein as a Target in Skin Disease and Beyond
Much of the original research on desmosomes and their biochemical components was through analysis of skin and mucous membranes. The identification of desmogleins 1 and 3, desmosomal adhesion glycoproteins, as targets in pemphigus, a fatal autoimmune blistering disease of the skin and mucous membranes, provided the first link between desmosomes, desmogleins, and human diseases. The clinical and histological similarities of staphylococcal scalded skin syndrome or bullous impetigo and pemphigus foliaceus led us to identify desmoglein 1 as the proteolytic target of staphylococcal exfoliative toxins. Genetic analysis of striate palmoplantar keratoderma and hypotrichosis identified their responsible genes as desmogleins 1 and 4, respectively. More recently, these fundamental findings in cutaneous biology were extended beyond the skin. Desmoglein 2, which is expressed earliest among the four isoforms of desmoglein in development and found in all desmosome-bearing epithelial cells, was found to be mutated in arrythmogenic right ventricular cardiomyopathy and has also been identified as a receptor for a subset of adenoviruses that cause respiratory and urinary tract infections. The story of desmoglein research illuminates how dermatological research, originally focused on one skin disease, pemphigus, has contributed to understanding the biology and pathophysiology of many seemingly unrelated tissues and diseases.
Journal Article
Nature Scripts to Promote Social Sustainability: Monetizing Wellbeing Benefits of Group-Based Nature Exposure for Young Adults with Mild to Moderate Mental Illness
The mental health of young adults is a widespread and growing concern in many communities, impacting social sustainability. At the same time, there is growing evidence of the value that nature can provide towards improving health and wellbeing. However, there is little research on the scale of the monetized value of relevant wellbeing benefits from nature exposure. Nature prescribing draws on the growing base of evidence about nature and its health and wellbeing connections, with medical practitioners and/or allied health workers providing a prescription to selected patients to participate in a program that offers interventions intended to improve participant health and/or wellbeing, using a nature setting. This paper is the first to undertake a cost–benefit analysis of nature prescribing, involving a program aimed to improve the wellbeing of young adults with mild to moderate mental illness in regional/rural Victoria, Australia. The evaluation demonstrates that a curated, group-based nature exposure program can yield significant improvement in levels of life satisfaction and mental health in this cohort. Paired sample comparisons and multiple regression analyses suggest that the program produced an increase in mean participant life satisfaction scores of ~0.7 units, measured using Personal Wellbeing Index scores. A project benefit–cost ratio of over four resulted from this. Mental health, as measured by Kessler scale scores, also showed solid improvement, and loneliness was reduced. The unique contributions of nature and of the group-based delivery mode to the measured benefits were not identifiable but the combined effect was evident, improving participants’ likelihood of social inclusion, a major social sustainability goal. Furthermore, the solid program benefit–cost ratios indicate an economically sustainable program, which uses an environmental platform (nature) for its delivery. This links all three triple bottom line sustainability outcomes to this program. Topping up group-based nature exposure, after completion of the six-session, two-hours-per-session program, was important for many participants to sustain benefit levels. Participants emphasized the importance of the program being delivered by trained professionals. Achieving involvement of a suitably sized project comparison or control group through the 8-month program evaluation period to follow-up proved challenging, which somewhat weakens the power of the evaluation findings.
Journal Article
Persistence of Anti-Desmoglein 3 IgG+ B-Cell Clones in Pemphigus Patients over Years
Pemphigus vulgaris (PV) is a prototypic tissue-specific autoantibody-mediated disease, in which anti-desmoglein 3 (Dsg3) IgG autoantibodies cause life-threatening blistering. We characterized the autoimmune B-cell response over 14 patient years in two patients with active and relapsing disease, then in one of these patients after long-term remission induced by multiple courses of rituximab (anti-CD20 antibody). Characterization of the anti-Dsg3 IgG+ repertoire by antibody phage display (APD) and PCR indicated that six clonal lines persisted in patient 1 (PV3) over 5.5 years, with only one new clone detected. Six clonal lines persisted in patient 2 (PV1) for 4 years, of which five persisted for another 4.5 years without any new clones detected. However, after long-term clinical and serologic remission, ∼11 years after initial characterization, we could no longer detect any anti-Dsg3 clones in PV1 by APD. Similarly, in another PV patient, ∼4.5 years after a course of rituximab that induced long-term remission, anti-Dsg3 B-cell clones were undetectable. These data suggest that in PV a given set of non-tolerant B-cell lineages causes autoimmune diseases and that new sets do not frequently or continually escape tolerance. Therapy such as rituximab, aimed at eliminating these aberrant sets of lineages, may be effective for disease because new ones are unlikely to develop.
Journal Article
Mobility, Social Capital and Sense of Community
Recent research by the authors has shown that increasing trip making and improving a person's social capital and sense of community is likely to reduce risks of social exclusion. That research has enabled values to be assigned to additional trip making, in the context of reducing risk of social exclusion. This paper extends that analysis to impute values to increasing a person's sense of community and social capital. The social capital extension requires strong assumptions for the derivation of values, given the available data, but the valuation of sense of community is likely to be an important new support for policy measures intended to achieve this purpose.
Journal Article