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"Stein, Mike"
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Fodor's essential Great Britain
Presents a travel guide to England, Scotland, and Wales, providing recommendations on hotels, restaurants, shopping, local transportation, sights of interest, and nightlife.
Book
Bioinformatics for cancer immunotherapy target discovery
The mechanisms of immune response to cancer have been studied extensively and great effort has been invested into harnessing the therapeutic potential of the immune system. Immunotherapies have seen significant advances in the past 20 years, but the full potential of protective and therapeutic cancer immunotherapies has yet to be fulfilled. The insufficient efficacy of existing treatments can be attributed to a number of biological and technical issues. In this review, we detail the current limitations of immunotherapy target selection and design, and review computational methods to streamline therapy target discovery in a bioinformatics analysis pipeline. We describe specialized bioinformatics tools and databases for three main bottlenecks in immunotherapy target discovery: the cataloging of potentially antigenic proteins, the identification of potential HLA binders, and the selection epitopes and co-targets for single-epitope and multi-epitope strategies. We provide examples of application to the well-known tumor antigen HER2 and suggest bioinformatics methods to ameliorate therapy resistance and ensure efficient and lasting control of tumors.
Journal Article
Quality Matters in Children's Services
Quality Matters in Children's Services brings together authoritative research to explore critical concerns for those working with vulnerable children, young people and their families. Subjects covered include reunification, stability and wellbeing, kinship care, educating vulnerable young people, child protection, domestic violence and parental substance misuse, the participation of disabled young people and advocacy services.
Mike Stein discusses key issues for policy and practice in the development of quality services including identifying and sustaining quality through involving stakeholders, integrated working and quality services, the development of policies, procedures and organisational processes and carrying out quality assessments, training and workforce reform.
This book is essential reading for practitioners, senior staff, commissioners, managers and anyone involved in developing quality children's services.
eBook
The Hands-On Guide for Junior Doctors
Are you about to start the Foundation Programme?Do you know what to expect and how to thrive?The Hands-on Guide for Junior Doctors , Fourth Edition, is the ultimate, practical guide for junior doctors and medical students.
eBook
Young people's transitions from care to adulthood : international research and practice
The transition from care into adulthood is a difficult step for any young person, but young people leaving care have a high risk of social exclusion, both in terms of material disadvantage and marginalisation.
In Young People's Transitions from Care to Adulthood leading academics gather together the latest international research relating to the transition of young people leaving care, outlining and comparing the range of legal and policy frameworks, welfare regimes and innovative practice across 16 countries. The book also highlights the variations that exist between different groups leaving care.
Featuring key messages for policy and practice, this book will give academics, practitioners and policymakers valuable insights into how to encourage resilience and improve outcomes for care leavers.
eBook
Adolescent Neglect
This book outlines how adolescent neglect differs from child neglect, the context of why it is overlooked, how it is defined, the causes and consequences of neglect, young people's views, and what professionals can do. Based on original research, the book establishes an evidence base and considers the implications for policy and practice.
eBook
Leaving Care
How can social workers best support young people as they make the transition from care to independent living? This authoritative study investigates the successes and failures of care services for young people, identifying factors that hinder effective transition from care and the types of support that help to promote positive life choices.
eBook
Leaving Care, Education and Career Trajectories
This paper explores the career trajectories of young people aged 16-19 years who were 'looked after' by local authority social service departments. This will include a discussion of four substantive areas, first of all the educational attainment of young people at the minimum school-leaving age; second the perceptions of 'looked after' young people of their educational experiences; third, young people's further education, employment and training routes and, finally, some of the influences connected with their career trajectories, as well as policy and practice recommendations. The paper is based substantially upon three 'leaving care' research studies carried out at the University of Leeds (Stein and Carey, 1986; Stein, 1990; Biehal et al., 1992). Table I presents a summary of these studies.
Journal Article
Kinship care : fostering effective family and friends placements
Children are frequently cared for by relatives and friends when parents, for whatever reason, are unable to care for their children themselves. Yet there has been very little information about how well children do when placed with kin or how safe they are in these placements.
This book compares formal kinship care to traditional foster placements in order to ascertain which children are placed with kin, in what circumstances, how well such children progress, and how often these placements disrupt. The authors explore whether children placed with family and friends fare better or worse than other foster children, what services are provided and needed, and how kin care is experienced by carers, children and social workers.
This book will be essential reading for social workers, policy makers, students and all those working with looked-after children, and will enable local authorities to make informed decisions about where best to place children and the support needed by family and friend carers.
eBook
Therapeutic Residential Care for Children and Youth
Therapeutic Residential Care For Children and Youth takes a fresh look at therapeutic residential care as a powerful intervention in working with the most troubled children who need intensive support.
Featuring contributions from distinguished international contributors, it critically examines current research and innovative practice and addresses the key questions: how does it work, what are its critical \"active ingredients\" and does it represent value for money? The book covers a broad spectrum of established and emerging approaches pioneered around with world, with contributors from the USA, Canada, Scandinavia, Spain, Australia, Israel and the UK offering a mix of practice and research exemplars. The book also looks at the research relating to critical issues for child welfare service providers: the best time to refer children to residential care, how children can be helped to make the transition into care, the characteristics of children entering and exiting care, strategies for engaging families as partners, how the substantial cost of providing intensive is best measured against outcomes, and what research and development challenges will allow therapeutic residential care to be rigorously compared with its evidence-based community-centered alternatives. Importantly, the volume also outlines how to set up and implement intensive child welfare services, considering how transferable they are, how to measure success and value for money, and the training protocols and staffing needed to ensure that a programme is effective.
This comprehensive volume will enable child welfare professionals, researchers and policymakers to develop a refined understanding of the potential of therapeutic residential care, and to identify the highest and best uses of this intensive and specialized intervention.
eBook