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Although economic geography has made considerable progress in explaining the emergence of new industrial development paths, a number of issues have yet to be sufficiently explored. The purpose of this article is to contribute to economic geography research on path creation by developing a conceptual framework that specifies key conditions and reinforcing mechanisms for path creation, on the one hand, and barriers to the materialization of such conditions and mechanisms, on the other hand. As such, the framework moves beyond firm-centric perspectives and argues that path creation needs to be understood as a collective endeavor incorporating both firm and nonfirm actors. By implication, this necessitates an understanding of the broader contexts that shape path creation processes, including how the dynamics of an emerging path are affected by the dynamics of established paths. The authors employ this framework to analyze Norway's offshore wind power (OWP) industry. Their analysis reveals that an initial enabling context for OWP path creation turned into more constrained conditions. Similar to findings from a number of other studies, they identify branching between related sectors as a primary path creation mechanism. However, they find that this mechanism is vulnerable to shifting contextual conditions, which for various reasons resulted in the studied emerging path losing resources and legitimacy, thus implying potential negative path interdependence. The authors also identify barriers to path creation in the institutional environment, particularly in terms of lack of policy coherence in support for key resource formation processes that are pivotal for path creation processes to generate sustained momentum.

Abstract The increasing deployment of renewable energy (RE) hinges on the development and upscaling of manufacturing and logistics capacities, offering industrial development opportunities for regions and countries. In this paper, we analyse how contextual factors pertaining to pre-existing regional assets and multi-scalar institutional environments influence RE-related industrial development at the regional scale. To this avail, we purposefully selected two contrasting regional case studies of offshore wind energy-related industry developments in Southern Denmark (a pioneering region) and Normandy (France, a latecomer region) and discuss developments until 2020. Our qualitative analysis is informed by theoretical and empirical insights from the economic geography and sustainability transitions research fields. The identified contrasting regional path creation processes reflect substantial differences in context conditions, providing insights into how regions can capture value in the ongoing energy transitions. There has been significant interest regarding the development of new regional green industries and how to promote them to achieve desired objectives, such as meeting national climate goals, industrialization and creating new green jobs. Amid this growing regional and national interest in developing new regional green industries, the paper provides novel insights regarding the key factors that can make some regions more successful while others are less successful. Graphical Abstract Graphical Abstract

Abstract The growing attention to the political goal of achieving net-zero emissions by mid-century reflects past failures to alter the trajectory of increasing greenhouse gas (GHG) emissions. As a consequence, the world now needs to decarbonize all systems and sectors at an unprecedented pace. This commentary discusses how the net-zero challenge presents transition scholarship with four enhanced research challenges that merit more attention: (1) the speed, (2) breadth and (3) depth of transitions as well as (4) tensions and interactions between these. Graphical Abstract Graphical Abstract Governments, cities and companies are increasingly adopting goals of reducing GHG emissions to net-zero by mid-century to limit global warming, but concrete and credible plans to achieve these goals are largely absent. This commentary article suggests directions for research on net-zero transitions that can ultimately inform and support formulation of concrete net-zero plans. We discuss several research topics including how transitions can move faster with attention to both new technology and new social practices and ways of living the variety of systems and sectors, the interactions between them, and the social tensions that can emerge in the face of rapid change.

The recent growing sense of urgency in dealing with societal challenges has made both scholars and practitioners focus their attention on new frames of innovation policy, and in particular-how to make them work. However, while the conceptual debate has blossomed, there is still scarce empirical evidence on the actual development and implementation of such policy. We contribute to literature on innovation policy by empirically investigating the Norwegian Pilot-E programme-an integrated policy instrument that aims to support the development of radical innovations that can contribute to solving societal challenges. With a special focus on maritime shipping, the findings show that Pilot-E ensures directionality, achieves mobilization of key actors, and accelerates the development of novel solutions as well as necessary related improvements of supporting infrastructure. However, the findings also indicate that the lack of policy coordination creates barriers for realization of the broader mission of a maritime transportation that is emission-free.

