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91 result(s) for "Stern, Judith M"
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Putting on the brakes : understanding and taking control of your ADD or ADHD
\"Self-help guide and resource for preteens with attention deficit disorder (ADD) or attention deficit-hyperactivity disorder (ADHD). Includes strategies to manage disorder and practical ways to improve organization, focus, studying, and homework skills. Also tips for making friends, controlling emotions, and being healthy\"-- Provided by publisher.
Maternal Behavior Stimulates c-fos Activity within Estrogen Receptor Alpha-Containing Neurons in Lactating Rats
Estradiol and other hormones are thought to be critical for the onset, but not maintenance, of maternal behavior in rats. Maternal behavior is instead maintained postpartum by tactile stimulation that dams receive during interactions with pups, and many neural sites implicated in the control of maternal behavior show elevated c-fos activity in response to this stimulation. Many of these sites also contain neurons that express the alpha subtype of the estrogen receptor (ERα). Because of possible interactions between tactile stimulation from pups, c-fos, and ERα in the lactating rat brain, we determined if populations of cells that show increased c-fos activity after maternal behavior in lactating rats also contain ERα. Dams were separated from their pups for 48 h beginning on day 5 postpartum. On day 7 postpartum, experimental dams were reunited with pups and mother-litter interactions were observed for 60 min. Control dams received no pup stimulation. Subjects were sacrificed 60 min later and brain sections were double immunolabeled for the Fos and ERα proteins. As expected, the number of ERα-immunoreactive (ERα-ir) neurons did not differ between the two groups in the eight areas analyzed (lateral region of the lateral septum, posterodorsal medial amygdala, dorsal and ventral medial preoptic area, dorsal and ventral bed nucleus of the stria terminalis, lateral habenula, and ventrolateral caudal periaqueductal gray). Consistent with previous reports, maternal dams had 2- to 7-fold more Fos-immunoreactive (Fos-ir) neurons in these sites compared with nonstimulated controls. Maternal dams had significantly more Fos-ir neurons that also contained ERα-ir in all sites, with the greatest increases in the ventral medial preoptic area, lateral habenula, and ventral bed nucleus of the stria terminalis. Between ∼25 and 45% of the Fos-ir cells in the sites examined also expressed ERα. Thus, a substantial number of neurons that are genomically activated during maternal behavior contain ERα, raising the possibility that the postpartum display of maternal behavior can be influenced by ERα activity.
Traumatic brain injury: An effect and cause of domestic violence and child abuse
In sum, physicians and other healthcare professionals should play a more effective role in reducing the impact of CA and DV by instituting in their practices, and encouraging in their local hospitals, a routine screening for and assessment of physical abuse that is thorough enough to detect TBI. Longitudinal studies of victims with and without TBI would greatly buttress findings based on retrospective self-reports. Knowledge and awareness of domestic abuse by physicians would be heightened by courses in medical school and beyond and facilitated by a recent book [37] and a video [38] on violence against women from the American College of Physicians. Surely the modest costs in time and money of these efforts are worth the long-term benefits of reducing the enormous individual and societal costs of domestic abuse.[PUBLICATION ABSTRACT]
Androgen Accumulation and Binding to Macromolecules in Seminal Vesicles: Inhibition by Cyproterone
Cyproterone reduces the accumulation of testosterone and dihydro-testosterone in seminal vesicles 30 minutes after intravenous administration of tritiated testosterone to castrated rats. Testosterone, added in vitro, binds to macromolecules from the supernatant fraction of the seminal vesicle homogenates; this interaction is antagonized competitively by cyproterone. Cyproterone may diminish androgenic effects by competition for binding molecules.