The question of how regions and nations develop new sources of industrial growth is of recurring interest in economic geography and planning studies. From an evolutionary economic geography (EEG) perspective, new growth paths emerge out of existing economic activities and their associated assets and conditions. In response to the micro-economic and endogenous focus of much EEG research, this paper utilises a broader evolutionary perspective on path creation which stresses the dynamic interplay between four sets of factors: regional assets; key economic and organisational actors; mechanisms of path creation; and multi-scalar institutional environments and policy initiatives. Reflecting the importance of extra-regional networks and institutions, this framework is also informed by the Global Production Networks (GPN) approach, which highlights the process of strategic coupling between firms and regions and its political and institutional mediation by state institutions at different spatial scales. We deploy this framework to investigate regional path creation in the context of renewable energy technologies, focusing specifically on the offshore wind industry. We adopt a comparative cross-national approach, examining the evolution of offshore wind in Germany, the UK and Norway. Of the three cases, Germany has developed the most deep-rooted and holistic path to date, characterised by leading roles in both deployment and manufacturing. By contrast, path creation in the UK and Norway has evolved in more partial and selective ways. The UK's growth path is developing in a relatively shallow manner, based largely upon deployment and 'outside in' investment, whilst Norway?s path is emerging in an exogenous, ?inside-out? fashion around a fairly confined set of actors and deployment and supply functions. In conclusion, the paper emphasises the important role of national states in orchestrating the strategic coupling of regional and national assets to particular mechanisms of pat

ObjectiveInjuries in women’s football (soccer) have scarcely been investigated, and no study has been conducted in the highest competitive level involving club teams from different countries. Our aim was to investigate the time-loss injury epidemiology and characteristics among women’s elite football players over four seasons.Methods596 players from 15 elite women’s teams in Europe were studied prospectively during the 2018/2019 to 2021/2022 seasons (44 team seasons). Medical staff recorded individual player exposure and time-loss injuries. Injury incidence was calculated as the number of injuries per 1000 playing hours and injury burden as the number of days lost per 1000 hours.Results1527 injuries were recorded in 463 players with an injury incidence of 6.7 (95% CI 6.4 to 7.0) injuries per 1000 hours and a nearly fourfold higher incidence during match play compared with training (18.4, 95% CI 16.9 to 19.9 vs 4.8, 95% CI 4.5 to 5.1; rate ratio 3.8, 95% CI 3.5 to 4.2). Thigh muscle injuries (hamstrings 12%, 188/1527, and quadriceps 11%, 171/1527) were the most frequent injury, while anterior cruciate ligament (ACL) injury had the highest burden (38.0 days lost per 1000 hours, IQR 29.2–52.1) with median days lost of 292 (IQR 246–334) days. Concussions constituted 3% (47/1527) of all injuries, with more than half of them (55%, 26/47) due to ball-related impact.ConclusionAn elite women’s football team can expect approximately 35 time-loss injuries per season. Thigh muscle injury was the most common injury and ACL injury had the highest injury burden.

Background Depression is the leading cause of global disability and can develop following the change in body image and functional capacity associated with stoma surgery. However, reported prevalence across the literature is unknown. Accordingly, we performed a systematic review and meta-analysis aiming to characterise depressive symptoms after stoma surgery and potential predictive factors. Methods PubMed/MEDLINE, Embase, CINAHL and Cochrane Library were searched from respective database inception to 6 March 2023 for studies reporting rates of depressive symptoms after stoma surgery. Risk of bias was assessed using the Downs and Black checklist for non-randomised studies of interventions (NRSIs), and Cochrane RoB2 tool for randomised controlled trials (RCTs). Meta-analysis incorporated meta-regressions and a random-effects model. Registration: PROSPERO, CRD42021262345. Results From 5,742 records, 68 studies were included. According to Downs and Black checklist, the 65 NRSIs were of low to moderate methodological quality. According to Cochrane RoB2, the three RCTs ranged from low risk of bias to some concerns of bias. Thirty-eight studies reported rates of depressive symptoms after stoma surgery as a proportion of the respective study populations, and from these, the median rate across all timepoints was 42.9% 42.9% (IQR: 24.2–58.9%). Pooled scores for respective validated depression measures (Hospital Anxiety and Depression Score (HADS), Beck Depression Inventory (BDI), and Patient Health Questionnaire-9 (PHQ-9)) across studies reporting those scores were below clinical thresholds for major depressive disorder according to severity criteria of the respective scores. In the three studies that used the HADS to compare non-stoma versus stoma surgical populations, depressive symptoms were 58% less frequent in non-stoma populations. Region (Asia–Pacific; Europe; Middle East/Africa; North America) was significantly associated with postoperative depressive symptoms ( p  = 0.002), whereas age ( p  = 0.592) and sex ( p  = 0.069) were not. Conclusions Depressive symptoms occur in almost half of stoma surgery patients, which is higher than the general population, and many inflammatory bowel disease and colorectal cancer populations outlined in the literature. However, validated measures suggest this is mostly at a level of clinical severity below major depressive disorder. Stoma patient outcomes and postoperative psychosocial adjustment may be enhanced by increased psychological evaluation and care in the perioperative period.

Objectives The aim of this study was to determine the joint association of multimorbidity and work ability with the risk of long-term sickness absence (LTSA) in the general working population. Methods Cox regression analysis censoring for competing events (statutory retirement, early retirement, disability pension, immigration, or death) was performed to estimate the joint association of chronic diseases and work ability in relation to physical and mental demands of the job with the prospective risk for LTSA (defined as ≥6 consecutive weeks during 2-year follow-up) among 10 427 wage earners from the general working population (2010 Danish Work Environment Cohort Study). Control variables were age, gender, psychosocial work environment, smoking, leisure physical activity, body mass index, job group, and previous LTSA. Results Of the 10 427 respondents, 56.8% had experienced ≥1 chronic disease at baseline. The fully adjusted model showed an association between number of chronic diseases and risk of LTSA. This association was stronger among employees with poor work ability (either physical or mental). Compared to employees with no diseases and good physical work ability, the risk estimate for LTSA was 1.95 [95% confidence interval (95% CI) 1.50-2.52] for employees with ≥3 chronic diseases and good physical work ability, whereas it was 3.60 (95% CI 2.50-5.19) for those with ≥3 chronic diseases and poor physical work ability. Overall, the joint association of chronic disease and work ability with LTSA appears to be additive. Conclusions Poor work ability combined with ≥1 chronic diseases is associated with high risk of long-term sickness absence in the general working population. Initiatives to improve or maintain work ability should be highly prioritized to secure sustainable employability among workers with ≥1 chronic diseases.

Daratumumab was associated with impressive antitumor responses, including complete and very good partial responses, in heavily pretreated patients with myeloma. Infusion reactions were the main adverse effect. Current therapies, including proteasome inhibitors and immunomodulatory agents, have improved outcomes substantially in patients with multiple myeloma. 1 Unfortunately, the majority of these patients have a relapse and have limited treatment options after exposure to these classes of agents. 2 , 3 Patients with disease that is refractory to both proteasome inhibitors and immunomodulatory drugs have poor prognoses; the estimated median overall survival is 9 months, and the estimated event-free survival is 5 months at best. 2 , 3 CD38 is a 45-kD, type II transmembrane glycoprotein that associates with cell-surface receptors in lipid rafts, regulates cytoplasmic Ca 2+ flux, and mediates signal transduction in lymphoid . . .

Major mental disorders are highly prevalent and make a substantial contribution to the global disease burden. It is known that mental disorders share clinical characteristics, and genome-wide association studies (GWASs) have recently provided evidence for shared genetic factors as well. Genetic overlaps are usually identified at the single-marker level. Here, we aimed to identify genetic overlaps at the gene level between 7 mental disorders (schizophrenia, autism spectrum disorder, major depressive disorder, anorexia nervosa, ADHD, bipolar disorder and anxiety), 8 brain morphometric traits, 2 cognitive traits (educational attainment and general cognitive function) and 9 personality traits (subjective well-being, depressive symptoms, neuroticism, extraversion, openness to experience, agreeableness and conscientiousness, children’s aggressive behaviour, loneliness) based on publicly available GWASs. We performed systematic conditional regression analyses to identify independent signals and select loci associated with more than one trait. We identified 48 genes containing independent markers associated with several traits (pleiotropy at the gene level). We also report 9 genes with different markers that show independent associations with single traits (allelic heterogeneity). This study demonstrates that mental disorders and related traits do show pleiotropy at the gene level as well as the single-marker level. The identification of these genes might be important for prioritizing further deep genotyping, functional studies, or drug targeting.